IGF-1、IL-18在妊娠大鼠下丘脑—垂体—性腺轴的表达及IFN-γ对其表达和对妊娠的影响
|
摘要
正常妊娠时,一些细胞因子通过复杂的神经-内分泌-免疫网络的相互调节作用,在下丘脑-垂体-性腺轴的表达有所变化,这些细胞因子受某些内外界因素的影响表达紊乱时,往往会引发各种妊娠疾病,严重时会造成妊娠终止。目前,调控妊娠的一些细胞因子在有机体的调控特性及其相互作用的机理还不是十分清楚。有资料显示,白细胞介素-18(Interleukin-18, IL-18)、胰岛素样生长因子-1(Insulin-like growth factor 1 ,IGF-1)和γ-干扰素(Interferon-gamma ,IFN-γ)、均参与妊娠调控,但IL-18、IGF-1和IFN-γ在妊娠中的相互调控作用还不太清楚。本研究采用免疫组化SP法对妊娠各期大鼠下丘脑-垂体-性腺轴中IGF-1和IL-18的分布及IFN-γ对IGF-1和IL-18表达的影响进行了研究,并采用图象分析系统对其表达进行了分析。采用荧光定量RT-PCR法分别检测了植入后期大鼠卵巢和子宫中IL-18mRNA和IGF-1mRNA的表达变化及阴道壁注射IFN-γ后对卵巢和子宫中IL-18和IGF-1表达的影响,用ELISA法检测了外周血中IL-18和IGF-1水平的变化,并结合显微及形态分析法进一步研究了不同剂量IFN-γ对妊娠的影响,以期为妊娠早期胚胎丢失机理增添神经生物学研究资料。研究结果如下:
1. IGF-1和IL-18在各妊娠期大鼠下丘脑视前室周核、视上核、视前大细胞核、视前内侧核、视前外侧核、视交叉上核、弓状核等21个核团均有表达,分布范围较广;在腺垂体及神经垂体均有表达;在卵巢表达于黄体的粒性黄体细胞、生长卵泡、成熟卵泡;子宫内膜基质细胞、子宫腺上皮细胞、子宫壁平滑肌细胞、血管内皮中也有IGF-1和IL-18阳性产物分布。提示IGF-1和IL-18通过下丘脑-垂体-性腺轴的途径对妊娠发挥着重要的功能。
2.IGF-1和IL-18在妊娠大鼠下丘脑-垂体-性腺轴的表达在妊娠各期存在一定的差异:如IGF-1在下丘脑主要核团胚胎植入前期、植入期、植入后期表达持续升高,妊娠中期表达较低,妊娠晚期表达明显高于妊娠中期,IL-18在下丘脑主要核团胚胎植入前期和植入期的表达不断下降,植入后期表达显著升高。说明两者的表达具有一定的时间程序和空间特性,也有各自的特点。IGF-1在胚胎的植入后期及妊娠晚期表达较多,说明IGF-1可能在胚胎的发育及分娩的启动方面具有重要的时间程序调控作用,同时表现了在下丘脑及垂体水平上参与妊娠的空间调控特性,而在卵巢及子宫的表达则说明,IGF-1能够调节卵泡和黄体的功能,从而影响卵巢中类固醇的生成;并参与了母胎界面的免疫耐受调节。同时IGF-1和IL-18的协同作用也为妊娠的维持创造了有利的免疫微环境。
3. IGF-1和IL-18在妊娠各期大鼠的下丘脑变化主要在下丘脑视前室周核、视上核、视前大细胞核、视前内侧核、视前外侧核、视前交叉上核、弓状核等主要核团,说明下丘脑视前区的核团与妊娠调控密切相关。
4.妊娠大鼠阴道壁注射不同剂量的IFN-γ后,下丘脑-垂体-性腺轴中IGF-1和IL-18的表达变化各不相同。注射100IU/g体重、500IU/g体重的IFN-γ后,下丘脑视前区视前室周核等核团中IGF-1和IL-18的表达均下调,下丘脑其它核团及垂体、子宫和卵巢中IGF-1和IL-18的表达也有不同程度的变化。在外周血中,妊娠早期的植入后期IGF-1和IL-18的表达水平有不同程度的下调。提示,高剂量的IFN-γ对妊娠期大鼠下丘脑-垂体-性腺轴中IGF-1和IL-18的表达及植入后期大鼠外周血中IGF-1和IL-18的水平均具有调控作用。表明IFN-γ对妊娠的调控是非常复杂和精细的。
5.给妊娠早期大鼠注射高剂量的IFN-γ(500IU/g体重),会造成胚胎丢失和妊娠终止。这可能是IFN-γ不同程度的下调了子宫和卵巢中IGF-1和IL-18的表达及外周血中IGF-1和IL-18的水平而造成的妊娠终止,结果提示,注射高剂量IFN-γ是机体免疫调控紊乱,妊娠失败的原因之一。
6.阴道壁注射小剂量(2IU/g体重)的IFN-γ,可上调流产大鼠子宫和卵巢中IL-18mRNA及IL-18蛋白表达的同时还可以上调外周血中IL-18的水平,使其接近正常妊娠组,结果提示外源注射小剂量的IFN-γ可以通过调节机体内一些细胞因子的水平,在维持妊娠中具有重要作用。7.米非司酮致大鼠流产后,其外周血血清中IGF-1和IL-18的水平均有所降低,而注射小剂量的IFN-γ其水平又有所回升,IFN-γ可能是通过调节妊娠大鼠下丘脑-垂体-性腺轴IL-18和IGF-1的水平来抑制流产引发的炎症过程,从而通过免疫途径调控并维持妊娠。提示临床检测妊娠早期大鼠外周血中IL-18和IGF-1的水平对于预防胚胎丢失和流产具有一定的参考价值。8. IFN-γ与IGF-1、IL-18的表达存在密切关系。正常妊娠时,注射高剂量IFN-γ引起IGF-1和IL-18的表达下调,打破了Th1/Th2型细胞因子平衡关系,造成妊娠终止。注射小剂量的IFN-γ则通过下丘脑-垂体-性腺轴的途径及血液反馈途径上调IGF-1和IL-18的表达,影响母胎界面的免疫微环境,调节流产大鼠Th1/Th2型细胞因子平衡,维持妊娠。IFN-γ在预防妊娠早期流产中发挥着重要作用。
During pregnancy, the expression of several cytokines in the hypothalamus-pituitary gland-gonad axis were regulated through the complex neuro - endocrine - immune network, the changes or disorders of the expression of these cytokines caused by certain external factorsoften cause a variety of diseases and even pregnancy termination. Currently, the regulation and mechanism of the control and interaction of these cytokines during pregnancy were not confirmed. As reported that, Interleukin -18 (IL-18), insulin-like growth factor -1 (IGF-1) andγ-interferon (IFN-γ) are involved in the regulation of pregnancy, but the mutual regulation of these cytokines during pregnancy was less clear. In this research, immunohistochemical SP method was used to study the distribution of IGF-1 and IL-18 expression in the hypothalamus-pituitary gland-gonad axis during pregnancy, the influence between IFN-γ, IGF-1 and IL-18 expression, also image analysis system was use to analyzed its expression too. Fluorescent quantitative RT-PCR was used to detect the expression of IL-18 mRNA and IGF-1mRNA of the rat ovary and uterus after embryo implanted, and its expression after injection of IFN-γin the vaginal wall meanwhile, ELISA method was used to assay the expression of IL-18 and IGF-1 of the peripheral blood, and combined with microscopic and morphological analysis of the infection of IFN-γto pregnancy. All these offer the nerve biological research data for the mechanism of embryo loss during early pregnancy. The results of this research were as follows:
1.During rat pregnancy, IGF-1 and IL-18 were expressed in a wide range of rat’s 21 thalamencephalon nuclei, such as hypothalamus, periventricular nucleus, supraoptic nucleus, preoptic large nucleus, medial preoptic nucleus, preoptic nucleus, suprachiasmatic nucleus, the bow shaped nucleus, and so on; existed in the adenohypophysis and the neurohypophysis; and also expressed in the ovarian granulosa luteal cells, the growth of follicles, mature follicles, endometrial stromal cells, uterine epithelial cells, uterine smooth muscle cells, and vascular endothelium. This showed that IGF-1 and IL-18 play an important way on the function of pregnancy through the pathway of hypothalamus - pituitary - gonadal axis.
