齐刺头部穴配合中药生发喷剂治疗脂溢性脱发临床研究
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摘要
脂溢性脱发(Seborrheic Alopecia, SA),以往称为早秃、男性型脱发(Male Pattern Alopecia, MPA),雄激素源性秃发(Androgenetic Alopecia, AGA),弥漫性秃发,普通性脱发,遗传脱发等；中医称之为“发蛀脱发”,病名首见于清《外科全生集》,而后清《外科证治全书》又提出“蛀发癣”病名。西医学认为与遗传、雄性激素、皮脂溢出…等有关。中医学认为“发为肾之外候”,“发为血之余”,故发的生长全赖于精和血,并与脏腑气血息息相关,多为虚实夹杂或本虚标实。本虚多为肾精亏损,精不化血,血不养发,发无生长之源而脱落,标实多为肝风、痰湿、火热、血瘀。
该病是皮肤科临床常见病和多发病,也是难治性疾病之一。此病好发于20-30岁的男性青壮年,但近年来年轻女性发病有逐年升高的趋势,本病是一种主要发生在青壮年的慢性脱发性疾病,临床表现为脱发从前额和头顶或两侧鬓角开始,逐渐向上发展,致头顶部头发稀疏、柔软,严重者整个头顶大部份或全部头发脱落,后枕部及颞部两侧头发一般不受影响。脱发区头发或遗留少许细软毛发,该病一般无自觉症状,少数患者有轻微麻痒,常伴有皮脂溢出或脂溢性皮炎,病程发展缓慢,常有脱发家族史。近年来随着社会生活环境的发展变化,发病人数显着增多,发病年龄趋于年轻化。由于本病影响美观,常给患者带来很大的精神压力和心理负担,且治疗较为困难,至今尚无十分理想的治疗方案,因此对脂溢性脱发的研究受到广泛重视。
研究目的：
本课题透过应用齐刺法、喷剂外用与针药结合等治疗方法,对确诊脂溢性脱发的患者进行治疗并比较观察,重点为：
(1)观察统计分析三组之间的疗效差异关系。
(2)探讨脂溢性脱发中医的病因病机。
(3)探讨齐刺法与乌须生发喷剂对该病起到的治疗作用。
(4)探讨加拿大温哥华的脂溢性脱发患者现状,并做系统性的临床初步总结。
以期进一步提高中医对脂溢性脱发病因病机的认识,为临床使用齐刺法与乌须生法喷剂治疗脂溢性脱发提供依据,从而提高中医对脂溢性脱发的疗效、减少脂溢性脱发的复发。
本研究针对加拿大温哥华的脂溢性脱发患者做系统性的临床针灸对照研究,进行了齐刺头部穴与乌须生发喷剂的观察,表明不论使用齐刺法或是喷剂治疗脂溢性脱发均有好的疗效,弥补了迄今尚无针对加拿大族群使用中医治疗脂溢性脱发的相关研究之空白,故本研究具有一定创新性。
研究方法：
通过对天佑中医诊所二年门诊脂溢性脱发患者的收录,搜集90个病例,实际完成80个病例,其中9例因疗程太长而未能坚持治疗,1例因回流中断治疗退出观察,填写临床观察表,然后随机分为三个治疗组：齐刺法组26人、喷剂外用组30人、针药结合组24人,并参照以下方法加以研究：
西医诊断标准：参照西方医学院校皮肤专科书籍,于1990年由C. E. Orfanos与R. Happle主编的Hair and Hair Diseases(头发与头发相关疾病)之诊断标准：
(1) Patient hair-loss pattern should exhibit the clinical male and female modeling pattern.(For male and female hair-loss pattern, please see Fig图2and Fig图3,respectively.)(患者的脱发进展应与男性、女性临床脱发表现之型态图相同,男见图2、女见图3。)
(2) Gradual time course of hair loss and progressive transformation of terminal hairs into intermediate, vellus, and finally lanugo hairs.(病程缓慢,头发末梢逐渐变得稀少纤细,颜色转淡,最后变成疏软而淡色的细毛。)
(3) Hereditary predisposition in the family with simultaneous presence of other symtoms of SAHA syndrome (seborrhea, acne, hirsutism, alopecia) in women.(女性患者常有家族史,如脂溢性皮炎、痤疮、体毛过剩、脱发等。)
中医诊断标准：参照人民卫生出版社高等医药院校统编教材《中医外科学》脂溢性脱发诊断标准为准。临床症状：先从前额的鬓角开始,经过徐缓,头发逐渐细软、稀疏、脱落、秃发。数十年后,额上和顶上头发可完全脱光。皮肤光滑,毛孔缩小或遗留有少量细毛,两枕部和两侧颞部仍保留正常。
操作方法：
(1)齐刺法组：局部选穴采用安旗牌无菌单手针灸针,见附图6(生产厂家：台湾台北市忠孝东路7段570号4F,型号：单手型,规格30G X1.0-1.5)。患者取坐位,在选好的穴位上做常规消毒后,用安旗牌无菌单手针进针,行针手法采用抽添法与针向迎随补泻法操作,脂溢性脱发的部位按实际大小选择进针位置,在脱发平均范围内使用齐刺,针身与头皮呈30°夹角,快速将针刺入头皮下,当针尖刺到帽状腱膜下层时,指下感到阻力减小,然后使针与头皮平行,继续进针,患者以感觉头皮有麻胀感为止,针尖方向迎着经脉走向平刺,由于脱发的部位因人而异,选穴时依照经脉所过主治所及,随脱发部位按经在太阳膀胱经、督眽、少阳胆经上取穴,面积大者则按部位分布涵盖经络针刺,先在所属主要经络上顺着经络走向针刺一针,在针刺部位两旁再分别左右平行与主针同向或逆向各刺入一针。辅助整体选穴按辨证分型为四型各有不同,以体现中医因人而异的治疗特色,湿热熏蒸者取合谷、丰隆、足三里、阴陵泉、后溪、腕骨等…以健脾去湿、清热泻火；血热风燥(包含血虚风燥)者取合谷、曲池、血海、太冲、腕骨、足三里等…以疏风清热、养血润燥；肝肾不足(包含肝肾阴虚)者取太溪、照海、太冲、足三里、三阴交、合谷等…以健脾益胃、补益肝肾；血瘀毛窍者取合谷、大椎、足三里、血海、太冲、三阴交、百会、前顶、通天等…以疏通局部毛窍并活血化瘀。进针得气后不再行针,每次留针60分钟,每2日针刺1次,20天为1个疗程,共观察三个疗程。
(2)喷剂外用组：患者取坐位,在脱发部位上做常规清洗后,用天佑中医诊所乌须生发喷剂,见附图1(组成：侧柏叶、骨碎补、何首乌等),喷抹患处,待局部充分湿润后,嘱患者自行使用大拇指指腹按揉头皮直至有发热感为度,增加患处对药物的吸收。每日喷3次,20天为1个疗程,共观察三个疗程。
(3)针药结合组：操作同齐刺法组和喷剂外用组,如针刺与喷药同时进行,则先针刺后喷药,每2日针刺1次,喷药每日3次,20天为1个疗程,共观察三个疗程。
观察内容：
脱发(根)数/日、油腻性、瘙痒和脱屑程度,治疗前后各记录一次,并采用打分法以积分多少用作衡量治疗效果的指标。方法如下：
脱发：无头发脱落记0分,<30根/日记作2分,30-60根/日记作4分,61-100根/日记作6分,>100根/日记8分。
瘙痒：无瘙痒记0分,轻度记2分,中度记4分,重度记6分。
油腻性：适中记0分,少量(两天不洗显油腻)记2分,中等量(一天不洗显油腻)记4分,明显(头发油腻腻光亮)记6分。
脱屑：无脱屑记0分,轻度记2分,中度记4分,重度记6分。
注：计算公式(尼莫地平法)为：[(治疗前积分-治疗后积分)/治疗前积分]X100%。疗效评定标准：
参照中华人民共和国卫生部《中药新药临床研究指导原则》第3辑。
痊愈：毛发停止脱落,脱发全部长出,其分布密度、粗细、色泽与健发区相同,皮脂分泌恢复正常,或症状、体征积分减少≥95%。
显效：毛发停止脱落,脱发再生达70%以上,其分布密度、粗细、色泽均接近健发区,皮脂分泌明显减少,或症状、体征积分减少≥70%,<95%。
有效：毛发停止脱落,脱发再生达30%以上,包括细毛及白发长出,或症状、体征积分减少≥35%,<70%。
无效：脱发再生不足30%或毛发仍继续脱落,上述症状、体征无明显改善,或积分减少<35%。
统计方法：
