VEGF在甲状腺肿瘤组织中的表达及其与肿瘤血管生成的相关性研究
详细信息 查看官网全文
- 英文论文题名：Expression of VEGF and correlation with tumor angiogenesis in thyroid tumors
- 论文作者：杨光 ; 王宇 ; 赵佳佳
- 英文论文作者：Yang Guang ; Wang Yu ; Zhao Jiajia
- 年：2016
- 作者机构：北京军区总医院263临床部;
- 论文关键词：VEGF ; 甲状腺瘤 ; 肿瘤血管 ; 免疫组化
- 英文论文关键词：VEGF ; Thyroid tumors ; Tumor angiogenesis ; Immunohistochemistry
- 会议召开时间：2016年6月
- 会议录名称：2016《中国组织化学与细胞化学》杂志临床研究研讨会论文汇编
- 语种：中文
- 分类号：R736.1
- 学会代码：ZHXB
- 会议名称：2016《中国组织化学与细胞化学》杂志临床研究研讨会
- 会议地点：中国北京
- 主办单位：《中国组织化学与细胞化学杂志》社有限公司
- 学会名称：《中国组织化学与细胞化学杂志》社有限公司
- 页数：2
- 文件大小：243k
- 原文格式：O
- 会议级别：全国
摘要
目的:分析VEGF(内皮生长因子)在甲状腺肿瘤组织中的表达和肿瘤血管生成的相关性,为临床检测提供参考。方法:选取我院甲状腺肿瘤患者211例为研究对象,依照肿瘤性质不同分为良性肿瘤组92例、甲状腺癌组119例,另外选取同期健康体检人员80例作为对照组,采用免疫组化方法测定VEGF含量,并分析VEGF与肿瘤血管生成关系。结果:甲状腺肿瘤良性组VEGF蛋白表达阳性率(14.1%)和甲状腺癌组患者(77.3%)显著高于对照组(2.5%)(P<0.05)。甲状腺癌不同病理分期类型VEGF表达存在显著差异(P<0.05),未分化癌患者VEGF阳性表达显著高于其他三组(P<0.05)。年龄、性别、肿瘤大小等与VEGF表达无明显相关性(P>0.05),VEGF表达与颈部存在淋巴结转移、AJCC分期以及侵润深度存在密切关系(P<0.05)。结论:VEGF检测对于甲状腺肿瘤诊断有重要价值,甲状腺癌患者VEGF阳性率高,VEGF表达升高预示高侵袭性和易转移性,可以作为预测甲状腺转移和预后参考指标之一。
Objective:To analysize the expression of VEGF and correlation with tumor angiogenesis in thyroid tumors,and provide reference for clinical testing.Methods:211 patients with thyroid tumors in hospital were selected,patients were divided into Benign group(92 cases) and thyroid cancer group(119 cases),80 cases Healthy volunteers were selected as control group.VEGF levels were measured by immunohistochemistry,VEGF positive rate and tumor angiogenesis were compared.Results:Benign thyroid tumor VEGF protein positive rate(14.1%) and thyroid cancer patients(77.3%) were significantly higher than control group(2.5%)(P < 0.05).VEGF expression in different types of staging of thyroid cancer were significant differences(P < 0.05),VEGF expression in patients with undifferentiated carcinoma was significantly higher than the other three groups(P < 0.05).Age,gender,tumor size and VEGF expression was not significantly correlated(P > 0.05),there was a close relationship between VEGF expression and the presence of cervical lymph node metastasis,depth of invasion,AJCC stage(P < 0.05).Conclusion:VEGF detection for thyroid cancer diagnosis has important value,VEGF positive rate of thyroid cancer,VEGF expression increases indicate highly invasive and easy portability,can be used as one of the reference predict thyroid metastasis and prognostic factors.
Objective:To analysize the expression of VEGF and correlation with tumor angiogenesis in thyroid tumors,and provide reference for clinical testing.Methods:211 patients with thyroid tumors in hospital were selected,patients were divided into Benign group(92 cases) and thyroid cancer group(119 cases),80 cases Healthy volunteers were selected as control group.VEGF levels were measured by immunohistochemistry,VEGF positive rate and tumor angiogenesis were compared.Results:Benign thyroid tumor VEGF protein positive rate(14.1%) and thyroid cancer patients(77.3%) were significantly higher than control group(2.5%)(P < 0.05).VEGF expression in different types of staging of thyroid cancer were significant differences(P < 0.05),VEGF expression in patients with undifferentiated carcinoma was significantly higher than the other three groups(P < 0.05).Age,gender,tumor size and VEGF expression was not significantly correlated(P > 0.05),there was a close relationship between VEGF expression and the presence of cervical lymph node metastasis,depth of invasion,AJCC stage(P < 0.05).Conclusion:VEGF detection for thyroid cancer diagnosis has important value,VEGF positive rate of thyroid cancer,VEGF expression increases indicate highly invasive and easy portability,can be used as one of the reference predict thyroid metastasis and prognostic factors.