2.The expression of IGF-1 and IL-18 in the pregnant rat hypothalamus - pituitary - gonadal axis are different during the stages of pregnancy. The expression of IGF-1 in thalamencephalon was increased during early implantation, implantation, plant continues, lower during the middle of pregnant, and espression higher in the third trimester of pregnancy than the middle. The expressed of IL-18 in thalamencephalon was descended during early implantation and implantation, and significantly increased post-implantation. This showed that IGF-1 and IL-18 have different characteristics spatially and temporally. IGF-1 expression in embryo implantation and late pregnancy showed that IGF-1 had important role in regulating embryonic development and delivery, while expression in the ovary and uterus, showed that IGF-1 could regulate the function of follicle and corpus luteum, thus affecting the generation of ovarian steroid, and involved in the regulation of immune of the maternal-fetal interface. Therefore IGF-1 and IL-18 synergy created the immune microenvironment for the maintenance of pregnancy.
3. IGF-1 and IL-18 expression in rat thalamencephalon was different during the pregnancy phase, mainly in the hypothalamus preoptic periventricular nucleus, supraoptic nucleus, preoptic large nucleus, medial preoptic nucleus, preoptic nucleus, suprachiasmatic nucleus, arcuate nucleus and other major nuclei, which indicated that the hypothalamic preoptic area was concerned with the regulation of the pregnancy. 4. The expression of IGF-1 and IL-18 of the hypothalamus - pituitary - gonadal axis in pregnant rats acted different after injecting with different doses of IFN-γ. In detail, after the IFN-γinjection of 100IU/g, 500IU/g to rats, the expression of IGF-1 and IL-18 in hypothalamic preoptic nucleus and other nucleus all decreased. The different expressions of IGF-1 and IL-18 were also observed in other nuclei of the hypothalamus and pituitary, uterus and ovary. In peripheral blood, The expressions of IGF-1 and IL-18 in the hypothalamus - pituitary - gonadal axis were decreased in a different extent. These results suggested that the high dose of IFN-γshowed the downregulation effecton the expression of IGF-1 and IL-18 in the pregnant rat hypothalamus - pituitary - gonadal axis and that in the peripheral blood during early pregnancy. This demonstrated that the regulation of IFN-γon the pregnancy was a complex process.
5. High dose injection of IFN-γ(500 IU/g) to the early pregnant rats could result fetal loss and pregnancy termination. The possible reason was the downregulation of the IGF-1 in the uterine and ovarian and IL-18 in blood. This result suggested that high doses of IFN-γwas one of keys that disorder the disorder of immune regulation system.
6. Low dose of IFN-γto aborted rats could increase the expression of IL-18mRNA and IL-18 protein, in the uterus and ovary. Meanwhile, it also increased the IL-18 level, which was close to the normal group. The result suggested that low dose of IFN-γcould regulate the level of some cytokines, which was important to the maintenance of pregnancy.
7. After mifepristone induced abortion, the levels of IGF-1 and IL-18 in the serum were all decreased, however, a little re-increase has been determined after the injection of IFN-γ. The possible reason was the regulation of IL-18 and IGF-1 levels of the pregnant rats hypothalamus - pituitary - reproductive axis for the inhibition to the inflammation caused by abortion, also for the the maintenance of pregnancy. This result suggested that the levels of IL-18 and IGF-1 in the peripheral blood of early pregnancy rats, was something valuable to fetal loss and abortion.
8. There was a close expression relationship among IFN-γand IGF-1, IL-18. During the normal pregnancy, the decrease of IGF-1 and IL-18 expression broke down the balance of Th1/Th2 type cytokines and resulted the termination of pregnancy. However, the low dose of IFN-γcould influence the immune microenvirionment of maternal-fetal interface, regulate the balance of Th1/Th2 type cytokines, and maintain pregnancy. This suggested that IFN-γact an an important role in the prevention of abortion in early pregnancy.
1. IGF-1和IL-18在各妊娠期大鼠下丘脑视前室周核、视上核、视前大细胞核、视前内侧核、视前外侧核、视交叉上核、弓状核等21个核团均有表达,分布范围较广;在腺垂体及神经垂体均有表达;在卵巢表达于黄体的粒性黄体细胞、生长卵泡、成熟卵泡;子宫内膜基质细胞、子宫腺上皮细胞、子宫壁平滑肌细胞、血管内皮中也有IGF-1和IL-18阳性产物分布。提示IGF-1和IL-18通过下丘脑-垂体-性腺轴的途径对妊娠发挥着重要的功能。
2.IGF-1和IL-18在妊娠大鼠下丘脑-垂体-性腺轴的表达在妊娠各期存在一定的差异:如IGF-1在下丘脑主要核团胚胎植入前期、植入期、植入后期表达持续升高,妊娠中期表达较低,妊娠晚期表达明显高于妊娠中期,IL-18在下丘脑主要核团胚胎植入前期和植入期的表达不断下降,植入后期表达显著升高。说明两者的表达具有一定的时间程序和空间特性,也有各自的特点。IGF-1在胚胎的植入后期及妊娠晚期表达较多,说明IGF-1可能在胚胎的发育及分娩的启动方面具有重要的时间程序调控作用,同时表现了在下丘脑及垂体水平上参与妊娠的空间调控特性,而在卵巢及子宫的表达则说明,IGF-1能够调节卵泡和黄体的功能,从而影响卵巢中类固醇的生成;并参与了母胎界面的免疫耐受调节。同时IGF-1和IL-18的协同作用也为妊娠的维持创造了有利的免疫微环境。
3. IGF-1和IL-18在妊娠各期大鼠的下丘脑变化主要在下丘脑视前室周核、视上核、视前大细胞核、视前内侧核、视前外侧核、视前交叉上核、弓状核等主要核团,说明下丘脑视前区的核团与妊娠调控密切相关。
4.妊娠大鼠阴道壁注射不同剂量的IFN-γ后,下丘脑-垂体-性腺轴中IGF-1和IL-18的表达变化各不相同。注射100IU/g体重、500IU/g体重的IFN-γ后,下丘脑视前区视前室周核等核团中IGF-1和IL-18的表达均下调,下丘脑其它核团及垂体、子宫和卵巢中IGF-1和IL-18的表达也有不同程度的变化。在外周血中,妊娠早期的植入后期IGF-1和IL-18的表达水平有不同程度的下调。提示,高剂量的IFN-γ对妊娠期大鼠下丘脑-垂体-性腺轴中IGF-1和IL-18的表达及植入后期大鼠外周血中IGF-1和IL-18的水平均具有调控作用。表明IFN-γ对妊娠的调控是非常复杂和精细的。
5.给妊娠早期大鼠注射高剂量的IFN-γ(500IU/g体重),会造成胚胎丢失和妊娠终止。这可能是IFN-γ不同程度的下调了子宫和卵巢中IGF-1和IL-18的表达及外周血中IGF-1和IL-18的水平而造成的妊娠终止,结果提示,注射高剂量IFN-γ是机体免疫调控紊乱,妊娠失败的原因之一。
6.阴道壁注射小剂量(2IU/g体重)的IFN-γ,可上调流产大鼠子宫和卵巢中IL-18mRNA及IL-18蛋白表达的同时还可以上调外周血中IL-18的水平,使其接近正常妊娠组,结果提示外源注射小剂量的IFN-γ可以通过调节机体内一些细胞因子的水平,在维持妊娠中具有重要作用。7.米非司酮致大鼠流产后,其外周血血清中IGF-1和IL-18的水平均有所降低,而注射小剂量的IFN-γ其水平又有所回升,IFN-γ可能是通过调节妊娠大鼠下丘脑-垂体-性腺轴IL-18和IGF-1的水平来抑制流产引发的炎症过程,从而通过免疫途径调控并维持妊娠。提示临床检测妊娠早期大鼠外周血中IL-18和IGF-1的水平对于预防胚胎丢失和流产具有一定的参考价值。8. IFN-γ与IGF-1、IL-18的表达存在密切关系。正常妊娠时,注射高剂量IFN-γ引起IGF-1和IL-18的表达下调,打破了Th1/Th2型细胞因子平衡关系,造成妊娠终止。注射小剂量的IFN-γ则通过下丘脑-垂体-性腺轴的途径及血液反馈途径上调IGF-1和IL-18的表达,影响母胎界面的免疫微环境,调节流产大鼠Th1/Th2型细胞因子平衡,维持妊娠。IFN-γ在预防妊娠早期流产中发挥着重要作用。
