氨基酸-有机共价化合物设计、合成、组装结构和材料性质研究
详细信息 查看官网全文
- 英文论文题名：The Study on Design, Synthesis, Assembly Structure and Properties of Amino Acid-organic Covalent Compounds
- 论文作者：李亿保 ; 程林秀 ; 范玉兰 ; 李勋 ; 范小林
- 英文论文作者：Linxiu Cheng ; Yulan Fan ; Xun Li ; Yibao Li ; Xiaolin Fan ; Department of Chemistry and Chemical Engineering ; Gannan Normal University ; Department of Material and Chemical Engineering ; Pingxiang University
- 年：2016
- 作者机构：赣南师范学院化学化工学院江西省有机药物化学重点实验室;萍乡学院材料与化学工程学院;
- 论文关键词：氨基酸-有机共价化合物 ; 自组装 ; 功能性生物材料 ; 药物缓释
- 会议召开时间：2016-08-25
- 会议录名称：全国第十八届大环化学暨第十届超分子化学学术讨论会会议论文集（下）
- 语种：中文
- 分类号：O641.3;R318.08
- 学会代码：ZGHY
- 会议名称：全国第十八届大环化学暨第十届超分子化学学术讨论会
- 会议地点：中国湖南长沙
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：702k
- 原文格式：D
- 会议级别：全国
摘要
利用生物分子形成有序纳米结构及其生物相容性优势来制备生物基自组装材料,是近期国内外研究热点。我们课题组设计、合成与表征了一系列氨基酸-有机共价化合物~([1-5])。利用扫描探针显微镜技术、光谱技术、扫描电镜和透射电镜研究了氨基酸侧基对自组装结构的影响;在此基础上,构筑了溶剂控制、pH响应、酶响应和光响应的超分子生物材料;并探讨了材料在药物缓释方面的应用。
It is a hot topic to prepare ordered biological nanomaterials using biological molecules with biocompatibility advantages. A series of amino acid-organic covalent compounds have been designed, synthesized and characterized. The effects of amino acid side groups on the self-assembly structures have been investigated by scanning probe microscopy, spectral technique, scanning electron microscopy and transmission electron microscopy. On the basis of above molecules, the solvent, p H, enzyme and light responsive biomaterials were constructed. And the application of materials in drug release was also discussed.
It is a hot topic to prepare ordered biological nanomaterials using biological molecules with biocompatibility advantages. A series of amino acid-organic covalent compounds have been designed, synthesized and characterized. The effects of amino acid side groups on the self-assembly structures have been investigated by scanning probe microscopy, spectral technique, scanning electron microscopy and transmission electron microscopy. On the basis of above molecules, the solvent, p H, enzyme and light responsive biomaterials were constructed. And the application of materials in drug release was also discussed.
引文
[1]Li,Y.B.;Cheng,L.X.;Liu,C.H.;Liu,Wei,Zhu,L.;Fan,Y.L.;Wu,Y.Q.;Li,X.;Zeng,Q.D.;Fan,X.L.RSC Adv.,2015,5:97629–97634.
[2]Li,Y.B.;Cheng,L.X.;Liu,C.H.;Liu,Wei,Fan,Y.L.;Fan,X.L.;Zeng,Q.D.Scientific Reports,2015,5:10972.
[3]Liu,L.;Li,Y.B.;Xia,D.;Bortolini,C.;Zhang,S.;Yang,Y.L.;Pedersen,J.S.;Wang,C.;Besenbacher,F.;Dong,M.D.Nanoscale,2015,7:2250–2254.
[4]Li,Y.B.;Cheng,L.X.;Liu,C.H.;Xie,Y.Z.;Liu,W.;Fan,Y.L.;Li,X.;Fan,X.L.Soft Matter,2014,10:8261–8266.
[5]Fan,Y.L.;Cheng,L.X.;Liu,C.H.;Xie,Y.Z.;Liu,W.;Li,Y.D.;Li,X.;Li,Y.B.;*Fan,X.L.RSC Adv.,2014,4:52245–52249.
[2]Li,Y.B.;Cheng,L.X.;Liu,C.H.;Liu,Wei,Fan,Y.L.;Fan,X.L.;Zeng,Q.D.Scientific Reports,2015,5:10972.
[3]Liu,L.;Li,Y.B.;Xia,D.;Bortolini,C.;Zhang,S.;Yang,Y.L.;Pedersen,J.S.;Wang,C.;Besenbacher,F.;Dong,M.D.Nanoscale,2015,7:2250–2254.
[4]Li,Y.B.;Cheng,L.X.;Liu,C.H.;Xie,Y.Z.;Liu,W.;Fan,Y.L.;Li,X.;Fan,X.L.Soft Matter,2014,10:8261–8266.
[5]Fan,Y.L.;Cheng,L.X.;Liu,C.H.;Xie,Y.Z.;Liu,W.;Li,Y.D.;Li,X.;Li,Y.B.;*Fan,X.L.RSC Adv.,2014,4:52245–52249.