叶酸吸收代谢途径基因多态性与新生儿出生缺陷的相关性分析
详细信息 查看官网全文
- 英文论文题名：Folic acid absorption metabolic pathway gene polymorphism and correlation analysis of birth defects
- 论文作者：潘慧
- 英文论文作者：Pan Hui
- 年：2017
- 作者机构：四川仁寿县妇幼保健院妇女保健科;
- 论文关键词：叶酸 ; 代谢途径 ; 新生儿缺陷 ; 新生儿护理
- 英文论文关键词：Folic acid ; Metabolic pathways ; Birth defects
- 会议召开时间：2017-05-26
- 会议录名称：2017年《中国组织化学与细胞化学杂志》临床研讨会论文集
- 语种：中文
- 分类号：R174
- 学会代码：ZHXB
- 会议名称：2017年《中国组织化学与细胞化学杂志》临床研讨会
- 会议地点：中国湖北武汉
- 主办单位：《中国组织化学与细胞化学杂志》社有限公司
- 学会名称：《中国组织化学与细胞化学杂志》社有限公司
- 页数：1
- 文件大小：107k
- 原文格式：O
- 会议级别：全国
摘要
目的:观察叶酸吸收代谢途径基因的多态性与新生儿出生缺陷的相关性。方法:回顾性分析我院妇产科收治110例的孕产妇,根据其妊娠初期增补叶酸的情况分为叶酸增补组和未增补组,比较两组产妇不同孕期的新生儿一般情况,并分析两组新生儿的缺陷类型和妊娠结局。结果:两组在分娩方式、妊娠期高血压、妊娠期糖尿病之间的差异无统计学意义(P>0.05)。增补组的总畸形率明显低于未增补组(P<0.05)。两组的婴儿出生体重和身长差异有统计学意义(P<0.05)。讨论:叶酸缺乏会增加新生儿出生缺陷的概率,及新生儿的体重和身长有关,因此,孕妇补充适量的叶酸是减低新生儿出生缺陷率的关键措施。
Objective:Investigate the relationship between the genetic polymorphisms of folate uptake and metabolism pathway and neonatal birth defects.Methods:a retrospective analysis of pregnant women from June 2014 to June 2016 in our hospital from 110 cases,according to the early pregnancy folic acid of folic acid supplement group(70 cases) and no supplementation group(40 cases),two groups were compared in different periods of pregnancy in general,and analyze the defect types and two groups of neonates the relationship between pregnancy outcome;statistical supplement group of plasma and erythrocyte folate levels and neonatal body weight,body length,head circumference.Result:there was no significant difference between the two groups in the mode of delivery,gestational hypertension,gestational diabetes mellitus(P > 0.05).The total malformation rate of the supplement group was significantly lower than that of the non supplemented group(P < 0.05).Birth weight and length difference between the two groups of infants were statistically significant(P < 0.05);the two groups had no statistical significance in early pregnancy,pregnancy baby weight,length and head circumference difference(P > 0.05).With the changes in erythrocyte folate levels in neonatal birth weight and birth length correlation(P < 0.05).Discuss:the lack of folic acid will increase the probability of birth defects,and neonatal weight and length,therefore,the amount of folic acid supplementation of pregnant women is a key measure to reduce the rate of birth defects.
Objective:Investigate the relationship between the genetic polymorphisms of folate uptake and metabolism pathway and neonatal birth defects.Methods:a retrospective analysis of pregnant women from June 2014 to June 2016 in our hospital from 110 cases,according to the early pregnancy folic acid of folic acid supplement group(70 cases) and no supplementation group(40 cases),two groups were compared in different periods of pregnancy in general,and analyze the defect types and two groups of neonates the relationship between pregnancy outcome;statistical supplement group of plasma and erythrocyte folate levels and neonatal body weight,body length,head circumference.Result:there was no significant difference between the two groups in the mode of delivery,gestational hypertension,gestational diabetes mellitus(P > 0.05).The total malformation rate of the supplement group was significantly lower than that of the non supplemented group(P < 0.05).Birth weight and length difference between the two groups of infants were statistically significant(P < 0.05);the two groups had no statistical significance in early pregnancy,pregnancy baby weight,length and head circumference difference(P > 0.05).With the changes in erythrocyte folate levels in neonatal birth weight and birth length correlation(P < 0.05).Discuss:the lack of folic acid will increase the probability of birth defects,and neonatal weight and length,therefore,the amount of folic acid supplementation of pregnant women is a key measure to reduce the rate of birth defects.
引文
[1]刘菊芬,任爱国.口服避孕药添加叶酸:育龄妇女增补叶酸的新途径[J].中国生育健康杂志,2015,15(2):181-183,187.
[2]魏亮瑜,栾晓林,孙鹏程,等.新生儿出生缺陷类型医疗纠纷的探讨[J].中华医院管理杂志,2014,30(6):444-446.
[3]徐叶清,翁婷婷,严双琴,等.增补叶酸与孕期抑郁相关性的队列研究[J].中华流行病学杂志,2014,23(6):641-645.
[2]魏亮瑜,栾晓林,孙鹏程,等.新生儿出生缺陷类型医疗纠纷的探讨[J].中华医院管理杂志,2014,30(6):444-446.
[3]徐叶清,翁婷婷,严双琴,等.增补叶酸与孕期抑郁相关性的队列研究[J].中华流行病学杂志,2014,23(6):641-645.