During pregnancy, the expression of several cytokines in the hypothalamus-pituitary gland-gonad axis were regulated through the complex neuro - endocrine - immune network, the changes or disorders of the expression of these cytokines caused by certain external factorsoften cause a variety of diseases and even pregnancy termination. Currently, the regulation and mechanism of the control and interaction of these cytokines during pregnancy were not confirmed. As reported that, Interleukin -18 (IL-18), insulin-like growth factor -1 (IGF-1) andγ-interferon (IFN-γ) are involved in the regulation of pregnancy, but the mutual regulation of these cytokines during pregnancy was less clear. In this research, immunohistochemical SP method was used to study the distribution of IGF-1 and IL-18 expression in the hypothalamus-pituitary gland-gonad axis during pregnancy, the influence between IFN-γ, IGF-1 and IL-18 expression, also image analysis system was use to analyzed its expression too. Fluorescent quantitative RT-PCR was used to detect the expression of IL-18 mRNA and IGF-1mRNA of the rat ovary and uterus after embryo implanted, and its expression after injection of IFN-γin the vaginal wall meanwhile, ELISA method was used to assay the expression of IL-18 and IGF-1 of the peripheral blood, and combined with microscopic and morphological analysis of the infection of IFN-γto pregnancy. All these offer the nerve biological research data for the mechanism of embryo loss during early pregnancy. The results of this research were as follows:
1.During rat pregnancy, IGF-1 and IL-18 were expressed in a wide range of rat’s 21 thalamencephalon nuclei, such as hypothalamus, periventricular nucleus, supraoptic nucleus, preoptic large nucleus, medial preoptic nucleus, preoptic nucleus, suprachiasmatic nucleus, the bow shaped nucleus, and so on; existed in the adenohypophysis and the neurohypophysis; and also expressed in the ovarian granulosa luteal cells, the growth of follicles, mature follicles, endometrial stromal cells, uterine epithelial cells, uterine smooth muscle cells, and vascular endothelium. This showed that IGF-1 and IL-18 play an important way on the function of pregnancy through the pathway of hypothalamus - pituitary - gonadal axis.
2.The expression of IGF-1 and IL-18 in the pregnant rat hypothalamus - pituitary - gonadal axis are different during the stages of pregnancy. The expression of IGF-1 in thalamencephalon was increased during early implantation, implantation, plant continues, lower during the middle of pregnant, and espression higher in the third trimester of pregnancy than the middle. The expressed of IL-18 in thalamencephalon was descended during early implantation and implantation, and significantly increased post-implantation. This showed that IGF-1 and IL-18 have different characteristics spatially and temporally. IGF-1 expression in embryo implantation and late pregnancy showed that IGF-1 had important role in regulating embryonic development and delivery, while expression in the ovary and uterus, showed that IGF-1 could regulate the function of follicle and corpus luteum, thus affecting the generation of ovarian steroid, and involved in the regulation of immune of the maternal-fetal interface. Therefore IGF-1 and IL-18 synergy created the immune microenvironment for the maintenance of pregnancy.
3. IGF-1 and IL-18 expression in rat thalamencephalon was different during the pregnancy phase, mainly in the hypothalamus preoptic periventricular nucleus, supraoptic nucleus, preoptic large nucleus, medial preoptic nucleus, preoptic nucleus, suprachiasmatic nucleus, arcuate nucleus and other major nuclei, which indicated that the hypothalamic preoptic area was concerned with the regulation of the pregnancy. 4. The expression of IGF-1 and IL-18 of the hypothalamus - pituitary - gonadal axis in pregnant rats acted different after injecting with different doses of IFN-γ. In detail, after the IFN-γinjection of 100IU/g, 500IU/g to rats, the expression of IGF-1 and IL-18 in hypothalamic preoptic nucleus and other nucleus all decreased. The different expressions of IGF-1 and IL-18 were also observed in other nuclei of the hypothalamus and pituitary, uterus and ovary. In peripheral blood, The expressions of IGF-1 and IL-18 in the hypothalamus - pituitary - gonadal axis were decreased in a different extent. These results suggested that the high dose of IFN-γshowed the downregulation effecton the expression of IGF-1 and IL-18 in the pregnant rat hypothalamus - pituitary - gonadal axis and that in the peripheral blood during early pregnancy. This demonstrated that the regulation of IFN-γon the pregnancy was a complex process.
5. High dose injection of IFN-γ(500 IU/g) to the early pregnant rats could result fetal loss and pregnancy termination. The possible reason was the downregulation of the IGF-1 in the uterine and ovarian and IL-18 in blood. This result suggested that high doses of IFN-γwas one of keys that disorder the disorder of immune regulation system.
6. Low dose of IFN-γto aborted rats could increase the expression of IL-18mRNA and IL-18 protein, in the uterus and ovary. Meanwhile, it also increased the IL-18 level, which was close to the normal group. The result suggested that low dose of IFN-γcould regulate the level of some cytokines, which was important to the maintenance of pregnancy.
