柔性纳米神经电极技术的发展及应用
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- 英文论文题名：Soft nanoscale materials and electronics for neural interfacing
- 论文作者：段小洁 ; 路林林 ; 付雪峰 ; 殷荣康 ; 徐政 ; 张菁 ; 张永毅
- 英文论文作者：Xiaojie Duan ; Linlin Lu ; Xuefeng Fu ; Rongkang Yin ; Zheng Xu ; Jing Zhang ; Yongyi Zhang ; Department of Biomedical Engineering ; College of Engineering ; Peking University ; Suzhou Institute of Nano-Tech and Nano-Bionics (SINANO) ; Chinese Academy of Sciences
- 年：2016
- 作者机构：北京大学;中国科学院苏州纳米技术与纳米仿生研究所;
- 论文关键词：柔性电子学 ; 低维碳材料 ; 神经电极 ; 神经记录和刺激
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第四十一分会：纳米材料与器件
- 语种：中文
- 分类号：R318;O613.71
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第四十一分会 ; 纳米材料与器件
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：142k
- 原文格式：D
- 会议级别：全国
摘要
近年来,由于其潜在的高生物相容性和高密度集成能力,基于柔性材料和柔性电子学的神经技术受到了广泛的关注。本工作制备了基于低维碳纳米材料包括碳纳米管和石墨烯的具有高度柔性的大脑植入电极和表面电极,发展了柔性电极向大鼠大脑的高效植入方法。利用柔性电极,成功的记录到了高信噪比的局域场电位和单个神经元放电的动作电位信号,信号可在数周内持续记录。组织学研究表明,相对于同尺寸的传统非柔性电极,柔性电极周围无明显的神经元空缺区域和胶质细胞聚集,这与神经元放电的慢性连续记录结果一致。电生理记录和组织学研究从两方面证明了碳基柔性神经电极的高生物相容性,此高生物相容性使得碳基柔性电极在神经信号的长期记录中有巨大的应用潜力。
Currently, there is intense interest in the development of materials and electronic devices that can extend and/or provide new capabilities for probing neural circuitry and providing long-term minimally invasive brain-electronics interfaces. Here, we report the design, fabrication and demonstration of novel neural electrodes that combine small size and high flexibility based on low-dimensional carbon materials. These highly flexible electrodes were used to record single-unit action potentials and local field potentials from rat hippocampus. Significantly, histology studies show that these electrodes exhibit high biocompatibility as evidenced by the close proximity of neurons to the electrodes. These studies suggest that nanoscale flexible neural electrodes can provide new opportunities for neural activity mapping and implants for next generation brain-machine interfaces.
Currently, there is intense interest in the development of materials and electronic devices that can extend and/or provide new capabilities for probing neural circuitry and providing long-term minimally invasive brain-electronics interfaces. Here, we report the design, fabrication and demonstration of novel neural electrodes that combine small size and high flexibility based on low-dimensional carbon materials. These highly flexible electrodes were used to record single-unit action potentials and local field potentials from rat hippocampus. Significantly, histology studies show that these electrodes exhibit high biocompatibility as evidenced by the close proximity of neurons to the electrodes. These studies suggest that nanoscale flexible neural electrodes can provide new opportunities for neural activity mapping and implants for next generation brain-machine interfaces.
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