所有数据均输入Microsoft Office Excel2010统一整理,并导入SPSS17.0For Windows统计分析软件进行数据管理和统计分析,计数资料采用卡方(x2)检验,计量资料用均数±标准差(x±S)表示,三组之间用方差分析(F检验),组的自身前后比较用t检验,正态分布的计量资料用Q检验,不符合正态分布用秩和检验,以P<0.05为有统计学意义、P<0.01为有显着统计学意义。
研究结果：
(1)脂溢性脱发发病率男女比例约为9：1,且以18-30岁为最多,与传统发病多为青年男性的理论相符,男性发病率高于女性,好发于白领脑力劳动者。
(2)脂溢性脱发病程从未满1年到5年以上均有,为难治性疾病,缠绵难愈,病程较长。
(3)脂溢性脱发患者中男性湿热熏蒸人数为最多。
(4)脂溢性脱发患者生活习惯与抽烟喝酒密切相关。
(5)脂溢性脱发与患者食用乳制品、油炸品、烧烤、西式糕点甜品、西式快餐的次数密切相关。
(6)使用的洗发水是否含硅灵与脂溢性脱发的发病没有密切关系。
(7)过晚就寝与脂溢性脱发密切相关。
(8)治疗第一个疗程后,齐刺法组有效率为61.5%；喷剂外用组效率为56.7%；针药结合组有效率为66.7%。三组总和平均有效率为61.3%。
(9)治疗第二个疗程后,齐刺法组有效率为84.6%；喷剂外用组有效率为76.7%；针药结合组有效率为91.7%。三组总和平均有效率为83.8%。
(10)治疗第三个疗程后,齐刺法组有效率为96.2%；喷剂外用组有效率为96.7%；针药结合组有效率为100.0%。三组总和平均有效率为97.5%。
(11)治疗脂溢性脱发的过程中,均以齐刺法配上乌须生发喷剂疗效最好。三个疗程后,齐刺法配上乌须生发喷剂疗效优于单纯使用齐刺法,或是单纯外用乌须生发喷剂。
(12)不论是齐刺法、喷剂外用法还是针药结合法治疗脂溢性脱发临床均有很好的疗效。
(13)使用齐刺法治疗脂溢性脱发与乌须生发喷剂治疗脂溢性脱发,疗效没有差异。
(14)不论病程长短,使用齐刺法、喷剂外用法或针药结合法治疗脂溢性脱发均有疗效。
(15)齐刺头部穴配合乌须生发喷剂治疗脂溢性脱发,临床上无任何不良反应与副作用。
结论：
根据针对加拿大温哥华地区患者所收集到的相关资料显示,脂溢性脱发与患者食用当地特色饮食(乳制品、油炸品、烧烤、西式糕点甜品、西式快餐)的次数密切相关。
不论病程长短,使用齐刺法、喷剂外用法或针药结合法治疗脂溢性脱发均有良好的疗效,且临床上无任何不良反应与副作用,充分体现了中医的治疗特色,值得大力推广。
Study background:
Seborrheic alopecia is often referred to as male pattern alopecia or androgenetic alopecia in Western medical literature. In traditional Chinese medicine, it was first described in the Qing text "Waike Quansheng Ji (Life-saving Manual of Diagnosis and Treatment of External Diseases)" as "fazhu hair-loss" or "zhufa tinea". Western medicine recognizes the incidence of androgenetic alopecia to be related to genetic inheritance, imbalances in androgen hormone, and abnormal sebaceous activity. Traditional Chinese medicine, on the other hand, believes that hair-loss is mainly due to deficiency of the kidney essence, which is the basis for the generation of blood that is indispensable for healthy hair growth. Thus, the health of the hair is intimately related to the health of the viscera. In clinical terms, hair-loss is often caused by "liver wind, phlegm dampness, fire heat, or blood stasis"
Androgenetic alopecia is one of the most common, and yet hard to treat, chronic dermatological disorders that typically affects young males20-30years of age. However, there has been a trend of increasing incidence in young females in recent years. Clinical representations of patients suffering from androgenetic alopecia include gradual receding hair line starting from the temples (alopecia triangularis) and hair-loss in the vertex of the head. Course of the disease is often slow, chronic, and progressive. Often light and fragile lanugo hairs are seen in place of normal healthy hair prior to complete hair-loss. Hair in the temporal and parietal areas is typically not affected. Most patients do not complain of symptoms other than hair-loss, though some patients complain of slight itching or numbness on the affected scalp. Androgenetic alopecia is often accompanied with excessive sebaceous secretions and inflammation, and there is often a family history of hair-loss. In recent years, due to the changes in life-style, there has been an increasing incidence of androgenetic alopecia in the younger generations. Since alopecia affects physical appearance; it can severely depress a patient's self-esteem. Treatment for this disorder is typically long term, and currently there are no treatments proven to be effective in curing androgenetic alopecia. For these reasons, research into the pathogenesis of the disorder, as well as the availability of treatment options are direly needed.
