食品包装纸中有害化学物的分析测定及迁移研究
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摘要
目前,国内外包装安全事件屡见报道,严重威胁着人民群众的健康。纸以其良好的机械操作性能等多方面的优势,已成为食品工业中重要的包装材料。但是纸在生产以及后续的加工过程中添加的一些化学物会在纸张中残留；其中的有毒有害物质,与食品接触后会向食品发生迁移,从而危害消费者的健康。由此,纸质食品包装材料中有害化学物的分析、迁移理论的建立已成为国际性的研究热点。
第一章：简述了纸包装在食品行业的应用现状、纸中潜在残留污染物、各国制定的相关法律法规,以及有关食品包装纸中化学物的国内外研究进展,并在此基础上提出了本论文的研究内容及创新之处。
第二章：建立了微波消解-电感耦合等离子体原子发射光谱法(ICP-AES)测定食品包装纸中的铅、镉、铬、汞的方法。优化了主要的消解条件,包括硝酸与双氧水的比值、温度和时间。该方法前处理效果好,检出限低,能同时进行多元素检测,能够对纸质食品包装中多种重金属元素进行有效的测定。
第三章：建立了超高效液相色谱-串联质谱法(UPLC-MS/MS)检测食品包装纸中2,4,6-三氯酚、五氯酚、4-氯-3,5-二甲基-苯酚和4-t-辛基酚的分析方法。通过优化流动相、质谱监测参数、超声提取溶剂以及净化条件,提高了方法的灵敏度和准确度。
第四章：建立了超高效液相色谱-串联质谱法(UPLC-MS/MS)检测食品包装纸中2-甲基-4-异噻唑啉-3-酮、5-氯2-甲基-4-异噻唑啉-3-酮、1,2-苯并-异噻唑啉-3-酮和2-辛基-4-异噻唑啉-3-酮四种杀菌剂的方法。通过优化流动相、质谱监测参数及超声提取溶剂,提高了方法的灵敏度和准确度。
第五章：对食品包装纸中2-甲基-4-异噻唑啉-3-酮、1,2-苯并-异噻唑啉-3-酮和2-辛基-4-异噻唑啉-3-酮三种杀菌剂向固体食品模拟物Tenax和Proapak的动力学迁移进行了研究。建立了快速、有效的迁移方法和定量分析方法,并通过改变迁移的温度、时间和接触的模拟物,找出迁移量的变化趋势。最后采用所建立的方法,对市售的两种食品包装纸进行迁移测试。
Currently, both domestic and international press on unhealthy packaging security incidents frequently reports. Due to having various advantages in mechanical properties and other aspects, paper packaging is becoming the main kind of materials in food industry. However, during manufacture and subsequent treatment, some chemical additives were still within the paper packaging. Some of those toxic chemicals can migrate into foods and threat the health of consumers. So the researches on toxic chemicals analysis and migration theory within food paper packaging materials become an international hot topic.
Chapter 1:Brief introduction to current status of using paper materials in food packaging industry, the potential contaminants in paper packaging, relevant rules and regulations, the domestic and international research progress and achievements, and based on these reviewers research content of this thesis and innovative points were put forward in this chapter.
Chapter 2:The inductively coupled plasma-emission spectrometry (ICP-AES) analysis method was developed for the determination of Pb, Cd, Cr and Hg in food contact paper. Under the optimal conditions of digestion temperature, time and the ratio of nitric acid and hydrogen peroxide, the proposed method get effective pre-treatment and low detection limit, are suitable for the determination metal elements in food paper packaging.
Chapter 3:The ultra performance liquid chromatography-tandem mass spectrometric (UPLC-MS/MS) method was developed for the determination of phenols, including 2,4,6-trichlorophenol(TCP), pentachlorophenol(PCP), 4-chloro-3,5-dimethylphenol (PCMX) and 4-tert-octylphenol (4-tert-OP), in food paper packaging. Under the optimal conditions of mobile phase, MS acquisition parameters, ultrasonic extract solvent and solid-phase extract purification, and the proposed method has been applied to determination of the phenols in commercial paper food packages.
Chapter 4:A novel and simple method to detect isothiazolinone biocides (2-methyl-3-isothiazolinone(MI),5-chloro-2-methyl-3-isothiazolinone(CMI), 1,2-benzisothiazolinone (BIT) and 2-octyl-3-isothiazolinone (OIT)) in food paper packaging by ultrasonic extraction coupled with ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was developed. Under the optimal conditions of mobile phase, MS acquisition parameters and ultrasonic extract solvent, and the proposed method has been applied to determination of the isothiazolinones in commercial paper food packages.
Chapter 5:Migration investigations were creatively carried out a series of biocides (2-methyl-3-isothiazolinone (MI), 1,2-benzisothiazolinone(BIT) and 2-octyl-3-isothiazolinone (OIT) on paper packaging materials in contact with solid food simulants Tenax and Porapak. After developing methods for migration test and quantitative determination, the migration behavior of these contaminants in paper were studied at varying temperatures, migration times and food simulants, finally two kinds of paper packaging for food purchased from local market were tested with the developing method.
