生物分子与多金属氧簇在水溶液中的协同组装
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- 英文论文题名：Co-assembly of biomolecules and polyoxometalates in aqueous solution
- 论文作者：李文 ; 李敬芳 ; 吴立新
- 英文论文作者：Wen Li ; Jingfang Li ; Lixin Wu ; State key laboratory of supramolecular structure and materials ; Jilin University
- 年：2016
- 作者机构：吉林大学超分子结构与材料国家重点实验室;
- 论文关键词：阳离子肽 ; 多阴离子 ; 离子组装 ; 纳米纤维 ; 抗菌性
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第三十一分会：胶体与界面化学
- 语种：中文
- 分类号：O641.3
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第三十一分会 ; 胶体与界面化学
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：2
- 文件大小：161k
- 原文格式：D
- 会议级别：全国
摘要
生物分子的组装在模拟天然生物结构,调节药物传输与释放,控制细菌感染,发展组织工程材料等方面具有重要应用。本文致力于研究阳离子短肽与无机多阴离子在水溶液中的离子自组装过程,复合纳米结构的构筑及相应生物活性的调控。研究表明无机多金属氧簇通过多重离子键合作用诱导阳离子短肽形成一维复合纳米纤维,这种纳米纤维表面具有多价效应,表现出明显增强的抗菌活性(如图1所示)。我们发现通过调节阳离子短肽中疏水效应,静电作用等组装驱动力可控制复合物纳米结构在水溶液中的组装形貌及稳定性。此外,我们利用天然氨基酸与多金属氧簇间的多重非共价作用获得了具有质子导电性能的粘附剂。这些研究工作为进一步开发生物/无机复合物材料提供了新的启发。本文突出强调了静电作用在控制生物活性分子的组装结构与功能特性方面的重要作用。
Self-assembly of biomolecules has great potential for the creation of desired materials in terms of biological applications,including the regulation of tissue regeneration,drug delivery and bacterial infection.In the present work,we want to touch upon the ionic self-assembly of short cationic peptides and inorganic polyanions in aqueous solution.It is observed that polyoxometalates have the ability to drive self-assembly of short cationic peptides into multivalent nanofibers,which exhibited enhanced antimicrobial efficacy.The morphology and the stability of the hierarchical nanostructures can be controlled by modulating the driving forces behind the molecular self-assembly.In another example,we demonstrated that the multivalent non-covalent interactions can be used to create functional adhesives with high proton conduction through the co-assembly of polyoxometalates and basic amino acids.We highlight the important role of the multivalent electrostatic interactions on the self-assembly structures and functions of biomolecules.
Self-assembly of biomolecules has great potential for the creation of desired materials in terms of biological applications,including the regulation of tissue regeneration,drug delivery and bacterial infection.In the present work,we want to touch upon the ionic self-assembly of short cationic peptides and inorganic polyanions in aqueous solution.It is observed that polyoxometalates have the ability to drive self-assembly of short cationic peptides into multivalent nanofibers,which exhibited enhanced antimicrobial efficacy.The morphology and the stability of the hierarchical nanostructures can be controlled by modulating the driving forces behind the molecular self-assembly.In another example,we demonstrated that the multivalent non-covalent interactions can be used to create functional adhesives with high proton conduction through the co-assembly of polyoxometalates and basic amino acids.We highlight the important role of the multivalent electrostatic interactions on the self-assembly structures and functions of biomolecules.
引文
[1]De Santis,E.;Ryadnov,M.G.Chem.Soc.Rev.2015,44,8288.
[2]Li,J.F.;Chen,Z.J.;Zhou,M.C.;Jing,J.B.;Li,W.;Wang,Y.;Wu,L.X.;Wang,L.Y.;Wang Y.Q.;Lee,M.S.Angew.Chem.Int.Ed.2016,55:2592.
[2]Li,J.F.;Chen,Z.J.;Zhou,M.C.;Jing,J.B.;Li,W.;Wang,Y.;Wu,L.X.;Wang,L.Y.;Wang Y.Q.;Lee,M.S.Angew.Chem.Int.Ed.2016,55:2592.