一种可能的原始细胞膜模型:2-酮辛酸囊泡
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- 英文论文题名：A Novel Model of Protocell-like Membranes:2-ketooctanoic acid Vesicles
- 论文作者：胥会芳 ; 杜娜 ; 李海平 ; 侯万国
- 英文论文作者：Huifang Xu ; Na Du ; Haiping Li ; Wanguo Hou ; Key Laboratory of Colloid and Interface Chemistry (Ministry of Education) ; Shandong University ; National Engineering Technology Research Center for Colloidal Materials ; Shandong University
- 年：2016
- 作者机构：山东大学化学与化工学院胶体与界面化学教育部重点实验室;山东大学国家胶体材料工程技术研究中心;
- 论文关键词：囊泡 ; 单链两亲分子 ; 原始细胞膜
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第三十一分会：胶体与界面化学
- 语种：中文
- 分类号：Q2-3
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第三十一分会 ; 胶体与界面化学
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：285k
- 原文格式：D
- 会议级别：全国
摘要
细胞膜或膜结构被认为是生命出现的基础条件,而小囊泡可能是最初的原始细胞。单链脂肪酸分子被广泛认为可能是早期细胞膜的膜组分,但其存在囊泡形成的pH范围窄、所需浓度高和不耐二价金属阳离子等问题,其可能性受到质疑。本文报道了2-酮辛酸(KOO-H)囊泡,其形成的pH宽、浓度低,且抗盐(含二价金属阳离子)能力强,具有良好的热稳定性和冻融稳定性等,可能是一个比传统脂肪酸更好的原始细胞模型。
Early cellular membranes are presumably composed of simple single-tailed amphiphiles(STAs) such as fatty acids,fatty alcohols and monoglycerides arising from their facile prebiotic synthesis and the bilayer-forming ability.We report a novel model system of protocell-like vesicles based on a prebiotic STA,2-ketooctanoic acid(KOO-H),focusing on spontaneous vesicle formation in very dilute solution without any cosurfactants or additives.More interestingly,the 2-KOA vesicles displayed good stability upon long-term storage and even exposure to high-salinity artificial seawater,which qualified them to be a protocell-like membrane model.
Early cellular membranes are presumably composed of simple single-tailed amphiphiles(STAs) such as fatty acids,fatty alcohols and monoglycerides arising from their facile prebiotic synthesis and the bilayer-forming ability.We report a novel model system of protocell-like vesicles based on a prebiotic STA,2-ketooctanoic acid(KOO-H),focusing on spontaneous vesicle formation in very dilute solution without any cosurfactants or additives.More interestingly,the 2-KOA vesicles displayed good stability upon long-term storage and even exposure to high-salinity artificial seawater,which qualified them to be a protocell-like membrane model.
引文
[1]Kapoor,S.;Berghaus,M.;Suladze,S.;Prumbaum,D.;Grobelny,S.;Degen,P.;Raunser,S.;Winter,R.Angew.Chem.Int.Ed.,2014,53:8397-8401.
[2]Monnard,P.A.;Deamer,D.W.The Anat.Record,2002,268:196-207.
[2]Monnard,P.A.;Deamer,D.W.The Anat.Record,2002,268:196-207.