城市水环境中耐药菌和抗生素抗性基因的分布与传播
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摘要
随着环境保护和健康意识的提高,耐药菌和抗生素抗性基因(antibiotics resistance genes,ARGs)对水环境造成的污染越来越受到人们的关注。本文在介绍国内外对于城市水环境中抗生素抗性基因研究的基础上,着重探讨了城市污水处理厂对抗生素抗性基因传播的影响,指出传统的污水处理方式不能有效地去除抗生素抗性基因,且有可能增加出水中ARGs的种类和多重耐药菌的比例。今后应加强对城市污水处理厂出水中耐药菌和ARGs的检测,并努力发展相应的控制技术。
引文
[1]Tambo N.Urban metabolic system of water for the 21st century.Water Science and Technology:Water Supply,2004,4(1):1-5.
[2]Poole K.Efflux-Mediated Resistance.Journal of Antimicrobial Chemotherapy,2005,59(2):20-51.
[3]Pruden A,Pei R T,Storteboom H,et al.Antibiotic Resistance Genes as Emerging Contaminants;Studies in Northern Colorado.Environmental Science and Technology,2006,40(23):7445-7450.
[4]Korzeniewska E,Korzeniewska A,Harnisz M.Antibiotic resistant Escherichia coli in hospital and municipal sewage and their emission to the environment Ecotoxicology and Environmental Safety,2013,91:96-102.
[5]Jakobsen L,Sandvang D,Hansen L H,et al.Characterisation,dissemination and persistence of gentamicin resistant Escherichia coli from a Danish university hospital to the waste water environment Environment international,2008,34(1):108-115.
[6]Rodriguez-Mozaz S,Chamorro S,Marti E,et al.Occurrence of antibiotics and antibiotic resistance genes in hospital and urban wastewaters and their impact on the receiving river.Water Research,2015,69:234-242.
[7]K(u|¨)mmerer K.Resistance in the environment Journal of Antimicrobial Chemotherapy,2004,54(2);311-320.
[8]He L Y,Ying G G,Liu Y S,et al.Discharge of swine wastes risks water quality and food safety;Antibiotics and antibiotic resistance genes from swine sources to the receiving environments.Environment International,2016,s 92-93:210-219.
[9]Peak N,Knapp C W,Yang R K,et al.Abundance of six tetracycline resistance genes in wastewater lagoons at cattle feedlots with different antibiotic use strategies.Environmental Microbiology,2007,9(1):143-151.
[10]冀秀玲,刘芳,沈群辉,等.养殖场废水中磺胺类和四环素抗生素及其抗性基因的定量检测.生态环境学报,2011,20(5):927-933.
[11]王瑞旋,耿玉静,王江勇,等.水产致病菌耐药基因的研究.海洋环境科学,2012,21(3):323-328.
[12]Li J,Cheng W,Xu L,et al.Antibiotic-resistant genes and antibiotic-resistant bacteria in the effluent of urban residential areas,hospitals,and a municipal wastewater treatment plant system.Environmental Science&Pollution Research,2015,22(6):4587-96.
[13]Lefkowitz J R,Duran M.Changes in antibiotic resistance patterns of Escherichia coli during domestic wastewater treatment Water Environment Research,2009,81(9):878-85.
[14]Chen H,Zhang M.Occurrence and removal of antibiotic resistance genes in municipal wastewater and rural domestic sewage treatment systems in eastern China.Environment International,2013,55C(4):9-14.
[15]Chen J,Wei X D,Liu Y S,et al.Removal of antibiotics and antibiotic resistance genes from domestic sewage by constructed wetlands:Optimization of wetland substrates and hydraulic loading.Science of the Total Environment,2016,565:240-248.
[16]Xu Y,Guo C,Luo Y,et al.Occurrence and distribution of antibiotics,antibiotic resistance genes in the urban rivers in Beijing,China.Environmental Pollution,2016,213:833-840.
[17]张崇淼,王燕,杜聪.城市河流异养菌耐药状况及微生物群落结构特征.环境科学研究,2015,28(5):713-719.
[18]Wang C,Gu X C,Zhang S,et al.Characterization of Antibiotic-Resistance Genes in Antibiotic Resistance Escherichia coli,Isolates From a Lake.Archives of Environmental Contamination&Toxicology,2013,65(4):635-41.
[19]Sapkota A R,Curriero F C,Gibson K E,et al.Antibiotic-resistant enterococci and fecal indicators in surface water and groundwater impacted by a concentrated Swine feeding operation.Environmental Health Perspectives,2007,115(7):1040-5.
[20]Koike S,Krapac IG,Oliver HD,et al.Monitoring and source tracking of tetracycline resistance genes in lagoons and groundwater adjacent to swine production facilities over a 3-year period.Applied&Environmental Microbiology,2007,73(15):4813-23.
[21]Papandreou S,Pagonopoulou O,Vantarakis A,et al.Multiantibiotic resistance of gram-negative bacteria isolated from drinking water samples in southwest Greece.Journal of Chemotherapy,2000,12(4):267-73.