Objective:
This study compares the treatment effect of triple needle therapy, application of Chinese medical hair regrown spray, and the combination of the two therapies in patients suffering from seborrheic alopecia. Specific focuses of the study include:
(1) Statistically analyze and compare the differences in response between the three treatment groups.
(2) Investigate the pathogenesis and mechanism of seborrheic alopecia
(3) Investigate the effectiveness of triple needle therapy and the application of Chinese medical hair regrown spray on the treatment of seborrheic alopecia.
(4) Investigate the current state of patients suffering from seborrheic alopecia in the Vancouver Canada region, as well as performing a systematic and initial conclusive clinical analysis of the data collected.
(5) Attempt to further the understanding of the pathogenesis and mechanism of seborrheic alopecia in traditional Chinese medicine, and to provide a basis for the usage of triple needle therapy and the application of Chinese medical hair regrown spray in the treatment of seborrehic alopecia, with the goal of enhancing treatment benefits and reduce potential recurrence of the disease.
This study focused on Vancouver Canada patients as subjects in the systematic and clinical study on the treatment effect of triple needle therapy and the application of Chinese medical hair regrown spray. This study has found that regardless of the treatment options, both the triple needle therapy and the application of Chinese medical hair regrown spray have produced good results for patients suffering from seborrheic alopecia. This study has made up for the lack of study and Chinese medical treatment of seborrheic alopecia on patient groups based in Canada, and is innovative in this regard.
Methods:
Patient information:
Through the patient base in Tian You Acupuncture Clinic,90patients suffering from seborrheic alopecia have volunteered to participate in this study.80patients successfully completed the treatment program. Nine patients did not complete the study due to the length of time required by the treatment program, and1patient stopped treatment due to a geographical move. Patients in the study were asked to complete a clinical observation form, and were randomly selected into one of the three groups:26patients in the triple needle therapy group,30patients in the application of Chinese medical hair regrown spray group, and24patients in the combination of triple needle therapy and application of the Chinese medical hair regrown spray group.
Diagnostic criteria of the study:
Clinical standard of the diagnostic criteria of seborrheic alopecia were outlined in the Western dermatology medical text "Hair and Hair Diseases" by C. E. Orfanos and R. Happle in1990:
(1) Patient hair-loss pattern should exhibit the clinical male and female modeling pattern.(For male and female hair-loss pattern, please see Figure图2and图3, respectively).
(2) Gradual time course of hair-loss and progressive transformation of terminal hairs into intermediate, vellus, and finally lanugo hairs.
(3) Hereditary predisposition in the family with simultaneous presence of other symtoms of SAHA syndrome (seborrhea, acne, hirsutism, alopecia) in women.
Traditional Chinese medical standard of diagnostic criteria for seborrheic alopecia were referenced from Chinese medical text "Surgery of Traditional Chinese Medicine" by People's Medical Publishing House. Clinical features include a slowly receding hair line starting from the temples. Hair in affected areas gradually becomes thinner, softer, sparse, and eventually fall out. After about10years, the frontal and top portion of the hair can completely fall out. Scalp of the bald areas appears shiny, smooth, and the pores are small. Some lanugo hair may remain in the affected area. Hair in other parts of the scalp is typically not affected. Three treatment groups used in the study:
(1) Triple needle therapy group:
An Chi handy acupuncture needles were used on selected local meridians. Manufacturer address for An Chi is4F, No.570, Sec.7, Zhongxiaodong road, Taipei, Taiwan. Model of acupuncture needle used: single handy acupuncture needle,30G X1.0-1.5.
Allow the patient to sit comfortably, then select and sterilize the selected meridian points. Insert An Chi handy acupuncture needles at the selected points. Needling manipulation techniques used include needling direction of pulling and pushing, and needling direction of arriving and departing.
Select the acupuncture points by judging the size of the balding patch, then insert needle and perform the three needle technique on the average points of the balding area. Needle should be inserted under the scalp in a30°angle. When the point of the needle has reached the subgaleal layer, your finger should feel lesser resistance coming from the needle. At this point, position the needle parallel to the scalp and continue to insert the needle, until the patient reports sensations of numbness and distention.
The needle point should face the flow of the meridian points at a parallel angle. Since the area of hair-loss is unique to each patient, select the meridian points that cover the area of hair-loss. According to the area of hair-loss, you may wish to select meridian points on the bladder meridians, du meridians, or gall bladder meridians. For large areas of hair-loss, all these meridian points could be used. First insert a needle following the flow of the meridian points parallel to the scalp, and then insert another two needles beside the first insertion point. These two needles may point toward the same or opposite direction to the first needle inserted.
A characteristic feature of traditional Chinese medicine is to tailor the treatment to the unique clinical presentation and constitution of each patient. There are four types of patient constitution that should be considered when selecting the meridian points for treatment of seborrheic alopecia:
For patients that fall into the dampness-heat constitution type, meridian points LI4, ST40, ST36, SP9, SI3, SI4…should be selected. These points allow for tonification of spleen and lessening of dampness, as well as to cool down heat and fire.
For patients that fall into the blood-heat and wind-dryness or blood-deficiency and wind-dryness constitution type, meridian points LI4, LIU, SP1O, LR3, SI4, ST36… should be selected, these points allow for dispersion of wind and cooling of heat, as well as to nourish blood and moisten dryness.
For patients that fall into the liver and kidney insufficiency or liver and kidney yin deficiency constitution type, meridian points KI3, KI6, LR3, ST36, SP6, LI4… should be selected, these points allow for tonification of spleen and stomach, as well as liver and kidneys.
For patients that fall into the blood-stasis constitution type, meridian points LI4, DU14, ST36, SP10, LR3, SP6, DU2O, DU21, BL7-should be selected, these points allow for dispersion of local circulation, as well as to activate blood and resolve stasis.
After qi has been obtained in these meridian points, you may stop further needling. Acupuncture should be performed once every two days, each time for60minutes. One course of treatment consists of20days, which includes10acupuncture sessions. Observe the patients for a total of three courses of treatment.
