壮药溃结栓治疗溃疡性结肠炎的临床与实验研究
|
摘要
目的：1.观察壮药溃结栓治疗UC的临床疗效。2.观察壮药溃结栓对溃结模型动物血浆PAF、肠内容物中大肠杆菌计数及结肠组织病理改变等的影响。3.通过本课题的研究,揭示壮药溃结栓治疗UC的作用机理,开发一种治疗UC的新药。
方法：1.所观察病例60例随机分为治疗组与对照组各30例,分别予以壮药溃结栓,柳氮磺胺吡啶栓剂肛栓给药治疗,观察治疗前后各指标的变化。2.溃结模型动物编号抽签随机分为壮药溃结栓组,柳氮磺胺吡啶栓剂组.模型动物组,每组8只。另取8只健康Wistar大鼠为健康对照组。分别予以壮药溃结栓,柳氮磺胺吡啶栓剂及不含药物的基质肛栓剂肛栓给药治疗,观察治疗前后各指标的变化。
结果：1.1治疗组临床疗效明显优于对照组(u值为2.09,P<0.05)。1.2治疗组中医证候疗效明显优于对照组(u值为3.25,P<0.05)。1.3两组证候积分治疗前后情况比较,两组临床疗效均可靠(组内治疗前后比较P*<0.05)。治疗组临床疗效优于对照组(治疗后两组之间比P**＜0.05)。1.4治疗组腹泻临床疗效明显优于对照组(u=2.65,P＜0.05)。结果显示：治疗组临床疗效明显优于对照组。治疗组黏液脓血便临床疗效明显优于对照组(u=2.39,P＜0.05)。治疗组腹痛临床疗效与对照组无明显区别(u=1.87,P>O.05)。治疗组里急后重症状临床疗效明显优于对照组(u=2.66,P＜0.05)。1.5治疗组镜检肠黏膜疗效明显优于对照组(u=2.71,P＜0.05)。1.6治疗组肠黏膜活检病理疗效明显优于对照组(u=2.15P＜0.05)。1.7两组治疗前后大便常规白(脓)细胞及红细胞阴转率有显著性差异(x2分别为6.57,5.02,均‘P＜0.05)。1.8两组不良反应率无显著差别(X2=0.52,P>0.05)。
2.1模型动物组体重明显低于健康对照组(P<0.05)；壮药溃结栓组,柳氮磺胺吡啶栓剂组,健康对照组三组体重相互比较均无明显差异(P>0.05)。2.2模型动物组PAF含量明显高于健康对照组(P<0.05);壮药溃结栓组PAF含量明显低于模型动物组(P<0.05)；柳氮磺胺吡啶栓剂组PAF含量明显低于模型动物组(P<0.05)；壮药溃结栓组,柳氮磺胺吡啶栓剂组,健康对照组三组PAF含量相互比较均无明显差异(P>0.05)。2.3壮药溃结栓组和柳氮磺胺吡啶栓剂组肉眼观察损伤与模型动物组比较有明显差异,P<0.05；壮药溃结栓组与柳氮磺胺吡啶栓剂组比较无明显差异,P>0.05。壮药溃结栓组损伤积分明显低于模型动物组(P＜0.05),柳氮磺胺吡啶栓剂组损伤积分明显低于模型动物组(P<0.05),壮药溃结栓组损伤积分明显低于柳氮磺胺吡啶栓剂组(P＜0.05)。2.4壮药溃结栓组溃疡数明显低于模型动物组(P<0.05),柳氮磺胺吡啶栓剂组溃疡数明显低于模型动物组(P<0.05),壮药溃结栓组溃疡数明显低于柳氮磺胺吡啶栓剂组(P＜0.05)。壮药溃结栓组溃疡面积明显低于模型动物组(P<0.05),柳氮磺胺吡啶栓剂组溃疡面积明显低于模型动物组(P<0.05),壮药溃结栓组溃疡面积明显低于柳氮磺胺吡啶栓剂组(P<0.05)。2.5壮药溃结栓组大肠杆菌计数明显低于模型动物组(P<0.05)；柳氮磺胺吡啶栓剂组大肠杆菌计数明显低于模型动物组(P<0.05),壮药溃结栓组,柳氮磺胺吡啶栓剂组,健康对照组三组大肠杆菌计数相互比较均无明显差异(P>0.05)。
结论：1.壮药溃结栓治疗UC临床疗效确切。2.壮药溃结栓可改善溃结模型动物结肠组织病理改变,降低其血浆PAF值,及肠内容物中大肠杆菌数,这可能是壮药溃结丸治疗UC的机理之一。
Goal:1. To observe the clinical effect of the Zhuang Medicine kuijie pill on UC.2. To Observe the effects of the Zhuang Medicine kuijie pill on model animal's plasma PAF, E. coli colonies amount in intestines content, and pathology changes of the colon organization, etc.3. Through this topic research, to reveal the mechanism of the Zhuang Medicine kuijie pill on treating UC, and to develops one kind of the new medicine of treating UC.
Method:1.60 patients were randomly divided into the treatment group and the comparison group, each group with 30 examples. Separately gives the Zhuang Medicine kuijie pill and SASP plug medicine through giving medicine after anus to observe the various targets change of treatment around。
2. After marking numbers and lotting, the model animal were randomly divided into the Zhuang Medicine kuijiepill group, the SASP plug group and model animal group, each group of 8. Takeing 8 health Wistar big rats in addition for the health comparison group.separately gives Zhuang Medicine kuijie pill, SASP plug medicine, and the matrix plug of not containing medicine, to observe the various targets change of treatment around。
Results:1. In the comparison of clinical effect, Chinese medicine symptom curative effect, Chinese medicine symptoms integral of treatment Around, symptoms clinical effect, intestines mucous membrane curative effect through mirror examines, and intestines mucous membrane pathology curative effect, and so on, the treatment group obviously surpasses the comparison group (P<0.05)。
2. In the comparison of model animals'weight, model animal plasma PAF, and the quantity of E.coli in intestines content, Zhuang Medicine kuijiepill group and with SASP plug group mutually quite even not obvious difference (P> 0.05). In the comparison of visual observation damage, the damage integral, the ulcer number, and the ulcer area, Zhuang Medicine kuijiepill group and with SASP plug group mutually quite has the obvious difference (P<0.05)
Conclusion:1. The Zhuang Medicine kuijie pill has good and accurate clinical curative effect on UC.
2. The Zhuang Medicine kuijie pill may improve the model animal pathology change on colon, reduces the amount of plasma PAF in blood, and the quantity of E.coli in intestines content. It is possibly the one of mechanisms for treating UC.
