Design, Characterization and Antimicrobial activity of Novel Antimicrobial Peptide from Temporin-PTa
详细信息 查看官网全文
- 英文论文题名：Design, Characterization and Antimicrobial activity of Novel Antimicrobial Peptide from Temporin-PTa
- 论文作者：Zuodong Qin ; Wei Liu ; Fulin He ; Changjian Li ; Xiaofang Luo
- 英文论文作者：Zuodong Qin ; Wei Liu ; Fulin He ; Changjian Li ; Xiaofang Luo ; Key Laboratory of Comprehensive Utilization of Advantage Plants Resources in Hunan South ; Hunan University of Science and Technology ; Department of Chemical and Biological Engineering ; Zhejiang University ; Plant protection and Microbiology Research Institute ; Zhejiang Academy of Agricultural Sciences
- 年：2017
- 作者机构：Key Laboratory of Comprehensive Utilization of Advantage Plants Resources in Hunan South,Hunan University of Science and Technology;Department of Chemical and Biological Engineering, Zhejiang University;Plant protection and Microbiology Research Institute, Zhejiang Academy of Agricultural Sciences;
- 英文论文关键词：Antimicrobial peptides ; Temporin-PTa ; Bactericidal activity
- 会议召开时间：2017-04-08
- 会议录名称：中国生物工程学会第二届青年科技论坛暨首届青年工作委员会学术年会论文集
- 语种：英文
- 分类号：R915
- 学会代码：IGSV
- 会议名称：中国生物工程学会第二届青年科技论坛暨首届青年工作委员会学术年会
- 会议地点：中国广东广州
- 主办单位：中国生物工程学会青年工作委员会
- 学会名称：中国生物工程学会
- 页数：1
- 文件大小：11k
- 原文格式：D
- 会议级别：全国
摘要
In order to meet the increasing challenge of global antibiotic resistance, a new generation of antimicrobials with broad spectrum and high efficiency must be developed. Based on previous studies and combined with data from the Antimicrobial Peptide Database, this project involves the design of a series of modified antimicrobial peptides with different compositions by a combination of structural analysis, molecular design, helical structure domain truncation and amino acid substitution with the 13 amino acid antimicrobial peptide Temporin-Pta as a template. Three antibacterial peptides, designated, 21#, 22# and 14# with good antibacterial activity were obtained by the combined technologies of microbiology and biochemistry. The main metabolic pathways and target genes of different antimicrobial peptides in anaerobic conditions were explored by comparing the antimicrobial activity of the antimicrobial peptide Temporin-Pta This work is of important scientific value for the study of the bactericidal mechanisms of different compositions of antibacterial peptides, and provides a theoretical basis for the design and development of a new type of antibacterial peptide.
In order to meet the increasing challenge of global antibiotic resistance, a new generation of antimicrobials with broad spectrum and high efficiency must be developed. Based on previous studies and combined with data from the Antimicrobial Peptide Database, this project involves the design of a series of modified antimicrobial peptides with different compositions by a combination of structural analysis, molecular design, helical structure domain truncation and amino acid substitution with the 13 amino acid antimicrobial peptide Temporin-Pta as a template. Three antibacterial peptides, designated, 21#, 22# and 14# with good antibacterial activity were obtained by the combined technologies of microbiology and biochemistry. The main metabolic pathways and target genes of different antimicrobial peptides in anaerobic conditions were explored by comparing the antimicrobial activity of the antimicrobial peptide Temporin-Pta This work is of important scientific value for the study of the bactericidal mechanisms of different compositions of antibacterial peptides, and provides a theoretical basis for the design and development of a new type of antibacterial peptide.
In order to meet the increasing challenge of global antibiotic resistance, a new generation of antimicrobials with broad spectrum and high efficiency must be developed. Based on previous studies and combined with data from the Antimicrobial Peptide Database, this project involves the design of a series of modified antimicrobial peptides with different compositions by a combination of structural analysis, molecular design, helical structure domain truncation and amino acid substitution with the 13 amino acid antimicrobial peptide Temporin-Pta as a template. Three antibacterial peptides, designated, 21#, 22# and 14# with good antibacterial activity were obtained by the combined technologies of microbiology and biochemistry. The main metabolic pathways and target genes of different antimicrobial peptides in anaerobic conditions were explored by comparing the antimicrobial activity of the antimicrobial peptide Temporin-Pta This work is of important scientific value for the study of the bactericidal mechanisms of different compositions of antibacterial peptides, and provides a theoretical basis for the design and development of a new type of antibacterial peptide.
引文