引文
[1]严旦红,张炽敏,胡中倩,等.CDFI联合VEGF测定鉴别甲状腺肿瘤良恶性的可行性研究[J].东南大学学报(医学版),2015,11(2):217-221.
[2]王军.血管内皮生长因子和血小板反应素-1在甲状腺乳头状癌中的表达及其与肿瘤血管生成的关系[J].中国医师进修杂志,2013,36(5):64-65,67.
[3]薛栋,张同军,李新军,等.IAvin、VEGF在甲状腺癌中的表达及其临床意义[J].中国现代普通外科进展,2013,16(4):270-273.
[4]Shaik S,Nucera C,Inuzuka H,el al.SCF(B-TRCP)suppresses angiogenesis and thyroid cancer cell migration by promoting ubiquitination and destruction of VEGF receptor 2.[J].Journal of Experimental Medicine,2012,209(7):1289-307.
[5]Jia W,X-J G,Z-D Z,et al.S100A4 silencing suppresses proliferation,angiogenesis and invasion of thyroid cancer cells through downregulation of MMP-9 and VEGF[J].European Review for Medical&Pharmacological Sciences,2013,17(11):1495-1508.
[6]杜日昌,李宇芳,邱卫东等.甲状腺乳头状癌中HIF-1α、VEGF、COX-2及VEGF-C表达与侵袭转移的关系[J].临床与实验病理学杂志,2013,29(9):991-995.
[7]Xi W,Ying L,Sheng Z,el al.Evaluation of thyroid cancer in Chinese females with breast cancer by vascular endothelial growth factor(VEGF),microvessel density,and contrast-enhanced ultrasound(CEUS).[J].Tumour Biology the Journal of the International Society for Oncodevelopmental Biology&Medicine,2014,35(7):6521-6529.
[8]吴伟群,何小杰,李延辉,等.VEGF在甲状腺肿瘤中的表达及与肿瘤血管生成的关系[J].中国医药科学,2013,(12):23-25.
[9]颜建军,王蕾,时志民,等.雌激素受体α与细胞外信号调节蛋白激酶和血管内皮生长因子在甲状腺癌组织中的表达及意义[J].山西医药杂志,2013,42(17):980-982.
[10]华特波,孟宪瑛,张强等.COX-2、MMP-9、VEGF在甲状腺肿瘤中的表达[J].中国老年学杂志,2011,31(9):1520-1522.
[11]巩雷,陈萍,刘宪军等.D2-40,CK19,galectin-3,VEGF和EGFR在甲状腺乳头状癌中的表达及其临床意义[J].中国普通外科杂志,2011,20(11):1203-1207.
[12]Gulubova M,Ivanova K,Ananiev J,et al.VEGF expression,microvessel density and dendritic cell decrease in thyroid cancer.[J].Biotechnology Biotechnological Equipment,2014,28(3):508-517.
[13]李兰梅,金东岭,王蕾,等.甲状腺肿瘤组织VEGF-C和ERβ的表达与LVD的相关性分析[J].现代生物医学进展,2013,13(4):681-684.
[14]Lai C W,Duh Q Y,Chen C W,et al.VEGF-D and A Preoperative Serum Levels Predict Nodal and Distant Metastases in Differentiated Thyroid Cancer Patients[J].World Journal of Surgery,2015,39(7):1-8.
[15]石东亮,赵苏远,陈倩倩,等.Gli1蛋白和血管内皮生长因子-C在甲状腺乳头状癌中的表达及其与颈部淋巴结转移的关系[J].中国医师进修杂志,2013,36(20):30-34.
[16]黄静,吴靖芳,张静,等.甲状腺乳头状癌组织VEGF-C/D及受体和D2-40表达与淋巴结转移相关性分析[J].中华肿瘤防治杂志,2013,20(24):1904-1907,1911.