方法：1.所观察病例60例随机分为治疗组与对照组各30例,分别予以壮药溃结栓,柳氮磺胺吡啶栓剂肛栓给药治疗,观察治疗前后各指标的变化。2.溃结模型动物编号抽签随机分为壮药溃结栓组,柳氮磺胺吡啶栓剂组.模型动物组,每组8只。另取8只健康Wistar大鼠为健康对照组。分别予以壮药溃结栓,柳氮磺胺吡啶栓剂及不含药物的基质肛栓剂肛栓给药治疗,观察治疗前后各指标的变化。
结果：1.1治疗组临床疗效明显优于对照组(u值为2.09,P<0.05)。1.2治疗组中医证候疗效明显优于对照组(u值为3.25,P<0.05)。1.3两组证候积分治疗前后情况比较,两组临床疗效均可靠(组内治疗前后比较P*<0.05)。治疗组临床疗效优于对照组(治疗后两组之间比P**＜0.05)。1.4治疗组腹泻临床疗效明显优于对照组(u=2.65,P＜0.05)。结果显示：治疗组临床疗效明显优于对照组。治疗组黏液脓血便临床疗效明显优于对照组(u=2.39,P＜0.05)。治疗组腹痛临床疗效与对照组无明显区别(u=1.87,P>O.05)。治疗组里急后重症状临床疗效明显优于对照组(u=2.66,P＜0.05)。1.5治疗组镜检肠黏膜疗效明显优于对照组(u=2.71,P＜0.05)。1.6治疗组肠黏膜活检病理疗效明显优于对照组(u=2.15P＜0.05)。1.7两组治疗前后大便常规白(脓)细胞及红细胞阴转率有显著性差异(x2分别为6.57,5.02,均‘P＜0.05)。1.8两组不良反应率无显著差别(X2=0.52,P>0.05)。
2.1模型动物组体重明显低于健康对照组(P<0.05)；壮药溃结栓组,柳氮磺胺吡啶栓剂组,健康对照组三组体重相互比较均无明显差异(P>0.05)。2.2模型动物组PAF含量明显高于健康对照组(P<0.05);壮药溃结栓组PAF含量明显低于模型动物组(P<0.05)；柳氮磺胺吡啶栓剂组PAF含量明显低于模型动物组(P<0.05)；壮药溃结栓组,柳氮磺胺吡啶栓剂组,健康对照组三组PAF含量相互比较均无明显差异(P>0.05)。2.3壮药溃结栓组和柳氮磺胺吡啶栓剂组肉眼观察损伤与模型动物组比较有明显差异,P<0.05；壮药溃结栓组与柳氮磺胺吡啶栓剂组比较无明显差异,P>0.05。壮药溃结栓组损伤积分明显低于模型动物组(P＜0.05),柳氮磺胺吡啶栓剂组损伤积分明显低于模型动物组(P<0.05),壮药溃结栓组损伤积分明显低于柳氮磺胺吡啶栓剂组(P＜0.05)。2.4壮药溃结栓组溃疡数明显低于模型动物组(P<0.05),柳氮磺胺吡啶栓剂组溃疡数明显低于模型动物组(P<0.05),壮药溃结栓组溃疡数明显低于柳氮磺胺吡啶栓剂组(P＜0.05)。壮药溃结栓组溃疡面积明显低于模型动物组(P<0.05),柳氮磺胺吡啶栓剂组溃疡面积明显低于模型动物组(P<0.05),壮药溃结栓组溃疡面积明显低于柳氮磺胺吡啶栓剂组(P<0.05)。2.5壮药溃结栓组大肠杆菌计数明显低于模型动物组(P<0.05)；柳氮磺胺吡啶栓剂组大肠杆菌计数明显低于模型动物组(P<0.05),壮药溃结栓组,柳氮磺胺吡啶栓剂组,健康对照组三组大肠杆菌计数相互比较均无明显差异(P>0.05)。
结论：1.壮药溃结栓治疗UC临床疗效确切。2.壮药溃结栓可改善溃结模型动物结肠组织病理改变,降低其血浆PAF值,及肠内容物中大肠杆菌数,这可能是壮药溃结丸治疗UC的机理之一。
Goal:1. To observe the clinical effect of the Zhuang Medicine kuijie pill on UC.2. To Observe the effects of the Zhuang Medicine kuijie pill on model animal's plasma PAF, E. coli colonies amount in intestines content, and pathology changes of the colon organization, etc.3. Through this topic research, to reveal the mechanism of the Zhuang Medicine kuijie pill on treating UC, and to develops one kind of the new medicine of treating UC.
Method:1.60 patients were randomly divided into the treatment group and the comparison group, each group with 30 examples. Separately gives the Zhuang Medicine kuijie pill and SASP plug medicine through giving medicine after anus to observe the various targets change of treatment around。
2. After marking numbers and lotting, the model animal were randomly divided into the Zhuang Medicine kuijiepill group, the SASP plug group and model animal group, each group of 8. Takeing 8 health Wistar big rats in addition for the health comparison group.separately gives Zhuang Medicine kuijie pill, SASP plug medicine, and the matrix plug of not containing medicine, to observe the various targets change of treatment around。
Results:1. In the comparison of clinical effect, Chinese medicine symptom curative effect, Chinese medicine symptoms integral of treatment Around, symptoms clinical effect, intestines mucous membrane curative effect through mirror examines, and intestines mucous membrane pathology curative effect, and so on, the treatment group obviously surpasses the comparison group (P<0.05)。
2. In the comparison of model animals'weight, model animal plasma PAF, and the quantity of E.coli in intestines content, Zhuang Medicine kuijiepill group and with SASP plug group mutually quite even not obvious difference (P> 0.05). In the comparison of visual observation damage, the damage integral, the ulcer number, and the ulcer area, Zhuang Medicine kuijiepill group and with SASP plug group mutually quite has the obvious difference (P<0.05)
Conclusion:1. The Zhuang Medicine kuijie pill has good and accurate clinical curative effect on UC.
2. The Zhuang Medicine kuijie pill may improve the model animal pathology change on colon, reduces the amount of plasma PAF in blood, and the quantity of E.coli in intestines content. It is possibly the one of mechanisms for treating UC.
引文
[1]叶任高.内科学,北京：人民卫生出版社,2000,428-434.
[2]欧阳钦.炎症性肠病诊治新进展.当代医学,2001,7(5)：36-40.
[3]欧阳钦.炎性肠病的研究进展.新医学,2001,32(6)：365-366.
