Myc-induced Nrf2 activation promotes ROS detoxification and cell viability in tamoxifen resistant breast cancer cell lines

详细信息    查看官网全文

• 英文论文题名：Myc-induced Nrf2 activation promotes ROS detoxification and cell viability in tamoxifen resistant breast cancer cell lines
• 论文作者：Xiaofeng Lai ; Jian Zhang
• 英文论文作者：Xiaofeng Lai ; Jian Zhang ; State Key Laboratory of Cancer Biology ; Department of Biochemistry and Molecular Biology ; the Fourth Military Medical University
• 年：2016
• 作者机构：State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology,the Fourth Military Medical University;
• 英文论文关键词：Tamoxifen resistant ; Nrf2 ; c-Myc ; ROS ; Niclosamide
• 会议召开时间：2016-10-20
• 会议录名称：中国生物化学与分子生物学会2016年全国学术会议论文集
• 语种：英文
• 分类号：R737.9
• 学会代码：IGSS
• 会议名称：中国生物化学与分子生物学会2016年全国学术会议
• 会议地点：中国浙江杭州
• 主办单位：中国生物化学与分子生物学会
• 学会名称：中国生物化学与分子生物学会
• 页数：1
• 文件大小：6866k
• 原文格式：D
• 会议级别：全国

摘要

<正>Tamoxifen (TAM) has been one of the most widely applied endocrine drugs for the treatment of ER positive breast cancer.Unfortunately,clinical resistance to tamoxifen is frequent and precedes death from metastases.In our recent study,we found that Nrf2 showed higher expression in MCF-7 tamoxifen resistant cells(MCF-7/TR)than in MCF-7 parental cells(MCF-7/P),so as other anti-oxidant genes,such as SOD1,ME1,HO1,GPX2 and so on.All these higher expression genes led to

引文