双重刺激响应纳米胶囊的制备及其在药物递送系统中的应用
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- 英文论文题名：Dual stimuli-responsive polymer nanocapsules as nanocarrier for triggered drug delivery system
- 论文作者：赵亭亭 ; 周鹏 ; 丁岩 ; 王静文 ; 席国圆 ; 杨文静 ; 汪联辉
- 英文论文作者：Tingting Zhao ; Peng Zhou ; Yan Ding ; Jingwen Wang ; Guoyuan Xi ; Wen Jing Yang ; Lianhui Wang ; Institute of Advanced Materials (IAM) ; Nanjing University of Posts & Telecommunications
- 年：2016
- 作者机构：南京邮电大学信息材料与纳米技术研究院;
- 论文关键词：药物递送 ; 回流沉淀聚合 ; 点击化学
- 英文论文关键词：Drug delivery ; Reflux-precipitation polymerization ; Click chemistry
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第三十八分会：纳米生物效应与纳米药物化学
- 语种：中文
- 分类号：R943;TB383.1
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第三十八分会 ; 纳米生物效应与纳米药物化学
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：191k
- 原文格式：D
- 会议级别：全国
摘要
纳米材料由于其独特的物理和化学性质,在许多领域中应用广泛,尤其在药物递送系统中具有巨大的潜力和优势[1]。本文通过两步回流沉淀聚合法[2]制备了"可点击"的双重刺激响应聚合物(聚(N-异丙基丙烯酰胺-co-甲基丙烯酸丙炔基酯)(P(NIPAM-co-PMA)))纳米胶囊,用于抗癌药物的智能传输和肿瘤细胞的靶向治疗。该纳米胶囊表面具有大量炔基官能团,可通过点击反应进行表面的多功能化,如连接各种靶向识别分子实现对癌细胞的靶向治疗作用。基于P(NIPAM)的温敏性,可实现纳米胶囊在温度刺激下的药物释放行为;同时纳米胶囊具有氧化还原刺激响应,在肿瘤细胞的还原环境中也具有快速释放药物的特性。通过透射电镜、扫描电镜、红外吸收光谱和动态光散射等对纳米胶囊进行表征,胶囊直径约为200 nm,尺寸均一,分散性较窄。将阿霉素作为模型抗癌药物,载药率达到80%,载药量达到92%。结果表明这种"可点击"、具有双重刺激响应的纳米胶囊在药物递送系统和癌症治疗方面具有潜在的应用前景。
Various nano-vehicles, such as micelles, nanoparticles and nanocapsules, have shown tremendous potential in drug delivery applications. Design of dual/multiple stimuli-responsive nanocapsules with tumor targeting ability provides a promising means for intelligent drug delivery system. In the present work, "clickable" nanocapsules with dual stimuli-responsive properties were developed for targeted drug delivery. The redox/temperature stimuli-responsive poly(N-isopropyl acrylamide-co-propargyl methacrylate)(P(NIPAM-co-PMA)) nanocapsules were prepared through a two-stage reflux-precipitation polymerization. As characterized by transmission electron microscopy(TEM), the resultant polymer nanocapsules show a size of the about 200 nm with spherical shape. The anti-cancer drug doxorubicin(Dox) was loaded efficiently into the nanocapsules. The loaded drug was released rapidly in response to the reducing intracellular environment and higher temperature inside of the tumor cells. Therefore, the redox/temperature stimuli-responsive P(NIPAM-co-PMA) nanocapsules can be employed as a promising drug delivery nanocarrier.
Various nano-vehicles, such as micelles, nanoparticles and nanocapsules, have shown tremendous potential in drug delivery applications. Design of dual/multiple stimuli-responsive nanocapsules with tumor targeting ability provides a promising means for intelligent drug delivery system. In the present work, "clickable" nanocapsules with dual stimuli-responsive properties were developed for targeted drug delivery. The redox/temperature stimuli-responsive poly(N-isopropyl acrylamide-co-propargyl methacrylate)(P(NIPAM-co-PMA)) nanocapsules were prepared through a two-stage reflux-precipitation polymerization. As characterized by transmission electron microscopy(TEM), the resultant polymer nanocapsules show a size of the about 200 nm with spherical shape. The anti-cancer drug doxorubicin(Dox) was loaded efficiently into the nanocapsules. The loaded drug was released rapidly in response to the reducing intracellular environment and higher temperature inside of the tumor cells. Therefore, the redox/temperature stimuli-responsive P(NIPAM-co-PMA) nanocapsules can be employed as a promising drug delivery nanocarrier.
引文
[1]Chiang,W.H.,Ho,V.T.,Huang,W.C.,Chiu,H.C.Langmuir 2012,28,15056.
[2]Wang,F.,Zhang,Y.T.,Yang,P.,Jin,S.,Meng,Y.,Wang,C.C.J.Mater.Chem.B 2014,2,2575.
[2]Wang,F.,Zhang,Y.T.,Yang,P.,Jin,S.,Meng,Y.,Wang,C.C.J.Mater.Chem.B 2014,2,2575.