[4]郭霭春,《黄帝内经素问语译》。人民卫生出版社,1995
[5]中国中西医结合学会消化系统疾病委员会.第四届全国学术交流会慢性非特异性溃疡性结肠炎中西医结合诊断、辨证和疗性标准(试行方案)中国中西医结合杂志,1994,14：239-240
[6]中华消化杂志,2001;21(4)：236
[7]贾黎明,周春立.炎症性肠病的内镜检查.见：郑家驹主编.炎症性肠病基础与临床.北京：科学出版社,2001.195
[8]张永艳,邓长生.溃疡性结肠炎.见：邓长生,夏冰主编.炎症性肠病.北京：人民卫生出版社,1998.183-189。
[9]中药新药临床研究指导原则(试行),中国医药科技出版社,2002：第1版：129-134。
[10]徐淑云,等。药理实验方法学,第一版,人民卫生出版社出版982：892。
[11]药理学实验。人民卫生出版社出版,1985年第一版。
[12]余佩武,肖光夏,府伟灵,袁建成,秦孝健,周立新.血小板活化因子在烧伤大鼠早期肠源性内毒素血症发病中的作用.中华医学杂志1999;79：136-138。
[13]田海河,李庆荣.中医药治疗溃疡性结肠炎思路方法的分析.中国中医药信息杂志,1995,2(9)：23
[14]李乾构.溃疡性结肠炎的辨证论治体会.北京中医,2000,1：5-6
[15]戴宝林.溃疡性结肠炎病因病机探讨及辨治体会.天津中医学院学报,2001,20(2)37-：38
[16]李有田,迟宝荣,李冰,李洋.复方山芪颗粒剂治疗溃疡性结肠炎疗效及作用机理[J]吉林大学学报(医学版),2003,(05).125-127
[17]焦君良,要丽瑛,李士军.刘桂缺从痈论治溃疡性结肠炎初探中国中西医结合脾胃杂志.2000；8(2)：100-101
[18]许济群.方剂学.上海：上海科学技术出版社.1985,217
[19]Biancone L, MandalA, Yang H, et al. Production of imnunoglobulin G and Gl antibodies to cytosFeletal protein by lamina propria cells in ulcerative colitis[J]. Gastroenterology,1995,109(1):3-12
[20]Takahashi F, FimWH, Lander CJ, etal. Roleofantineutrophil cytoplasmi cantibodies in anethnically distinct population:Forean paients with ulcerative colitis[J]. Am J Gastroenterol,1995,90(2):1953-1958
[21]Perez Machado MA, Espinosa LM. dela Madrigal EJ, et aL Impaired mitogenic response of peripheral blood T cells in ulcerative colitis is not due to apoptosis [J]. Dig Dis Sci,1999,44,2530-2537
[22]Orholm M, Binder V, Sorensen TI, Rasmussen LP, Kyvik K0. Concordance of inflammatory bowel disease among Danish twins:results of a nationwidestudy. Scand J Gastroenterol 2000; 35:1075-1081
[23]沈关心,周汝麟.现代免疫学实验技术,武汉：湖北科学技术出版社,2002,516.
[24]杜意平,叶红军,王俊萍,等.溃疡性结肠炎患者和人类白细胞抗原-DQA-1基因关联的研究.临床内科杂志,2003,20(6)：314-316.
[25]王军,申秀玲,曹峰林.溃疡性结肠炎的红细胞免疫与HLA相关性研究.哈尔滨医药,2003,23(4)：5-7.
[26]Beaugerie L, Massot N, Carbonnel F, Cattan S, Gendre JP, Cosnes J. Impact of cessation of smoking on the course of ulcerative colitis. Am J Gastroenterol 2001; 96:2113-2116
[27]Richardson CE, Morgan JM, Jasani B, Green JT, Rhodes J, Williams GT, Lindstrom J, Wonnacott S, Peel S, Thomas GA. Effectof smoking and transdermal nicotine on colonic nicotinic acetylcholinereceptors in ulcerative colitis. Q J Med 2003;96:57-65
[28]Coulie B, Camilleri M, Bharucha AE, Sandborn WJ, Burton D. Colonicmotility in chronic ulcerative proctosigmoiditis and the effects of nicotine on colonic motilityin patients and healthy subjects. Aliment Pharmacol Ther 2004; 15:653-663
[29]Sher ME, Bank S, Greenberg R, Sardinha TC, Weissman S, Bailey B,Gilliland R, Wexner SD. The influence of cigarette smoking on cytokine levels in patients withinflammatory bowel disease. Inflamm Bowel Dis 2005; 5:73-78
[30]Madretsma S, Wolters LM, Van Di jk JP, Tak CJ, Feyerabend C, WilsonJH, Zijlstra FJ. In-vivoeffect of nicotine on cytokine production by human non-adherentmononuclear cells. Eur J Gastroenterol Hepatol 2005; 8:1017-1020
[31]Theis MK, Boyko EJ. Patient perceptions of causes of inflammatorybowel disease. Am J Gastroenterol 1994;89:1920
[32]Mayer EA. The neurobiology of stress and gastrointestinal disease. Gut 2000;47:861-869
[33]Qiu BS, Vallance BA, Blennerhassett PA, Collins SM. The role of CD4+ lymphocytes in the susceptibility of mice to stress-induced reactivation of experimentalcolitis. Nat Med 1999;5:1178-1182
[34]Isolauri E. Probioticsin human disease. Am J Clin Nutr 2001; 73:1142-1146
[35]Shirazi T, Longman RJ, Corfield AP, Probert CS. Mucins and inflammatory bowel disease. Postgrad Med J 2000;76:473-478
[36]Granger DN RutiliG, MC Cord JM Superoxide radicals in felin intestinal ischemia[J]. Gastroenterology 1981,81(1):22-25
[37]Simmonds NJ, Rampton DS Inflammatory bowel disease a radical view[J]. Gt,1999; 37:865-867
[38]Yoshida Y, Iwai A, Itoh K, Tanaka M, Kato S, Hokari R, Miyahara T, Koyama H, Miura S, Kobayashi M. Roleof inducible nitric oxide synthase in dextran sulphatesodium-induced colitis. Aliment Pharmacol Ther 2000;14(Suppl 1):26-32
[39]Grisham MB. Oxidants and free radicals in inflammatory boweldisease. Lancet 2004;344:859-861
[40]贺国斌。溃疡性结肠炎的血栓前状态与肝素治疗[J].国外医学内科学分册,2000,27(6)：238-241
[41]卞红磊,魏艳静.活动期溃疡性结肠炎患者血浆血栓烷B_2和6-酮-前列腺素F1α的临床研究[J]临床荟萃,2004,(24)P 39
[42]魏艳静,卞红磊,武会珍.溃疡性结肠炎患者体内血小板功能状态研究[J]临床荟萃,2003,(11).P 13-14
[43]Collins CE Cihill MR, Newland AC et aL. Platelets circulation in an activated state in inflammatory bowel disease(J). Gastroenterology, 1994,106(4):840-845
[44]徐萍,吴锡深.血小板功能障碍：炎症性肠病研究的一种新动向[J].国外医学消化系统疾病分册,1990 16(1)：43
[45]Graef V Baggenstoss AH, Sauer WG, et aL Venous thromblsis occurring in nonspecific ulcerative colitis[J]. Arch InternMed,1996,117(3): 337
[46]张连峰,田曙光,王国新.溃疡性结肠炎患者血小板功能状态的研究[J].中国实用内科杂志,2000,20(2)：98-99
[47]许丽莉,王吉耀.活动期溃疡性结肠炎患者体内血小板激活状态的评价[J].中华消化杂志,2002,22(2)285-287
[48]黄乃健主编.中医肛肠病学,济南,山东中医学院,1995；167
[49]张德纯,林勇.溃疡性结肠炎的微生态学研究与防治,中国微生态学杂志,2002年第4期,P24-25
[50]陈渝萍.肠道菌群状态在溃疡性结肠炎患者中的价值探讨,《右江医学》2006年第5期,P499-500
[1]叶任高.内科学,北京：人民卫生出版社,2000,428-434.