7. After mifepristone induced abortion, the levels of IGF-1 and IL-18 in the serum were all decreased, however, a little re-increase has been determined after the injection of IFN-γ. The possible reason was the regulation of IL-18 and IGF-1 levels of the pregnant rats hypothalamus - pituitary - reproductive axis for the inhibition to the inflammation caused by abortion, also for the the maintenance of pregnancy. This result suggested that the levels of IL-18 and IGF-1 in the peripheral blood of early pregnancy rats, was something valuable to fetal loss and abortion.
8. There was a close expression relationship among IFN-γand IGF-1, IL-18. During the normal pregnancy, the decrease of IGF-1 and IL-18 expression broke down the balance of Th1/Th2 type cytokines and resulted the termination of pregnancy. However, the low dose of IFN-γcould influence the immune microenvirionment of maternal-fetal interface, regulate the balance of Th1/Th2 type cytokines, and maintain pregnancy. This suggested that IFN-γact an an important role in the prevention of abortion in early pregnancy.
引文
曹咏清,孙德明,陈幼珍,朱蓬弟.1999.人重组γ-干扰素抗生育效应及机理研究.生殖医学杂志,8(2):98-102.
陈敬国,蒋犁.缺氧缺血脑组织生化免疫成分的改变. 2002.国外医学:儿科学分册,29(5):260-262.
陈竹钦,胡冬梅.1999.蜕膜细胞因子网络平衡状态与流产.中国实用妇科与产科杂志, 15(3):145-146
底建敏,闫晓娟,郭影,孙宏勋.2006.妊娠高血压疾病患者IGF-1与脂代谢相关性分析.中国妇幼保健,21(11):1494-1496.
管成浓,廖湘晖,罗海清,陈星明,陈宝英,张培文.2009.良恶性原发性肿瘤患者血IL-18及IL-18BP含量测定及临床意义.中国肿瘤临床,36(7):365-367.
韩纯.1994第二版.微生物学与寄生虫学.安徽:安徽科技出版社.
胡昌东,归绥琪.2004.自然流产患者滋养细胞肝素表皮生长因子的表达和意义.上海医学,27(7):491- 494.
晋柏,陈文玮,王海琦,陈炳兰. 2005.重组小鼠γ-干扰素对弓形虫感染妊娠早期孕鼠及鼠胚的影响.江苏医药,31(3):206-208.
金海燕,王自能,徐建平.2000.育龄妇女输卵管胰岛素样生长因子和受体的测定.中华妇产科杂志, 35 ( 11) : 689-690.
兰艳丽,张昌军,江成龙,罗清炳,彭海英,董毅飞,徐鸿毅.2009.来曲唑微刺激超排卵对卵泡液中IGF-1和IGFBP-1水平的影响.鄢阳医学院学报,28(1):9-12.
李昭荣,韩香,吕海侠,李牧,于玲,樊江波,王玉珍.2006.Th1/Th2型细胞因子与反复自然流产的关系.西安交通大学学报,24(3):255-257.
刘喆，杨颖，陈云,彭景楩.2002.人重组组γ-干扰素对兔妊娠的影响.动物学报,48(2):277-280.
骆方军.2006.重组小鼠干扰素-γ对感染弓形虫孕鼠T细胞亚群自然杀伤细胞的影响[J].中国寄生虫与寄生虫病杂志,24(2):125-128.
陶亚雄.灵长类的滋养层干扰素.1994.生理科学进展,25(2):137-140.
王根林. 1997.下丘脑-垂体-性腺轴在动物生殖中的作用.畜牧与兽医,29(4): 182-184.
吴浩,常雅萍,于永利.1999.Th1型/Th2型细胞因子与妊娠的免疫调节.国外医学.免疫学分册,22(2):57-66.
武季峰,李红真,范正红,郑淑蓉.2004.IGF-Ⅰ对卵泡内膜细胞增殖及其LH受体表达的影响.生殖与避孕,22(2):84-87.
谢端薇,欧汝强,杨宁.1999.卵巢早衰与细胞因子TNF-α,IFN-γ和IL-2的相关性研究.广东医学,20(11):23-25.
闫风亭.母胎界面免疫微环境及其功能.2000.国外医学:妇幼保健分册, 11(3): 107-110.
杨瑞宁,江淑芳.2002.脐血、孕妇外周血IL-18检测意义的初探.临床检验杂志,20(5):301-303.
姚文,庄临之.1998.干扰素-γ对妊娠小鼠黄体细胞孕酮分泌的影响.南京师范大学学报,21(3):88-89.
周坚红,石一复,董岳,贺晶,王正平.1999.胰岛素样生长因子-1及胰岛素与胎儿宫内发育迟缓发病的关系.中华妇产科杂志,1999,34(4):222-224.
钟文英,普雄明.2005.热休克蛋白的分子生物学研究进展.医学综述,11(2):148-150.
朱铭伟,夏燕萍,张振钧.1998.胰岛素样生长因子-1与胎儿出生体重的关系.中华妇产科杂志,33(11):667-669.
朱晓勇,李大金. 2000.母胎免疫调节机理的研究进展.生物医学杂志, 9(1): 56-60.
Aguet M.,Dembic Z.,Merlin G.1988.Molecular cloning and expression of the human interferon-gamma receptor.Cell,55(2),273-280.
Aloe L.,Iannitelli A. 2001.Neurotrophic factors and brain damage in hypoxicischemic encephalopathy: a role of nerve growth factor. Ann Ist Super Sanita, 37(4):73-80.
Andrea, R.,Wheelerb R.D., Collinsa P.D. 2003. Identification of a truncated IL-18Rh mRNA: a putative regulator of IL-18 expressed in rat brain. Biol Reprod, 145(1-2):40–45.
Ashkar A.A.,Croy B.A. 1999.Interferon-gamma contributes to the normalcy of murine pregnancy biology of reproduction.Biology of Reproduction,61:493-502.
Ashkat A.A.,Croy B.A.2001.Functions of uterine naturel killer cells are mediated by interferon gamma production during murine pregnancy.Semin Immunology,13:235-241.
Athanassakis I.,Thanassakis s.2002. Interplay between T helper type 1 and type 2 cytokines and soluble major histocompatibility complex molecules: a paradigm in pregnancy. Immunology, 107(3): 281–287.
Bazan J .F.,Timans T. C., Kastelein R. A.1996. A newly def-ined interleukin-1? Nature,379(6566):591. Bulla R.F, Fischetti F., Bossi F.2004.Feto-matemal immune interaction at the pleraction level.Lupus,13:155-157.
Bushley A.W.,Ferrell R.,Mcduffie K.,Terada K.y.,Carmey M.E.,Thompson P.J.,Wilkens L.R.,Tung K.H.,Ness R.B.,Goodmam M.T.2004.Polymorphisms of interleukin(IL)-1alpha, IL-1beta, IL-6,IL-10,and IL-18 and the risk of ovarian cancer. Gynecol Oncol,95(3):672-679.
Chandrasekar, B.2004. Activation of intrinsic and extrinsic pro-apoptotic signaling pathways in interleukin-18-mediated human cardiac endothelial cell death. J Biol. Chem, 279: 20221- 20233.
