Site-directed mutagenesis and codon optimization of Rhizopus oryzae pyruvate carboxylase in combination with CO_2 supplementation in fermentation broth elevate fumaric acid biosynthesis in engineered Saccharomyces cerevisiae cells
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- 英文论文题名：Site-directed mutagenesis and codon optimization of Rhizopus oryzae pyruvate carboxylase in combination with CO_2 supplementation in fermentation broth elevate fumaric acid biosynthesis in engineered Saccharomyces cerevisiae cells
- 论文作者：Guoqiang Xu ; Yang Liu ; Pengyue Li ; Manzhen Wu ; Linghuo Jiang
- 英文论文作者：Guoqiang Xu ; Yang Liu ; Pengyue Li ; Manzhen Wu ; Linghuo Jiang ; The Key Laboratory of Industrial Biotechnology ; Ministry of Education ; School of Biotechnology ; Jiangnan University ; National Engineering Laboratory for Cereal Fermentation Technology ; Jiangnan University ; School of Biotechnology ; Jiangnan University
- 年：2016
- 作者机构：The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology,Jiangnan University;National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University;School of Biotechnology,Jiangnan University;
- 英文论文关键词：Fumaric acid ; Saccharomyces cerevisiae ; pyruvate carboxylase ; site-saturation mutagenesis ; CO_2
- 会议召开时间：2016-06-17
- 会议录名称：第九届中国模式真菌研讨会摘要集
- 语种：英文
- 分类号：TQ921
- 学会代码：IGSS
- 会议名称：第九届中国模式真菌研讨会
- 会议地点：中国上海
- 主办单位：中国遗传学会微生物遗传学专业委员会、中国生物化学与分子生物学会基因专业委员会
- 学会名称：中国生物化学与分子生物学会
- 页数：1
- 文件大小：312k
- 原文格式：D
- 会议级别：全国
摘要
Dicarboxylic acids are widely used organic acids in food,pharmaceutical and chemical industries.Pyruvate carboxylase plays a pivotal role in production of dicarboxylic acids.In this study,we have constructed a synthetic pathway of fumaric
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