非酒精性脂肪性肝病患者血清同型半胱氨酸浓度的意义

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• 英文论文题名：Significance of serum homocysteine level in patients with nonalcoholic fatty liver disease
• 论文作者：卫波 ; 罗丹英 ; 张治华 ; 程斌
• 英文论文作者：Wei Bo ; Luo Danying ; Zhang Zhihua ; Chengbin ; Shanghai PuDong New Area People's Hospital
• 年：2017
• 作者机构：上海市浦东新区人民医院;
• 论文关键词：非酒精性脂肪肝 ; 非酒精性脂肪肝炎 ; 同型半胱氨酸
• 英文论文关键词：Non alcoholic fatty liver ; Nonalcoholic Steatohepatitis ; homocysteine
• 会议召开时间：2017-05-26
• 会议录名称：2017年《中国组织化学与细胞化学杂志》临床研讨会论文集
• 语种：中文
• 分类号：R575.5
• 学会代码：ZHXB
• 会议名称：2017年《中国组织化学与细胞化学杂志》临床研讨会
• 会议地点：中国湖北武汉
• 主办单位：《中国组织化学与细胞化学杂志》社有限公司
• 学会名称：《中国组织化学与细胞化学杂志》社有限公司
• 页数：2
• 文件大小：250k
• 原文格式：O
• 会议级别：全国

摘要

目的:分析非酒精性脂肪性肝病(NAFLD)患者不同血清同型半胱氨酸浓度的临床意义;方法:根据诊疗指南、磁共振结果并结合天冬氨酸转移酶(AST)、丙氨酸氨基转移酶(ALT)、谷氨酰转肽酶(GGT)将患者分为:非酒精性脂肪肝组(A组):25例,非酒精性脂肪肝炎(B组)19例,C组为正常对照者20例,空腹抽取静脉血,检查同型半胱氨酸(HCY)、总胆固醇(TC),三酰甘油(TG),AST,ALT,GGT、前白蛋白(PA)、空腹血糖(FBG)、空腹胰岛素(FINS)、肿瘤坏死因子α(TNF-α)、高敏C反应蛋白(hs-CRP)、脂联素(ADPN)、白细胞介素-6(IL-6)、血管生长因子(VEGF)、叶酸、维生素B12等并计算胰岛素抵抗指数(HOMA-IS)。结果:A、B两组的TC、TG、ALT、GGT、FINS、HOMA-IS、比较无差别(P>0.05),但明显高于C组(P<0.05);B组hs-CRP、AST、TNF-α、IL-6、VEG浓度高于A组(P<0.05),A组高于C组(P<0.05);A、C两组的PA浓度无明显差异(P>0.05),但均高于B组(P<0.05);C组APN浓度高于A组(P<0.05),A组高于B组(P<0.05);A组HCY明显高于B、C两组(P<0.05),B、C两组比较无区别。结论:血清HCY水平较低可以提示NASH患者肝脏损伤程度较重,血清HCY或许可以成为NAFLD的非侵入性诊断指标之一。
Objective:To analyze the clinical significance of serum homocysteine concentration in patients with nonalcoholic fatty liver disease(NAFLD);.Methods:According to the guidelines for diagnosis and treatment and the result of magnetic resonance and aspartate aminotransferase(AST),and alanine amino transferase(ALT) transfer,valley ammonia acyl turn peptidase(GGT) patients were divided into:Nonalcoholic Fatty Liver Group(group A):25 cases,19 cases of nonalcoholic steatohepatitis(group B),group C was normal control in 20 cases.Fasting venous blood,check the homocysteine(Hcy),total cholesterol(TC),triglyceride(TG),AST,alt,GGT,prealbumin(PA),fasting blood glucose(FBG),fasting insulin(fins),tumor necrosis factor alpha(TNF alpha),hypersensitive C-reactive protein(hs CRP) and adiponectin(ADPN),leukocyte mediated IL-6(IL-6),vascular growth factor(VEGF),folic acid,vitamin B12 and calculate the insulin resistance index(HOMA-IS).Results:Concentration of PA in group C were higher than that of A and B two groups of TC,TG,alt,GGT,fins,HOMA-IS and there is no difference(P>0.05),but was significantly higher than that of group C(P<0.05);B group,hs CRP,AST,TNF alpha,IL-6,VEGF concentration was higher than group A(P<0.05).In group A(P<0.05);a,C two groups had no significant difference(P>0.05),but was higher than that in group B(P<0.05);C group of APN concentrations higher than group A(P<0.05),a group was higher than that in group B(P<0.05);a group of Hcy was significantly higher than that in group B and C(P<0.05),and there was no difference in groupB and C.Conclusion:The lower level of serum HCY may indicate that the liver damage of NASH patients is heavy,and serum HCY may be one of the non invasive diagnostic indexes of NAFLD.

引文

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