基于Gemini表面活性剂C_(12)-6-C_(12)·2Br/丁二酸钠pH响应体系的构建及其对紫杉醇的可控释放
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- 英文论文题名：Construction of pH-responsive system based on Gemini surfactant C_(12)-6-C_(12).2Br/sodium succinate and its controlled release for paclitaxel
- 论文作者：员乐 ; 杨杰 ; 张峰 ; 陈亚芍
- 英文论文作者：Le Yun ; Jie Yang ; Feng Zhang ; Yashao Chen ; Key Laboratory of Applied Surface and Colloid Chemistry of Ministry of Education ; School of Chemistry & Chemical Engineering ; Shaanxi Normal University
- 年：2016
- 作者机构：陕西师范大学化学化工学院应用表面与胶体化学教育部重点实验室;
- 论文关键词：Gemini表面活性剂 ; 丁二酸钠 ; 静电相互作用 ; pH响应 ; 紫杉醇
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第三十一分会：胶体与界面化学
- 语种：中文
- 分类号：O647.2
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第三十一分会 ; 胶体与界面化学
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：357k
- 原文格式：D
- 会议级别：全国
摘要
Gemini表面活性剂具有表面活性高、CMC低以及成胶束能力强等诸多优点,而被广泛应用于药物释放、纳米材料合成等领域~([1])。在一定条件下,表面活性剂分子在亲疏水作用、静电相互作用及π-π堆积等分子间相互作用下会形成胶束、囊泡、液晶等不同结构的有序聚集体~([2]),通过改变分子间相互作用力可以使表面活性剂有序聚集体的结构发生变化,从而丰富其应用范围。本研究探索了丁二酸钠与Gemini表面活性剂分子间的静电相互作用对Gemini表面活性剂在水中聚集行为的影响。在此基础上,通过控制体系的pH,构筑了一种具有响应性质的表面活性剂自组装体系,并研究了该pH响应体系对紫杉醇的控制释放性能。
Gemini surfactant has been widely applied to nanomaterials,drug delivery and release for its many advantages,such as high surface activity,low CMC.Under certain conditions,the surfactant could form different orderly aggregations which include micelles,vesicles,liquid crystal by hydrophobic,electrostatic,π-π stacking and other interaction.The structure and morphology of aggregations could be changed through adjusting the molecular interaction,which making its application more abundant.In this study,the electrostatic interactional rule between Gemini surfactants C_(12)-6-C_(12)·2Br and sodium succinate in water was researched.On the basis,a pH-responsive surfactant self-assembly system was constructed.Moreover,we also studied the controllable released performance for paclitaxel.
Gemini surfactant has been widely applied to nanomaterials,drug delivery and release for its many advantages,such as high surface activity,low CMC.Under certain conditions,the surfactant could form different orderly aggregations which include micelles,vesicles,liquid crystal by hydrophobic,electrostatic,π-π stacking and other interaction.The structure and morphology of aggregations could be changed through adjusting the molecular interaction,which making its application more abundant.In this study,the electrostatic interactional rule between Gemini surfactants C_(12)-6-C_(12)·2Br and sodium succinate in water was researched.On the basis,a pH-responsive surfactant self-assembly system was constructed.Moreover,we also studied the controllable released performance for paclitaxel.
引文
[1]Zana,R.Advances in Colloid and Interface.Science,2002,97(205):205-253.
[2]Shi,L.J.;Wei,Y.Sun,N.;Zheng L.Q.Chem.Commun.,2013,49,11388-11390.
[2]Shi,L.J.;Wei,Y.Sun,N.;Zheng L.Q.Chem.Commun.,2013,49,11388-11390.