Controlled delivery of GHRP-6 from PLGA-PEG-PLGA copolymer and the effect of GHRP-6-copolymer hydrogel on the growth of rex rabbits
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- 英文论文题名：Controlled delivery of GHRP-6 from PLGA-PEG-PLGA copolymer and the effect of GHRP-6-copolymer hydrogel on the growth of rex rabbits
- 论文作者：Guan yuan ; Li xinwei ; Zhang xin ; Cheng yunyun ; Su dan ; Lu chao ; Fang xibi ; Ma qiang ; Zhang dawei ; Yu hao ; Hao linlin ; Liu songcai
- 英文论文作者：Guan yuan ; Li xinwei ; Zhang xin ; Cheng yunyun ; Su dan ; Lu chao ; Fang xibi ; Ma qiang ; Zhang dawei ; Yu hao ; Hao linlin ; Liu songcai ; College of Animal Science.Jilin University ; College of Veterinary Medicine ; Jilin University ; Teaching Center of Basic Courses ; Jilin University
- 年：2016
- 作者机构：College of Animal Science.Jilin University;College of Veterinary Medicine,Jilin University;Teaching Center of Basic Courses,Jilin University;
- 会议召开时间：2016-05-25
- 会议录名称：第七届中国畜牧科技论坛论文集
- 英文会议录名称：Proceeding of the 7th China Animal Husbandry Sci-tech Forum
- 语种：英文
- 分类号：S829.1
- 学会代码：ZGXJ
- 会议名称：第七届中国畜牧科技论坛
- 会议地点：中国重庆
- 主办单位：中国畜牧兽医学会
- 学会名称：中国畜牧兽医学会
- 页数：2
- 文件大小：109k
- 原文格式：O
- 会议级别：全国
摘要
Growth hormone releasing peptide-6(GHRP-6) plays an important role in animal growth.However,there was few study focused on the effect of GHRP-6 on animal growth through controlied-release system.We have synthesized PLGA-PEG-PLGA copolymer to investigate its control-released effect on GHRP-6 in vitro and to study the effect of GHRP-6-copolymer hydrogel on the growth of rex rabbits.The copolymer was synthesized using ring-opening copolymerization and characterized by ~1H NMR.The interaction between GHRP-6 and copolymer was characterized by Fourier transform infrared(FTIR) and X-ray diffraction(XRD).The body weight,serum level of insulin-like growth factor-1(IGF-1) and hair coat quality were studied in rex rabbits.The results showed that hydrogen bonding forms between N-H group in GHRP-6 and C=O group in copolymer.The release mechanism of GHRP-6 was the combination of diffusion-controlled and erosion-controlled in the copolymer.The serum level of IGF-1,hair coat quality and body weight was both significantly higher in the GHRP-6-copolymer hydrogel group than other groups.These results indicate that the copolymer can effectively control the release of GHRP-6.In addition,the GHRP-6-copolymer hydrogel can increase the synthesis of IGF-1 for a prolonged period,thereby increasing the rex rabbits growth and hair coat quality.
Growth hormone releasing peptide-6(GHRP-6) plays an important role in animal growth.However,there was few study focused on the effect of GHRP-6 on animal growth through controlied-release system.We have synthesized PLGA-PEG-PLGA copolymer to investigate its control-released effect on GHRP-6 in vitro and to study the effect of GHRP-6-copolymer hydrogel on the growth of rex rabbits.The copolymer was synthesized using ring-opening copolymerization and characterized by ~1H NMR.The interaction between GHRP-6 and copolymer was characterized by Fourier transform infrared(FTIR) and X-ray diffraction(XRD).The body weight,serum level of insulin-like growth factor-1(IGF-1) and hair coat quality were studied in rex rabbits.The results showed that hydrogen bonding forms between N-H group in GHRP-6 and C=O group in copolymer.The release mechanism of GHRP-6 was the combination of diffusion-controlled and erosion-controlled in the copolymer.The serum level of IGF-1,hair coat quality and body weight was both significantly higher in the GHRP-6-copolymer hydrogel group than other groups.These results indicate that the copolymer can effectively control the release of GHRP-6.In addition,the GHRP-6-copolymer hydrogel can increase the synthesis of IGF-1 for a prolonged period,thereby increasing the rex rabbits growth and hair coat quality.
Growth hormone releasing peptide-6(GHRP-6) plays an important role in animal growth.However,there was few study focused on the effect of GHRP-6 on animal growth through controlied-release system.We have synthesized PLGA-PEG-PLGA copolymer to investigate its control-released effect on GHRP-6 in vitro and to study the effect of GHRP-6-copolymer hydrogel on the growth of rex rabbits.The copolymer was synthesized using ring-opening copolymerization and characterized by ~1H NMR.The interaction between GHRP-6 and copolymer was characterized by Fourier transform infrared(FTIR) and X-ray diffraction(XRD).The body weight,serum level of insulin-like growth factor-1(IGF-1) and hair coat quality were studied in rex rabbits.The results showed that hydrogen bonding forms between N-H group in GHRP-6 and C=O group in copolymer.The release mechanism of GHRP-6 was the combination of diffusion-controlled and erosion-controlled in the copolymer.The serum level of IGF-1,hair coat quality and body weight was both significantly higher in the GHRP-6-copolymer hydrogel group than other groups.These results indicate that the copolymer can effectively control the release of GHRP-6.In addition,the GHRP-6-copolymer hydrogel can increase the synthesis of IGF-1 for a prolonged period,thereby increasing the rex rabbits growth and hair coat quality.
引文