应激时A型行为者血浆皮质醇、甲状腺激素水平、中性粒细胞功能及动脉血压变化的相似性研究
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摘要
目的 探讨医科学生A行为类型与应激反应的特征；①A和B行为者安静与应激时血浆皮质醇(cortisol)和甲状腺激素(T_3,T_4)反应的特征，以及行为因子与血浆皮质醇(cortisol)反应的特征的关系；②A和B行为者安静与应激时中性粒细胞吞噬功能的变化特征；③A和B行为者安静与应激时外周心血管反应的特征。
方法 采用A型行为类型量表将75名医科学生测量分型后；在以限时心算测验为应激源下，在3-5min完成血液样本的采集，立即送检：1周后安静状态再次采血样送检；经放射免疫法分别测定血浆皮质醇和甲状腺激素水平值：分别在运动前，运动中，运动后采集血样，采用化学发光法测定他们的中性粒细胞吞噬功能变化：在考试应激状态，测量血压的变化，考试后安静状态再测量血压值。同时采用逻辑质的方法分析相互的逻辑关系。
结果 ①在安静时，A型和B型行为者应激时血浆皮质醇水平的差值△cortisol(应激值-安静值)有显著差异性(t=2.376．P＜0.05)；A型行为者应激时血浆T3水平比安静时显著减少(t=2.875，P＜0.01)；全体A型和B型应激时T4水平比安静时显著减少(t=2.687，P＜0.01)。②安静状态，非运动组的中性粒细胞吞噬功能较运动组强(t=2.132，P＜0.05)，而在运动中和运动后两种状态下，运动型组的增幅均明显高于非运动型组(P＜0.01)；在运动员和非运动员应激反应时中性粒细胞吞噬功能强度也有显著逻辑差异(t_(phago)=0.2106，P＞0.05：t_(phago)≥3.9713，P＜0.05)。在考试应激时，B型脉压比A型的增大：A脉压型比B型的减小。A型和B型组外周心血管反应指标血压变化比较有显著逻辑差异(t=11.001，P＜0.01；t≤1.920，P＞0.05)。③分别在应激和安静时，其cortisol和T3指标之间均无统计差异(t_(应激)≤0.05058，t_(安静)≤1.1095，均P＞0.05)；每项指标(cortisol或T_3)在A型和B型行为者间应激反应差别具有显著差性
安徽医科大学硕士学位论文
(t。。rtis护2.373，P>0.05:tcortis。，全2.843，p<0.05:tT3全4.744，p<0.05，tT3=0.000，P>.05)，两种指
标的逻辑性相同即相似性;同时比较A型和B型行为者应激反应的差值△cortisol
和△T;指标有逻辑差异(t三1.681，P>0.05:t全4.435p<0.05):而且△eortisol，△T4，CH因子
三指标在A型和B型的应激反应也有逻辑差异(t么三2.239，尸>0.05，t之2.993，P<0 .05);
表明行为类型的CH因子特性与两种指标的特性是逻辑一致(即相似性);
结论①A型行为者应激时col·tisol水平和T3水平比安静时显著减少;应激时
A型脉压比B型的减小:安静时、非运动组的中性粒细胞吞噬功能较运动组强，相
反，在运动时，运动型组的增幅均明显高于非运动型组;②行为类型CH因子与生
理指标△T;和/或△cortisol之间具有逻辑一致性;在逻辑上肯定A型行为者的应激
反应相似性。
Objective To study on relationship of type A behavior to stress response with plasma cortisol(orAcortisol i.e difference value of cortisol level between rest and stress) and thyroxin (T3 or T4) for type A and B behaviors, the same with change in phagocytotic function of neutrophils between excising and non-excising group in excise stress or post-excise and rest, and it is compared with change of blood pressure in type A behavior with examining stressor to rest, and more, their relationships between CH (competition and hostility)factor and plasma cortisol difference (orAcortisol) for type A and B behaviors by logic-qualitative research.
Method 75 student cases tested were determined for A type behavior using psychological questionnaire. Then they tested by mental stress of limited time arithmetic testing in 3 minutes or so.meanwhile, their blood sample were obtained during 5minutes after stress under empty abadomn at 7~8 a.m. Second blood samples were obtained in 1 week late in rest (no stressing).in final, their plasma cortisol and thyroxin(T3,T4) levels were measured with y-radio-immune analysis by the same specialist. While type A behaviors under examing stressor,their blood pressure changing were detected and while under rest again.and more,while under excising stress,their change in phagocytotic function of neutrophils between excising and non-excising group in excise stress or post-excise and rest.
