线粒体呼吸链复合物的结构与作用机理研究
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- 英文论文题名：The structure of the mitochondrial respiratory chain complexes and mechanism research
- 论文作者：张蓓 ; 杨文超 ; 杨光富
- 英文论文作者：Bei Zhang ; WenChao Yang ; GuangFu Yang ; Key Laboratory of Pesticide & Chemical Biology ; Ministry of Education ; College of Chemistry ; Central China Normal University
- 年：2016
- 作者机构：华中师范大学化学学院农药与化学生物学教育部重点实验室;
- 论文关键词：杀菌剂 ; 线粒体呼吸链复合物 ; 抑制剂 ; 作用机理 ; 合理设计
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第二十八分会：化学生物学
- 语种：中文
- 分类号：TQ455
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第二十八分会 ; 化学生物学
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：215k
- 原文格式：D
- 会议级别：全国
摘要
人口增长是新世界人类面临的三大挑战之一,也是我国的基本国情。而人口的持续增长也在不断提高对粮食产量的需求,而农药在确保粮食安全方面发挥着不可替代的作用,是关系国家经济社会发展的重要战略物质。但近年来植物病原菌对我国农业生产的危害极为严重,呈现出逐年增加的趋势,严重制约着粮食产量的提高。化学杀菌剂是目前防控植物病害最经济有效的手段,线粒体呼吸链复合物则是当前最具发展前景的农用杀菌剂靶标之一,因此对线粒体呼吸链复合物的结构和作用机理进行研究就显得尤为重要。线粒体呼吸链由复合物Ⅰ、Ⅱ、Ⅲ、Ⅳ以及电子传递载体泛醌和细胞色素c组成,共同完成生物氧化和氧化磷酸化过程,并产生ATP。复合物Ⅱ与复合物Ⅲ都是杀菌剂的重要靶标,研究线粒体呼吸链复合物的结构与作用机理,可为新型杀菌剂的发现与创制提供理论指导。
Population growth is one of three big challenges humanity faced in the new world.Pesticides play an irreplaceable role in ensuring food security,but in recent years,plant pathogens severely restricts the improvement of food production.Chemical fungicide is now the most economic and effective prevention and control of plant diseases,and mitochondrial respiratory chain complexes is currently one of the most potential agricultural fungicide targets.Mitochondrial respiratory chain is consists of complexes Ⅰ,Ⅱ,Ⅲ,Ⅳ and electron transport carrier ubiquinone and cytochrome c,with biological oxidation and oxidative phosphorylation process,and produces ATP.Complexes Ⅱand Ⅲ are important target of fungicide,research on structure and mechanism of mitochondrial respiratory chain complexes can provide theoretical guidance for the discovery of novel fungicide and initiative.
Population growth is one of three big challenges humanity faced in the new world.Pesticides play an irreplaceable role in ensuring food security,but in recent years,plant pathogens severely restricts the improvement of food production.Chemical fungicide is now the most economic and effective prevention and control of plant diseases,and mitochondrial respiratory chain complexes is currently one of the most potential agricultural fungicide targets.Mitochondrial respiratory chain is consists of complexes Ⅰ,Ⅱ,Ⅲ,Ⅳ and electron transport carrier ubiquinone and cytochrome c,with biological oxidation and oxidative phosphorylation process,and produces ATP.Complexes Ⅱand Ⅲ are important target of fungicide,research on structure and mechanism of mitochondrial respiratory chain complexes can provide theoretical guidance for the discovery of novel fungicide and initiative.
引文
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[3]孙飞,周强军,孙吉,翟宇佳,饶子和.生命科学,2008,20(4):566-578.
[2]Sun,F.;Huo,X.;Zhai,Y.;Wang,A.;Xu,J.;Su,D.;Bartlam,M.;Rao,Z.Cell.2005,121(7):1043-1057.
[3]孙飞,周强军,孙吉,翟宇佳,饶子和.生命科学,2008,20(4):566-578.