[2]田海河,李庆荣.中医药治疗溃疡性结肠炎思路方法的分析.国中医药信息杂志,1995,2(9)：23
[3]李乾构.溃疡性结肠炎的辨证论治体会.北京中医,2000,1：56
[4]戴宝林.溃疡性结肠炎病因病机探讨及辨治体会.天津中医学院学报,2001,20(2)37-：38
[5]田德禄,田海河.慢性非特异性溃疡性结肠炎中医研究述评.北京中医药大学学报,1994,17(6)：2-6
[6]焦君良,要丽瑛,李士军.刘桂缺。从痈论治溃疡性结肠炎初探中国中西医结合脾胃杂志.2000；8(2)：100-101
[7]许济群.方剂学.上海：上海科学技术出版社.1985,217
[8]中国中医药学会内科学会.临床中医内科学(下)[M].北京：北京出版社,1994,1807-1809
[9]陈治水,危北海,陈泽民.慢性非特异性溃疡性结肠炎中西医结合诊断、辨证和疗效标准(试行方案)[J].中国中西医结合杂志,1994,14(4)：239-240
[10]杨静.中医辨证治疗溃疡性结肠炎64例[J]陕西中医,2003,(07)P 41-42
[11]张苏颖,李淑云.溃疡性结肠炎中医辨治浅析[J]山东中医杂志,2003,(10).P3-5
[12]王奎平.辨证结合辨病分期治疗溃疡性结肠炎30例[J]中医药学报,2002,(05).P41
[13]刘丽芳.辨证配合中药保留灌肠治疗溃疡性结肠炎60例临床观察[J].湖南中医学院学报,2002,(03).P59-60
[14]陆霞、伊春锦,加味香连汤治疗溃疡性结肠炎30例,福建中医药,2000年8月第31卷第4期：28
[15]焦君良,要丽瑛,李士军,等.从痈论治溃疡性结肠炎初探[J].中国中西医结合脾胃杂志,2000,8(2)：100-101
[16]王星田,刘国军。溃肠汤治疗溃疡性结肠炎56例临床观察[J].四川中医,2003,(12)P 33-34
[17]李有田,迟宝荣,李冰,李洋.复方山芪颗粒剂治疗溃疡性结肠炎疗效及作用机理[J]吉林大学学报(医学版),2003,(05).125-127
[18]柳文,沈琳.乌梅丸合痛泻要方治疗溃疡性结肠炎30例[J].上海中医药杂志,2003,(01).35-36
[19]张永艳.宣肺健脾汤治疗慢性溃疡性结肠炎68例.新中医,2001；33(2)：61
[20]张金炎.败酱草为主治疗慢性溃疡性结肠炎80例.中医杂志,2002；43(12)：892
[21]李虎臣,刘光茂,赵素云.愈疡灵治疗溃疡性结肠炎96例[J].中国中西医结合消化杂志,2002,10(1)：17
[22]王小婷.升阳除湿汤加味治疗慢性溃疡性结肠炎70例总结[J].湖南中医杂志,2002,18(1)：20-21
[23]林锡芬,陈金泉,张苏闽.气药灌肠法治疗慢性溃疡性结肠炎36例疗效观察[J]新中医,2003,(07).P25-26
[24]洪银芳.中药灌肠治疗慢性溃疡性结肠炎34例观察[J]中医药临床杂志,2004,(04)P28
[25]乔樵,周亨德,朱曙东,钦丹萍.云母粉灌肠治疗溃疡性结肠炎30例[J]浙江中医学院学报,2003,(01).P 31
[26]张禄芳,翁世美.中西药结合灌肠治疗慢性溃疡性结肠炎临床观察[J]国际医药卫生导报,2003,(10)P 59-60
[27]董宝玲.温通止泻汤灌肠治疗溃疡性结肠炎28例[J]安徽中医学院学报,2002,(06).P27
[28]黄赞松,周喜汉.活血化瘀汤与西药合用保留灌肠治疗溃疡性结肠炎[J].右江医学,2006,(02)P 21-22
[29]宋传娣,冯乃涛,李明吾,等.黄茂汤保留灌肠治疗慢性非特异性溃疡性结肠炎临床研究[J].中国肛肠病杂志,2001,21(7)：22-23
[30]李景玉.锡榆汤灌肠治疗慢性溃疡性结肠炎30例.安徽中医药学院学报,2002;19(2)：18
[31]史亚祥.肠愈l号冲剂合祛疡散治疗溃疡性结肠炎128例[J].中国中西医结合杂志,2002,22(5)：392-393
[32]刘王君.综合治疗溃疡性结肠炎42例[J].湖南中医杂志,2002,18(2)：41
[33]李劲,周立武,荣新奇.综合疗法治疗慢性非特异性溃疡性结肠炎122例[J].湖南中医杂志,2002,18(2)：42
[34]林健,等.整肠汤灌肠治疗慢性非特异性溃疡性结肠炎135例.河南中医,2003；23(3)：22
[35]李敏,刘兰英血竭联合柳氮磺吡啶治疗非特异性溃疡性结肠炎疗效观察[J]中成药研究,2004,(03)P43-44
[36]任新南,中西医结合治疗溃疡性结肠炎68例,江苏中医1999年第20卷第二期
[37]杜国权,思密达加中药保留灌肠治疗溃疡性结肠炎,浙江中西医结合杂志2000年12卷第1期：61
[38]郑高峰.中医辩证加西药治疗慢性非特异性溃疡性结肠炎120例.中国肛肠病杂志,2000,20(7)：41
[39]高淑宝.中西医结合治疗溃疡性结肠炎29例.河南中医药学刊,2002,17(16)38-39
[40]张瑞刚,等.中西医结合辨证分型治疗慢性非特异性溃疡性结肠炎86例.黑龙江中医药,2002,(6)：25-26
[1]Biancone L, MandalA,Yang H, et al. Production of imnunoglobulin G and G1 antibodies to cytosFeletal protein by lamina propria cells in ulcerative colitis [J]. Gastroenterology,1995,109(1):3-12
[2]Takahashi F, FimWH,Lander CJ, etal. Roleofantineutrophil cytoplasmicantibodies in anethnically distinct population:Forean paients with ulcerative colitis[J]. Am J Gastroenterol,1995,90(2):1953-1958
[3]Perez Machado MA,Espinosa LM. dela Madrigal EJ, et aL Impaired mitogenic response of peripheral blood T cells in ulcerative colitis is not due to apoptosis [J]. Dig Dis Sci,1999,44,2530-2537
[4]Orholm M, Binder V, Sorensen TI, Rasmussen LP, Kyvik KO. Concordance of inflammatory bowel disease among Danish twins:results of a nationwidestudy. Scand J Gastroenterol 2000;35:1075-1081
[5]沈关心,周汝麟.现代免疫学实验技术,武汉：湖北科学技术出版社,2002,516.
[6]杜意平,叶红军,王俊萍,等.溃疡性结肠炎患者和人类白细胞抗原-DQA-1基因关联的研究.临床内科杂志,2003,20(6)：314-316.
[7]王军,申秀玲,曹峰林.溃疡性结肠炎的红细胞免疫与HLA相关性研究.哈尔滨医药,2003,23(4)：5-7.
