护胰汤对急性胰腺炎患者血清TNF-α、IL-8水平的影响
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- 论文作者：朱锦腾 ; 王银娘 ; 沈益君 ; 马腾飞 ; 林介贤 ; 李力农 ; 赵汉鹏 ; 万进
- 年：2016
- 作者机构：深圳市宝安区中医院外科;
- 论文关键词：胰腺炎 ; TNF-α ; IL-8
- 英文论文关键词：acute pancreatitis ; tumor necrosis factor-α ; interleukin-8
- 会议召开时间：2016-11-25
- 会议录名称：湖南中医药大学学报2016/专集：国际数字医学会数字中医药分会成立大会暨首届数字中医药学术交流会论文集
- 语种：中文
- 分类号：R576
- 学会代码：HNZY
- 会议名称：国际数字医学会数字中医药分会成立大会暨首届数字中医药学术交流会
- 会议地点：中国广东珠海
- 主办单位：国际数字医学会、Digital Chinese Medicine
- 学会名称：湖南中医药大学期刊杂志社
- 页数：1
- 文件大小：2016k
- 原文格式：D
- 会议级别：全国
摘要
目的系统研究护胰汤灌肠法对急性胰腺炎的疗效,揭示其临床规律,为临床治疗急性胰腺炎提供安全、可靠、有效的新方法,以便推广运用。方法 48例急性胰腺炎患者,随机分为治疗组和对照组各24例。对照组进行常规西医治疗方案,包括禁食、持续胃肠减压、生长抑素抑制胰腺外分泌功能、抑酸、补液、补充水电解质、抗感染、对症及营养支持的治疗。治疗组在对照组治疗的基础上,同时加用护胰汤灌肠。分别记录患者治疗前(发病24h内)及发病后第2、4、7天APACHE II评分、血清TNF-α、IL-8的水平。并对以上数据进行统计学分析。结果治疗组的总体疗效91.67%明显优于对照组总体疗效83.33%(P<0.05),治疗组达到痊愈标准的患者(3例)比对照组痊愈患者(1例)多。两组患者的APACHE II评分及血清TNF-α、IL-8水平均在治疗前最高,经治疗后逐渐下降。两组比较,治疗组在第2d、第4d、第7d,各项观察指标的下降幅度均较对照组的快(P<0.05)。治疗组在第7d的各观察指标基本下降至正常范围,而对照组的各项观察指,在第7天时仍明显超出正常值。结论在传统西医治疗的基础上加用护胰汤灌肠,可以提高急性胰腺炎的疗效,可有效降低急性胰腺炎患者的APACHE II评分及血清TNF-α、IL-8水平,有助于急性胰腺炎病情的恢复,可明显改善疾病的预后。
Objective System research to protect the pancreatic decoction enema approach curative effect of acute pancreatitis, reveal the clinical rule, for clinical treatment of acute pancreatitisto provide safe, reliable and effective new approach, in order to promote application. Methods The 48 patients with acute pancreatitis, were randomly divided into treatment group and control group(n = 24). Conventional western medicine treatment control group, including fast, continuous gastrointestinal decompression, somatostatin inhibiting pancreatic exocrine function, acid suppression, rehydration, supplement water electrolyte, anti-infection, symptomatic and nutritional support treatment. On the basis of the treatment group in the control group therapy and add enema with pancreatic guard soup.(within 24 h of the records of patients before treatment respectively) and 2, 4, 7 days after the onset Acute Physiology and Chronic Health Evaluation II(APACHE II) score, the levels of serum TNF-α, IL- 8. And the above data for statistical analysis. Results The overall efficacy of treatment group 91.67% overall curative effect was better than control group 83.33%(P < 0.05), treatment group reachedstandard recovery of patients(3 cases) than the control group recovered patients(1 case). Two groups of patients with APACHE II score and the level of serum TNF-α, IL- 8 highest before treatment, aftertreatment gradually decline. Comparing the two groups, the treatment group in 2 d, 4 d, 7 d, drop the observation indexes were faster than in the control group(P < 0.05). Treatment group on the 7 d eachobservation index of basic descend to the normal range, and the control group refers to the observation, are still significantly above normal in 7 days. Conclusion On the basis of conventional westernmedicine therapy plus enema with pancreatic guard soup, can improve the curative effect of acute pancreatitis, can effectively reduce the patients with acute pancreatitis APACHE II score and the serumTNF-α, IL- 8 levels, contributes to the recovery of acute pancreatitis condition, can significantly improve the prognosis of the disease.
Objective System research to protect the pancreatic decoction enema approach curative effect of acute pancreatitis, reveal the clinical rule, for clinical treatment of acute pancreatitisto provide safe, reliable and effective new approach, in order to promote application. Methods The 48 patients with acute pancreatitis, were randomly divided into treatment group and control group(n = 24). Conventional western medicine treatment control group, including fast, continuous gastrointestinal decompression, somatostatin inhibiting pancreatic exocrine function, acid suppression, rehydration, supplement water electrolyte, anti-infection, symptomatic and nutritional support treatment. On the basis of the treatment group in the control group therapy and add enema with pancreatic guard soup.(within 24 h of the records of patients before treatment respectively) and 2, 4, 7 days after the onset Acute Physiology and Chronic Health Evaluation II(APACHE II) score, the levels of serum TNF-α, IL- 8. And the above data for statistical analysis. Results The overall efficacy of treatment group 91.67% overall curative effect was better than control group 83.33%(P < 0.05), treatment group reachedstandard recovery of patients(3 cases) than the control group recovered patients(1 case). Two groups of patients with APACHE II score and the level of serum TNF-α, IL- 8 highest before treatment, aftertreatment gradually decline. Comparing the two groups, the treatment group in 2 d, 4 d, 7 d, drop the observation indexes were faster than in the control group(P < 0.05). Treatment group on the 7 d eachobservation index of basic descend to the normal range, and the control group refers to the observation, are still significantly above normal in 7 days. Conclusion On the basis of conventional westernmedicine therapy plus enema with pancreatic guard soup, can improve the curative effect of acute pancreatitis, can effectively reduce the patients with acute pancreatitis APACHE II score and the serumTNF-α, IL- 8 levels, contributes to the recovery of acute pancreatitis condition, can significantly improve the prognosis of the disease.
引文
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[5]刘志鹏,邹利权,游斌血清TNF-α、s TNF-1R及IL-10在急性胰腺炎中的变化及意义[J].重庆医学报,2011,40(5):433-437.
[2]Lankisch;Paul Ceorg MD;Bruns Anja MD,et al.The Second Attack of Acute Pancreatitis Is Not Harmless[J].Pancreas,2008,36(3):207-208.
[3]李智,韩文斌,等.清胰解毒汤为主治疗重症胰腺炎41例[J].陕西中医报,2009,30(9)1107-1108.
[4]Halonen KI,Pettila V,Leppaniemi AK,et al.Mutiple organ disfuntionassociated with severe acute pancreatitis[J].Crit Care Med,2002,30(6):1274-1279.
[5]刘志鹏,邹利权,游斌血清TNF-α、s TNF-1R及IL-10在急性胰腺炎中的变化及意义[J].重庆医学报,2011,40(5):433-437.