儿童紫癜性肾炎使用糖皮质激素与免疫球蛋白的疗效观察
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- 论文作者：郑小萍 ; 唐莉
- 年：2016
- 作者机构：开县人民医院儿内科;
- 论文关键词：儿童紫癜性肾炎 ; 糖皮质激素 ; 免疫球蛋白 ; 疗效
- 英文论文关键词：the children with purpura nephritis ; glucocorticoid ; immune globulin ; curative effect
- 会议召开时间：2016-11-25
- 会议录名称：湖南中医药大学学报2016/专集：国际数字医学会数字中医药分会成立大会暨首届数字中医药学术交流会论文集
- 语种：中文
- 分类号：R726.9
- 学会代码：HNZY
- 会议名称：国际数字医学会数字中医药分会成立大会暨首届数字中医药学术交流会
- 会议地点：中国广东珠海
- 主办单位：国际数字医学会、Digital Chinese Medicine
- 学会名称：湖南中医药大学期刊杂志社
- 页数：1
- 文件大小：1809k
- 原文格式：D
- 会议级别：全国
摘要
目的:探讨糖皮质激素与免疫球蛋白的疗效观察对儿童紫癜性肾炎的治疗效果。方法:将68例过敏性紫癜性肾炎患儿随机分成免疫球蛋白组34例、激素治疗组34例,另设常规对照组20例,观察临床症状、尿蛋白情况、治疗恢复情况等,并对结果进行统计学分析。结果:1治疗后免疫球蛋白治疗组、激素治疗及常规对照组治疗有效率分别为:94.1%,91.1%,80.0%,三组患儿平均24小时尿蛋白量、血浆白蛋白、血尿氮素及血肌酐等水平均优于治疗前。2免疫球蛋白治疗组及激素治疗组在皮疹、腹痛、关节症状消失时间及尿蛋白转阴时间均显著短于常规对照组(P<0.05)3免疫球蛋白治疗组与激素治疗组相比,在腹痛、关节症状消失时间方面差异不显著(P>0.05),但在皮疹消退及尿蛋白转阴时间上两组比较差异有显著性意义(p<0.05),应用免疫球蛋白组皮疹消退较快,尿蛋白转阴时间缩短。结论:免疫球蛋白及糖皮质激素均是治疗儿童过敏性紫癜性肾炎的有效治疗方法,特别是免疫球蛋白效果明显,值得临床推广应用。
Objective: To investigate the effect of glucocorticoid and immunoglobulin in the treatment of children with purpura nephritis. Methods: 68 cases of allergic purpura nephritiswere randomly divided into 34 cases of immune globulin group, 34 cases of hormone treatment group, 20 cases were randomly divided into control group, observation of clinical symptoms, urinaryprotein, recovery of treatment, and the outcomings were statistically analyzed. Results: the effective rate of the treatment group, hormone therapy and conventional control group were 94.1%, 91.1%, 80%, 24, three,, respectively, and the level of urinary protein, plasma albumin, blood urea nitrogen and serum creatinine were better than before treatment. The immune globulin treatmentgroup and hormone treatment group in a rash, abdominal pain, joint symptoms disappeared time and urinary protein clearance time were significantly shorter than the control group(P<0.05) compared to the immune globulin treatment group and hormone treatment group, the abdominal pain, joint symptoms disappeared time difference was not significant(P>0.05), but in the rashsubsided and urinary protein clearance time difference between the two groups was significant(p<0.05), immunoglobulin group rash subsided quickly, shorten the time of disappearance of urinaryprotein. Conclusion: immune globulin and glucocorticoid are effective approachs for treating children with allergic purpura nephritis, especially the effect of immune globulin is obvious, it isworthy of clinical application.
Objective: To investigate the effect of glucocorticoid and immunoglobulin in the treatment of children with purpura nephritis. Methods: 68 cases of allergic purpura nephritiswere randomly divided into 34 cases of immune globulin group, 34 cases of hormone treatment group, 20 cases were randomly divided into control group, observation of clinical symptoms, urinaryprotein, recovery of treatment, and the outcomings were statistically analyzed. Results: the effective rate of the treatment group, hormone therapy and conventional control group were 94.1%, 91.1%, 80%, 24, three,, respectively, and the level of urinary protein, plasma albumin, blood urea nitrogen and serum creatinine were better than before treatment. The immune globulin treatmentgroup and hormone treatment group in a rash, abdominal pain, joint symptoms disappeared time and urinary protein clearance time were significantly shorter than the control group(P<0.05) compared to the immune globulin treatment group and hormone treatment group, the abdominal pain, joint symptoms disappeared time difference was not significant(P>0.05), but in the rashsubsided and urinary protein clearance time difference between the two groups was significant(p<0.05), immunoglobulin group rash subsided quickly, shorten the time of disappearance of urinaryprotein. Conclusion: immune globulin and glucocorticoid are effective approachs for treating children with allergic purpura nephritis, especially the effect of immune globulin is obvious, it isworthy of clinical application.
引文
[1]明.雷公藤多苷联合糖皮质激素治疗儿童紫癜性肾炎的临床疗效观察[J].上海医药.2014(17):25-27.
[2]古娜娜·托列提别克.儿童紫癜性肾炎危险因素分析[D].新疆医科大学2012(02):606-609.
[3]冯仕品,罗苇,张伟,翟洋,方钰,李莎,王莉.儿童紫癜性肾炎200例临床与病理分析[J].临床儿科杂志.2011(07):652-655.
[4]Jae Il Shin,Jee Min Park,Ji Hong Kim,Jae Seung Lee,Hyeon Joo Jeong.Factors affecting histological regression of crescentic Henoch–Sch?nlein nephritis in children[J].Pediatric Nephrology.2006(1):527-528.
[5]夏珣,鹿玲.过敏性紫癜患儿肾脏损害的危险因素分析[J].实用儿科临床杂志.2010(09):654-655.
[2]古娜娜·托列提别克.儿童紫癜性肾炎危险因素分析[D].新疆医科大学2012(02):606-609.
[3]冯仕品,罗苇,张伟,翟洋,方钰,李莎,王莉.儿童紫癜性肾炎200例临床与病理分析[J].临床儿科杂志.2011(07):652-655.
[4]Jae Il Shin,Jee Min Park,Ji Hong Kim,Jae Seung Lee,Hyeon Joo Jeong.Factors affecting histological regression of crescentic Henoch–Sch?nlein nephritis in children[J].Pediatric Nephrology.2006(1):527-528.
[5]夏珣,鹿玲.过敏性紫癜患儿肾脏损害的危险因素分析[J].实用儿科临床杂志.2010(09):654-655.