Result(1)the finding showed that for A and B type behavious students the difference of their plasma cortisol levels was not significant(p>0.05)at rest,whereas in mental stress plasma cortisol levels of B type was distinctly high than at rest ,and that of A type,on the other hand ,lower than at rest.Hence a sharp contrast between type A and
B behaviors(t=2.376, P<0.05),and more,The result also showed that their plasma levels of T4 was distinctly lower under mental stress than at rest (t=2.687,P<0.05),for the type A behavior,the plasma levels of T3 reduced more significantly than at rest(t=2.875, P<0.05);There was also significant different response of phagocytotic function of neutrophils between excising and non-excising groups in excise stress or post-excise and rest (t=2.132,P<0.05) , the same results as in logic qualitative research(tphago=0.2106,P>0.05, tphago>3.9713.7. P<0.05)respectively. There was also significant difference changes in logic of their blood pressures between (tneutro<1.6160,.P >.05;tneutro>.4558,P <0.05)(2)There was no different response of between plasma cortisol and thyroid hormone(T3) for type A and B behaviors either in stress or rest (tsTRESs<0.05058,tREST<1.1095,all P>.05)respectively in logic,and there was significant difference between type B and A behaviors with either plasma
cortisol (tcoRTISOL= 2.373,P>0.05,tCORTISOL >2.843,P<0.05 ) or thyroid hormone(T3)(tT3=4.7436, P<0.05;tT3=0.000,P>.05) in stress and rest with logic-qualitative research.In another exame strcssing,it was finding that blood pressure differences (pulse pressure) of cardiovascular response is decreased in type A behaviors but increased in type B behaviors(t=2.678, P<0.05)although their blood pressures is higher in stress than that in resilience there was significant difference of diastolic,systolic and pulse pressure in logical 1.00 l,P<0.01;t<1.920,P>.05)between type A and B behaviors.(3)Moreover,there was significant difference between type A and B behaviors to stress (t<1.681, P >.05;t>.435,P <0.05) in different response of plasma Aconisol and AT4 in logic. There was significant difference between type A and B behaviors to stress response with three indexes of plasma Acortisol, AT4 and behavior CH factor(t <2.239, P >.05, t>. 993, P <0.05)in logic-qualily research, meanwhile there was consistence between behavior CH factor and changes of plasma cortisol and T4(called stress similarity).
Conclusion (1)There is, in logic, stress similarity of type A and B behaviors to
stress responses of either plasma cortisol or thyroid hormone(T3)in HPA, phagocytotic function
方法 采用A型行为类型量表将75名医科学生测量分型后；在以限时心算测验为应激源下，在3-5min完成血液样本的采集，立即送检：1周后安静状态再次采血样送检；经放射免疫法分别测定血浆皮质醇和甲状腺激素水平值：分别在运动前，运动中，运动后采集血样，采用化学发光法测定他们的中性粒细胞吞噬功能变化：在考试应激状态，测量血压的变化，考试后安静状态再测量血压值。同时采用逻辑质的方法分析相互的逻辑关系。
结果 ①在安静时，A型和B型行为者应激时血浆皮质醇水平的差值△cortisol(应激值-安静值)有显著差异性(t=2.376．P＜0.05)；A型行为者应激时血浆T3水平比安静时显著减少(t=2.875，P＜0.01)；全体A型和B型应激时T4水平比安静时显著减少(t=2.687，P＜0.01)。②安静状态，非运动组的中性粒细胞吞噬功能较运动组强(t=2.132，P＜0.05)，而在运动中和运动后两种状态下，运动型组的增幅均明显高于非运动型组(P＜0.01)；在运动员和非运动员应激反应时中性粒细胞吞噬功能强度也有显著逻辑差异(t_(phago)=0.2106，P＞0.05：t_(phago)≥3.9713，P＜0.05)。在考试应激时，B型脉压比A型的增大：A脉压型比B型的减小。A型和B型组外周心血管反应指标血压变化比较有显著逻辑差异(t=11.001，P＜0.01；t≤1.920，P＞0.05)。③分别在应激和安静时，其cortisol和T3指标之间均无统计差异(t_(应激)≤0.05058，t_(安静)≤1.1095，均P＞0.05)；每项指标(cortisol或T_3)在A型和B型行为者间应激反应差别具有显著差性
安徽医科大学硕士学位论文
(t。。rtis护2.373，P>0.05:tcortis。，全2.843，p<0.05:tT3全4.744，p<0.05，tT3=0.000，P>.05)，两种指
标的逻辑性相同即相似性;同时比较A型和B型行为者应激反应的差值△cortisol
和△T;指标有逻辑差异(t三1.681，P>0.05:t全4.435p<0.05):而且△eortisol，△T4，CH因子
三指标在A型和B型的应激反应也有逻辑差异(t么三2.239，尸>0.05，t之2.993，P<0 .05);
表明行为类型的CH因子特性与两种指标的特性是逻辑一致(即相似性);
结论①A型行为者应激时col·tisol水平和T3水平比安静时显著减少;应激时
A型脉压比B型的减小:安静时、非运动组的中性粒细胞吞噬功能较运动组强，相
反，在运动时，运动型组的增幅均明显高于非运动型组;②行为类型CH因子与生
理指标△T;和/或△cortisol之间具有逻辑一致性;在逻辑上肯定A型行为者的应激
反应相似性。