[8]Beaugerie L, Massot N, Carbonnel F, Cattan S, Gendre JP, Cosnes J.Impact of cessation of smoking on the course of ulcerative colitis. Am J Gastroenterol 2001;96:2113-2116
[9]Richardson CE, Morgan JM, Jasani B, Green JT, Rhodes J, Williams GT,Lindstrom J, Wonnacott S, Peel S, Thomas GA. Effectof smoking and transdermal nicotine on colonic nicotinic acetylcholinereceptors in ulcerative colitis. Q J Med 2003;96:57-65
[10]Coulie B, Camilleri M, Bharucha AE, Sandborn WJ, Burton D. Colonicmotility in chronic ulcerative proctosigmoiditis and the effects of nicotine on colonic motilityin patients and healthy subjects. Aliment Pharmacol Ther 2004;15:653-663
[11]Sher ME, Bank S, Greenberg R, Sardinha TC, Weissman S, Bailey B,Gilliland R, Wexner SD. The influence of cigarette smoking on cytokine levels in patients withinflammatory bowel disease. Inflamm Bowel Dis 2005;5:73-78
[12]Madretsma S, Wolters LM, Van Dijk JP, Tak CJ, Feyerabend C, WilsonJH, Zijlstra FJ. In-vivoeffect of nicotine on cytokine production by human non-adherentmononuclear cells. Eur J Gastroenterol Hepatol 2005;8:1017-1020
[13]Theis MK, Boyko EJ. Patient perceptions of causes of inflammatorybowel disease. Am J Gastroenterol 1994;89:1920
[14]Mayer EA. The neurobiology of stress and gastrointestinal disease.Gut 2000;47:861-869
[15]Qiu BS, Vallance BA, Blennerhassett PA, Collins SM. The role of CD4+ lymphocytes in the susceptibility of mice to stress-induced reactivation of experimentalcolitis. Nat Med 1999;5:1178-1182
[16]Isolauri E. Probioticsin human disease. Am J Clin Nutr 2001;73:1142-1146
[17]Shirazi T, Longman RJ, Corfield AP, Probert CS. Mucins and inflammatory bowel disease. Postgrad Med J 2000;76:473-478
[18]Granger DN RutiliG,MC Cord JM Superoxide radicals in felin intestinal ischemia[J]. Gastroenterology 1981,81(1):22-25
[19]Simmonds NJ, Rampton DS Inflammatory bowel disease a radical view(J]. Gt,2003,87:865-867
[20]Yoshida Y, Iwai A, Itoh K, Tanaka M, Kato S, Hokari R, Miyahara T,Koyama H, Miura S, Kobayashi M. Roleof inducible nitric oxide synthase in dextran sulphatesodium-induced colitis. Aliment Pharmacol Ther 2000;14(Suppl 1):26-32
[21]Grisham MB. Oxidants and free radicals in inflammatory boweldisease. Lancet 2004;344:859-861
[22]贺国斌.溃疡性结肠炎的血栓前状态与肝素治疗[J).国外医学内科学分册,2000,27(6)：238-241
[23]卞红磊,魏艳静.活动期溃疡性结肠炎患者血浆血栓烷B_2和6-酮-前列腺素Fla的临床研究[J]临床荟萃,2004,(24)P 39
[24]魏艳静,卞红磊,武会珍.溃疡性结肠炎患者体内血小板功能状态研究[J]临床荟萃,2003,(11).P13-14
[25]Collins CE Cihi11 MR, Newland AC et aL. Platelets circulation in an activated state in inflammatory bowel disease (J).Gastroenterology,1994, 106(4):840-845
[26]徐萍,吴锡深.血小板功能障碍：炎症性肠病研究的一种新动向(J).国外医学消化系统疾病分册,199016(1)：43
[27]Graef V Baggenstoss AH, Sauer WG, et aL Venous thromblsis occurring in nonspecific ulcerative colitis (J).Arch InternMed,1996,117(3):337
[28]张连峰,田曙光,王国新.溃疡性结肠炎患者血小板功能状态的研究(J).中国实用内科杂志,200020(2)：98-99
[29]许丽莉,王吉耀.活动期溃疡性结肠炎患者体内血小板激活状态的评价(J).中华消化杂志,2002,22(2)285-287
[30]行琦.炎症性肠病的药物治疗进展.见：郑家驹主编.炎症性肠病.上海科技文献出版社,1998.140-149
[31]Rutigeerts P.Medical therapy of inflammatory bowel disease. Digestion,1998, 59;453-469
[32]Kirsner JB.Inflammatory bowel disease(5th edition).2001,520-529
[33]Muijsers RB, Goa KL. Balsalazide:A review of its therapeutic use in mild-to-moderate ulcerative colitis. Drugs,2002,62(11):1689
[34]Campitri M. Gut,2002;50(Suppl 3):43-46.
[35]Malchow H, Gertz B. A new mesalazine foam enema (ClaversalFoam) compared witha standard liquid enema in patients with active distal ulcerative colitis. Alimentary Pharmacology andThera-peutics,2002,16(3):415
[36]行琦.炎症性肠病的药物治疗进展.见：郑家驹主编.炎症性肠病.上海科技文献出版社,1998.140-149
[37]Rutigeerts P.Medical therapy of inflammatory bowel disease.Digestion,1998,59; 453-469
[38]Mantzaris GJ, Petraki K, Archavlis E, et al. A prospective randomized controlled trial of intravenous ciprofloxacin as an adjunct to corticosteroids in acute, severe ulcerative colitis.ScandinavianJournal of Gastroenterology,2001, 36(9):971
[39]Ben AE, Goldin E, Wengrower D, et al. Wheat grass juice in thetreatment of active distal ulcerative colitis:A randomizeddouble-blind placebo-controlled trial. Scandinavian Journal of Gastroenterology,2002,37(4):444
[40]Langmead L, Dawson C, Hawkins C, et al. Antioxidant effects of herbal therapies used by patients with inflammatorybowel disease:an in vitro study. Alimentary Ph armacology and Therapeutics,2002,16(2):197
[41]Middleton SJ, Naylor S, Woolner J, et al. A double-blind,randomized, placebo-control led trial of essential fatty acid suppl ementation in the maintenance of remiss ion of ulcerative colitis.Alimentary P harmacology and Therapeutics,2002,16(6):1131
[42]Sand BE.Novel therapies for inflammatory bowel disease.Gastroenterol Clin N Am,1999,28(2):323-341
[43]Sandbon WJ.Therapyfor ulcerative colitis.Curr Opin Gastroenteral,1998, 14:312-316
[44]Madsen KL,Doyle JS,Jewell LD.Lactobacillus species prevents colits in interleukin 10 genedeficient mice.Gastroenterology,1999,116:1107-1114
[45]张雪燕,韩涛.溃疡性结肠炎动物模型制作的研究进展[J]甘肃中医,2004,(06).P3-7
[46]范恒,邱明义.溃疡性结肠炎大鼠实验模型的建立与评价[J]中医药学刊,2004,(05).P94-95+134
[47]邓莉,胡晋红.化学诱导型结肠炎动物模型的研究进展[J].中国药理学通报,2005,(05)P 14-18
[2]欧阳钦.炎症性肠病诊治新进展.当代医学,2001,7(5)：36-40.
[3]欧阳钦.炎性肠病的研究进展.新医学,2001,32(6)：365-366.