[22]Guo X,Jing L,Fan Y,et al.Prevalence of sulfonamide and tetracycline resistance genes in drinking water treatment plants in the Yangtze River Delta,China.Science of the Total Environment,2014,493:626-631.
[23]Schwartz T,Kohnen W,Jansen B,et al.Detection of antibiotic-resistant bacteria and their resistance genes in wastewater,surface water,and drinking water biofilms.Ferns Microbiology Ecology,2003,43(3):325-35.
[24]Inoue D,Sei K,Soda S,et al.Potential of predominant activated sludge bacteria as recipients in conjugative plasmid transfer.Journal of Bioscience&Bioengineering,2005,100(6):600-605.
[25]Yang D,Wang J,Qiu Z,et al.Horizontal transfer of antibiotic resistance genes in a membrane bioreactor.Journal of biotechnology,2013,167(4):441-447.
[26]Kim S,Jensen J N,Aga D S,et al.Tetracycline as a selector for resistant bacteria in activated sludge.Chemosphere,2007,66(9):1643-1651.
[27]Gao P,Munir M,Xagoraraki I.Correlation of tetracycline and sulfonamide antibiotics with corresponding resistance genes and resistant bacteria in a conventional municipal wastewater treatment plant Science of the Total Environment,2012,421-422(3):173-83.
[28]Di Cesare A,Eckert E M,D'Urso S,et al.Co-occurrence of integrase 1,antibiotic and heavy metal resistance genes in municipal wastewater treatment plants.Water Research,2016,94:208-214.
[29]张明美.污水处理系统中抗生素抗性基因污染研究.浙江大学,2013.
[30]Munir M,Wong K,Xagoraraki I.Release of antibiotic resistant bacteria and genes in the effluent and biosolids of five wastewater utilities in Michigan.Water research,2011,45(2):681-693.
[31]Kim S,Park H,Chandran K.Propensity of activated sludge to amplify or attenuate tetracycline resistance genes and tetracycline resistant bacteria;a mathematical modeling approach.Chemosphere,2010,78(9);1071-1077.
[32]Szczepanowski R,Krahn I,Linke B,et al.Antibiotic multiresistance plasmid pRSBlOl isolated from a wastewater treatment plant is related to plasmids residing in phytopathogenic bacteria and carries eight different resistance determinants including a multidrug transport system.Microbiology,2004,150(11):3613-3630.
[33]Zhang Y,Marrs C F,Simon C,et al.Wastewater treatment contributes to selective increase of antibiotic resistance among Acinetobacter spp.Science of the Total Environment,2009,407(12):3702-06.
[34]Guo M T,Yuan Q B,Yang J.Microbial selectivity of UV treatment on antibiotic-resistant heterotrophic bacteria in secondary effluents of a municipal wastewater treatment plant Water Research,2013,47(16);6388-94.
[35]张崇淼,徐欢,刘静,等.城市污水处理系统中沙门氏菌对四环素和磺胺甲恶唑的耐药性.环境科学研究,2014,27(3):309-313.
[2]Poole K.Efflux-Mediated Resistance.Journal of Antimicrobial Chemotherapy,2005,59(2):20-51.
[3]Pruden A,Pei R T,Storteboom H,et al.Antibiotic Resistance Genes as Emerging Contaminants;Studies in Northern Colorado.Environmental Science and Technology,2006,40(23):7445-7450.
[4]Korzeniewska E,Korzeniewska A,Harnisz M.Antibiotic resistant Escherichia coli in hospital and municipal sewage and their emission to the environment Ecotoxicology and Environmental Safety,2013,91:96-102.
[5]Jakobsen L,Sandvang D,Hansen L H,et al.Characterisation,dissemination and persistence of gentamicin resistant Escherichia coli from a Danish university hospital to the waste water environment Environment international,2008,34(1):108-115.
[6]Rodriguez-Mozaz S,Chamorro S,Marti E,et al.Occurrence of antibiotics and antibiotic resistance genes in hospital and urban wastewaters and their impact on the receiving river.Water Research,2015,69:234-242.
[7]K(u|¨)mmerer K.Resistance in the environment Journal of Antimicrobial Chemotherapy,2004,54(2);311-320.
[8]He L Y,Ying G G,Liu Y S,et al.Discharge of swine wastes risks water quality and food safety;Antibiotics and antibiotic resistance genes from swine sources to the receiving environments.Environment International,2016,s 92-93:210-219.
[9]Peak N,Knapp C W,Yang R K,et al.Abundance of six tetracycline resistance genes in wastewater lagoons at cattle feedlots with different antibiotic use strategies.Environmental Microbiology,2007,9(1):143-151.
[10]冀秀玲,刘芳,沈群辉,等.养殖场废水中磺胺类和四环素抗生素及其抗性基因的定量检测.生态环境学报,2011,20(5):927-933.
[11]王瑞旋,耿玉静,王江勇,等.水产致病菌耐药基因的研究.海洋环境科学,2012,21(3):323-328.
[12]Li J,Cheng W,Xu L,et al.Antibiotic-resistant genes and antibiotic-resistant bacteria in the effluent of urban residential areas,hospitals,and a municipal wastewater treatment plant system.Environmental Science&Pollution Research,2015,22(6):4587-96.
