Red light still alters sleep-wake behavior until the intensity as low as 10 lx in mice
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- 英文论文题名：Red light still alters sleep-wake behavior until the intensity as low as 10 lx in mice
- 论文作者：Ze Zhang ; Hui-Jing Wang ; Wei-Min Qu ; Zhi-Li Huang
- 英文论文作者：Ze Zhang ; Hui-Jing Wang ; Wei-Min Qu ; Zhi-Li Huang ; Institutes of Brain Science and Collaborative Innovation Center for Brain Science ; Department of Pharmacology ; and State Key Laboratory of Medical Neurobiology ; Shanghai Medical College ; Fudan University
- 年：2016
- 作者机构：Institutes of Brain Science and Collaborative Innovation Center for Brain Science,Department of Pharmacology,and State Key Laboratory of Medical Neurobiology,Shanghai Medical College,Fudan University;
- 英文论文关键词：circadian ; light ; LED ; masking
- 会议召开时间：2016-05-27
- 会议录名称：中国睡眠研究会第九届学术年会汇编
- 语种：英文
- 分类号：R338
- 学会代码：OGSF
- 会议名称：中国睡眠研究会第九届学术年会
- 会议地点：中国上海
- 主办单位：中国睡眠研究会
- 学会名称：中国睡眠研究会
- 页数：1
- 文件大小：909k
- 原文格式：O
- 会议级别：全国
摘要
Sleep is regulated by two mechanisms,the homeostatic process and the circadian rhythm.Light affects sleep and alertness by entraining the circadian clock and inducing sleep/alertness acutely,which is mediated by intrinsically photosensitive retinal ganglion cells.Because intrinsically photosensitive retinal ganglion cells are believed to be minimally sensitive to red light,red light is widely used for illumination to reduce the photic disturbance to nocturnal animals during the dark phase.However,the appropriate intensity for the red light is unknown.In the present study,we recorded electroencephalogram and electromyogram in freely moving mice to investigate the effects of red light emitted by light-emitting diode lights with different intensities and illuminating durations on sleep-wake behavior in mice.White light was used as a control.Unexpectedly,red light also exerted potent sleep-inducing effects and changed the sleep architectures in terms of sleep episode duration and number,sleep latency and stage transition when the intensity was greater than 20 lx.Subsequently,we lowered light intensity and demonstrated that red light to the extent of 10 lx could not affect sleep-wake behavior.White light induced sleep and disrupted sleep architecture markedly even if the intensity was as low as 10 lx.Our findings highlight the importance of intensity limitation of red light(≤10 lx) to avoid optical influence in nocturnal behavioral experiments,particularly in the field of sleep and circadian researches.
Sleep is regulated by two mechanisms,the homeostatic process and the circadian rhythm.Light affects sleep and alertness by entraining the circadian clock and inducing sleep/alertness acutely,which is mediated by intrinsically photosensitive retinal ganglion cells.Because intrinsically photosensitive retinal ganglion cells are believed to be minimally sensitive to red light,red light is widely used for illumination to reduce the photic disturbance to nocturnal animals during the dark phase.However,the appropriate intensity for the red light is unknown.In the present study,we recorded electroencephalogram and electromyogram in freely moving mice to investigate the effects of red light emitted by light-emitting diode lights with different intensities and illuminating durations on sleep-wake behavior in mice.White light was used as a control.Unexpectedly,red light also exerted potent sleep-inducing effects and changed the sleep architectures in terms of sleep episode duration and number,sleep latency and stage transition when the intensity was greater than 20 lx.Subsequently,we lowered light intensity and demonstrated that red light to the extent of 10 lx could not affect sleep-wake behavior.White light induced sleep and disrupted sleep architecture markedly even if the intensity was as low as 10 lx.Our findings highlight the importance of intensity limitation of red light(≤10 lx) to avoid optical influence in nocturnal behavioral experiments,particularly in the field of sleep and circadian researches.
Sleep is regulated by two mechanisms,the homeostatic process and the circadian rhythm.Light affects sleep and alertness by entraining the circadian clock and inducing sleep/alertness acutely,which is mediated by intrinsically photosensitive retinal ganglion cells.Because intrinsically photosensitive retinal ganglion cells are believed to be minimally sensitive to red light,red light is widely used for illumination to reduce the photic disturbance to nocturnal animals during the dark phase.However,the appropriate intensity for the red light is unknown.In the present study,we recorded electroencephalogram and electromyogram in freely moving mice to investigate the effects of red light emitted by light-emitting diode lights with different intensities and illuminating durations on sleep-wake behavior in mice.White light was used as a control.Unexpectedly,red light also exerted potent sleep-inducing effects and changed the sleep architectures in terms of sleep episode duration and number,sleep latency and stage transition when the intensity was greater than 20 lx.Subsequently,we lowered light intensity and demonstrated that red light to the extent of 10 lx could not affect sleep-wake behavior.White light induced sleep and disrupted sleep architecture markedly even if the intensity was as low as 10 lx.Our findings highlight the importance of intensity limitation of red light(≤10 lx) to avoid optical influence in nocturnal behavioral experiments,particularly in the field of sleep and circadian researches.
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