头孢喹肟在罗非鱼体内的药代动力学
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- 英文论文题名：Pharmacokinetics of cefquinome in tilapia(Oreochromis niloticus)
- 论文作者：范晶晶 ; 单奇 ; 尹怡 ; 刘书贵 ; 李丽春 ; 郑光明
- 英文论文作者：FAN Jingjing ; SHAN Qi ; YIN Yi ; LIU Shugui ; LI Lichun ; ZHENG Guangming ; Key Laboratory of Tropical and Subtropical Fishery Resource Application and Cultivation of Ministry of Agriculture and Ministry of Agriculture Laboratory of Quality&Safety Risk Assessment for Aquatic Product ; Pearl River Fisheries Research Institute ; Chinese Academic of Fishery Science ; College of Fisheries and Life Science ; Shanghai Ocean University
- 年：2016
- 作者机构：中国水产科学研究院珠江水产研究所农业部热带亚热带水产资源利用与养殖重点实验室农业部水产品质量安全风险评估实验室(广州);上海海洋大学水产与生命学院;
- 论文关键词：头孢喹肟 ; 药物动力学 ; 消除半衰期 ; 最小抑菌浓度
- 英文论文关键词：cefquinome ; pharmacokinetics ; T_(1/2b) ; the minimum inhibitory concentrations
- 会议召开时间：2016-11-02
- 会议录名称：2016年中国水产学会学术年会论文摘要集
- 语种：中文
- 分类号：S948
- 学会代码：OGSB
- 会议名称：2016年中国水产学会学术年会
- 会议地点：中国四川成都
- 主办单位：中国水产学会、四川省水产学会
- 学会名称：中国水产学会
- 页数：1
- 文件大小：609k
- 原文格式：D
- 会议级别：全国
摘要
为临床合理用药提供参考,研究在单次给药(10 mg/kg)途径下,头孢喹肟在罗非鱼体内的药代动力学。单剂量肌肉注射和腹腔注射给药后,高效液相色谱法(HPLC)测定血浆中头孢喹肟含量,并用Win Nonlin药动学软件的对实验数据进行了分析。结果表明:头孢喹肟在罗非鱼体内的药动学曲线符合二室开放模型。肌肉注射给药后,药物吸收和消除均较快,体内分布广泛。主要药动学参数为:T_(max)为0.14 h,T1/2ka为0.028h,T1/2b为5.81 h,Vd/F为0.41 L/kg,AUC为204.6μg h/mL。腹腔注射给药后,药物吸收和消除均较慢,体内分布广泛。T_(max)为0.17 h,T1/2ka为0.035 h,T1?2b为6.05h,Vd/F为0.33 L/kg,AUC为267.8μg·h/mL。通过测定头孢喹肟对30株感染罗非鱼体内分离的无乳链球菌的体外抑菌情况,得出其最小抑菌浓度(MIC)值在0.015-0.12μg/mL之间。鉴于以上结果可得出,每日10mg/kg剂量的头孢喹肟能够有效控制由大多数致病菌引起的罗非鱼感染。
The pharmacokinetics of cefquinome in tilapia(Oreochromis niloticus) after a single dose(10 mg/kg) was evaluated to provide references for clinical rational use of drugs. After intramuscular(i.m.) or intraperitoneal(i.p.) administration, the drug concentration in plasma was measured using the high performance liquid chromatography(HPLC), and analyzed by the compartment model of Win Nonlin software. The result was obtained that the concentrations versus time in plasma were well described by a two-department open model. After i.m.administration cefquinome, absorption and elimination were relatively faster and it was widely distributed throughout the body. The main pharmacokinetics parameters were T_(max) 0.14 h, T1/2ka0.028 h, T1/2b 5.81 h, Vd/F 0.41 L/kg, AUC 204.6 μg h/mL. Following i.p. injection, drug absorption and elimination were relatively slower and it was widely distributed throughout the body.
The pharmacokinetics of cefquinome in tilapia(Oreochromis niloticus) after a single dose(10 mg/kg) was evaluated to provide references for clinical rational use of drugs. After intramuscular(i.m.) or intraperitoneal(i.p.) administration, the drug concentration in plasma was measured using the high performance liquid chromatography(HPLC), and analyzed by the compartment model of Win Nonlin software. The result was obtained that the concentrations versus time in plasma were well described by a two-department open model. After i.m.administration cefquinome, absorption and elimination were relatively faster and it was widely distributed throughout the body. The main pharmacokinetics parameters were T_(max) 0.14 h, T1/2ka0.028 h, T1/2b 5.81 h, Vd/F 0.41 L/kg, AUC 204.6 μg h/mL. Following i.p. injection, drug absorption and elimination were relatively slower and it was widely distributed throughout the body.
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