(2) Application of Chinese medical hair regrown spray group:
These steps should be performed by the patient in the comfort of their own homes:first thoroughly wash the affected area with shampoo or other cleaning agents of choice, then sit in a comfortable position and fully moisten the affected areas with the Chinese medical hair regrown spray and massage until the area feels warm to the touch. This allow for better absorption of the medicinal ingredients into the affected scalp. Components of the Chinese medical hair regrown spray include herbs such as oriental arborvitae leafytwigs (cacumen platycladi orientalis), drynaria fortunei (fortune's drynaria rhizome), polygoni multiflori (polygonatum)… etc.
(3) Combination of triple needle and Chinese medical hair regrown spray group:
This group will receive a combination of the above two therapies. Patients will receive triple needle therapy prior to the application of the Chinese medical hair regrown spray. Triple needle therapy is done once every two days, while the spray is applied three times per day. A course of treatment lasts20days, and the study lasts three courses.
Observational scale used:
Prior to the beginning and at the end of the study, record the number of hair that is lost, and rate the degree of greasiness, itching, and amount of dandruff per day. These observations will be rated on a scale and used as a basis to evaluate the effectiveness of treatments.
For hair-loss:Record0for no hair loss,2for less than30strands of hair loss per day,4for betrween30to60strands of hair loss per day,6for between61and100strands of hair loss per day, and8for greater than100strands of hair loss per day.
Degree of itching:record0for no itching,2for mild itching,4for moderate itching, and6for severe itching.
Degree of greasiness:record0if there is no excessive greasiness,2for mild greasiness (hair appears greasy if not washed in two days),4for moderate greasiness (hair appears greasy if not washed in one day), and6for severe greasiness (hair always appears greasy and shiny).
Amount of dandruff:record0for no dandruff,2for light amount of dandruff,4for moderate amount of dandruff, and6for heavy amount of dandruff. Note:formula used: Standard for treatment evaluation:
Standard was referenced from "Clinical Teaching Standards in the Study of New Traditional Chinese Medical Drugs" third edition by the Ministry of Health of the People's Republic of China.
Cured:Hair-loss has ceased, and new hair has grown in bald areas. Hair density, thickness and color of the newly grown hair are the same as the healthy hair in other unaffected parts of the scalp. Sebaceous secretion has returned to normal, or the symptoms and the total score have decreased95%or more.
Highly effective:hair-loss has ceased, and new hair has grown to about70%in the bald areas. Hair density, thickness and color of the new grown hair are close to the healthy hair in other unaffected parts of the scalp. Sebaceous secretion has significantly lessened, or the symptoms and the total score have decreased70%of more but less than95%.
Effective:hair-loss has ceased, and new hair has grown to about30%in the bald areas, including lanugo and light colored hair. Symptoms and total score have decreased35%or more, but less than70%.
Not effective:hair-loss continues, and new hair has grown in less than30%in the bald areas. The above mentioned symptoms have not improved, and total score has decreased by less than35%. Statistical methods used in the study:
All scores were entered and organized using SPSS17.0in Microsoft Office Excel2010. Chi test (x2test) was used to statistically analyze the data, and the results were represented as the average plus or minus standard deviation (x±S). Differences among the three groups were evaluated using the F test, and comparisons of groups before and after treatments were evaluated using the T test. Data that represent standard probability distribution was examined using the Q test, and data that does not represent such distribution was examined using rank sum test. Data with P<0.05are deemed statistically meaningful, and data with P<0.01are deemed statistically significant.
Results:
(1) Incidence of seborrheic alopecia occurs in males and females in a9:1ratio. Most patients affected are between18to30years of age, which nicely corresponds with traditional notion that seborrheic alopecia typically affects young males. Most patients affected belonged to the white collar group that required heavy thinking on their jobs.
(2) Seborrheic alopecia is chronic and difficult to treat. Length of the disorder typically ranges from less than one year to more than5years.
(3) Seborrheic alopecia typically affects males with dampness-heat constitution.
(4) The incidence of seborrheic alopecia is closely correlated to daily habits, diet, smoking, and alcohol consumption.
(5) The incidence of seborrehic alopecia is closely correlated to the frequency of intake of dairy, deep fried, barbequed foods, and Western breads, desserts, and fast foods.
(6) There is not a close correlation of dimethicone in the shampoo and the incidence of seborrheic alopecia
(7) The incidence of seborrheic alopecia is closely correlated with staying up past11pm.
(8) After the first course of treatment, effectiveness of treatment was rated at61.5%for the triple needle therapy group, followed by61.3%in the combination of the triple needle therapy and the application of Chinese medical hair regrown spray group, and56.7%in the application of Chinese medical hair regrown spray group.
(9) After2courses of treatment, effectiveness of treatment was rated at91.7%for the combination of the triple needle therapy and the application of Chinese medical hair regrown spray group, followed by84.6%in the triple needle therapy group, then76.7%for the application of Chinese medical hair regrown spray group. Average effectiveness in all three groups was83.8%.
(10)After3courses of treatment, effectiveness of treatment was rated100%for the combination of the triple needle therapy and the application of Chinese medical hair regrown spray group,96.7%for the application of Chinese medical hair regrown spray group, and96.2%in the triple needle therapy group. Average effectiveness in all three groups was97.5%.
(11)During the course of treatment for seborrheic alopecia, the combination of triple needle therapy and the application of Chinese medical hair regrown spray produce the best treatment responses. After three courses of treatment, effectiveness of the combination of the triple needle therapy and the application of Chinese medical hair regrown spray group is better than that of triple needle therapy or the application of Chinese medical hair regrown spray group.
(12)Triple needle therapy, application of Chinese medical hair regrown spray, or the combination of the two therapies all produces positive treatment responses.
(13)There is no difference in the effectiveness of the triple needle therapy and the application of Chinese medical hair regrown spray in the treatment of seborrheic alopecia.
(14)Triple needle therapy, application of the Chinese medical hair regrown spray, or a combination of the two treatments all produce positive response in the treatment of alopecia, regardless of the length of the disease.
(15)There is no negative side effect observed in triple needle therapy, application of the Chinese medical hair regrown spray, or combination of the two therapies in the treatment of seborrheic alopecia.
Conclusion:
According the relevant information collected from Canadian patients in the Vancouver area, incidence of seborrheic alopecia is closely related to frequency of eating a local diet that includes a high proportion of dairy, deep-fried, barbequed foods, as well as Western breads, desserts, and other fast foods.
