聚多巴胺功能化纳米诊断治疗平台
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- 英文论文题名：Polydopamine Derivated Functional Theranostic Nanoplatform
- 论文作者：敖丽娇 ; 黄亮 ; 王伟 ; 粟武
- 英文论文作者：Lijiao Ao ; Liang Huang ; Wei Wang ; Wu Su ; Institute of Biomedicine and Biotechnology ; Shenzhen Institutes of Advanced Technology ; Chinese Academy of Sciences
- 年：2016
- 作者机构：中国科学院深圳先进技术研究院;
- 论文关键词：还原响应 ; 药物控释 ; 聚多巴胺 ; 分子影像 ; 光热治疗
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第三十八分会：纳米生物效应与纳米药物化学
- 语种：中文
- 分类号：TB383.1;R730.5
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第三十八分会 ; 纳米生物效应与纳米药物化学
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：151k
- 原文格式：D
- 会议级别：全国
摘要
多巴胺自聚合作为一种新型仿生合成及基体材料表面改性途径,在构建功能化及生物相容性纳米结构方面表现出了巨大潜力。本文以纳米级聚多巴胺(PDA)为模板,利用其天然的铁亲和表面(邻苯二酚基团),以高温热分解途径原位沉积了一层厚度可控的Fe_3O_4修饰层;以超声辅助的多巴胺自聚合过程,在Fe_3O_4表面包覆了一层PDA外壳;以含有二硫键的氧化还原活性linker(DTDPA)连接化疗药物阿霉素及氨基化PEG;将药物前体分子共价偶联于三明治型纳米颗粒表面,构建了聚多巴胺纳米诊断治疗试剂,并在体外表现出了还原(GSH)响应药物释放特性;经静脉注射后,该试剂可对4T1皮下移植瘤小鼠进行MRI及PAI肿瘤成像造影,经磁场诱导的肿瘤主动靶向以及近红外激光辐照后,获得了良好的肿瘤治疗效果。
Nano-sized polydopamine(PDA) spheres were employed as natural iron-affinity templates for in situ deposition of a compact and controllable Fe_3O_4 capping layer, via high temperature thermal-decomposition strategy. A thin layer of PDA was encapsulated onto Fe_3O_4 surface through sonication-assisted dopamine self-polymerization. A redox-reactive linker(DTDPA) was adopted to bridge the anti-cancer drug doxorubicin and amino-functionalized PEG. This pro-drug was covalently conjugated to the surface of sandwich structured polydopamine nanoparticles to build PDA based theranostic nanoagents, which revealed reduction(GSH) responsive drug release profile in vitro. After intravenously injection into 4T1 tumor-bearing mice, these nanoagents simultaneously improved MRI and PAI imaging contrasts at the tumor site. With magnetically guided active tumor targeting and NIR laser irradiation, satisfactory anti-tumor therapeutic effect was obtained.
Nano-sized polydopamine(PDA) spheres were employed as natural iron-affinity templates for in situ deposition of a compact and controllable Fe_3O_4 capping layer, via high temperature thermal-decomposition strategy. A thin layer of PDA was encapsulated onto Fe_3O_4 surface through sonication-assisted dopamine self-polymerization. A redox-reactive linker(DTDPA) was adopted to bridge the anti-cancer drug doxorubicin and amino-functionalized PEG. This pro-drug was covalently conjugated to the surface of sandwich structured polydopamine nanoparticles to build PDA based theranostic nanoagents, which revealed reduction(GSH) responsive drug release profile in vitro. After intravenously injection into 4T1 tumor-bearing mice, these nanoagents simultaneously improved MRI and PAI imaging contrasts at the tumor site. With magnetically guided active tumor targeting and NIR laser irradiation, satisfactory anti-tumor therapeutic effect was obtained.
引文
[1]Liu Y,Ai K,Lu L.Chem.Rev.2014,114,5057.