Bmi-1 expression as a new independent prognostic marker of hepatocellular carcinoma

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• 英文论文题名：Bmi-1 expression as a new independent prognostic marker of hepatocellular carcinoma
• 论文作者：Shao Yingjie ; Zhang Dachuan ; Li Xiaodong ; Yang Jing ; Chen Lujun ; Ning Zhonghua ; Xu Yun ; Deng Guohua ; Tao Min ; Zhu Yibei ; Jiang Jingting
• 英文论文作者：Shao Yingjie ; Zhang Dachuan ; Li Xiaodong ; Yang Jing ; Chen Lujun ; Ning Zhonghua ; Xu Yun ; Deng Guohua ; Tao Min ; Zhu Yibei ; Jiang Jingting ; Department of Tumor Biological Treatment ; The Third Affiliated Hospital of Soochow University ; Department of Radiation Oncology ; The Third Affiliated Hospital of Soochow University ; Jiangsu Engineering Research Center for Tumor Immunotherapy ; Institute of Cell Therapy ; Soochow University
• 年：2016
• 作者机构：Department of Tumor Biological Treatment,The Third Affiliated Hospital of Soochow University;Department of Radiation Oncology,The Third Affiliated Hospital of Soochow University;Jiangsu Engineering Research Center for Tumor Immunotherapy;Institute of Cell Therapy,Soochow University;
• 英文论文关键词：Bmi-1 ; Hepatocellular carcinoma ; Prognosis ; miR-203
• 会议召开时间：2016-11-04
• 会议录名称：第十一届全国免疫学学术大会摘要汇编
• 英文会议录名称：Abstracts of 2016 CSI Congress on Immunology
• 语种：英文
• 分类号：R735.7
• 学会代码：IGMD
• 会议名称：第十一届全国免疫学学术大会
• 会议地点：中国安徽合肥
• 主办单位：中国免疫学会
• 学会名称：中国免疫学会
• 页数：2
• 文件大小：1335k
• 原文格式：D
• 会议级别：全国

摘要

Objectives: Many studies have shown that the B-cell-specific moloney leukemia virus insertion site 1(Bmi-1) exhibit altered expression in various cancers and serve as prognostic biomarkers. However, the expression level and prognostic value of Bmi-1 in hepatocellular carcinoma(HCC) is still controversial. Materials and Methods: We investigated Bmi-1 expression and its prognostic significance in HCC by performing immunohistochemical analysis, using a total of 90 HCC clinical tissue samples and The Cancer Genome Atlas(TCGA) datasets.Results: High Bmi-1 protein and mRNA expression were significantly higher in HCC tissues than that in the adjacent normal tissues(P<0.001). Cox regression multivariate analyses revealed that Bmi-1 expression was a significant and independent prognostic parameter(HR=2.378, 95% CI=1.245-4.543, P=0.009) for HCC patients. We established a nomogram integrated Bmi-1 and TNM stage, which showed better performance in predicting clinical outcomes for patients with HCC. Furthermore, miR-203 was significantly lower in HCC tissues compared with matched adjacent normal liver tissues(P<0.001), and was negative correlated with Bmi-1 expression(P<0.001).Conclusions: Bmi-1, an identified independent prognostic factor, could improve predictive accuracy for survival in patients with HCC.
Objectives: Many studies have shown that the B-cell-specific moloney leukemia virus insertion site 1(Bmi-1) exhibit altered expression in various cancers and serve as prognostic biomarkers. However, the expression level and prognostic value of Bmi-1 in hepatocellular carcinoma(HCC) is still controversial. Materials and Methods: We investigated Bmi-1 expression and its prognostic significance in HCC by performing immunohistochemical analysis, using a total of 90 HCC clinical tissue samples and The Cancer Genome Atlas(TCGA) datasets.Results: High Bmi-1 protein and mRNA expression were significantly higher in HCC tissues than that in the adjacent normal tissues(P<0.001). Cox regression multivariate analyses revealed that Bmi-1 expression was a significant and independent prognostic parameter(HR=2.378, 95% CI=1.245-4.543, P=0.009) for HCC patients. We established a nomogram integrated Bmi-1 and TNM stage, which showed better performance in predicting clinical outcomes for patients with HCC. Furthermore, miR-203 was significantly lower in HCC tissues compared with matched adjacent normal liver tissues(P<0.001), and was negative correlated with Bmi-1 expression(P<0.001).Conclusions: Bmi-1, an identified independent prognostic factor, could improve predictive accuracy for survival in patients with HCC.

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