Chen H.L.,Kamath R.,Pace J.L.,Russell S.W.,Hunt J.S.1994.Expression of the interleion-r receptor gene in mouse placentas is related to stage of gestation and is restricted to specific subpopulations of trophoblast cells.Placenta,15(2):109-121.
Chungm K., Lee S.H., Cho S.W. 2002.The various mRNA expression pattern of insulin like growth factor IGF-1 and IGF-Ⅱand their receptor according to oocyte maturity in IVF cycle: compared with nonstimulated PCOS cycle.Fertil Steril,78(l1):278.
Claeys I. , Simonet G., Poels J., Van Loy T., Vercammen L., Loof A.D., Broeck J.V.2002. I nsulin-related peptides and their conserved signal transduction pathway. Peptides, 23 (4) : 807-816.
Conti B., Jahng J. W.,Tinti G., Son. J. H., Tong H. J. 1997.Induction of inter-feron-γinducing factor in the adrenal cortex.Biological Chemistry, 272:2035-2037.
Coughlin C .M., Salhany K E., Wysocka M. , Aruga E., Kurzawa H. , Chang A E., Hunter C. A ., Fox J. C., Trinchieri G. , Lee W. M . 1998.Interleukin-12 and interleukin-18 synergistically induce murine tumor regression which involves inhibition of angiogenesis.J Clin Invest, 101(6): 1441–1452.
Culhane A.C., Hall M.D., Rothwell N.J., Luheshi G.N. 1998.Cloning of rat brain interleukin-18 cDNA. Mol Psychiatry,3 (4) : 362-366.
Daher S., Kátia de Arruda Geraldes Denardi K., Blotta M.H., Mamoni R.L.,Reck A.P.,Camano L.,Mattar R.2004.Cytokines in recurrent pregnancy loss. Journal of Reproductive Immunology, 62(1-2):151-157.
Dao T., Ohashi K., Kayano T., Kurimoto M., Okamura H.1996. Interferon-gamma-inducing factor, a novelcytokine, enhances Fas ligand-mediated cytotoxicity of murine T helper 1 cells.Cell Immunol,173(2):230-235.
Daftary S.S.,Gore A.C. 2003.Developmental changes in hypothalamic in-sulin-like growth factorⅠrelationship to gonadotrop in release in hormone neurons. Endocrinology,144(5):2034-2045.
Darnell J.E.1997.Stats and gene regulation .Science,1997,277:1630.
Diaz E.,Halhali A.,Luna C.,Diaz L.,Larrea F.2002.Newborn birth weight correlates with placental zinc,umbilical insulinl ike growth factorI,and leptin levels in preeclampsia. Arch Med Res,33(1):40-47.
Druck Mann R., Rohr U. D.2002. IGF -1 in gynaecology and obstetrics:update . Maturitas, 41 (11) : S65-S83 .
Faulds G.,Conroy S.,Madaio M.,Isenberg D.,Latchman D.1995.Increased levels of antibodies to heat shock proteins with increasing age in Mrl/Mp-l/lpr mice.Br J Rheumatol ,34(7):610-615.
Feleder C., Arias P., Refojo D., Nacht S., Moguilevsky J.2000. Interleukin-1 inhibits NMDA-stimulated GnRH secretion: associated effects on the release of hypothalamic inhibitory amino acid neurotransmitters. Neuroimmunomodulation,7:46–50.
Felderhoff-Mueser U.,Schmidt O.I., Oberholzer A., Buhrer C.,Stahel P.F.2005.IL-18: a key player in neuroinflammation and neurodegeneration.Trends in Neurosciences, 28(9):487- 493.
Fink SL,Bergsbaken T.,Cookson R.T. 2008. Anthrax Iethal tox- in and Salmonella elicit the common cell death pathway of caspase-1-dependent pyroptosis via distinct mecha-nisms.Proc Natad Sci USA, 105(11):4312–4317.
Finotto S. 2004.Severe hepatic injury in interleukin-18 (IL-18) transgenic mice: a key role for IL-18 in regulating hepatocyte apoptosis in vivo. Gut , 53:392–400.
Fournel S., Aguerre-Girr M., Huc X., Lenfant F., Alam A., Toubert A., Bensussan A., Bouteiller P.L.2000. Cutting edge: soluble HLA-G1 triggers CD95/CD95 ligand-mediated apoptosis in activated CD8+ cells by interacting with CD8. The Journal of Immunology, 164: 6100-6104.
Fowden A.L. 2003.The insulin-like growth factors and feto-placental growth,Placenta,24(8-9):803-812. Gao H.M., Hong J.S.2008.Why neurodegenerative diseases are progressive:uncontrolled inflammation drives disease progression .Trends Immunology,29(8):357-365.
Giudice L.C.,Martin N.A.,Crystal R.A.,Tazuke S.,Druzin M.1997.Insulin-like growth factor binding protein1at the maternal fetal interfaceand insulin-like growth factor-1,insulin-like growth factor-Ⅱ,and insulin-like growth factor binding protein-1 in the circulation of women with severe preeclampsia. Am J Obstet Gynecol,1997,176(4):751-758.
Giudice L.G., Zegher F.D., Gargosky S.E., Dsupin B.A., Fuentes L.I., Crystal R.A., Hintz R.L., Rosenfeld R.G.1995. Insulin-like growth factors and their binding proteins in the term and preterm human fetus and neonate with normal and extremes of intrauterine growth . Journal of Clinical Endocrinology & Metabolism , 80: 1548-1555.
Gonzalez-Parra S.,Argente J.,Chowen J.A., Chowen M.,Van Kleffens M.,Van Neck J.W., Lindenbeigh-Kortleve D.J.,Drop S.L.S.2001.Gene exp ression of the insulin-like growth factor system during postnatal develop-ment of the rat pituitary gland. Neuroendocrinol,13(1):86-93.
Gracie J.A., Robertson S.E., McInnes I.B. 2003.Interleukin-18. J Leukoc Biol, 73(2):213–224. Gruber CJ, Huber JC. 2005.The role of dydrogesterone in recurrent abortion. J Steroid Biochen Mol Biol, 97 (5):426-430.
Guan J.,Williams C.E.,Skinner S.J.1996.The effects of insulin-like growth factor IGF-1,IGF-2,and des IGF-1 on neuronal loss aferhypoxic-ischemic brain in jur in adult rats: evidence for a role for IGF binding proteins . Endocrinolgy, 137(3):893-898.
Guilbert L. 1998.There is a bias against type 1 inflammatory cytokine expression and function in pregnancy. J Reprod Immunol,39:362-367.
Guillaudeux T., Rodriguez A.M., Girr M., Mallet V., Ellis S.A., Sargent I.L., Fauchet R., Alsat E., Bouteiller P.L.1995. Methylation status and transcriptional expression of the MHC class I loci in human trophoblast cells from term placenta. The Journal of Immunology,154(7):3283-3299.
Gurel D., Ozer E., Altunyurt S., Guclu S., Demir N.2003. Expression of IGR-IR and VEGF and trophoblastic proliferative activity in placentas from pregnancies complicated by IUGR.Pathol Res Pract, 199(12):803-809.
