基于聚氨基酸的钆基磁共振造影剂的制备及其肿瘤成像研究
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- 英文论文题名：Synthesis of polylysine-based magnetic resonance imaging contrast agents and in vivo tumor imaging
- 论文作者：祖广月 ; 江桂梅 ; 程慧 ; 刘敏 ; 裴仁军
- 英文论文作者：Guangyue Zu ; Guimei Jiang ; Hui Cheng ; Min Liu ; Renjun Pei ; Shanghai University ; Suzhou Institute of Nano-Tech and Nano-Bionics (SINANO) ; Chinese Academy of Sciences
- 年：2016
- 作者机构：上海大学;中国科学院苏州纳米技术与纳米仿生研究所;
- 论文关键词：聚氨基酸 ; 磁共振成像 ; 肿瘤靶向 ; 超支化大分子 ; 可还原裂解
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第三十八分会：纳米生物效应与纳米药物化学
- 语种：中文
- 分类号：TQ421.7
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第三十八分会 ; 纳米生物效应与纳米药物化学
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：188k
- 原文格式：D
- 会议级别：全国
摘要
MRI技术已成为基础医学和临床诊断中最有力的检测手段之一,特别用于肿瘤的较早期诊断。在临床上大约有50%的MRI检查使用了造影剂,用以增强信号对比度和提高组织图像的分辨率,因此,MRI造影剂的研究也是该领域很重要的方面。目前,临床上使用的造影剂多为小分子造影剂,在成像时间窗口和分辨率上不能满足需要。基于此,我们课题组在大分子造影剂上开展了一些研究:(1)基于赖氨酸采用热聚法制备超支化聚赖氨酸,然后修饰上Gd-DTPA和靶向分子,制备大分子造影剂;(2)以mPEG-NH_2为引发剂,引发天冬氨酸NCA开环聚合,制备分子量可以精确控制的大分子造影剂;(3)在大分子造影剂中引入双硫键,制备了可快速还原裂解的大分子造影剂。通过对不同结构、分子量造影剂的系统研究,探索基于聚氨基酸的钆基磁共振造影剂构建及肿瘤靶向的一般规律和内在机理。
Magnetic resonance imaging(MRI) is a powerful medical imaging modality to display anatomical structures of body, especially useful for the detection and characterization of diseased soft tissues such as solid tumors. According to statistics, nearly 50% of MRI has involved the use of MRI contrast agents(CAs) due to their ability to improve tissue contrast and provide pathological correlation for a wide range of diseases. Our group has worked on the following studies.(1) Hyperbranched polylysine was prepared by thermal polymerization of L-lysine via one-step polycondensation, followed by conjugating with Gd-DTPA and folic acid.(2) A PEGylated block copolymer was prepared by the ring-opening polymerization of β-benzyl-L-aspartate N-carboxy-anhydrideinitiated by the terminal group of mP EG-NH2, of which the molecular weight can by accurately controlled.(3) A macromolecular contrast agent containing biocleavable disulfide bonds was prepared, and its applicability as a MRI contrast agent was demonstrated both in vitro and in vivo.
Magnetic resonance imaging(MRI) is a powerful medical imaging modality to display anatomical structures of body, especially useful for the detection and characterization of diseased soft tissues such as solid tumors. According to statistics, nearly 50% of MRI has involved the use of MRI contrast agents(CAs) due to their ability to improve tissue contrast and provide pathological correlation for a wide range of diseases. Our group has worked on the following studies.(1) Hyperbranched polylysine was prepared by thermal polymerization of L-lysine via one-step polycondensation, followed by conjugating with Gd-DTPA and folic acid.(2) A PEGylated block copolymer was prepared by the ring-opening polymerization of β-benzyl-L-aspartate N-carboxy-anhydrideinitiated by the terminal group of mP EG-NH2, of which the molecular weight can by accurately controlled.(3) A macromolecular contrast agent containing biocleavable disulfide bonds was prepared, and its applicability as a MRI contrast agent was demonstrated both in vitro and in vivo.
引文
[1]Dong,J.J.;Liu,M.;Zhang,K.C.;Cao,Y.;Jiang,B.;Zu,G.Y.and Pei,R.J.Bioconjugate Chem.2016,27:151-158.
[2]Jiang,B.;Liu,M.;Zhang,K.C.;Zu,G.Y.;Dong,J.J.;Cao,Y.;Zhang,L.and Pei,R.J.J.Mater.Chem.B 2016,DOI:10.1039/C6TB00278A.
[2]Jiang,B.;Liu,M.;Zhang,K.C.;Zu,G.Y.;Dong,J.J.;Cao,Y.;Zhang,L.and Pei,R.J.J.Mater.Chem.B 2016,DOI:10.1039/C6TB00278A.
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