表面分子印迹的静电纺丝纤维的制备及其胆红素吸附性能研究
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- 英文论文题名：Molecular Imprinted Electrospun Polyethersulfone Nanofiber Mats for Selective Adsorption of Bilirubin
- 论文作者：吴可可 ; 杨武锋 ; 刘小燕 ; 焦延鹏 ; 周长忍
- 英文论文作者：Keke Wu ; Wufeng Yang ; Xiaoyan Liu ; Yanpeng Jiao ; Changren Zhou ; Department of Materials Science and Engineering ; Jinan University
- 年：2016
- 作者机构：暨南大学材料科学与工程系;
- 论文关键词：胆红素 ; 静电纺丝 ; 表面分子印迹 ; 选择性吸附
- 会议召开时间：2016-11-18
- 会议录名称：中国第四届静电纺丝大会（CICE 2016）摘要集
- 语种：中文
- 分类号：TQ340.64;O647.3
- 学会代码：ZGNM
- 会议名称：中国第四届静电纺丝大会(CICE 2016)
- 会议地点：中国北京
- 主办单位：中国复合材料学会超细纤维材料分会（筹）
- 学会名称：中关村科创纳米技术创新研究会
- 页数：1
- 文件大小：509k
- 原文格式：D
- 会议级别：全国
摘要
胆红素是人体衰老的红细胞中血红素的代谢产物,如果胆红素代谢途径受阻,会对人体产生系统毒性。静电纺丝技术制备的纳米纤维具有较高的孔隙率和比表面积,适合制备大容量的血液吸附材料,而分子印迹技术能够实现特异性识别目标分子,从而实现选择性吸附。本研究通过静电纺丝制备聚醚砜(PES)纳米纤维作为胆红素的吸附基材;通过表面分子印迹技术,利用多巴胺的自聚合性能和良好的血液相容性,制备出具有高吸附容量、高选择性以及良好血液相容性的血液吸附材料。结果表明,聚醚砜纺丝纤维对胆红素具有较高的吸附能力,平衡吸附量可达到105.84 mg/g;而表面胆红素分子印迹材料吸附能力明显增强,平衡吸附量达到184.24 mg/g。动态吸附实验表明,表面胆红素分子印迹材料吸附速率更快,平衡时间较短,同时,二元竞争体系吸附实验表明,表面胆红素分子印迹材料还具有较高的选择性。因此,静电纺丝和表面分子印迹制备得到的新型胆红素吸附材料具有重要的临床意义和应用前景。
Bilirubin, is a principal degradation product of hemoglobin. Disorders in the metabolism of bilirubin may cause hyperbilirubinemia, which will result in neurotoxicity. Electrospinning technique is used to prepare nanofiber mats with high porosity and specific surface area, which have high adsorption capacity. Moreover, the molecular imprinting technique can achieve selective adsorption. In this study, the surface molecular imprinted polymers was prepared on the surface of electrospun PES nanofiber mats by self-polymerization of dopamine, which was a functional monomer with good blood compatibility. The results showed that the surface molecular imprinted polymers had higher adsorption capacity(184.24 mg/g) and faster adsorption rate than electrospun PES nanofiber mats(105.84 mg/g). In addition, the surface molecular imprinted polymers had a good selective adsorption for bilirubin. Therefore, it would have an important application prospect in clinical.
Bilirubin, is a principal degradation product of hemoglobin. Disorders in the metabolism of bilirubin may cause hyperbilirubinemia, which will result in neurotoxicity. Electrospinning technique is used to prepare nanofiber mats with high porosity and specific surface area, which have high adsorption capacity. Moreover, the molecular imprinting technique can achieve selective adsorption. In this study, the surface molecular imprinted polymers was prepared on the surface of electrospun PES nanofiber mats by self-polymerization of dopamine, which was a functional monomer with good blood compatibility. The results showed that the surface molecular imprinted polymers had higher adsorption capacity(184.24 mg/g) and faster adsorption rate than electrospun PES nanofiber mats(105.84 mg/g). In addition, the surface molecular imprinted polymers had a good selective adsorption for bilirubin. Therefore, it would have an important application prospect in clinical.
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