Gutman G., Soussan-Gutman L., Malcov M., Lessing J.B., Amit A., Azem F. 2004.Interleukin-18 is high in the serum of IVF pregnancies with ovarian hyperstimulation syndrome. Am J Reprod Immunology, 51(5): 381- 394.
Gu Y., Kuida K., Tsutsui H., Ku G., Hsiao K., Fleming M.A., Hayashi N., Higashino K.,Okamura H., Nakanishi K., Kurimoto M., Tanimoto T., Flavell R.A., Sato V., Harding M.W.,Livingston D.J., Su M.S.1997.Activation of interf-eron-γinducing factor mediated by interleukin-1βconverting enzyme. Science, 275(5297):206-209.
Haddad E.K., Duclos A.J., Antecka E., Lapp W.S., Baines M.G.1997. Role of interferon-gamma in the priming of decidual macrophages for nitric oxide production and early pregnancy loss.Cell Immunology,181(1):68-75.
Hastie P.M., Onagbesan O.M., Haresign W. 2004.Co-expression of messenger ribonucleic acids encoding IGF-1,IGF-Ⅱ, type I andⅡIGF recep tors and IGF2 binding proteins( IGFBP-1 to-6) during follicular development in the ovary of seasonally anoestrous ewes. Anim Rep rod Sci,84(122):93-105.
Hata H.,Yoshimoto T. , Hayashi N.2004.Toshikazu Hada and Kenji Nakanishi. International Immunology,16 (2):1733- 1739.
Hayakawa S., Fujikawa T., Fukuoka H.,Chisima F., Karsaki-suzzki M.,Ohkoshi E., O Ohi H., Fujiit K.,Tochigi M.,Satoh K.,Shimizu T.,Nishinarita S.,Nemoto N., Sakurai I.2000.Murine fetal resorption and experimental pre-eclampsia are induced by both excessive Th1 and Th2 activation. Journal Reproductive Immunology, 47(2):121-138.
Hedtjarn M.,Leverin K.,Eriksson K.,Blomagren K.,Mallard C.,Hagberg H.2002. Interleukin-18 involvement in hypoxic-ischemic brain injury. The Journal of Neuroscience , 22(14):5910-5919.
Herington J.L., Bany B.M.2007. Effect of the conceptus on uterine natural killer cell numbers and function in the mouse uterus during decidualization.Biol Reprod,76(4):579-588.
Hettmer S., Dannecker L., Foell J., Martin W. 2005.Elmlinger and Guenther E. Dannecker. Effects of insulin-like growth factors and insulin-like growth factor binding protein-2 on the in vitro proliferation of peripheral blood mononuclear cells . Human Immunology ,66(2):95-103.
Hirota Y., Osuga Y., Koga K., Yoshino O., Hirata T., Morimoto C., Harada M., Takemura Y., Nose E., Yano T., Tsutsumi O., Taketani Y. 2006.The expression and possible roles of chemokine CXCL11 and its receptor CXCR3 in the human endometrium.J Immunology,177(12):8813-8821.
Huang X.D., Huang H.F., Dong M.Y., Yao Q.W., Wang H.Z. 2005.Relationship between serum andplacental interleukin-18 levels and preeclampsia.Zhejiang Da Xue Xue Bao Yi Xue Ban,34(6): 495-498.
IanOstoji(?) S., Volk M., Medica I.,Kapovi? M.,Meden-Vrtovec H.,Peterlin B.2007. Polymorphisms in the interleukin-12/18 genes and recurrent spontaneous abortion. Am J Reprod Immunol,58(5):403-408.
Ida A., Tsuji Y., Muranaka J., Kanazawa R., Nakata Y., Adachi S., Okamura H., Koyama K. 2000.IL-18 in pregnancy; the elevation of IL-18 in maternal peripheral blood during labour and complicated pregnancies. J Reprod Immunol, 47(1):65-74.
Igaz P., Salvi R., Rey J.P., Glauser M., Pralong F.P., Gaillard R.C. 2006.Effects of Cytokines on Gonadotropin- Releasing Hormone (GnRH) Gene Expression in Primary Hypothalamic Neurons and in GnRH Neurons Immortalized Conditionally. Endocrinology , 147(2):1037–1043.
Jacobson N. G.,Szabo S. J.,Weber-Nordt R. M., Robert D. Z. 1995.Schreiber, James E. Darnell, Jr, and Kenneth M. Murphy. Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4. Exp Med,181(5): 1755–1762.
Jacobsson B., Holst R.M., Mattsby-Baltzer I., Nikolaitchouk N.,Wennerolm U.B.,Hagberg H.2003. Interleukin-18 in cervical mucus and amniotic fluid: relationship to microbial inva sion of the amniotic fluid, intra-amniotic inflammation and preterm delivery.BJOG,110(6):598-603.
Jeon G.S.,Park S.K.,Park S.W.,Kim D.W.,Chung C.K.,Cho S.S.2008.Glial expression of interleukin-18 and its receptor after excitotoxie damage in the mouse hippocampus.Neurochemical Research,33(1):179-184.
Jin M., Jung H.J., Choi J.J., Jeon H., Oh J.H., Kim B., Shin S.S., Lee J.K., Yoon K., Kim S. 2003.Activation of selective transcription factors and cytokines by water-soluble extract from Lentinus lepideus. Exp Biol Med (Maywood), 228(6):749-758.
Kapur S.,Tamada H.,Dey S.K.1992.Expression of the insulin-like growth IGF-1 and its receptor in the peri implantation mouse and cell specific regulation of IGF-1 gene expression by estr adiol and progeslerone.Biol Reprod,46:208-209.
Kanno T., Nagata T., Yamamoto S., Okamura H., Nishizaki T. 2004.Interleukin-18 stimulates synaptically released glutamate and enhances postsynaptic AMPA receptor responses in the CA1 region of mouse hippocampal slices. Brain Res ,1012(1–2):190–193.
Kar S., Chabot J.G., Quirion R. 1993.Quantitative autoradiographic localization of insulin-like growth factor I, [125I]insulin-like growth factor II, and [125I]insulin receptor binding sites in developing and adult rat brain.Comp Neurol,333(3):375-397.
Kang S.S., Kim S.R., Leonhardt S., Wuttke. J.2000. Effect of interleukin-1βon gonadotropin- releasing hormone (GnRH) and GnRH receptor gene expression in castrated male rats. J Neuroendocrinol, 12(5):421–429.
Kevin D.1998. Bunting, Mark Y. Sangster, James N. Ihle & Brian P. Sorrentino. Resto ration of Lymphocyte function in Janus kinase deficient mice by retroviral-mediated gene transfer .Nature, 4(1):58-64.
Kiefer R., Kreutzberg G. W. 1990.Gamma interferon-like immunoreactivity in the rat nervous system.Neurosci,37(3):725-734.
Kikuchi T., Akasaki Y., Joki T., Abe T., Kurimoto M., Ohno T.2000. Antitumor activity of interleukin-18 on mouse glioma cells. Immunother,23(2):184-189.
Kim D. H.,Zhao X.,R.,Tu C. H., Casaccia-Bonnefil P.,Chao M.V.2004.Prevention of apoptotic but not necrotic cell death following neuronal injury by neurotrophins signaling through the tyrosine kinase receptor.Journal of Neurosurgery,100(1):79-87.