[4]郭霭春,《黄帝内经素问语译》。人民卫生出版社,1995
[5]中国中西医结合学会消化系统疾病委员会.第四届全国学术交流会慢性非特异性溃疡性结肠炎中西医结合诊断、辨证和疗性标准(试行方案)中国中西医结合杂志,1994,14：239-240
[6]中华消化杂志,2001;21(4)：236
[7]贾黎明,周春立.炎症性肠病的内镜检查.见：郑家驹主编.炎症性肠病基础与临床.北京：科学出版社,2001.195
[8]张永艳,邓长生.溃疡性结肠炎.见：邓长生,夏冰主编.炎症性肠病.北京：人民卫生出版社,1998.183-189。
[9]中药新药临床研究指导原则(试行),中国医药科技出版社,2002：第1版：129-134。
[10]徐淑云,等。药理实验方法学,第一版,人民卫生出版社出版982：892。
[11]药理学实验。人民卫生出版社出版,1985年第一版。
[12]余佩武,肖光夏,府伟灵,袁建成,秦孝健,周立新.血小板活化因子在烧伤大鼠早期肠源性内毒素血症发病中的作用.中华医学杂志1999;79：136-138。
[13]田海河,李庆荣.中医药治疗溃疡性结肠炎思路方法的分析.中国中医药信息杂志,1995,2(9)：23
[14]李乾构.溃疡性结肠炎的辨证论治体会.北京中医,2000,1：5-6
[15]戴宝林.溃疡性结肠炎病因病机探讨及辨治体会.天津中医学院学报,2001,20(2)37-：38
[16]李有田,迟宝荣,李冰,李洋.复方山芪颗粒剂治疗溃疡性结肠炎疗效及作用机理[J]吉林大学学报(医学版),2003,(05).125-127
[17]焦君良,要丽瑛,李士军.刘桂缺从痈论治溃疡性结肠炎初探中国中西医结合脾胃杂志.2000；8(2)：100-101
[18]许济群.方剂学.上海：上海科学技术出版社.1985,217
[19]Biancone L, MandalA, Yang H, et al. Production of imnunoglobulin G and Gl antibodies to cytosFeletal protein by lamina propria cells in ulcerative colitis[J]. Gastroenterology,1995,109(1):3-12
[20]Takahashi F, FimWH, Lander CJ, etal. Roleofantineutrophil cytoplasmi cantibodies in anethnically distinct population:Forean paients with ulcerative colitis[J]. Am J Gastroenterol,1995,90(2):1953-1958
[21]Perez Machado MA, Espinosa LM. dela Madrigal EJ, et aL Impaired mitogenic response of peripheral blood T cells in ulcerative colitis is not due to apoptosis [J]. Dig Dis Sci,1999,44,2530-2537
[22]Orholm M, Binder V, Sorensen TI, Rasmussen LP, Kyvik K0. Concordance of inflammatory bowel disease among Danish twins:results of a nationwidestudy. Scand J Gastroenterol 2000; 35:1075-1081
[23]沈关心,周汝麟.现代免疫学实验技术,武汉：湖北科学技术出版社,2002,516.
[24]杜意平,叶红军,王俊萍,等.溃疡性结肠炎患者和人类白细胞抗原-DQA-1基因关联的研究.临床内科杂志,2003,20(6)：314-316.
[25]王军,申秀玲,曹峰林.溃疡性结肠炎的红细胞免疫与HLA相关性研究.哈尔滨医药,2003,23(4)：5-7.
[26]Beaugerie L, Massot N, Carbonnel F, Cattan S, Gendre JP, Cosnes J. Impact of cessation of smoking on the course of ulcerative colitis. Am J Gastroenterol 2001; 96:2113-2116
[27]Richardson CE, Morgan JM, Jasani B, Green JT, Rhodes J, Williams GT, Lindstrom J, Wonnacott S, Peel S, Thomas GA. Effectof smoking and transdermal nicotine on colonic nicotinic acetylcholinereceptors in ulcerative colitis. Q J Med 2003;96:57-65
[28]Coulie B, Camilleri M, Bharucha AE, Sandborn WJ, Burton D. Colonicmotility in chronic ulcerative proctosigmoiditis and the effects of nicotine on colonic motilityin patients and healthy subjects. Aliment Pharmacol Ther 2004; 15:653-663
[29]Sher ME, Bank S, Greenberg R, Sardinha TC, Weissman S, Bailey B,Gilliland R, Wexner SD. The influence of cigarette smoking on cytokine levels in patients withinflammatory bowel disease. Inflamm Bowel Dis 2005; 5:73-78
[30]Madretsma S, Wolters LM, Van Di jk JP, Tak CJ, Feyerabend C, WilsonJH, Zijlstra FJ. In-vivoeffect of nicotine on cytokine production by human non-adherentmononuclear cells. Eur J Gastroenterol Hepatol 2005; 8:1017-1020
[31]Theis MK, Boyko EJ. Patient perceptions of causes of inflammatorybowel disease. Am J Gastroenterol 1994;89:1920
[32]Mayer EA. The neurobiology of stress and gastrointestinal disease. Gut 2000;47:861-869
[33]Qiu BS, Vallance BA, Blennerhassett PA, Collins SM. The role of CD4+ lymphocytes in the susceptibility of mice to stress-induced reactivation of experimentalcolitis. Nat Med 1999;5:1178-1182
[34]Isolauri E. Probioticsin human disease. Am J Clin Nutr 2001; 73:1142-1146
[35]Shirazi T, Longman RJ, Corfield AP, Probert CS. Mucins and inflammatory bowel disease. Postgrad Med J 2000;76:473-478
[36]Granger DN RutiliG, MC Cord JM Superoxide radicals in felin intestinal ischemia[J]. Gastroenterology 1981,81(1):22-25
[37]Simmonds NJ, Rampton DS Inflammatory bowel disease a radical view[J]. Gt,1999; 37:865-867
[38]Yoshida Y, Iwai A, Itoh K, Tanaka M, Kato S, Hokari R, Miyahara T, Koyama H, Miura S, Kobayashi M. Roleof inducible nitric oxide synthase in dextran sulphatesodium-induced colitis. Aliment Pharmacol Ther 2000;14(Suppl 1):26-32
[39]Grisham MB. Oxidants and free radicals in inflammatory boweldisease. Lancet 2004;344:859-861
[40]贺国斌。溃疡性结肠炎的血栓前状态与肝素治疗[J].国外医学内科学分册,2000,27(6)：238-241
[41]卞红磊,魏艳静.活动期溃疡性结肠炎患者血浆血栓烷B_2和6-酮-前列腺素F1α的临床研究[J]临床荟萃,2004,(24)P 39
[42]魏艳静,卞红磊,武会珍.溃疡性结肠炎患者体内血小板功能状态研究[J]临床荟萃,2003,(11).P 13-14
[43]Collins CE Cihill MR, Newland AC et aL. Platelets circulation in an activated state in inflammatory bowel disease(J). Gastroenterology, 1994,106(4):840-845
[44]徐萍,吴锡深.血小板功能障碍：炎症性肠病研究的一种新动向[J].国外医学消化系统疾病分册,1990 16(1)：43
[45]Graef V Baggenstoss AH, Sauer WG, et aL Venous thromblsis occurring in nonspecific ulcerative colitis[J]. Arch InternMed,1996,117(3): 337
[46]张连峰,田曙光,王国新.溃疡性结肠炎患者血小板功能状态的研究[J].中国实用内科杂志,2000,20(2)：98-99
[47]许丽莉,王吉耀.活动期溃疡性结肠炎患者体内血小板激活状态的评价[J].中华消化杂志,2002,22(2)285-287
[48]黄乃健主编.中医肛肠病学,济南,山东中医学院,1995；167
[49]张德纯,林勇.溃疡性结肠炎的微生态学研究与防治,中国微生态学杂志,2002年第4期,P24-25
[50]陈渝萍.肠道菌群状态在溃疡性结肠炎患者中的价值探讨,《右江医学》2006年第5期,P499-500
[1]叶任高.内科学,北京：人民卫生出版社,2000,428-434.