[13]Lefkowitz J R,Duran M.Changes in antibiotic resistance patterns of Escherichia coli during domestic wastewater treatment Water Environment Research,2009,81(9):878-85.
[14]Chen H,Zhang M.Occurrence and removal of antibiotic resistance genes in municipal wastewater and rural domestic sewage treatment systems in eastern China.Environment International,2013,55C(4):9-14.
[15]Chen J,Wei X D,Liu Y S,et al.Removal of antibiotics and antibiotic resistance genes from domestic sewage by constructed wetlands:Optimization of wetland substrates and hydraulic loading.Science of the Total Environment,2016,565:240-248.
[16]Xu Y,Guo C,Luo Y,et al.Occurrence and distribution of antibiotics,antibiotic resistance genes in the urban rivers in Beijing,China.Environmental Pollution,2016,213:833-840.
[17]张崇淼,王燕,杜聪.城市河流异养菌耐药状况及微生物群落结构特征.环境科学研究,2015,28(5):713-719.
[18]Wang C,Gu X C,Zhang S,et al.Characterization of Antibiotic-Resistance Genes in Antibiotic Resistance Escherichia coli,Isolates From a Lake.Archives of Environmental Contamination&Toxicology,2013,65(4):635-41.
[19]Sapkota A R,Curriero F C,Gibson K E,et al.Antibiotic-resistant enterococci and fecal indicators in surface water and groundwater impacted by a concentrated Swine feeding operation.Environmental Health Perspectives,2007,115(7):1040-5.
[20]Koike S,Krapac IG,Oliver HD,et al.Monitoring and source tracking of tetracycline resistance genes in lagoons and groundwater adjacent to swine production facilities over a 3-year period.Applied&Environmental Microbiology,2007,73(15):4813-23.
[21]Papandreou S,Pagonopoulou O,Vantarakis A,et al.Multiantibiotic resistance of gram-negative bacteria isolated from drinking water samples in southwest Greece.Journal of Chemotherapy,2000,12(4):267-73.
[22]Guo X,Jing L,Fan Y,et al.Prevalence of sulfonamide and tetracycline resistance genes in drinking water treatment plants in the Yangtze River Delta,China.Science of the Total Environment,2014,493:626-631.
[23]Schwartz T,Kohnen W,Jansen B,et al.Detection of antibiotic-resistant bacteria and their resistance genes in wastewater,surface water,and drinking water biofilms.Ferns Microbiology Ecology,2003,43(3):325-35.
[24]Inoue D,Sei K,Soda S,et al.Potential of predominant activated sludge bacteria as recipients in conjugative plasmid transfer.Journal of Bioscience&Bioengineering,2005,100(6):600-605.
[25]Yang D,Wang J,Qiu Z,et al.Horizontal transfer of antibiotic resistance genes in a membrane bioreactor.Journal of biotechnology,2013,167(4):441-447.
[26]Kim S,Jensen J N,Aga D S,et al.Tetracycline as a selector for resistant bacteria in activated sludge.Chemosphere,2007,66(9):1643-1651.
[27]Gao P,Munir M,Xagoraraki I.Correlation of tetracycline and sulfonamide antibiotics with corresponding resistance genes and resistant bacteria in a conventional municipal wastewater treatment plant Science of the Total Environment,2012,421-422(3):173-83.
[28]Di Cesare A,Eckert E M,D'Urso S,et al.Co-occurrence of integrase 1,antibiotic and heavy metal resistance genes in municipal wastewater treatment plants.Water Research,2016,94:208-214.
[29]张明美.污水处理系统中抗生素抗性基因污染研究.浙江大学,2013.
[30]Munir M,Wong K,Xagoraraki I.Release of antibiotic resistant bacteria and genes in the effluent and biosolids of five wastewater utilities in Michigan.Water research,2011,45(2):681-693.
[31]Kim S,Park H,Chandran K.Propensity of activated sludge to amplify or attenuate tetracycline resistance genes and tetracycline resistant bacteria;a mathematical modeling approach.Chemosphere,2010,78(9);1071-1077.
[32]Szczepanowski R,Krahn I,Linke B,et al.Antibiotic multiresistance plasmid pRSBlOl isolated from a wastewater treatment plant is related to plasmids residing in phytopathogenic bacteria and carries eight different resistance determinants including a multidrug transport system.Microbiology,2004,150(11):3613-3630.
[33]Zhang Y,Marrs C F,Simon C,et al.Wastewater treatment contributes to selective increase of antibiotic resistance among Acinetobacter spp.Science of the Total Environment,2009,407(12):3702-06.
[34]Guo M T,Yuan Q B,Yang J.Microbial selectivity of UV treatment on antibiotic-resistant heterotrophic bacteria in secondary effluents of a municipal wastewater treatment plant Water Research,2013,47(16);6388-94.
[35]张崇淼,徐欢,刘静,等.城市污水处理系统中沙门氏菌对四环素和磺胺甲恶唑的耐药性.环境科学研究,2014,27(3):309-313.