Triple needle therapy, application of the Chinese medical hair regrown spray, or a combination of the two therapies have been shown to be highly effective in the treatment of seborrheic alopecia, regardless of the length of the disease. No undesirable side effects on these treatments have been noted, which is characteristic of traditional Chinese medical treatments. For these reasons, triple needle therapy and the Chinese medical hair regrown spray are highly recommended as treatment options for seborrheic alopecia.
该病是皮肤科临床常见病和多发病,也是难治性疾病之一。此病好发于20-30岁的男性青壮年,但近年来年轻女性发病有逐年升高的趋势,本病是一种主要发生在青壮年的慢性脱发性疾病,临床表现为脱发从前额和头顶或两侧鬓角开始,逐渐向上发展,致头顶部头发稀疏、柔软,严重者整个头顶大部份或全部头发脱落,后枕部及颞部两侧头发一般不受影响。脱发区头发或遗留少许细软毛发,该病一般无自觉症状,少数患者有轻微麻痒,常伴有皮脂溢出或脂溢性皮炎,病程发展缓慢,常有脱发家族史。近年来随着社会生活环境的发展变化,发病人数显着增多,发病年龄趋于年轻化。由于本病影响美观,常给患者带来很大的精神压力和心理负担,且治疗较为困难,至今尚无十分理想的治疗方案,因此对脂溢性脱发的研究受到广泛重视。
研究目的：
本课题透过应用齐刺法、喷剂外用与针药结合等治疗方法,对确诊脂溢性脱发的患者进行治疗并比较观察,重点为：
(1)观察统计分析三组之间的疗效差异关系。
(2)探讨脂溢性脱发中医的病因病机。
(3)探讨齐刺法与乌须生发喷剂对该病起到的治疗作用。
(4)探讨加拿大温哥华的脂溢性脱发患者现状,并做系统性的临床初步总结。
以期进一步提高中医对脂溢性脱发病因病机的认识,为临床使用齐刺法与乌须生法喷剂治疗脂溢性脱发提供依据,从而提高中医对脂溢性脱发的疗效、减少脂溢性脱发的复发。
本研究针对加拿大温哥华的脂溢性脱发患者做系统性的临床针灸对照研究,进行了齐刺头部穴与乌须生发喷剂的观察,表明不论使用齐刺法或是喷剂治疗脂溢性脱发均有好的疗效,弥补了迄今尚无针对加拿大族群使用中医治疗脂溢性脱发的相关研究之空白,故本研究具有一定创新性。
研究方法：
通过对天佑中医诊所二年门诊脂溢性脱发患者的收录,搜集90个病例,实际完成80个病例,其中9例因疗程太长而未能坚持治疗,1例因回流中断治疗退出观察,填写临床观察表,然后随机分为三个治疗组：齐刺法组26人、喷剂外用组30人、针药结合组24人,并参照以下方法加以研究：
西医诊断标准：参照西方医学院校皮肤专科书籍,于1990年由C. E. Orfanos与R. Happle主编的Hair and Hair Diseases(头发与头发相关疾病)之诊断标准：
(1) Patient hair-loss pattern should exhibit the clinical male and female modeling pattern.(For male and female hair-loss pattern, please see Fig图2and Fig图3,respectively.)(患者的脱发进展应与男性、女性临床脱发表现之型态图相同,男见图2、女见图3。)
(2) Gradual time course of hair loss and progressive transformation of terminal hairs into intermediate, vellus, and finally lanugo hairs.(病程缓慢,头发末梢逐渐变得稀少纤细,颜色转淡,最后变成疏软而淡色的细毛。)
(3) Hereditary predisposition in the family with simultaneous presence of other symtoms of SAHA syndrome (seborrhea, acne, hirsutism, alopecia) in women.(女性患者常有家族史,如脂溢性皮炎、痤疮、体毛过剩、脱发等。)
中医诊断标准：参照人民卫生出版社高等医药院校统编教材《中医外科学》脂溢性脱发诊断标准为准。临床症状：先从前额的鬓角开始,经过徐缓,头发逐渐细软、稀疏、脱落、秃发。数十年后,额上和顶上头发可完全脱光。皮肤光滑,毛孔缩小或遗留有少量细毛,两枕部和两侧颞部仍保留正常。
操作方法：
(1)齐刺法组：局部选穴采用安旗牌无菌单手针灸针,见附图6(生产厂家：台湾台北市忠孝东路7段570号4F,型号：单手型,规格30G X1.0-1.5)。患者取坐位,在选好的穴位上做常规消毒后,用安旗牌无菌单手针进针,行针手法采用抽添法与针向迎随补泻法操作,脂溢性脱发的部位按实际大小选择进针位置,在脱发平均范围内使用齐刺,针身与头皮呈30°夹角,快速将针刺入头皮下,当针尖刺到帽状腱膜下层时,指下感到阻力减小,然后使针与头皮平行,继续进针,患者以感觉头皮有麻胀感为止,针尖方向迎着经脉走向平刺,由于脱发的部位因人而异,选穴时依照经脉所过主治所及,随脱发部位按经在太阳膀胱经、督眽、少阳胆经上取穴,面积大者则按部位分布涵盖经络针刺,先在所属主要经络上顺着经络走向针刺一针,在针刺部位两旁再分别左右平行与主针同向或逆向各刺入一针。辅助整体选穴按辨证分型为四型各有不同,以体现中医因人而异的治疗特色,湿热熏蒸者取合谷、丰隆、足三里、阴陵泉、后溪、腕骨等…以健脾去湿、清热泻火；血热风燥(包含血虚风燥)者取合谷、曲池、血海、太冲、腕骨、足三里等…以疏风清热、养血润燥；肝肾不足(包含肝肾阴虚)者取太溪、照海、太冲、足三里、三阴交、合谷等…以健脾益胃、补益肝肾；血瘀毛窍者取合谷、大椎、足三里、血海、太冲、三阴交、百会、前顶、通天等…以疏通局部毛窍并活血化瘀。进针得气后不再行针,每次留针60分钟,每2日针刺1次,20天为1个疗程,共观察三个疗程。
(2)喷剂外用组：患者取坐位,在脱发部位上做常规清洗后,用天佑中医诊所乌须生发喷剂,见附图1(组成：侧柏叶、骨碎补、何首乌等),喷抹患处,待局部充分湿润后,嘱患者自行使用大拇指指腹按揉头皮直至有发热感为度,增加患处对药物的吸收。每日喷3次,20天为1个疗程,共观察三个疗程。
(3)针药结合组：操作同齐刺法组和喷剂外用组,如针刺与喷药同时进行,则先针刺后喷药,每2日针刺1次,喷药每日3次,20天为1个疗程,共观察三个疗程。
观察内容：
脱发(根)数/日、油腻性、瘙痒和脱屑程度,治疗前后各记录一次,并采用打分法以积分多少用作衡量治疗效果的指标。方法如下：
脱发：无头发脱落记0分,<30根/日记作2分,30-60根/日记作4分,61-100根/日记作6分,>100根/日记8分。
瘙痒：无瘙痒记0分,轻度记2分,中度记4分,重度记6分。
油腻性：适中记0分,少量(两天不洗显油腻)记2分,中等量(一天不洗显油腻)记4分,明显(头发油腻腻光亮)记6分。
脱屑：无脱屑记0分,轻度记2分,中度记4分,重度记6分。
注：计算公式(尼莫地平法)为：[(治疗前积分-治疗后积分)/治疗前积分]X100%。疗效评定标准：
参照中华人民共和国卫生部《中药新药临床研究指导原则》第3辑。
痊愈：毛发停止脱落,脱发全部长出,其分布密度、粗细、色泽与健发区相同,皮脂分泌恢复正常,或症状、体征积分减少≥95%。
显效：毛发停止脱落,脱发再生达70%以上,其分布密度、粗细、色泽均接近健发区,皮脂分泌明显减少,或症状、体征积分减少≥70%,<95%。
有效：毛发停止脱落,脱发再生达30%以上,包括细毛及白发长出,或症状、体征积分减少≥35%,<70%。
