前列清颗粒治疗慢性前列腺炎及对前列腺液中IL-2和TNF-α因子影响的研究
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摘要
目的：观察前列清颗粒治疗慢性前列腺炎的疗效及对前列腺液中细胞因子(IL-2,TNF-α)的影响。
方法：选取慢性前列腺炎患者30例,采用前列清颗粒治疗1个月。所有受试者治疗前后均取EPS,一部分做EPS常规检查；另一部分保存在零下20℃冰箱中待测细胞因子(IL-2,TNF-α),采用酶联免疫吸附测定法(ELISA)检测；同时观察记录受试者治疗前后的症状和体征。用SPSS16.0软件对数据进行统计分析,用t检验对结果进行统计学分析
结果：前列清颗粒治疗慢性前列腺炎的总有效率为93.3%。前列清颗粒能够明显降低前列腺液中白细胞数和增加前列腺液卵磷脂小体密度,具有显著的统计学意义(P<0.05)；降低临床症状指数积分,具有显著的统计学意义(P<0.05)；降低前列腺液中IL-2和TNF-α水平,具有非常显著的统计学意义(P<0.01)。
结论：前列清颗粒可明显改善慢性前列腺炎患者的临床症状、体征；降低前列腺液中白细胞数量和增加前列腺液卵磷脂小体密度；能明显降低前玠腺液中IL-2和TNF-α的水平；前列清颗粒可能是影响免疫系统改变前列腺液内IL-2和TNF-α的水平而发挥其治疗作用。
Objective:To study the influence to the cytokines(IL-2, TNF-α) in prosta-te liquid of Chronic prostatitis treating with prostatitis healing granule,To evaluate the effect of clinical symptoms improvement of CP patients through prostatitis healing granule.
Methods:Select 30 cases of CP patients,who take prostatitis healing granule for one month.All patients fetch EPS before and after treatment,the others make EPS routine inspection;The others keep in-20℃refrigerator awaiting measuring cytokines(IL-2,TNF-α) through ELISA law.At the same time,observe and record the symptoms and signs of the patients before and after treatment.Toanalyze the data by SPSS16.0 software,the result were statistical analyzed with t-test.
Result:The total effective rate is 93.4%.Prostatitis healing granule can obviously reduce EPS-WBC and increase EPS-CORP, with significant differ-ence(P<0.05);reduce chronic prostatitis symptom index points,with signifi-cant difference(P<0.05);obviously reduce the level of IL-2 and TNF-α,with very significant difference(P<0.01).
Conclusion:Prostatitis healing granule can obviously improve the clinical symptom,physical sign;reduce EPS-WBC and increase EPS-CORP; obviously reduce the level of IL-2 and TNF-αin prostatic fluid of chronic prostatitis patient;prostatitis healing granule plays its treat function might by influence immune system to change the level of IL-2 and TNF-αof prostatic fluid.
方法：选取慢性前列腺炎患者30例,采用前列清颗粒治疗1个月。所有受试者治疗前后均取EPS,一部分做EPS常规检查；另一部分保存在零下20℃冰箱中待测细胞因子(IL-2,TNF-α),采用酶联免疫吸附测定法(ELISA)检测；同时观察记录受试者治疗前后的症状和体征。用SPSS16.0软件对数据进行统计分析,用t检验对结果进行统计学分析
结果：前列清颗粒治疗慢性前列腺炎的总有效率为93.3%。前列清颗粒能够明显降低前列腺液中白细胞数和增加前列腺液卵磷脂小体密度,具有显著的统计学意义(P<0.05)；降低临床症状指数积分,具有显著的统计学意义(P<0.05)；降低前列腺液中IL-2和TNF-α水平,具有非常显著的统计学意义(P<0.01)。
结论：前列清颗粒可明显改善慢性前列腺炎患者的临床症状、体征；降低前列腺液中白细胞数量和增加前列腺液卵磷脂小体密度；能明显降低前玠腺液中IL-2和TNF-α的水平；前列清颗粒可能是影响免疫系统改变前列腺液内IL-2和TNF-α的水平而发挥其治疗作用。
Objective:To study the influence to the cytokines(IL-2, TNF-α) in prosta-te liquid of Chronic prostatitis treating with prostatitis healing granule,To evaluate the effect of clinical symptoms improvement of CP patients through prostatitis healing granule.
Methods:Select 30 cases of CP patients,who take prostatitis healing granule for one month.All patients fetch EPS before and after treatment,the others make EPS routine inspection;The others keep in-20℃refrigerator awaiting measuring cytokines(IL-2,TNF-α) through ELISA law.At the same time,observe and record the symptoms and signs of the patients before and after treatment.Toanalyze the data by SPSS16.0 software,the result were statistical analyzed with t-test.
Result:The total effective rate is 93.4%.Prostatitis healing granule can obviously reduce EPS-WBC and increase EPS-CORP, with significant differ-ence(P<0.05);reduce chronic prostatitis symptom index points,with signifi-cant difference(P<0.05);obviously reduce the level of IL-2 and TNF-α,with very significant difference(P<0.01).
Conclusion:Prostatitis healing granule can obviously improve the clinical symptom,physical sign;reduce EPS-WBC and increase EPS-CORP; obviously reduce the level of IL-2 and TNF-αin prostatic fluid of chronic prostatitis patient;prostatitis healing granule plays its treat function might by influence immune system to change the level of IL-2 and TNF-αof prostatic fluid.
引文
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[5]刘步平,谢建兴.红藤清前汤治疗慢性前列腺炎267例总结,湖南中医杂志,2007,23(2)：26.
[6]江海身.舒利通颗粒治疗慢性前列腺炎/盆腔疼痛综合征的临床疗效[J]海军总医院学报2007(3)：18.
[7]曹福建.中西医结合治疗慢性前列腺炎的临床观察[J]基层医学论坛2006,10(11)：B版.
[8]张向辉,屈淼林。中药灌肠治疗慢性前列腺炎(气滞血瘀型)临床研究,河南中医学院学报,2009,24(2)：46-47。
[9]俞祝全.中药坐浴治疗慢性前列腺炎30例[J].中医外治杂志,1997,6(6)：25。
[10]马杰,韩鸿雁,李东辉.前列栓治疗慢性前列腺炎40例.中国中医急症,2002,11(6)：492-493.
[11]关慧玲,针灸辨证治疗慢性前列腺炎,中国针灸,1995,(9)：25。
[12]郝重耀.针刺”培精祛毒方”对慢性前列腺炎及前列腺痫患者尿流率的影响.针灸临床杂志,2001,17(12)：13-14.
[13]王跃先,姜永华。中药外敷治疗慢性前列腺炎50例[J],中医外治杂志,1999,8(3)：81。
[14]国家中医药管理局(中华本草)编委会.中华本草.上海：上海科技出版社1998.
[15]翁维良,等.34种传统活恤化瘀药对血液流变学作用的比较研究：《血瘀证与活血化瘀研究》,北京学苑出版社,1990(8).
[16]吴荷杰,中草药药理学,人民卫生出版社,第一版,1999
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[18]Mehik A,Hellstrom P,Lukkarinen O,etal.Epidemiology of prostatitis in Finnish men:a population-based cross-sectional study.BJU Int,2000, 86:443-448.
[19]Krieger JN,Riley DE,Cheah PY,etal.Epidemiology of prostatitis:new evidence for a world-wide problem,World J Urol,2003,21:70-74.
[20]郭应禄,李宏军.前列腺炎.北京：人民军医出版社.2007.68-92.
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