基于超分子聚合物胶束构筑两栖性蓝色荧光金属(Cu,Ni,Pt,Pd)纳米点及细胞成像应用研究
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- 英文论文题名：Blue-emitting and amphibious metal(Cu, Ni, Pt, Pd) nanodots prepared by supramolecular polymeric micelles and their application in bio-imaging
- 论文作者：石云峰 ; 杜记民
- 英文论文作者：Yunfeng Shi ; Jimin Du ; School of Chemistry and Chemical Engineering ; Anyang Normal University
- 年：2016
- 作者机构：安阳师范学院;
- 论文关键词：金属纳米点 ; 超分子聚合物胶束 ; 荧光 ; 细胞成像
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第三十六分会：纳米材料合成与组装
- 语种：中文
- 分类号：TB383.1;O657.3
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第三十六分会 ; 纳米材料合成与组装
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：179k
- 原文格式：D
- 会议级别：全国
摘要
本文提出了基于超分子聚合物胶束制备两栖性蓝色荧光金属(Cu,Ni,Pt,Pd)纳米点的新方法。基于超支化聚乙烯亚胺(HPEI)和十六酸(PA)的静电相互作用,我们构筑超分子聚合物胶束,封装金属离子,并通过NaBH_4还原,进而得到蓝色金属纳米点氯仿溶液。引入三乙胺调控静电复合物,金属纳米点/HPEI相转移至水相。这种水溶性的金属纳米点/HPEI具有优异的荧光性能,可用于细胞成像研究。此外,它结合了金属纳米点的荧光性能和HPEI的基因转染特性,可作为理想的荧光探针用于跟踪基因转染行为。
We propose a new method for the preparation of blue-emitting and amphibious metal(Cu, Ni, Pt, Pd) nanodots using supramolecular polymeric micelle nanoreactors. The supramolecular polymeric micelles were conducted by electrostatic interactions between hyperbranched poly(ethylenimine)s(HPEI) and palmitic acid(PA). After encapsulating metal ions and subsequent reduction by Na BH4, blue-emitting metal nanodots in chloroform phase are formed. The resulting metal nanodots could be phase transferred from chloroform phase to aqueous phase by adding triethylamine, thus aqueous metal nanodots in the form of metal nanodot/HPEI can be obtained. The aqueous metal nanodot/HPEI exhibited preeminent fluorescence property for bio-imaging. The fluorescent metal nanodot/HPEI integrates the fluorescence property of metal dots and the gene transfection character of HPEI together, indicating a great ideal fluorescence probe to track the gene transfection behaviour.
We propose a new method for the preparation of blue-emitting and amphibious metal(Cu, Ni, Pt, Pd) nanodots using supramolecular polymeric micelle nanoreactors. The supramolecular polymeric micelles were conducted by electrostatic interactions between hyperbranched poly(ethylenimine)s(HPEI) and palmitic acid(PA). After encapsulating metal ions and subsequent reduction by Na BH4, blue-emitting metal nanodots in chloroform phase are formed. The resulting metal nanodots could be phase transferred from chloroform phase to aqueous phase by adding triethylamine, thus aqueous metal nanodots in the form of metal nanodot/HPEI can be obtained. The aqueous metal nanodot/HPEI exhibited preeminent fluorescence property for bio-imaging. The fluorescent metal nanodot/HPEI integrates the fluorescence property of metal dots and the gene transfection character of HPEI together, indicating a great ideal fluorescence probe to track the gene transfection behaviour.
引文
[1]Lu Y.Z.;Chen,W.Chem.Soc.Rev.2012,41:3594.
[2]Goswami,N.;Zheng K.Y.;Xie,J.P.Nanoscale,2014,6:13328.
[2]Goswami,N.;Zheng K.Y.;Xie,J.P.Nanoscale,2014,6:13328.