无效：脱发再生不足30%或毛发仍继续脱落,上述症状、体征无明显改善,或积分减少<35%。
统计方法：
所有数据均输入Microsoft Office Excel2010统一整理,并导入SPSS17.0For Windows统计分析软件进行数据管理和统计分析,计数资料采用卡方(x2)检验,计量资料用均数±标准差(x±S)表示,三组之间用方差分析(F检验),组的自身前后比较用t检验,正态分布的计量资料用Q检验,不符合正态分布用秩和检验,以P<0.05为有统计学意义、P<0.01为有显着统计学意义。
研究结果：
(1)脂溢性脱发发病率男女比例约为9：1,且以18-30岁为最多,与传统发病多为青年男性的理论相符,男性发病率高于女性,好发于白领脑力劳动者。
(2)脂溢性脱发病程从未满1年到5年以上均有,为难治性疾病,缠绵难愈,病程较长。
(3)脂溢性脱发患者中男性湿热熏蒸人数为最多。
(4)脂溢性脱发患者生活习惯与抽烟喝酒密切相关。
(5)脂溢性脱发与患者食用乳制品、油炸品、烧烤、西式糕点甜品、西式快餐的次数密切相关。
(6)使用的洗发水是否含硅灵与脂溢性脱发的发病没有密切关系。
(7)过晚就寝与脂溢性脱发密切相关。
(8)治疗第一个疗程后,齐刺法组有效率为61.5%；喷剂外用组效率为56.7%；针药结合组有效率为66.7%。三组总和平均有效率为61.3%。
(9)治疗第二个疗程后,齐刺法组有效率为84.6%；喷剂外用组有效率为76.7%；针药结合组有效率为91.7%。三组总和平均有效率为83.8%。
(10)治疗第三个疗程后,齐刺法组有效率为96.2%；喷剂外用组有效率为96.7%；针药结合组有效率为100.0%。三组总和平均有效率为97.5%。
(11)治疗脂溢性脱发的过程中,均以齐刺法配上乌须生发喷剂疗效最好。三个疗程后,齐刺法配上乌须生发喷剂疗效优于单纯使用齐刺法,或是单纯外用乌须生发喷剂。
(12)不论是齐刺法、喷剂外用法还是针药结合法治疗脂溢性脱发临床均有很好的疗效。
(13)使用齐刺法治疗脂溢性脱发与乌须生发喷剂治疗脂溢性脱发,疗效没有差异。
(14)不论病程长短,使用齐刺法、喷剂外用法或针药结合法治疗脂溢性脱发均有疗效。
(15)齐刺头部穴配合乌须生发喷剂治疗脂溢性脱发,临床上无任何不良反应与副作用。
结论：
根据针对加拿大温哥华地区患者所收集到的相关资料显示,脂溢性脱发与患者食用当地特色饮食(乳制品、油炸品、烧烤、西式糕点甜品、西式快餐)的次数密切相关。
不论病程长短,使用齐刺法、喷剂外用法或针药结合法治疗脂溢性脱发均有良好的疗效,且临床上无任何不良反应与副作用,充分体现了中医的治疗特色,值得大力推广。
Study background:
Seborrheic alopecia is often referred to as male pattern alopecia or androgenetic alopecia in Western medical literature. In traditional Chinese medicine, it was first described in the Qing text "Waike Quansheng Ji (Life-saving Manual of Diagnosis and Treatment of External Diseases)" as "fazhu hair-loss" or "zhufa tinea". Western medicine recognizes the incidence of androgenetic alopecia to be related to genetic inheritance, imbalances in androgen hormone, and abnormal sebaceous activity. Traditional Chinese medicine, on the other hand, believes that hair-loss is mainly due to deficiency of the kidney essence, which is the basis for the generation of blood that is indispensable for healthy hair growth. Thus, the health of the hair is intimately related to the health of the viscera. In clinical terms, hair-loss is often caused by "liver wind, phlegm dampness, fire heat, or blood stasis"
Androgenetic alopecia is one of the most common, and yet hard to treat, chronic dermatological disorders that typically affects young males20-30years of age. However, there has been a trend of increasing incidence in young females in recent years. Clinical representations of patients suffering from androgenetic alopecia include gradual receding hair line starting from the temples (alopecia triangularis) and hair-loss in the vertex of the head. Course of the disease is often slow, chronic, and progressive. Often light and fragile lanugo hairs are seen in place of normal healthy hair prior to complete hair-loss. Hair in the temporal and parietal areas is typically not affected. Most patients do not complain of symptoms other than hair-loss, though some patients complain of slight itching or numbness on the affected scalp. Androgenetic alopecia is often accompanied with excessive sebaceous secretions and inflammation, and there is often a family history of hair-loss. In recent years, due to the changes in life-style, there has been an increasing incidence of androgenetic alopecia in the younger generations. Since alopecia affects physical appearance; it can severely depress a patient's self-esteem. Treatment for this disorder is typically long term, and currently there are no treatments proven to be effective in curing androgenetic alopecia. For these reasons, research into the pathogenesis of the disorder, as well as the availability of treatment options are direly needed.
