低场磁共振下纳米材料在疾病诊疗中的应用
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- 英文论文题名：The Application of Nanomaterials in Disease Diagnosis and Treatment by LF-NMR
- 论文作者：孙丹丹 ; 蒋伟 ; 卢海燕 ; 张英力 ; 杨培强
- 英文论文作者：Dandan Sun ; Haiyan Lu ; Wei Jiang ; Yingli Zhang ; Peiqiang Yang ; Shanghai Niumag Corporation
- 年：2016
- 作者机构：上海纽迈电子科技有限公司;
- 论文关键词：纳米材料 ; 低场磁共振技术 ; MRI造影剂 ; 肿瘤治疗
- 英文论文关键词：nanomaterials ; low field nuclear magnetic resonance ; MRI contrast agents ; tumor treatment
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第三十八分会：纳米生物效应与纳米药物化学
- 语种：中文
- 分类号：TB383.1;R4
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第三十八分会 ; 纳米生物效应与纳米药物化学
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：222k
- 原文格式：D
- 会议级别：全国
摘要
纳米材料由于其独特性能,已广泛应用于生物医药领域,特别是在疾病的早期诊断和治疗中~1。低场磁共振(LF-NMR)技术在造影剂体内外造影~2、肿瘤排查及治疗3~、纳米药物性能评价~4、小动物体成分分析~5等中已发挥重要作用。造影剂由于其显著的增强效果,已在医学影像中不可或缺。LF-NMR技术在MRI造影剂及多模态造影剂的体内外造影效能评价、造影剂的代谢及毒性研究、疾病的早期诊断中占有重要地位。此外,随着诊疗一体化及精准医疗的发展,LF-NMR技术也在靶向药物载体性能研究、肿瘤排查及治疗等领域得到应用。最后,展望了LF-NMR技术在纳米医学领域的应用前景。
The nanomaterials have been widely used in biomedical fields due to its unique properties, especially in disease early diagnosis and treatment~1. Low field nuclear magnetic resonance(LF-NMR) has played an important role in contrast agents~2, tumor diagnosis and treatment~3, performance evaluation of nanomedicines~4, body composition analysis for animals~5 and so on. Contrast agents are essential to medical image for its significant enhancement. LF-NMR is a significant tool in imaging evaluation of magnetic resonance imaging(MRI) or multi-modal contrast agents, metabolism and toxicity of contrast agents, and disease early diagnosis. Moreover, with the development of treatment integration and precision medicine, LF-NMR has applied in targeted drug carriers, tumor diagnosis, treatment and so on. Finally, the outlook for application prospect of LF-NMR are described in nanomedicines.
The nanomaterials have been widely used in biomedical fields due to its unique properties, especially in disease early diagnosis and treatment~1. Low field nuclear magnetic resonance(LF-NMR) has played an important role in contrast agents~2, tumor diagnosis and treatment~3, performance evaluation of nanomedicines~4, body composition analysis for animals~5 and so on. Contrast agents are essential to medical image for its significant enhancement. LF-NMR is a significant tool in imaging evaluation of magnetic resonance imaging(MRI) or multi-modal contrast agents, metabolism and toxicity of contrast agents, and disease early diagnosis. Moreover, with the development of treatment integration and precision medicine, LF-NMR has applied in targeted drug carriers, tumor diagnosis, treatment and so on. Finally, the outlook for application prospect of LF-NMR are described in nanomedicines.
引文
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2 .J Li,Y He,W Sun,et al.Biomaterials,2014,35(11),3666-3677.
3 .Y Chen,H Gu,D Zhang,et al.Biomaterials,2014,35(38),10058-10069.
4 .X Yang,Z Zhou,L Wang,et al.MATER RES BULL,2014,57,97-102.
5 .H K Chiu,K Qian,K Ogimoto,et al.Endocrinology,2010,151(3),993-1001.