Objective To study on relationship of type A behavior to stress response with plasma cortisol(orAcortisol i.e difference value of cortisol level between rest and stress) and thyroxin (T3 or T4) for type A and B behaviors, the same with change in phagocytotic function of neutrophils between excising and non-excising group in excise stress or post-excise and rest, and it is compared with change of blood pressure in type A behavior with examining stressor to rest, and more, their relationships between CH (competition and hostility)factor and plasma cortisol difference (orAcortisol) for type A and B behaviors by logic-qualitative research.
Method 75 student cases tested were determined for A type behavior using psychological questionnaire. Then they tested by mental stress of limited time arithmetic testing in 3 minutes or so.meanwhile, their blood sample were obtained during 5minutes after stress under empty abadomn at 7~8 a.m. Second blood samples were obtained in 1 week late in rest (no stressing).in final, their plasma cortisol and thyroxin(T3,T4) levels were measured with y-radio-immune analysis by the same specialist. While type A behaviors under examing stressor,their blood pressure changing were detected and while under rest again.and more,while under excising stress,their change in phagocytotic function of neutrophils between excising and non-excising group in excise stress or post-excise and rest.
Result(1)the finding showed that for A and B type behavious students the difference of their plasma cortisol levels was not significant(p>0.05)at rest,whereas in mental stress plasma cortisol levels of B type was distinctly high than at rest ,and that of A type,on the other hand ,lower than at rest.Hence a sharp contrast between type A and
B behaviors(t=2.376, P<0.05),and more,The result also showed that their plasma levels of T4 was distinctly lower under mental stress than at rest (t=2.687,P<0.05),for the type A behavior,the plasma levels of T3 reduced more significantly than at rest(t=2.875, P<0.05);There was also significant different response of phagocytotic function of neutrophils between excising and non-excising groups in excise stress or post-excise and rest (t=2.132,P<0.05) , the same results as in logic qualitative research(tphago=0.2106,P>0.05, tphago>3.9713.7. P<0.05)respectively. There was also significant difference changes in logic of their blood pressures between (tneutro<1.6160,.P >.05;tneutro>.4558,P <0.05)(2)There was no different response of between plasma cortisol and thyroid hormone(T3) for type A and B behaviors either in stress or rest (tsTRESs<0.05058,tREST<1.1095,all P>.05)respectively in logic,and there was significant difference between type B and A behaviors with either plasma
cortisol (tcoRTISOL= 2.373,P>0.05,tCORTISOL >2.843,P<0.05 ) or thyroid hormone(T3)(tT3=4.7436, P<0.05;tT3=0.000,P>.05) in stress and rest with logic-qualitative research.In another exame strcssing,it was finding that blood pressure differences (pulse pressure) of cardiovascular response is decreased in type A behaviors but increased in type B behaviors(t=2.678, P<0.05)although their blood pressures is higher in stress than that in resilience there was significant difference of diastolic,systolic and pulse pressure in logical 1.00 l,P<0.01;t<1.920,P>.05)between type A and B behaviors.(3)Moreover,there was significant difference between type A and B behaviors to stress (t<1.681, P >.05;t>.435,P <0.05) in different response of plasma Aconisol and AT4 in logic. There was significant difference between type A and B behaviors to stress response with three indexes of plasma Acortisol, AT4 and behavior CH factor(t <2.239, P >.05, t>. 993, P <0.05)in logic-qualily research, meanwhile there was consistence between behavior CH factor and changes of plasma cortisol and T4(called stress similarity).
Conclusion (1)There is, in logic, stress similarity of type A and B behaviors to
stress responses of either plasma cortisol or thyroid hormone(T3)in HPA, phagocytotic function
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