[17]杜日昌,李宇芳,邱卫东,等.甲状腺乳头状癌中HIF-1α、VEGF、COX-2及VEGF-C表达与侵袭转移的关系[J].临床与实验病理学杂志,2013,29(9):991-995.
[18]汪永旭,蒋伟丰,朱陈宏,等.STAT3和VEGF-C在甲状腺癌中表达及其与临床病理特征关系[J].肿瘤学杂志,2013,19(2):118-121
[2]王军.血管内皮生长因子和血小板反应素-1在甲状腺乳头状癌中的表达及其与肿瘤血管生成的关系[J].中国医师进修杂志,2013,36(5):64-65,67.
[3]薛栋,张同军,李新军,等.IAvin、VEGF在甲状腺癌中的表达及其临床意义[J].中国现代普通外科进展,2013,16(4):270-273.
[4]Shaik S,Nucera C,Inuzuka H,el al.SCF(B-TRCP)suppresses angiogenesis and thyroid cancer cell migration by promoting ubiquitination and destruction of VEGF receptor 2.[J].Journal of Experimental Medicine,2012,209(7):1289-307.
[5]Jia W,X-J G,Z-D Z,et al.S100A4 silencing suppresses proliferation,angiogenesis and invasion of thyroid cancer cells through downregulation of MMP-9 and VEGF[J].European Review for Medical&Pharmacological Sciences,2013,17(11):1495-1508.
[6]杜日昌,李宇芳,邱卫东等.甲状腺乳头状癌中HIF-1α、VEGF、COX-2及VEGF-C表达与侵袭转移的关系[J].临床与实验病理学杂志,2013,29(9):991-995.
[7]Xi W,Ying L,Sheng Z,el al.Evaluation of thyroid cancer in Chinese females with breast cancer by vascular endothelial growth factor(VEGF),microvessel density,and contrast-enhanced ultrasound(CEUS).[J].Tumour Biology the Journal of the International Society for Oncodevelopmental Biology&Medicine,2014,35(7):6521-6529.
[8]吴伟群,何小杰,李延辉,等.VEGF在甲状腺肿瘤中的表达及与肿瘤血管生成的关系[J].中国医药科学,2013,(12):23-25.
[9]颜建军,王蕾,时志民,等.雌激素受体α与细胞外信号调节蛋白激酶和血管内皮生长因子在甲状腺癌组织中的表达及意义[J].山西医药杂志,2013,42(17):980-982.
[10]华特波,孟宪瑛,张强等.COX-2、MMP-9、VEGF在甲状腺肿瘤中的表达[J].中国老年学杂志,2011,31(9):1520-1522.
[11]巩雷,陈萍,刘宪军等.D2-40,CK19,galectin-3,VEGF和EGFR在甲状腺乳头状癌中的表达及其临床意义[J].中国普通外科杂志,2011,20(11):1203-1207.
[12]Gulubova M,Ivanova K,Ananiev J,et al.VEGF expression,microvessel density and dendritic cell decrease in thyroid cancer.[J].Biotechnology Biotechnological Equipment,2014,28(3):508-517.
[13]李兰梅,金东岭,王蕾,等.甲状腺肿瘤组织VEGF-C和ERβ的表达与LVD的相关性分析[J].现代生物医学进展,2013,13(4):681-684.
[14]Lai C W,Duh Q Y,Chen C W,et al.VEGF-D and A Preoperative Serum Levels Predict Nodal and Distant Metastases in Differentiated Thyroid Cancer Patients[J].World Journal of Surgery,2015,39(7):1-8.
[15]石东亮,赵苏远,陈倩倩,等.Gli1蛋白和血管内皮生长因子-C在甲状腺乳头状癌中的表达及其与颈部淋巴结转移的关系[J].中国医师进修杂志,2013,36(20):30-34.
[16]黄静,吴靖芳,张静,等.甲状腺乳头状癌组织VEGF-C/D及受体和D2-40表达与淋巴结转移相关性分析[J].中华肿瘤防治杂志,2013,20(24):1904-1907,1911.
[17]杜日昌,李宇芳,邱卫东,等.甲状腺乳头状癌中HIF-1α、VEGF、COX-2及VEGF-C表达与侵袭转移的关系[J].临床与实验病理学杂志,2013,29(9):991-995.
[18]汪永旭,蒋伟丰,朱陈宏,等.STAT3和VEGF-C在甲状腺癌中表达及其与临床病理特征关系[J].肿瘤学杂志,2013,19(2):118-121
© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号 地址：北京市海淀区学院路29号 邮编：100083 电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700 |