自组装石墨烯凝胶对血液中胆红素的去除
详细信息 查看官网全文
- 英文论文题名：Hemocompatible heparin-modified graphene self-assembled hydrogel as a super bilirubin adsorbent
- 论文作者：韩璐璐 ; 韦厚良 ; 贾凌云
- 英文论文作者：Lulu Han ; Houliang Wei ; Lingyun Jia ; School of Life Science and Biotechnology ; Dalian University of Technology
- 年：2016
- 作者机构：大连理工大学生命科学与技术学院;
- 论文关键词：胆红素 ; 石墨烯 ; 肝素 ; 壳聚糖 ; 血液相容性
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第二十四分会：超分子组装与软物质材料
- 语种：中文
- 分类号：R446.1;O648.17
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第二十四分会 ; 超分子组装与软物质材料
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：248k
- 原文格式：D
- 会议级别：全国
摘要
胆红素作为一种血液致病毒素,在肝病病人的体内大量存在。临床上通常利用血液灌流对胆红素进行去除。由于血液中的疏水胆红素通常与白蛋白结合,血液灌流对胆红素的特异性吸附并不明显,导致临床去除效果并不理想。为解决这一问题,需要发展高吸附能力同时具有高机械强度的血液相容性吸附材料。本研究利用冻干法制备了肝素修饰的壳聚糖/氧化石墨烯(hep-CS/GH)自组装凝胶,并利用其吸附胆红素~([1])。结果表明hep-CS/GH具有多孔结构和高度的机械柔性,对胆红素的最大吸附量为92.59 mg/g。此外,hepC S/GH能选择性地从白蛋白溶液中吸附胆红素,并能够有效地从血清中去除胆红素。hepC S/GH还具有优异的血液相容性,可减少吸附过程中的凝血反应。因此,这种新材料能够在血液毒素去除方面具有潜在应用。
As a pathogenic toxin, bilirubin is generally removed from blood by hemoperfusion for the remission of liver disease and striving time for liver transplantation. However, the development of bilirubin adsorbents with excellent mechanical property, adsorption performance and hemocompatibility is still a big challenge. In this work, a heparin-modified chitosan/graphene oxide self-assembled hydrogel(hep-CS/GH) has been developed for bilirubin adsorption by a lyophilization-neutralization-modification strategy. The as-prepared hybrid hydrogel displayed a unique foam-like porous structure and excellent mechanical flexibility. The maximum adsorption capacity of hep-CS/GH for bilirubin was 92.59 mg/g. Moverover, hep-CS/GH performed high adsorption selectivity for bilirubin against albumin, and could effectively adsorb bilirubin from bilirubin-enriched serum, and a better hemocompatibility of hep-CS/GH. Therefore, this study may pave a significant way for improving the performance of the adsorbent for blood toxins removal.
As a pathogenic toxin, bilirubin is generally removed from blood by hemoperfusion for the remission of liver disease and striving time for liver transplantation. However, the development of bilirubin adsorbents with excellent mechanical property, adsorption performance and hemocompatibility is still a big challenge. In this work, a heparin-modified chitosan/graphene oxide self-assembled hydrogel(hep-CS/GH) has been developed for bilirubin adsorption by a lyophilization-neutralization-modification strategy. The as-prepared hybrid hydrogel displayed a unique foam-like porous structure and excellent mechanical flexibility. The maximum adsorption capacity of hep-CS/GH for bilirubin was 92.59 mg/g. Moverover, hep-CS/GH performed high adsorption selectivity for bilirubin against albumin, and could effectively adsorb bilirubin from bilirubin-enriched serum, and a better hemocompatibility of hep-CS/GH. Therefore, this study may pave a significant way for improving the performance of the adsorbent for blood toxins removal.
引文
[1]Houliang Wei,Lulu Han,Jun Ren,et al.ACS Applied Materials&Interfaces,2013,5:12571-12578