磁性纳米粒子多功能自组装体的构筑、性能及生物应用研究
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- 英文论文题名：Generation, characterization, and bioapplication of multifunctional self-assembly of magnetic nanoparticles
- 论文作者：姚立 ; 王秀瑜
- 英文论文作者：Li Yao ; Xiuyu Wang ; Institute of Chemistry ; Chinese Academy of Sciences
- 年：2016
- 作者机构：中国科学院化学研究所;
- 论文关键词：磁性纳米粒子 ; 自组装 ; 级次结构 ; 生物医学
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第三十八分会：纳米生物效应与纳米药物化学
- 语种：中文
- 分类号：TB383.1
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第三十八分会 ; 纳米生物效应与纳米药物化学
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：209k
- 原文格式：D
- 会议级别：全国
摘要
磁性纳米粒子在现代科学的众多领域具有广泛的应用,其优异的特性不仅可以通过调节粒子的尺度和几何外观来得到调节,还能通过可控的分级有序自组装来获得新颖的整体协同特性,可以利用磁性纳米粒子间的多种相互作用来调节他们的性质,满足不同尺度下多功能的迫切需求。因此,磁性粒子自组装结构的设计与调控已成为理解构效关系、提升性能与功能的关键点和难点。微纳米空心球在能量存储、催化、传感、生物医药等领域发挥着重要作用。其中,单孔空心球因其独特的结构具备高吸附量、高效扩散、选择性可控封装等特性,然而常规的聚合物和硅等惰性材料很难赋予其更多的功能化。我们采用分子调控的自组装方式,将磁性纳米粒子的多功能性与单孔中空的结构特性有机结合起来,构建了一个集选择型封装、磁导航输送、可控释放于一体的智能生物医学平台。更重要的是,整个过程可通过磁共振成像手段实时监控。这种磁性空心球用作智能纳米载药有望使癌症治疗可视化、更有效、更精准。
Diversified micro/nano-level hollow spheres have been developed for various applications in energy storage, catalysis, chemical sensors and biomedicine. In particular, many interesting phenomena, such as highly effective diffusivity, up-taking capacity for big guest molecules, and selective and controllable encapsulation, have been observed in a new type of single-hole hollow spheres due to the unique structural features compared to their closed-shell counterparts. However, the conventional inert materials such as polymer and silica can't provide multifunction to upgrade the current container performance. Herein, we developed a facile self-assembly strategy based on double emulsions to design hierarchically structured magnetic single-hole hollow spheres(MSHS) featured with uniform size, controllable hole and tunable magnetic properties. The obtained MSHS, with functionalities offered by both the magnetic nanomaterial and container features of hierarchical structure, could serve as a smart biomedical platform with multifunction including selective loading, precise transport, on-demand release and real-time location reporting.
Diversified micro/nano-level hollow spheres have been developed for various applications in energy storage, catalysis, chemical sensors and biomedicine. In particular, many interesting phenomena, such as highly effective diffusivity, up-taking capacity for big guest molecules, and selective and controllable encapsulation, have been observed in a new type of single-hole hollow spheres due to the unique structural features compared to their closed-shell counterparts. However, the conventional inert materials such as polymer and silica can't provide multifunction to upgrade the current container performance. Herein, we developed a facile self-assembly strategy based on double emulsions to design hierarchically structured magnetic single-hole hollow spheres(MSHS) featured with uniform size, controllable hole and tunable magnetic properties. The obtained MSHS, with functionalities offered by both the magnetic nanomaterial and container features of hierarchical structure, could serve as a smart biomedical platform with multifunction including selective loading, precise transport, on-demand release and real-time location reporting.
引文
[1]Wang,X.;Hou,Y.;Yao,L.;Gao,M.;Ge,M.J.Am.Chem.Soc.2016,138:2090.