第一章：简述了纸包装在食品行业的应用现状、纸中潜在残留污染物、各国制定的相关法律法规,以及有关食品包装纸中化学物的国内外研究进展,并在此基础上提出了本论文的研究内容及创新之处。
第二章：建立了微波消解-电感耦合等离子体原子发射光谱法(ICP-AES)测定食品包装纸中的铅、镉、铬、汞的方法。优化了主要的消解条件,包括硝酸与双氧水的比值、温度和时间。该方法前处理效果好,检出限低,能同时进行多元素检测,能够对纸质食品包装中多种重金属元素进行有效的测定。
第三章：建立了超高效液相色谱-串联质谱法(UPLC-MS/MS)检测食品包装纸中2,4,6-三氯酚、五氯酚、4-氯-3,5-二甲基-苯酚和4-t-辛基酚的分析方法。通过优化流动相、质谱监测参数、超声提取溶剂以及净化条件,提高了方法的灵敏度和准确度。
第四章：建立了超高效液相色谱-串联质谱法(UPLC-MS/MS)检测食品包装纸中2-甲基-4-异噻唑啉-3-酮、5-氯2-甲基-4-异噻唑啉-3-酮、1,2-苯并-异噻唑啉-3-酮和2-辛基-4-异噻唑啉-3-酮四种杀菌剂的方法。通过优化流动相、质谱监测参数及超声提取溶剂,提高了方法的灵敏度和准确度。
第五章：对食品包装纸中2-甲基-4-异噻唑啉-3-酮、1,2-苯并-异噻唑啉-3-酮和2-辛基-4-异噻唑啉-3-酮三种杀菌剂向固体食品模拟物Tenax和Proapak的动力学迁移进行了研究。建立了快速、有效的迁移方法和定量分析方法,并通过改变迁移的温度、时间和接触的模拟物,找出迁移量的变化趋势。最后采用所建立的方法,对市售的两种食品包装纸进行迁移测试。
Currently, both domestic and international press on unhealthy packaging security incidents frequently reports. Due to having various advantages in mechanical properties and other aspects, paper packaging is becoming the main kind of materials in food industry. However, during manufacture and subsequent treatment, some chemical additives were still within the paper packaging. Some of those toxic chemicals can migrate into foods and threat the health of consumers. So the researches on toxic chemicals analysis and migration theory within food paper packaging materials become an international hot topic.
Chapter 1:Brief introduction to current status of using paper materials in food packaging industry, the potential contaminants in paper packaging, relevant rules and regulations, the domestic and international research progress and achievements, and based on these reviewers research content of this thesis and innovative points were put forward in this chapter.
Chapter 2:The inductively coupled plasma-emission spectrometry (ICP-AES) analysis method was developed for the determination of Pb, Cd, Cr and Hg in food contact paper. Under the optimal conditions of digestion temperature, time and the ratio of nitric acid and hydrogen peroxide, the proposed method get effective pre-treatment and low detection limit, are suitable for the determination metal elements in food paper packaging.
Chapter 3:The ultra performance liquid chromatography-tandem mass spectrometric (UPLC-MS/MS) method was developed for the determination of phenols, including 2,4,6-trichlorophenol(TCP), pentachlorophenol(PCP), 4-chloro-3,5-dimethylphenol (PCMX) and 4-tert-octylphenol (4-tert-OP), in food paper packaging. Under the optimal conditions of mobile phase, MS acquisition parameters, ultrasonic extract solvent and solid-phase extract purification, and the proposed method has been applied to determination of the phenols in commercial paper food packages.
Chapter 4:A novel and simple method to detect isothiazolinone biocides (2-methyl-3-isothiazolinone(MI),5-chloro-2-methyl-3-isothiazolinone(CMI), 1,2-benzisothiazolinone (BIT) and 2-octyl-3-isothiazolinone (OIT)) in food paper packaging by ultrasonic extraction coupled with ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was developed. Under the optimal conditions of mobile phase, MS acquisition parameters and ultrasonic extract solvent, and the proposed method has been applied to determination of the isothiazolinones in commercial paper food packages.
Chapter 5:Migration investigations were creatively carried out a series of biocides (2-methyl-3-isothiazolinone (MI), 1,2-benzisothiazolinone(BIT) and 2-octyl-3-isothiazolinone (OIT) on paper packaging materials in contact with solid food simulants Tenax and Porapak. After developing methods for migration test and quantitative determination, the migration behavior of these contaminants in paper were studied at varying temperatures, migration times and food simulants, finally two kinds of paper packaging for food purchased from local market were tested with the developing method.
引文
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[1]余集锋.浅谈食品包装用纸中有毒有害物质的来源及其危害[J].湖北造纸.2007,2：36-38.
[2]《欧盟食品接触材料法规与指南》编译组.欧盟食品接触材料法规与指南[M].北京：中国轻工业出版社,2009.
[3]Aston D S J, Parry S J. Migration of inorganic contaminants into dry food from packaging made from recycled paper and board[J]. Food Additives and Contaminants.2004,21(5):506-511.
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