1,1′-磺酰基二(2-甲巯基)乙烷的合成
详细信息 查看官网全文
- 英文论文题名：Novel synthetic method of 1,l'-Sulphonylbis(2-methythio)ethane
- 论文作者：高润利 ; 卢晓刚 ; 王红梅 ; 裴承新
- 英文论文作者：Runli Gao ; Xiaogang Lu ; Hongmei Wang ; Chengxin Pei ; State Key Laboratory of NBC Protection for Civilian
- 年：2016
- 作者机构：国民核生化灾害防护国家重点实验室;
- 论文关键词：芥子气 ; SBMTE ; 生物标志物 ; 合成
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第三十四分会：公共安全化学
- 语种：中文
- 分类号：E913;O623.8
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第三十四分会 ; 公共安全化学
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：283k
- 原文格式：D
- 会议级别：全国
摘要
芥子气曾被称为"毒剂之王",在第一次世界大战和两伊战争中被使用过。在应对由于芥子气伤害而引起的化学应急事件时,对其进行快速、准确、可靠的检测是一切救援行动的关键。芥子气可与谷胱甘肽或半胱氨酸结合后经β-裂解酶裂解生成无毒的代谢物,如1,1′-磺酰基二(2-甲巯基)乙烷(SBMTE)、1,1′-磺酰基二(2-甲磺酰基)乙烷(SBMSE)、1-甲基亚磺酰基-2-(2-甲巯基乙基磺酰基)乙烷(MSBMTE)、1,1′-磺酰基-双[2-S-(N-乙酰半胱氨酸基)]乙烷(SBSANE)等,是检测芥子气染毒的重要标志物。本文利用极其简便、高效的方法合成了其重要生物标志物之一1,1′-磺酰基二(2-甲巯基)乙烷(SBMTE)(Fig.1)~([1,2])。
The use of bis(2-choroethyl)sulfide(sulfur mustard, SM) as a chemical warfare agent(CWA) was frequently encountered in the First World War and, more recently, in the Iran-Iraq war. The degradation of sulfur mustard in the environment and in biological systems is complex. 1,l'-Sulphonylbis(2-methythio)ethane has been synthesized for use as biomarker for the analysis in sulfur mustard injury.
The use of bis(2-choroethyl)sulfide(sulfur mustard, SM) as a chemical warfare agent(CWA) was frequently encountered in the First World War and, more recently, in the Iran-Iraq war. The degradation of sulfur mustard in the environment and in biological systems is complex. 1,l'-Sulphonylbis(2-methythio)ethane has been synthesized for use as biomarker for the analysis in sulfur mustard injury.
引文
[1]Black,R.M.;Brewster,K.;Harrison,J.M.;et al.The chemistry of 1,1′-thiobis-(2-chloroethane)(Sulfur mustard)Part I.some simple derivatives.Phosphorus,Sulfur,and Silicon and the Related Elements,1992,Val.71:31-47.
[2]Black,R.M.;Brewster,K.;Harrison,J.M.;et al.The chemistry of 1,1′-thiobis-(2-chloroethane)(Sulfur mustard)PartⅡ.The synthesis of some conjugates with cysteine,N-acetylcsteine and N-acetylcysyeine methyl ester.Phosphorus,Sulfur,and Silicon and the Related Elements,1992,Val.71:49-58.
[2]Black,R.M.;Brewster,K.;Harrison,J.M.;et al.The chemistry of 1,1′-thiobis-(2-chloroethane)(Sulfur mustard)PartⅡ.The synthesis of some conjugates with cysteine,N-acetylcsteine and N-acetylcysyeine methyl ester.Phosphorus,Sulfur,and Silicon and the Related Elements,1992,Val.71:49-58.