GSK3β activity that can be regulated by AICAR via stimulated AKT in preadipocytes is involved in the regulation of adipogenesis, glucose metabolism and insulin action in adipocytes

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• 英文论文题名：GSK3β activity that can be regulated by AICAR via stimulated AKT in preadipocytes is involved in the regulation of adipogenesis, glucose metabolism and insulin action in adipocytes
• 论文作者：Li Wang ; Lijun Di
• 英文论文作者：Li Wang ; Lijun Di ; Metabolomics Core ; Faculty of Health Sciences ; University of Macau ; Faculty of Health Sciences ; University of Macau
• 年：2016
• 作者机构：Metabolomics Core, Faculty of Health Sciences, University of Macau;Faculty of Health Sciences, University of Macau;
• 英文论文关键词：AICAR ; GSK3 ; AKT ; Adipogenesis ; Glucose uptake
• 会议召开时间：2016-10-20
• 会议录名称：中国生物化学与分子生物学会2016年全国学术会议论文集
• 语种：英文
• 分类号：R58
• 学会代码：IGSS
• 会议名称：中国生物化学与分子生物学会2016年全国学术会议
• 会议地点：中国浙江杭州
• 主办单位：中国生物化学与分子生物学会
• 学会名称：中国生物化学与分子生物学会
• 页数：1
• 文件大小：6866k
• 原文格式：D
• 会议级别：全国

摘要

<正>Adipogenesis is a tightly regulated cellular differentiation process and the understanding of mechanism and manipulation of adipogenesis might contribute to a reduction in the burden of obesity and diabetes.Multiple transcription factors and signaling pathways are involved in the regulation of adipogenesis.Here we report that in preadipocytes,AMP-activated protein kinase activator,5-aminoimidazole-4-carboxamide ribonucleoside(AICAR)can activate AMPK to increase GSK3β

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