[2]田海河,李庆荣.中医药治疗溃疡性结肠炎思路方法的分析.国中医药信息杂志,1995,2(9)：23
[3]李乾构.溃疡性结肠炎的辨证论治体会.北京中医,2000,1：56
[4]戴宝林.溃疡性结肠炎病因病机探讨及辨治体会.天津中医学院学报,2001,20(2)37-：38
[5]田德禄,田海河.慢性非特异性溃疡性结肠炎中医研究述评.北京中医药大学学报,1994,17(6)：2-6
[6]焦君良,要丽瑛,李士军.刘桂缺。从痈论治溃疡性结肠炎初探中国中西医结合脾胃杂志.2000；8(2)：100-101
[7]许济群.方剂学.上海：上海科学技术出版社.1985,217
[8]中国中医药学会内科学会.临床中医内科学(下)[M].北京：北京出版社,1994,1807-1809
[9]陈治水,危北海,陈泽民.慢性非特异性溃疡性结肠炎中西医结合诊断、辨证和疗效标准(试行方案)[J].中国中西医结合杂志,1994,14(4)：239-240
[10]杨静.中医辨证治疗溃疡性结肠炎64例[J]陕西中医,2003,(07)P 41-42
[11]张苏颖,李淑云.溃疡性结肠炎中医辨治浅析[J]山东中医杂志,2003,(10).P3-5
[12]王奎平.辨证结合辨病分期治疗溃疡性结肠炎30例[J]中医药学报,2002,(05).P41
[13]刘丽芳.辨证配合中药保留灌肠治疗溃疡性结肠炎60例临床观察[J].湖南中医学院学报,2002,(03).P59-60
[14]陆霞、伊春锦,加味香连汤治疗溃疡性结肠炎30例,福建中医药,2000年8月第31卷第4期：28
[15]焦君良,要丽瑛,李士军,等.从痈论治溃疡性结肠炎初探[J].中国中西医结合脾胃杂志,2000,8(2)：100-101
[16]王星田,刘国军。溃肠汤治疗溃疡性结肠炎56例临床观察[J].四川中医,2003,(12)P 33-34
[17]李有田,迟宝荣,李冰,李洋.复方山芪颗粒剂治疗溃疡性结肠炎疗效及作用机理[J]吉林大学学报(医学版),2003,(05).125-127
[18]柳文,沈琳.乌梅丸合痛泻要方治疗溃疡性结肠炎30例[J].上海中医药杂志,2003,(01).35-36
[19]张永艳.宣肺健脾汤治疗慢性溃疡性结肠炎68例.新中医,2001；33(2)：61
[20]张金炎.败酱草为主治疗慢性溃疡性结肠炎80例.中医杂志,2002；43(12)：892
[21]李虎臣,刘光茂,赵素云.愈疡灵治疗溃疡性结肠炎96例[J].中国中西医结合消化杂志,2002,10(1)：17
[22]王小婷.升阳除湿汤加味治疗慢性溃疡性结肠炎70例总结[J].湖南中医杂志,2002,18(1)：20-21
[23]林锡芬,陈金泉,张苏闽.气药灌肠法治疗慢性溃疡性结肠炎36例疗效观察[J]新中医,2003,(07).P25-26
[24]洪银芳.中药灌肠治疗慢性溃疡性结肠炎34例观察[J]中医药临床杂志,2004,(04)P28
[25]乔樵,周亨德,朱曙东,钦丹萍.云母粉灌肠治疗溃疡性结肠炎30例[J]浙江中医学院学报,2003,(01).P 31
[26]张禄芳,翁世美.中西药结合灌肠治疗慢性溃疡性结肠炎临床观察[J]国际医药卫生导报,2003,(10)P 59-60
[27]董宝玲.温通止泻汤灌肠治疗溃疡性结肠炎28例[J]安徽中医学院学报,2002,(06).P27
[28]黄赞松,周喜汉.活血化瘀汤与西药合用保留灌肠治疗溃疡性结肠炎[J].右江医学,2006,(02)P 21-22
[29]宋传娣,冯乃涛,李明吾,等.黄茂汤保留灌肠治疗慢性非特异性溃疡性结肠炎临床研究[J].中国肛肠病杂志,2001,21(7)：22-23
[30]李景玉.锡榆汤灌肠治疗慢性溃疡性结肠炎30例.安徽中医药学院学报,2002;19(2)：18
[31]史亚祥.肠愈l号冲剂合祛疡散治疗溃疡性结肠炎128例[J].中国中西医结合杂志,2002,22(5)：392-393
[32]刘王君.综合治疗溃疡性结肠炎42例[J].湖南中医杂志,2002,18(2)：41
[33]李劲,周立武,荣新奇.综合疗法治疗慢性非特异性溃疡性结肠炎122例[J].湖南中医杂志,2002,18(2)：42
[34]林健,等.整肠汤灌肠治疗慢性非特异性溃疡性结肠炎135例.河南中医,2003；23(3)：22
[35]李敏,刘兰英血竭联合柳氮磺吡啶治疗非特异性溃疡性结肠炎疗效观察[J]中成药研究,2004,(03)P43-44
[36]任新南,中西医结合治疗溃疡性结肠炎68例,江苏中医1999年第20卷第二期
[37]杜国权,思密达加中药保留灌肠治疗溃疡性结肠炎,浙江中西医结合杂志2000年12卷第1期：61
[38]郑高峰.中医辩证加西药治疗慢性非特异性溃疡性结肠炎120例.中国肛肠病杂志,2000,20(7)：41
[39]高淑宝.中西医结合治疗溃疡性结肠炎29例.河南中医药学刊,2002,17(16)38-39
[40]张瑞刚,等.中西医结合辨证分型治疗慢性非特异性溃疡性结肠炎86例.黑龙江中医药,2002,(6)：25-26
[1]Biancone L, MandalA,Yang H, et al. Production of imnunoglobulin G and G1 antibodies to cytosFeletal protein by lamina propria cells in ulcerative colitis [J]. Gastroenterology,1995,109(1):3-12
[2]Takahashi F, FimWH,Lander CJ, etal. Roleofantineutrophil cytoplasmicantibodies in anethnically distinct population:Forean paients with ulcerative colitis[J]. Am J Gastroenterol,1995,90(2):1953-1958
[3]Perez Machado MA,Espinosa LM. dela Madrigal EJ, et aL Impaired mitogenic response of peripheral blood T cells in ulcerative colitis is not due to apoptosis [J]. Dig Dis Sci,1999,44,2530-2537
[4]Orholm M, Binder V, Sorensen TI, Rasmussen LP, Kyvik KO. Concordance of inflammatory bowel disease among Danish twins:results of a nationwidestudy. Scand J Gastroenterol 2000;35:1075-1081
[5]沈关心,周汝麟.现代免疫学实验技术,武汉：湖北科学技术出版社,2002,516.
[6]杜意平,叶红军,王俊萍,等.溃疡性结肠炎患者和人类白细胞抗原-DQA-1基因关联的研究.临床内科杂志,2003,20(6)：314-316.