King A, Birkby L, Loke YW.1989. Early human decidual cells exhibit NK activity against the K562 cell line but not against first trimester trophoblast. Cellular Immunology,118(7):337-344.
King A., Boocock C., Sharkey A.M., Gardner L., Beretta A., Siccardi A.G., Loke Y.W.1996. Evidence for the expression of HLA-C class I mRNA and protein by human first trimester trophoblast. The Journal of Immunology, 156(6):2068-2076.
Kohka H., Yoshino T., Iwagaki H., Sakuma I., Tanimoto T., Matsuo Y., Kurimoto M., Orita K., Akagi T., Tanaka N.1998.Interleukin-18/Interferon-gamma-ingucing factor,a novel cytokine,up-regulates ICAM-1(CD54)expression in KG-1 cells.J Leukoc Biol,64(6):519-527.
Kohno K., Kataoka J., Ohtsuki T., Suemoto Y., Okamoto I., Usui M., Ikeda M and M Kurimoto. 1997.IFN-gamma-inducing factor (IGIF) is a costimulatory factor on the activation of Th1 but not Th2 cells and exerts its effect independently of IL-12.The Journal of Immunology, 158(4): 1541-1550.
Kovats S., Main E.K., Librach C., Stubblebine M., Fisher S.J., DeMars R.D.1990. A class I antigen HLA-G, expressed in human trophoblasts. Science,248(4952):220-223.
Krishnan L., Guibert L.J., Wegmann T.G., Belosevic M., Mosmann T.R.1996.Thelper 1 response against leishmnia major in pregnant C57BL/6 mice increases implantation failure and fetal resorptions Correlation with increased IFN-gamma and TNF and reduced IL-10 production by placental cells.The Journal of Immunology,156(2): 653-662.
Lackey B.R., Gray S.L., Henricks D.M. 1999.The insulin-like growth factor (IGF) system and gonadotropin regulation: actions and interactions. Cytokine Growth Factor Rev,10(3-4):201-217.
Laskarin G., Strbo N., Bogovic Crncic T., Juretic K., Ledee Bataille N., Chaouat G., Rukavina D. 2005.Physiological role of IL-15 and IL-18 at the maternal-fetal interface. Immunology of Pregnancy ,Chem Immunoogyl Allergy, 89:10- 25.
Lanier LL, Phillips JH.1996. Inhibitory MHC class I receptors on NK cells and T cells. Immunology Today, 17(2):86-91.
Lédée-Bataille N.,Dubanchet S., Lombroso R., Ville Y., Chaouat G. 2006.Downregulation of human endometrial IL-18 by exogenous ovarian steroids.Am J Reprod Immunol. 56(2):119-123.
Lédée-Bataille N., Olivennes F., Kadoch J., Dubanchet S., Frydman N., Chaouat G.,Frydman R. 2004.Detectable levels of interleukin-18 in uterine luminal secretions at oocyte retrieval predict failure of the embryo transfer. Hum Reprod, 19(9):1968-1973.
Leng J., Yao H., Shen J.2008.Co-expression of IL-18 binding protein and IL-4 regulates Th1?Th2 cylokine response in murine collagen-induced arthritis.Acta Biochim Biophys Sin,40(2):116-124.
Liu J.P., Baker J., Perkins A.S., Robertson E.J., Efstratiadis A. 1993.Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r).Cell,75(1):59-72.
Liu Z., Chen Y., Yang Y., Peng J.P. 2002.The effeet on MHC classⅡexpression and apoptosis in placenta by IFN- administration.Annu Rev Immunol,65(2):177-184.
Lin H., Mosmann T.R., Guilbert L., Tuntipopipat S., Wegmann T.G. 1993.Synthesis of T helper 2-type cytokines at the maternal-fetal interface.The Journal of Immunology, 151(9): 4562-4573.
Lopez M.F., Dikkes P., Zurakowski D., Villa-Komaroff L., Majzoub J.A.1999. Regulation of hepatic 113glycogen in the insulin-like growth factor II-deficient mouse.Endocrinology, 140(3):1442-1448.
Luo Q., Ning W., Wu Y., Zhu X.,Jin F.,Sheng J.,Huang H.2006.Altered expression of interleukin-18 in the ectopic and eutopic endometrium of women with endometriosis. Journal of Reproductive Immunology,72 (1-2):108-117.
Makarevich A .V., Sirotki N. 1997.The involvement of the GH / IGF-Ⅰaxis in the regulation on of secret ory activity by bovine oviduct ep ithelial cells . Anim Reprod Sci,48(2-4):197-207.
Marzi M., Vigano A., Trabattoni D., Villa M.L.,Salvaggio A.,Clerici E.,Clerici M.1996. Characterization of Type 1 and Type 2 cytokine production profile in physiologic and pathologic human pregnancy. Clinical & Experimental Immunology , 106(1):127-133.
Matsui K., Yoshimoto T., Tsutsui H., Hyodo Y., Hayashi N., Hiroishi K., Kawada N., Okamura H., Nakanishi K., Higashino K.1997. Propionibacterium acnes treatment diminishes CD~(4+) NK1.1~+ T cells but induces type I T cells in the liver by induction of IL-12 and IL-18 production from Kupffer cells. Immunology, 159(1):97-106.
Matsumoto S., Tsuji-Takayama K., Aizawa Y., Koide K., Takeuchi M., Ohta T., Kurimoto M.1997. Interleukin-18 activates NF-kappaB in murine T helper type 1 cells.Biochem Biophys Res Commun, 234(2):454-457.
Mattsson R., Mattsson A.,Holmdahl R. Scheynius A., Van der Meide P.H. 1992.In vivo treatment with interferon-gamma during early pregnancy in mice induces strong expression of major histocompatibility complex classⅠandⅡmolecules in uterus and decidua but not in extra-embryonic tissues. Bio Reprod, 46(6):1176-1186.
Mansouri R., Akbari F., Vodjgani M., Mahboudi F., Kalantar F., Mirahmadian M .2007.Serum cytokines profiles in Iranian patients with preeclampsia. Iran J Immunol. 4(3):179-185.
Micallef M.J., Ohtsuki T., Kohno K., Tanabe F., Ushio S., Namba M., Tanimoto T., Torigoe K., Fujii M., Ikeda M., Fukuda S., Kurimoto M.1996. Interferon-gamma-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin-12 for interferon-gamma production.Immunology, 26(7):1647-1651.
Micallef M.J., Yoshida K., Kawai S., Hanaya T., Kohno K., Arai S., Tanimoto T., Torigoe K., Fujii M., Ikeda M., Kurimoto M. 1997.In vivo antitumor effects of murine interferon-gamma-inducing factor/interleukin-18 in mice bearing syngeneic Meth A sarcoma malignant ascites. Cancer Immunol Immunother, 43(6):361-367.
Moreira F., Paula-Lopes F.F., Hansen P.J., Badinga L., Thatcher W.W.2002.Effects of growth hor mone and insulin-like growth fact or-Ion de-velopment of in vitro derived bovine embryos. Theriogenology,57(2):895–907.
Murakami Y., Otsuki M., Kusumoto K., Takeuchi S., Takahashi S.2005. Estrogen inhibits interleukin-18 mRNA expression in the mouse uterus.J Reprod Dev, 51(5):639-647.
