首发精神分裂症及其一级亲属大脑灰质容量差异研究
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- 英文论文题名：Study of differences in the brain gray matter volume of first-episode schizophrenia and their first-degree relatives
- 论文作者：黄鹏 ; 朱霞 ; 席一斌 ; 苗丹民
- 英文论文作者：Huang Peng ; Zhu Xia ; Xi Yibin ; Miao Dnmin ; Department of Medical Psychology ; Fourth Military Medical University ; Department of Radiology ; Xijing Hospital ; Fourth Military Medical University
- 年：2015
- 作者机构：第四军医大学医学心理系;第四军医大学西京医院放射科;
- 论文关键词：精神分裂症 ; 功能核磁共振 ; 灰质 ; 基于体素形态学分析
- 英文论文关键词：Schizophrenia ; fMRI ; Gray matter ; Voxel-based morphometry
- 会议召开时间：2015-10-16
- 会议录名称：第十八届全国心理学学术会议摘要集——心理学与社会发展
- 英文会议录名称：Proceedings of the 18th National Academic Congress of Psychology
- 语种：中文
- 分类号：B845.1
- 学会代码：ZGXG
- 会议名称：第十八届全国心理学学术会议
- 会议地点：中国天津
- 主办单位：中国心理学会
- 学会名称：中国心理学会
- 页数：2
- 文件大小：764k
- 原文格式：D
- 会议级别：全国
摘要
当前,我国的精神障碍(包括自杀)占全部疾病负担的20%。其中,精神分裂症属于精神障碍的一种,但由于其发病率较低且极少导致直接死亡,因此,它的危害性被严重低估了。实际上,精神分裂症的高致残率,对家庭和社会影响极大,而且容易复发。本研究的目的是为了对比首发未服药的精神分裂症患者、一级亲属与正常对照组三组之间的灰质体积差异情况。该研究共纳入首发未服药的精神分裂症患者36名,作为精神分裂症患者组;患者的一级亲属18名,作为亲属组;以及正常被试18名,作为对照组。采用基于体素的形态学分析(voxel-based morphometry,VBM)技术对三组的灰质容量进行比较,得出存在差异的脑区。进一步采用FIRST、SIENAX等脑区分割提取分析技术,提取三组被试的深部核团,比如丘脑、尾状核等脑区的灰质容量,分析对比三组被试在以上具体核团的容量差异情况。以年龄、性别、头的大小(大脑的总容量)作为协变量,结果显示,在左侧丘脑、中央后回、额下回、额内侧回、脑岛、小脑前叶、小脑后叶和海马旁回等脑区,发现三组间存在显著差异(F_(2,65)=7.697,P<0.001未校正,体素数>63),并且发现患者组与正常组相比较,差异脑区主要分布在双侧丘脑、颞叶、脑岛、额下回等脑区,而亲属组与正常组相比,显著差异脑区只出现在颞中回。三组之间的深部核团容量比较发现,丘脑(F_(2,55)=4.32,P=0.017)、伏隔核容量在三组间存在显著差异(F_(2,55)=3.83,P=0.027)。研究结果表明,三组之间的大脑灰质容量存在显著差异,差异脑区主要分布在额叶、丘脑、小脑等脑区。
At present, mental disorders(including suicide) accounted for 20% of the total disease burden in China. Among the mental disorders, schizophrenia is one kind of them. But because of its low incidence and rarely directly lead to death, therefore, its' dangers has been seriously underestimated. In fact, the high disability of schizophrenia influences family and social a lot, and easy to relapse. The aim of this study is to compare the gray matter volume differences among first-episode drug-na?ve schizophrenia, first-degree relatives and normal controls. 36 patients, 18 relatives and 18 normal controls were included in this study. Voxel-based morphometric analysis was used to compare the differences of gray matter volume among three groups, and then find the significant brain regions. Further use of FIRST and SIENAX analysis techniques, which are focusing on segmentation and extraction, to extract the volume capacity of deep gray matter, such as thalamus, caudate and so on, from the three groups, and then make a comparison of deep gray matter volume among the three groups. Age, gender and head size were included as covariates, the results showed that difference in gray matter volume was found in left thalamus, Postcentral Gyrus, Inferior Frontal Gyrus, Medial Frontal Gyrus, Insula, Cerebellum Anterior Lobe, Cerebellum Posterior Lobe, Parahippocampa Gyrus among the three groups(F(2,65)= 7.697,P < 0.001 uncorrected, cluster size > 63(expected voxels per cluster). In the further analysis, we found the significant brain regions located in bilateral thalamus, Temporal Gyrus, insula and Inferior Frontal Gyrus between patients and normal controls. Just one significant brain region, Middle Temporal Gyrus, was found between relatives and normal controls. Analysis of deep gray matter among three groups showed that thalamus(F(2, 55) = 4.32,P = 0.017) and accumbens(F(2, 55) = 3.83,P = 0.027)have significant difference effect. The above results showed that the significant brain areas among three groups mainly located in frontal gyrus, thalamus, cerebellum and so on.
At present, mental disorders(including suicide) accounted for 20% of the total disease burden in China. Among the mental disorders, schizophrenia is one kind of them. But because of its low incidence and rarely directly lead to death, therefore, its' dangers has been seriously underestimated. In fact, the high disability of schizophrenia influences family and social a lot, and easy to relapse. The aim of this study is to compare the gray matter volume differences among first-episode drug-na?ve schizophrenia, first-degree relatives and normal controls. 36 patients, 18 relatives and 18 normal controls were included in this study. Voxel-based morphometric analysis was used to compare the differences of gray matter volume among three groups, and then find the significant brain regions. Further use of FIRST and SIENAX analysis techniques, which are focusing on segmentation and extraction, to extract the volume capacity of deep gray matter, such as thalamus, caudate and so on, from the three groups, and then make a comparison of deep gray matter volume among the three groups. Age, gender and head size were included as covariates, the results showed that difference in gray matter volume was found in left thalamus, Postcentral Gyrus, Inferior Frontal Gyrus, Medial Frontal Gyrus, Insula, Cerebellum Anterior Lobe, Cerebellum Posterior Lobe, Parahippocampa Gyrus among the three groups(F(2,65)= 7.697,P < 0.001 uncorrected, cluster size > 63(expected voxels per cluster). In the further analysis, we found the significant brain regions located in bilateral thalamus, Temporal Gyrus, insula and Inferior Frontal Gyrus between patients and normal controls. Just one significant brain region, Middle Temporal Gyrus, was found between relatives and normal controls. Analysis of deep gray matter among three groups showed that thalamus(F(2, 55) = 4.32,P = 0.017) and accumbens(F(2, 55) = 3.83,P = 0.027)have significant difference effect. The above results showed that the significant brain areas among three groups mainly located in frontal gyrus, thalamus, cerebellum and so on.
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