[7]王军,申秀玲,曹峰林.溃疡性结肠炎的红细胞免疫与HLA相关性研究.哈尔滨医药,2003,23(4)：5-7.
[8]Beaugerie L, Massot N, Carbonnel F, Cattan S, Gendre JP, Cosnes J.Impact of cessation of smoking on the course of ulcerative colitis. Am J Gastroenterol 2001;96:2113-2116
[9]Richardson CE, Morgan JM, Jasani B, Green JT, Rhodes J, Williams GT,Lindstrom J, Wonnacott S, Peel S, Thomas GA. Effectof smoking and transdermal nicotine on colonic nicotinic acetylcholinereceptors in ulcerative colitis. Q J Med 2003;96:57-65
[10]Coulie B, Camilleri M, Bharucha AE, Sandborn WJ, Burton D. Colonicmotility in chronic ulcerative proctosigmoiditis and the effects of nicotine on colonic motilityin patients and healthy subjects. Aliment Pharmacol Ther 2004;15:653-663
[11]Sher ME, Bank S, Greenberg R, Sardinha TC, Weissman S, Bailey B,Gilliland R, Wexner SD. The influence of cigarette smoking on cytokine levels in patients withinflammatory bowel disease. Inflamm Bowel Dis 2005;5:73-78
[12]Madretsma S, Wolters LM, Van Dijk JP, Tak CJ, Feyerabend C, WilsonJH, Zijlstra FJ. In-vivoeffect of nicotine on cytokine production by human non-adherentmononuclear cells. Eur J Gastroenterol Hepatol 2005;8:1017-1020
[13]Theis MK, Boyko EJ. Patient perceptions of causes of inflammatorybowel disease. Am J Gastroenterol 1994;89:1920
[14]Mayer EA. The neurobiology of stress and gastrointestinal disease.Gut 2000;47:861-869
[15]Qiu BS, Vallance BA, Blennerhassett PA, Collins SM. The role of CD4+ lymphocytes in the susceptibility of mice to stress-induced reactivation of experimentalcolitis. Nat Med 1999;5:1178-1182
[16]Isolauri E. Probioticsin human disease. Am J Clin Nutr 2001;73:1142-1146
[17]Shirazi T, Longman RJ, Corfield AP, Probert CS. Mucins and inflammatory bowel disease. Postgrad Med J 2000;76:473-478
[18]Granger DN RutiliG,MC Cord JM Superoxide radicals in felin intestinal ischemia[J]. Gastroenterology 1981,81(1):22-25
[19]Simmonds NJ, Rampton DS Inflammatory bowel disease a radical view(J]. Gt,2003,87:865-867
[20]Yoshida Y, Iwai A, Itoh K, Tanaka M, Kato S, Hokari R, Miyahara T,Koyama H, Miura S, Kobayashi M. Roleof inducible nitric oxide synthase in dextran sulphatesodium-induced colitis. Aliment Pharmacol Ther 2000;14(Suppl 1):26-32
[21]Grisham MB. Oxidants and free radicals in inflammatory boweldisease. Lancet 2004;344:859-861
[22]贺国斌.溃疡性结肠炎的血栓前状态与肝素治疗[J).国外医学内科学分册,2000,27(6)：238-241
[23]卞红磊,魏艳静.活动期溃疡性结肠炎患者血浆血栓烷B_2和6-酮-前列腺素Fla的临床研究[J]临床荟萃,2004,(24)P 39
[24]魏艳静,卞红磊,武会珍.溃疡性结肠炎患者体内血小板功能状态研究[J]临床荟萃,2003,(11).P13-14
[25]Collins CE Cihi11 MR, Newland AC et aL. Platelets circulation in an activated state in inflammatory bowel disease (J).Gastroenterology,1994, 106(4):840-845
[26]徐萍,吴锡深.血小板功能障碍：炎症性肠病研究的一种新动向(J).国外医学消化系统疾病分册,199016(1)：43
[27]Graef V Baggenstoss AH, Sauer WG, et aL Venous thromblsis occurring in nonspecific ulcerative colitis (J).Arch InternMed,1996,117(3):337
[28]张连峰,田曙光,王国新.溃疡性结肠炎患者血小板功能状态的研究(J).中国实用内科杂志,200020(2)：98-99
[29]许丽莉,王吉耀.活动期溃疡性结肠炎患者体内血小板激活状态的评价(J).中华消化杂志,2002,22(2)285-287
[30]行琦.炎症性肠病的药物治疗进展.见：郑家驹主编.炎症性肠病.上海科技文献出版社,1998.140-149
[31]Rutigeerts P.Medical therapy of inflammatory bowel disease. Digestion,1998, 59;453-469
[32]Kirsner JB.Inflammatory bowel disease(5th edition).2001,520-529
[33]Muijsers RB, Goa KL. Balsalazide:A review of its therapeutic use in mild-to-moderate ulcerative colitis. Drugs,2002,62(11):1689
[34]Campitri M. Gut,2002;50(Suppl 3):43-46.
[35]Malchow H, Gertz B. A new mesalazine foam enema (ClaversalFoam) compared witha standard liquid enema in patients with active distal ulcerative colitis. Alimentary Pharmacology andThera-peutics,2002,16(3):415
[36]行琦.炎症性肠病的药物治疗进展.见：郑家驹主编.炎症性肠病.上海科技文献出版社,1998.140-149
[37]Rutigeerts P.Medical therapy of inflammatory bowel disease.Digestion,1998,59; 453-469
[38]Mantzaris GJ, Petraki K, Archavlis E, et al. A prospective randomized controlled trial of intravenous ciprofloxacin as an adjunct to corticosteroids in acute, severe ulcerative colitis.ScandinavianJournal of Gastroenterology,2001, 36(9):971
[39]Ben AE, Goldin E, Wengrower D, et al. Wheat grass juice in thetreatment of active distal ulcerative colitis:A randomizeddouble-blind placebo-controlled trial. Scandinavian Journal of Gastroenterology,2002,37(4):444
[40]Langmead L, Dawson C, Hawkins C, et al. Antioxidant effects of herbal therapies used by patients with inflammatorybowel disease:an in vitro study. Alimentary Ph armacology and Therapeutics,2002,16(2):197
[41]Middleton SJ, Naylor S, Woolner J, et al. A double-blind,randomized, placebo-control led trial of essential fatty acid suppl ementation in the maintenance of remiss ion of ulcerative colitis.Alimentary P harmacology and Therapeutics,2002,16(6):1131
[42]Sand BE.Novel therapies for inflammatory bowel disease.Gastroenterol Clin N Am,1999,28(2):323-341
[43]Sandbon WJ.Therapyfor ulcerative colitis.Curr Opin Gastroenteral,1998, 14:312-316
[44]Madsen KL,Doyle JS,Jewell LD.Lactobacillus species prevents colits in interleukin 10 genedeficient mice.Gastroenterology,1999,116:1107-1114
[45]张雪燕,韩涛.溃疡性结肠炎动物模型制作的研究进展[J]甘肃中医,2004,(06).P3-7
[46]范恒,邱明义.溃疡性结肠炎大鼠实验模型的建立与评价[J]中医药学刊,2004,(05).P94-95+134
[47]邓莉,胡晋红.化学诱导型结肠炎动物模型的研究进展[J].中国药理学通报,2005,(05)P 14-18