基于一维声表面波芯片的二维操控研究
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- 英文论文题名：Research on two-dimensional manipulation by one-dimensional surface acoustic wave device
- 论文作者：周伟 ; 王凯悦 ; 牛丽丽 ; 孟龙 ; 郑海荣
- 英文论文作者：ZHOU Wei ; WANG Kai-yue ; NIU Li-li ; MENG Long ; ZHENG Hai-rong ; Paul C.Lauterbur Research Center for Biomedical Imaging ; Shenzhen Institutes of Advanced Technology ; Chinese Academy of Sciences
- 年：2016
- 作者机构：中国科学院深圳先进技术研究院,保罗·C·劳特伯生物医学成像研究中心;
- 论文关键词：微流控 ; 声表面波芯片 ; 超声辐射力
- 英文论文关键词：Microfluidics ; Surface acoustic wave devices ; Acoustic radiation force
- 会议召开时间：2016-10-28
- 会议录名称：2016年全国声学学术会议论文集
- 语种：中文
- 分类号：TB552;R312
- 学会代码：OGSM
- 会议名称：2016年全国声学学术会议
- 会议地点：中国湖北武汉
- 主办单位：中国声学学会
- 学会名称：中国声学学会
- 页数：3
- 文件大小：522k
- 原文格式：D
- 会议级别：全国
摘要
本文提出了一种基于一对倾斜型叉指换能器构成的一维声表面波芯片实现二维操控的方法。由于倾斜型叉指换能器的指条宽度连续的变化,使得芯片的共振频率在沿着声孔径方向上线性的变化。在一对倾斜型叉指换能器形成的驻波场中,超声造影微泡受到超声辐射力的作用会被捕获在驻波波节位置。通过改变输入信号的相对相位和频率可以分别改变驻波波节在垂直于声孔径和平行于声孔径方向的位置,从而实现微泡的二维操控。二维操控在垂直于声孔径方向和平行于声孔径方向的分辨率分别为7.53±0.68μm和9.83±0.65μm。
In this article, one-dimensional surface acoustic wave device generated by a pair of slant-finger interdigital transducers(SFITs) has been used to realize two-dimensional manipulation. Because of the continuous variation of the width of finger electrodes, the resonance frequency of SFITs changes linearly along the acoustic aperture. In a standing wave field generated by SFITs, microbubbles was trapped at pressure node because of acoustic radiation force. By adjusting the relative phase and frequency, pressure node has been moved in the direction perpendicular to acoustic aperture and parallel to acoustic aperture, respectively. Therefore, microbubbles can be manipulated in two dimensions. The resolution of manipulation was 7.53 ± 0.68 μm and 9.83 ± 0.65 μm in the direction perpendicular to acoustic aperture and parallel to acoustic aperture, respectively.
In this article, one-dimensional surface acoustic wave device generated by a pair of slant-finger interdigital transducers(SFITs) has been used to realize two-dimensional manipulation. Because of the continuous variation of the width of finger electrodes, the resonance frequency of SFITs changes linearly along the acoustic aperture. In a standing wave field generated by SFITs, microbubbles was trapped at pressure node because of acoustic radiation force. By adjusting the relative phase and frequency, pressure node has been moved in the direction perpendicular to acoustic aperture and parallel to acoustic aperture, respectively. Therefore, microbubbles can be manipulated in two dimensions. The resolution of manipulation was 7.53 ± 0.68 μm and 9.83 ± 0.65 μm in the direction perpendicular to acoustic aperture and parallel to acoustic aperture, respectively.
引文
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[2]Mirowski E,Moreland J,Russek SE,Donahue MJ:Integrated microfluidic isolation platform for magnetic particle manipulation in biological systems.Appl Phys Lett 2004,84(10):1786-1788.
[3]Ahn K,Kerbage C,Hunt TP,Westervelt RM,Link DR,Weitz DA:Dielectrophoretic manipulation of drops for high-speed microfluidic sorting devices.Appl Phys Lett 2006,88(2):024104.
[4]Mao X,Waldeisen JR,Huang TJ:“Microfluidic drifting”—implementing three-dimensional hydrodynamic focusing with a single-layer planar microfluidic device.Lab on a Chip 2007,7(10):1260-1262.
[5]Friend J,Yeo LY:Microscale acoustofluidics:Microfluidics driven via acoustics and ultrasonics.Rev Mod Phys 2011,83(2):647-704.
[6]Courtney CRP,Demore CEM,Wu H,Grinenko A,Wilcox PD,Cochran S,Drinkwater BW:Independent trapping and manipulation of microparticles using dexterous acoustic tweezers.Appl Phys Lett 2014,104(15):154103.
[7]Yeo LY,Friend JR:Surface acoustic wave microfluidics.Annual Review of Fluid Mechanics 2014,46:379-406.
[8]Wu J,Nyborg WL:Ultrasound,cavitation bubbles and their interaction with cells.Adv Drug Delivery Rev 2008,60(10):1103-1116.
[9]Meng L,Cai F,Chen J,Niu L,Li Y,Wu J,Zheng H:Precise and programmable manipulation of microbubbles by two-dimensional standing surface acoustic waves.Appl Phys Lett 2012,100(17):173701.
[10]Doinikov AA:Acoustic radiation forces:Classical theory and recent advances.Recent Res Devel Acoustics 2003,661(2):39-67.
[11]Doinikov AA,Haac JF,Dayton PA:Resonance frequencies of lipid-shelled microbubbles in the regime of nonlinear oscillations.Ultrasonics 2009,49(2):263-268.