去甲肾上腺素和垂体后叶素对脓毒症休克患者细胞因子的影响
详细信息 查看官网全文
- 英文论文题名：Effect of norepinephrine and vasopressin on cytokine levels of septic shock patients
- 论文作者：赵扬 ; 徐洋 ; 谢继 ; 杨志洲 ; 孙兆瑞 ; 聂时南
- 英文论文作者：ZHAO Yang ; XU Yang ; XIE Ji ; YANG Zhi-zou ; SUN Zhao-rui ; NIE Shi-nan ; Department of Emergency Medicine ; Nanjing General Hospital of Nanjing Military Command ; PLA/Jinling Hospital ; Medical School of Nanjing University
- 年：2016
- 作者机构：南京军区南京总医院(南京大学医学院附属金陵医院)急救医学科;
- 论文关键词：去甲肾上腺素 ; 垂体后叶素 ; 脓毒症休克 ; 细胞因子 ; 死亡率
- 英文论文关键词：norepinephrine ; vasopressin ; septic shock ; cytokine ; mortality
- 会议召开时间：2016-06-17
- 会议录名称：2016中国中毒救治首都论坛——暨第八届全国中毒及危重症救治学术会议论文集
- 语种：中文
- 分类号：R459.7
- 学会代码：ZGDV
- 会议名称：2016中国中毒救治首都论坛——暨第八届全国中毒及危重症救治学术会议
- 会议地点：中国北京
- 主办单位：中国毒理学会中毒与救治专业委员会
- 学会名称：中国毒理学会
- 页数：3
- 文件大小：251k
- 原文格式：O
- 会议级别：全国
摘要
目的:探讨去甲肾上腺素和垂体后叶素对脓毒症休克患者细胞因子水平的影响,为临床使用去甲肾上腺素及垂体后叶素提供理论依据。方法:回顾性分析2012年1月至2014年12月入住我院急诊重症监护病房的脓毒症休克患者病历资料,按照血管活性药(去甲肾上腺素和垂体后叶素)使用情况将入选患者分为对照组(未使用血管活性药物)、去甲肾上腺素组和垂体后叶素组,比较两组患者急性生理学与慢性健康评分Ⅱ(APACHEⅡ)、细胞因子水平及28天死亡率。结果:三组患者入院时APACHEⅡ评分无差异;和对照组相比,去甲肾上腺素和垂体后叶素均能降低脓毒症患者早期细胞因子浓度,去甲肾上腺素降低脓毒症休克患者细胞因子水平的作用比垂体后叶素更明显:三组患者的28天死亡率无明显差别。结论:去甲肾上腺素和垂体后叶素能降低脓毒症休克患者早期细胞因子水平,但对28天死亡率无影响。
Objective:To investigate to the effect of norepinephrine and vasopressin on cytokine levels of septic shock patients,which can provided rational consultation for clinical using of norepinephrine and vasopressin.Methods:We performed a retrospective analysis form medical records of septic shock patients who admitted to our emergency intensive care unit from January 2012 to December 2014.According to the usage of vasoactive drugs(noradrenaline and vasopressin),patients were divided into control group(no vasoactive drugs),norepinephrine group and vasopressin group.We compared the acute physiology and chronic health evaluation Ⅱ(APACHE Ⅱ),cytokine levels and 28-day mortality of the three group patients.Results:There are no differences between the three groups of hospitalized APACHE Ⅱ score;Compared with the control group,norepinephrine and vasopressin could decrease early cytokine concentrations septic shock patients,Compared with the vasopressin group,norepinephrine reduce cytokine levels in septic shock patients cells more obvious than vasopressin.There were no significant difference in 28-day mortality of the three group patients.Conclusion:Norepinephrine and vasopressin can reduce early cytokine levels of septic shock patients,but can not reduce 28-day mortality.
Objective:To investigate to the effect of norepinephrine and vasopressin on cytokine levels of septic shock patients,which can provided rational consultation for clinical using of norepinephrine and vasopressin.Methods:We performed a retrospective analysis form medical records of septic shock patients who admitted to our emergency intensive care unit from January 2012 to December 2014.According to the usage of vasoactive drugs(noradrenaline and vasopressin),patients were divided into control group(no vasoactive drugs),norepinephrine group and vasopressin group.We compared the acute physiology and chronic health evaluation Ⅱ(APACHE Ⅱ),cytokine levels and 28-day mortality of the three group patients.Results:There are no differences between the three groups of hospitalized APACHE Ⅱ score;Compared with the control group,norepinephrine and vasopressin could decrease early cytokine concentrations septic shock patients,Compared with the vasopressin group,norepinephrine reduce cytokine levels in septic shock patients cells more obvious than vasopressin.There were no significant difference in 28-day mortality of the three group patients.Conclusion:Norepinephrine and vasopressin can reduce early cytokine levels of septic shock patients,but can not reduce 28-day mortality.
引文