Objective:
This study compares the treatment effect of triple needle therapy, application of Chinese medical hair regrown spray, and the combination of the two therapies in patients suffering from seborrheic alopecia. Specific focuses of the study include:
(1) Statistically analyze and compare the differences in response between the three treatment groups.
(2) Investigate the pathogenesis and mechanism of seborrheic alopecia
(3) Investigate the effectiveness of triple needle therapy and the application of Chinese medical hair regrown spray on the treatment of seborrheic alopecia.
(4) Investigate the current state of patients suffering from seborrheic alopecia in the Vancouver Canada region, as well as performing a systematic and initial conclusive clinical analysis of the data collected.
(5) Attempt to further the understanding of the pathogenesis and mechanism of seborrheic alopecia in traditional Chinese medicine, and to provide a basis for the usage of triple needle therapy and the application of Chinese medical hair regrown spray in the treatment of seborrehic alopecia, with the goal of enhancing treatment benefits and reduce potential recurrence of the disease.
This study focused on Vancouver Canada patients as subjects in the systematic and clinical study on the treatment effect of triple needle therapy and the application of Chinese medical hair regrown spray. This study has found that regardless of the treatment options, both the triple needle therapy and the application of Chinese medical hair regrown spray have produced good results for patients suffering from seborrheic alopecia. This study has made up for the lack of study and Chinese medical treatment of seborrheic alopecia on patient groups based in Canada, and is innovative in this regard.
Methods:
Patient information:
Through the patient base in Tian You Acupuncture Clinic,90patients suffering from seborrheic alopecia have volunteered to participate in this study.80patients successfully completed the treatment program. Nine patients did not complete the study due to the length of time required by the treatment program, and1patient stopped treatment due to a geographical move. Patients in the study were asked to complete a clinical observation form, and were randomly selected into one of the three groups:26patients in the triple needle therapy group,30patients in the application of Chinese medical hair regrown spray group, and24patients in the combination of triple needle therapy and application of the Chinese medical hair regrown spray group.
Diagnostic criteria of the study:
Clinical standard of the diagnostic criteria of seborrheic alopecia were outlined in the Western dermatology medical text "Hair and Hair Diseases" by C. E. Orfanos and R. Happle in1990:
(1) Patient hair-loss pattern should exhibit the clinical male and female modeling pattern.(For male and female hair-loss pattern, please see Figure图2and图3, respectively).
(2) Gradual time course of hair-loss and progressive transformation of terminal hairs into intermediate, vellus, and finally lanugo hairs.
(3) Hereditary predisposition in the family with simultaneous presence of other symtoms of SAHA syndrome (seborrhea, acne, hirsutism, alopecia) in women.
Traditional Chinese medical standard of diagnostic criteria for seborrheic alopecia were referenced from Chinese medical text "Surgery of Traditional Chinese Medicine" by People's Medical Publishing House. Clinical features include a slowly receding hair line starting from the temples. Hair in affected areas gradually becomes thinner, softer, sparse, and eventually fall out. After about10years, the frontal and top portion of the hair can completely fall out. Scalp of the bald areas appears shiny, smooth, and the pores are small. Some lanugo hair may remain in the affected area. Hair in other parts of the scalp is typically not affected. Three treatment groups used in the study:
(1) Triple needle therapy group:
An Chi handy acupuncture needles were used on selected local meridians. Manufacturer address for An Chi is4F, No.570, Sec.7, Zhongxiaodong road, Taipei, Taiwan. Model of acupuncture needle used: single handy acupuncture needle,30G X1.0-1.5.
Allow the patient to sit comfortably, then select and sterilize the selected meridian points. Insert An Chi handy acupuncture needles at the selected points. Needling manipulation techniques used include needling direction of pulling and pushing, and needling direction of arriving and departing.
Select the acupuncture points by judging the size of the balding patch, then insert needle and perform the three needle technique on the average points of the balding area. Needle should be inserted under the scalp in a30°angle. When the point of the needle has reached the subgaleal layer, your finger should feel lesser resistance coming from the needle. At this point, position the needle parallel to the scalp and continue to insert the needle, until the patient reports sensations of numbness and distention.
The needle point should face the flow of the meridian points at a parallel angle. Since the area of hair-loss is unique to each patient, select the meridian points that cover the area of hair-loss. According to the area of hair-loss, you may wish to select meridian points on the bladder meridians, du meridians, or gall bladder meridians. For large areas of hair-loss, all these meridian points could be used. First insert a needle following the flow of the meridian points parallel to the scalp, and then insert another two needles beside the first insertion point. These two needles may point toward the same or opposite direction to the first needle inserted.
A characteristic feature of traditional Chinese medicine is to tailor the treatment to the unique clinical presentation and constitution of each patient. There are four types of patient constitution that should be considered when selecting the meridian points for treatment of seborrheic alopecia:
For patients that fall into the dampness-heat constitution type, meridian points LI4, ST40, ST36, SP9, SI3, SI4…should be selected. These points allow for tonification of spleen and lessening of dampness, as well as to cool down heat and fire.
For patients that fall into the blood-heat and wind-dryness or blood-deficiency and wind-dryness constitution type, meridian points LI4, LIU, SP1O, LR3, SI4, ST36… should be selected, these points allow for dispersion of wind and cooling of heat, as well as to nourish blood and moisten dryness.
For patients that fall into the liver and kidney insufficiency or liver and kidney yin deficiency constitution type, meridian points KI3, KI6, LR3, ST36, SP6, LI4… should be selected, these points allow for tonification of spleen and stomach, as well as liver and kidneys.
For patients that fall into the blood-stasis constitution type, meridian points LI4, DU14, ST36, SP10, LR3, SP6, DU2O, DU21, BL7-should be selected, these points allow for dispersion of local circulation, as well as to activate blood and resolve stasis.
After qi has been obtained in these meridian points, you may stop further needling. Acupuncture should be performed once every two days, each time for60minutes. One course of treatment consists of20days, which includes10acupuncture sessions. Observe the patients for a total of three courses of treatment.
(2) Application of Chinese medical hair regrown spray group:
These steps should be performed by the patient in the comfort of their own homes:first thoroughly wash the affected area with shampoo or other cleaning agents of choice, then sit in a comfortable position and fully moisten the affected areas with the Chinese medical hair regrown spray and massage until the area feels warm to the touch. This allow for better absorption of the medicinal ingredients into the affected scalp. Components of the Chinese medical hair regrown spray include herbs such as oriental arborvitae leafytwigs (cacumen platycladi orientalis), drynaria fortunei (fortune's drynaria rhizome), polygoni multiflori (polygonatum)… etc.
