消癜汤对过敏性紫癜患者免疫球蛋白及尿β_2微球蛋白影响的研究
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摘要
目的:
探讨过敏性紫癜的病变机理,观察消癜汤治疗过敏性紫癜的临床疗效及作用机理。
方法:
将58例过敏性紫癜急性期及慢性病人急性发作者分为中药治疗组30例和西药对照组28例,西药对照组应用强的松和常规西药治疗,中药治疗组在常规应用西药治疗的基础上加服消癜汤,观察比较两组在临床疗效与免疫球蛋白IgA、IgG、IgM及补体C_3和C_4和尿β_2微球蛋白等生化指标方面的疗效差异。结果:
1.消殿汤治疗组疗效确切,总有效率为90%,优于强的松对照组。
2.过敏性紫癜患者免疫球蛋白IgA水平升高,补体C_3水平升高;消癜汤可以使AP患者IgA水平明显下降,使C_3的表达下降。免疫球蛋白IgG、IgM及补体C_4可能由于搜集病例数量有限,无明显表达。AP患者尿β_2微球蛋白亦高于正常人,消癜汤可以使β_2-MG的表达下降。
3.消癜汤可降低过敏性紫癜患者免疫球蛋白IgA的水平,纠正AP患者免疫功能紊乱的状态,减轻组织、器官的损伤,使相应的临床症状得到缓解。消癜汤也能明显的降低尿β_2微球蛋白含量,使肾脏的损害得以修复。
结论:
在常规西药治疗基础上加用消癜汤在消除过敏性紫癜的临床症状,降低肾脏受累发生率及降低副作用方面优于常规西药治疗,提示消癜汤是治疗过敏性紫癜的有效方药。
Objective:To observe the clinical which is used to treat acute and the acute breakout of the chronic allergic purpura. To explore the mechanism of allergic purpura, to observe the mechanism and the clinical curative effect of the Xiaodian soup. Methods:The 50 acute allergic purpura patients and the acute breakout of the chronic ones were randomly divided into two groups: the observation group 30 and the control group 28. The glucocorticoid and conventional treatment were given to the control groups, The Xiaodian soup treatment and conventional treatment were given to the observaton group. Compared the difference of curative effect between the two group in the indexes such as clinical symptom and biology-chemical target that Immunoglobulin A、 Immunoglobulin G、 Immunoglobulin M and Complement 3、 Complement 4 and β_2 microglobulin. Results:i.The total effective rate of Xiaodian soup was 90.0%, The observation group were better than the methylprednisolone group.ii.Allergic purpura patients ' Immunoglobulin A and Complement 3 is high. Xiaodian soup can reduce Immunoglobulin A and Complement 3. Immunoglobulin G、 M and Complement 4 is not expressed, because quantity is finited. Allergic purpura patients' β_2 microglobulin is high. Xiaodian soup can reduce β_2 microglobulin.iii. Xiaodian soup can reduce Immunoglobulin A and improve the abnormal immune status of patients. Xiaodian soup can reduce β_2 microglobulin. It is find that traditional Chinese medicinal herb'
control get a better curative effect and significantly the remissiontime of clinical manifestation.Conclusion:On the basis of conventional western medicine xiaodian soup was superior to conventional western medicine which can clearly improve clinical manifestation of allergic purpura, decrease the recurrence ratio, abase the damage of kidney function and scant the side function. It is pointed out that xiaodian soup is an effectect recipe to the allergic purpura.
探讨过敏性紫癜的病变机理,观察消癜汤治疗过敏性紫癜的临床疗效及作用机理。
方法:
将58例过敏性紫癜急性期及慢性病人急性发作者分为中药治疗组30例和西药对照组28例,西药对照组应用强的松和常规西药治疗,中药治疗组在常规应用西药治疗的基础上加服消癜汤,观察比较两组在临床疗效与免疫球蛋白IgA、IgG、IgM及补体C_3和C_4和尿β_2微球蛋白等生化指标方面的疗效差异。结果:
1.消殿汤治疗组疗效确切,总有效率为90%,优于强的松对照组。
2.过敏性紫癜患者免疫球蛋白IgA水平升高,补体C_3水平升高;消癜汤可以使AP患者IgA水平明显下降,使C_3的表达下降。免疫球蛋白IgG、IgM及补体C_4可能由于搜集病例数量有限,无明显表达。AP患者尿β_2微球蛋白亦高于正常人,消癜汤可以使β_2-MG的表达下降。
3.消癜汤可降低过敏性紫癜患者免疫球蛋白IgA的水平,纠正AP患者免疫功能紊乱的状态,减轻组织、器官的损伤,使相应的临床症状得到缓解。消癜汤也能明显的降低尿β_2微球蛋白含量,使肾脏的损害得以修复。
结论:
在常规西药治疗基础上加用消癜汤在消除过敏性紫癜的临床症状,降低肾脏受累发生率及降低副作用方面优于常规西药治疗,提示消癜汤是治疗过敏性紫癜的有效方药。
Objective:To observe the clinical which is used to treat acute and the acute breakout of the chronic allergic purpura. To explore the mechanism of allergic purpura, to observe the mechanism and the clinical curative effect of the Xiaodian soup. Methods:The 50 acute allergic purpura patients and the acute breakout of the chronic ones were randomly divided into two groups: the observation group 30 and the control group 28. The glucocorticoid and conventional treatment were given to the control groups, The Xiaodian soup treatment and conventional treatment were given to the observaton group. Compared the difference of curative effect between the two group in the indexes such as clinical symptom and biology-chemical target that Immunoglobulin A、 Immunoglobulin G、 Immunoglobulin M and Complement 3、 Complement 4 and β_2 microglobulin. Results:i.The total effective rate of Xiaodian soup was 90.0%, The observation group were better than the methylprednisolone group.ii.Allergic purpura patients ' Immunoglobulin A and Complement 3 is high. Xiaodian soup can reduce Immunoglobulin A and Complement 3. Immunoglobulin G、 M and Complement 4 is not expressed, because quantity is finited. Allergic purpura patients' β_2 microglobulin is high. Xiaodian soup can reduce β_2 microglobulin.iii. Xiaodian soup can reduce Immunoglobulin A and improve the abnormal immune status of patients. Xiaodian soup can reduce β_2 microglobulin. It is find that traditional Chinese medicinal herb'
control get a better curative effect and significantly the remissiontime of clinical manifestation.Conclusion:On the basis of conventional western medicine xiaodian soup was superior to conventional western medicine which can clearly improve clinical manifestation of allergic purpura, decrease the recurrence ratio, abase the damage of kidney function and scant the side function. It is pointed out that xiaodian soup is an effectect recipe to the allergic purpura.
引文
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