RNF169 drives high-fidelity DNA repair via a bifunctional NLS
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- 英文论文题名：RNF169 drives high-fidelity DNA repair via a bifunctional NLS
- 论文作者：Liwei An ; Yiyang Jiang ; Howin H.W.Ng ; Jie Chen ; Qingguo Gong ; Michael S.Y.Huen
- 英文论文作者：Liwei An ; Yiyang Jiang ; Howin H.W.Ng ; Jie Chen ; Qingguo Gong ; Michael S.Y.Huen ; School of Biomedical Sciences ; LKS Faculty of Medicine ; The University of Hong Kong ; School of Life Sciences ; University of Science and Technology of China ; State Key Laboratory of Brain and Cognitive Sciences ; The University of Hong Kong
- 年：2016
- 作者机构：School of Biomedical Sciences,LKS Faculty of Medicine,The University of Hong Kong;School of Life Sciences,University of Science and Technology of China;State Key Laboratory of Brain and Cognitive Sciences,The University of Hong Kong;
- 会议召开时间：2016-12-19
- 会议录名称：中国晶体学会第六届学术年会暨会员代表大会（大分子晶体学分会）论文摘要集
- 英文会议录名称：Abstracts of the 6th Annual Conference of Chinese Crystallographic Society
- 语种：英文
- 分类号：Q75
- 学会代码：ZGJY
- 会议名称：中国晶体学会第六届学术年会暨会员代表大会（大分子晶体学分会）
- 会议地点：中国广东广州
- 主办单位：中国晶体学会
- 学会名称：中国晶体学会
- 页数：1
- 文件大小：114k
- 原文格式：D
- 会议级别：全国
摘要
<正>Loading of 53BP1 and RAP80 at DNA double-strand breaks(DSBs)drives cell cycle checkpoint activation but is counterproductive to high-fidelity DNA repair.RNF169 maintains the balance by limiting the deposition of DNA damage mediator proteins at the damaged chromatin.We report here that this is accomplished,in part,by a predicted NLS that not only shuttles
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