(3) Combination of triple needle and Chinese medical hair regrown spray group:
This group will receive a combination of the above two therapies. Patients will receive triple needle therapy prior to the application of the Chinese medical hair regrown spray. Triple needle therapy is done once every two days, while the spray is applied three times per day. A course of treatment lasts20days, and the study lasts three courses.
Observational scale used:
Prior to the beginning and at the end of the study, record the number of hair that is lost, and rate the degree of greasiness, itching, and amount of dandruff per day. These observations will be rated on a scale and used as a basis to evaluate the effectiveness of treatments.
For hair-loss:Record0for no hair loss,2for less than30strands of hair loss per day,4for betrween30to60strands of hair loss per day,6for between61and100strands of hair loss per day, and8for greater than100strands of hair loss per day.
Degree of itching:record0for no itching,2for mild itching,4for moderate itching, and6for severe itching.
Degree of greasiness:record0if there is no excessive greasiness,2for mild greasiness (hair appears greasy if not washed in two days),4for moderate greasiness (hair appears greasy if not washed in one day), and6for severe greasiness (hair always appears greasy and shiny).
Amount of dandruff:record0for no dandruff,2for light amount of dandruff,4for moderate amount of dandruff, and6for heavy amount of dandruff. Note:formula used: Standard for treatment evaluation:
Standard was referenced from "Clinical Teaching Standards in the Study of New Traditional Chinese Medical Drugs" third edition by the Ministry of Health of the People's Republic of China.
Cured:Hair-loss has ceased, and new hair has grown in bald areas. Hair density, thickness and color of the newly grown hair are the same as the healthy hair in other unaffected parts of the scalp. Sebaceous secretion has returned to normal, or the symptoms and the total score have decreased95%or more.
Highly effective:hair-loss has ceased, and new hair has grown to about70%in the bald areas. Hair density, thickness and color of the new grown hair are close to the healthy hair in other unaffected parts of the scalp. Sebaceous secretion has significantly lessened, or the symptoms and the total score have decreased70%of more but less than95%.
Effective:hair-loss has ceased, and new hair has grown to about30%in the bald areas, including lanugo and light colored hair. Symptoms and total score have decreased35%or more, but less than70%.
Not effective:hair-loss continues, and new hair has grown in less than30%in the bald areas. The above mentioned symptoms have not improved, and total score has decreased by less than35%. Statistical methods used in the study:
All scores were entered and organized using SPSS17.0in Microsoft Office Excel2010. Chi test (x2test) was used to statistically analyze the data, and the results were represented as the average plus or minus standard deviation (x±S). Differences among the three groups were evaluated using the F test, and comparisons of groups before and after treatments were evaluated using the T test. Data that represent standard probability distribution was examined using the Q test, and data that does not represent such distribution was examined using rank sum test. Data with P<0.05are deemed statistically meaningful, and data with P<0.01are deemed statistically significant.
Results:
(1) Incidence of seborrheic alopecia occurs in males and females in a9:1ratio. Most patients affected are between18to30years of age, which nicely corresponds with traditional notion that seborrheic alopecia typically affects young males. Most patients affected belonged to the white collar group that required heavy thinking on their jobs.
(2) Seborrheic alopecia is chronic and difficult to treat. Length of the disorder typically ranges from less than one year to more than5years.
(3) Seborrheic alopecia typically affects males with dampness-heat constitution.
(4) The incidence of seborrheic alopecia is closely correlated to daily habits, diet, smoking, and alcohol consumption.
(5) The incidence of seborrehic alopecia is closely correlated to the frequency of intake of dairy, deep fried, barbequed foods, and Western breads, desserts, and fast foods.
(6) There is not a close correlation of dimethicone in the shampoo and the incidence of seborrheic alopecia
(7) The incidence of seborrheic alopecia is closely correlated with staying up past11pm.
(8) After the first course of treatment, effectiveness of treatment was rated at61.5%for the triple needle therapy group, followed by61.3%in the combination of the triple needle therapy and the application of Chinese medical hair regrown spray group, and56.7%in the application of Chinese medical hair regrown spray group.
(9) After2courses of treatment, effectiveness of treatment was rated at91.7%for the combination of the triple needle therapy and the application of Chinese medical hair regrown spray group, followed by84.6%in the triple needle therapy group, then76.7%for the application of Chinese medical hair regrown spray group. Average effectiveness in all three groups was83.8%.
(10)After3courses of treatment, effectiveness of treatment was rated100%for the combination of the triple needle therapy and the application of Chinese medical hair regrown spray group,96.7%for the application of Chinese medical hair regrown spray group, and96.2%in the triple needle therapy group. Average effectiveness in all three groups was97.5%.
(11)During the course of treatment for seborrheic alopecia, the combination of triple needle therapy and the application of Chinese medical hair regrown spray produce the best treatment responses. After three courses of treatment, effectiveness of the combination of the triple needle therapy and the application of Chinese medical hair regrown spray group is better than that of triple needle therapy or the application of Chinese medical hair regrown spray group.
(12)Triple needle therapy, application of Chinese medical hair regrown spray, or the combination of the two therapies all produces positive treatment responses.
(13)There is no difference in the effectiveness of the triple needle therapy and the application of Chinese medical hair regrown spray in the treatment of seborrheic alopecia.
(14)Triple needle therapy, application of the Chinese medical hair regrown spray, or a combination of the two treatments all produce positive response in the treatment of alopecia, regardless of the length of the disease.
(15)There is no negative side effect observed in triple needle therapy, application of the Chinese medical hair regrown spray, or combination of the two therapies in the treatment of seborrheic alopecia.
Conclusion:
According the relevant information collected from Canadian patients in the Vancouver area, incidence of seborrheic alopecia is closely related to frequency of eating a local diet that includes a high proportion of dairy, deep-fried, barbequed foods, as well as Western breads, desserts, and other fast foods.
Triple needle therapy, application of the Chinese medical hair regrown spray, or a combination of the two therapies have been shown to be highly effective in the treatment of seborrheic alopecia, regardless of the length of the disease. No undesirable side effects on these treatments have been noted, which is characteristic of traditional Chinese medical treatments. For these reasons, triple needle therapy and the Chinese medical hair regrown spray are highly recommended as treatment options for seborrheic alopecia.
引文
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