Naeimi S, Ghiam A. F., Mojtahedi Z.,Dehaghani A.S.,Amani D.,Ghaderi A.2006. Interleukin-18 gene promoter polymorphisms and recurrent spontaneous abortion[J]. Eur J Obstet Gynecol Reprod Biol, 128(1-2): 5- 9.
Nagai Y., Nochi T., Watanabe K., Watanabe K., Aso H., Kitazawa H., Matsuzaki M., Ohwada S., Yamaguchi T. 2005.Localization of interleukin-18 and its receptor in somatotrophs of the bovine anterior pituitary gland.Cell Tissue Res, 322(3):455- 462.
Nagai Y., Watanabe K., Aso H., Ohwada S., Muneta Y., Yamaguchi T. 2006.Cellular localization of IL-18 and IL-18 receptor in pig anterior pituitary gland.Domest Anim Endocrinol, 30(2):144-154.
Naumnik W., Chyczewska E., Kovalchuk O., Ta?a?aj J., Izycki T., Panek B. 2004.Serum levels of interleukin-18 (IL-18) and soluble interleukin-2 receptor (sIL-2R) in lung cancer. Rocz Akad Med Bialymst, 49:246 -251.
Numan S., Russell D.S. 1999.Discrete expression of insulin re-ceptor substrate-4 mRNA in adult rat brain. Brain Res MolBrain Res72 (1) : 97-102 .
Okamura H., Nagata K., Komatsu T., Tanimoto T., Nukata Y., Tanabe F., Akita K., Torigoe K., Okura T., Fukuda S. 1995.A novel costimulatory factor for gamma interferon induction found in the livers of mice causes endotoxic shock..Infect Immun,63(11):3966-3972.
Okamura H., Tsutsi H., Komatsu T., Yutsudo M., Hakura A., Tanimoto T., Torigoe K., Okura T., Nukada Y., Hattori K.1995. Cloning of a new cytokine that induces IFN-gamma production by T cells.Nature,378(6552):88-91.
Okano F., Yamada K. 2000.Canine interleukin-18 induced apop tosis and enhances Fas ligand mRNA exp ression in a canine carcinoma cell line. Anticancer Res, 20: 3411-3416.
Ostoji(?) S., Volk M., Medica I.,Kapovi? M.,Meden-Vrtovec H.,Peterlin B.2007.Polymorphisms in the interleukin-12/18 genes and recurrent spontaneous abortion. American Journal of Reproductive Immunology. 58(5):403-408.
O’Shea J.J.1997. Cytokine signal transduction and immunoregulation are we there yet?.Jmunity,7:1-11. Park C.C., Morel J.C., Amin M.A., Connors M.A., Harlow LA, Koch A.E. 2001.Evidence of IL-18 as a novel angiogenic mediator. J Immunology,167(3):1644-1653.
Park J.,Liu A.Y.2001.JNK phosphorylates the HSF1 transcriptional activation domain: role of JNK in the regulation of the heat shock response.J Cell Biochem,82(2):326-338.
Pazos F., SanchezZ-Franco F., Balsa J., Escalada J.,Cacicedo L.2004.Differential regulation of gonadotrop ins and glycop rotein hormone alpha2subunit by IGF-1 in anterior p ituitary cells from male rats[J].J Endocrinol Invest,27(7):670-675.
Petersen A.M., Penkowa M., Lversen M., Frydelund-Larsen L.,Andersen J.,Mortensen J.,Lange P.,Pedersen B.K.2007.Elevated levels of IL-18 in plasma and skeletal muscle in chronic obstructive pulmonary disease.Lung,185(3):161-171.
Piccinni M.P., Maggi E., Romagnani S.2000.Role of hormone-controlled T-cell cytokines in the maintenance of pregency. Biochemical Society Transactions, 28(2): 212-215.
Rabinovitch A. ,Suarez-pinzon W.L .,Strynadka K.,Lakey J.R.,Rajotte R.V.1996.Human pancreatic islet βcell destruction by cytokines involves oxygen free radi-cals and Aldehyde production.J Clin Endocrinol Metab, 81(9):3197 - 3202.
Raghupathy R. 1997.Th1-type immunity is incompatible with sucessful pregency. Immunol Today, 18(10):78-82.
Reddy P. 2004.Interleukin-18: recent advances.Curr Opin Hematol, 11(6):405-410.
Reece E.A.,Wiznitzer A.,Le E. Homko C.J., Behrman H.,Spencer E.M.1994.The relation between human fetal growth and fetal blood levels of insulinlike growth factorⅠandⅡ,their binding proteins,and receptors. Obstet Gynecol,84(1):88-95.
Rehfeldt C., Nissen P.M., Kuhn G., Vestergaard M., Ender K., Oksbjerg N.2004. Effects of maternalnutrition and porcine growth hormone (pGH) treatment during gestation on endocrine and metabolic factors in sows, fetuses and pigs, skeletal muscle development, and postnatal growth.Domest Anim Endocrinol,27(3):267-285.
Reid G.J., Flozak A.S., Simmons R.A.2002.Placental expression of insulin-like growth factor receptor-1 and insulin receptor in the growth-restricted fetal rat .J Soc Gynecol Investig.9(4):210-214.
Renhai C., Farnebo J., Kurimoto M., Cao Y .1999. Interleukin-18 acts as an angiogenesis and tumor suppressor. FASEB J, 13(15):2195-2202.
Richardson H.N,.Parfitt D.B.,Thomp son R.C., Thompson R.C.,Sisk C.L.2002. Redefining gonadotrop in-releasing hormone (GnRH) cell groups in the male Syrian hamster testosterone regulates GnRH mRNA in the tenia tecta.. Neuroendocrinol,14(5):375-383.
Rothe H., Jenkins N.A., Copeland N.G., Kolb H.1997.Active stage of autoimmune diabetes is associated with the expression of a novel cytokine, IGIF, which is located near Idd2.Clin Invest,99(3):469-474.
Roy R.N., Gerulath A.H., Cecutti A., Bhavnani B.R. 2000.Effect of tamoxifen treatment on the endometrial expression of human insulin-like growth factors and their receptor mRNAs. Mol Cell Endocrinol. 165(1-2):173-178.
Richards R.G., Klotz D.M., Walker M.P., DiAugustine R.P.2004. Mammary gland branchingmorphogenesis is diminished in mice with a deficiency of insulin-like gr owth factor-I ( IGF-I) , but not in mice with a liver-specific deleti on of IGF-I. Endocrinology, 145(7) : 31062-3110.
Sakai M., Shiozaki A., Sasaki Y., Yoneda S., Saito S. 2004.The ratio of interleukin (IL)-18 to IL-12 secreted by peripheral blood mononuclear cells is increased in normal pregnant subjects and decreased in pre-eclamptic patients. J Reprod Immunol.,61(2):133-143.
Sarkar N.N. 2002.The potential of mifepristone (RU486) as a female contraceptive drug. Int J Clin Pract ,56 (2) :140-144.
Schams D., Berisha B., Kosmann M., Amselgruber W.M.2002. Expression and localization of IGF familymembers in bovine antral follicles during final growth and in luteal tissue during different stages of estrous cycle and pregnancy . Domest Anim Endocrinol,22(1):51-72.
Schneider E., Tonanny M.B., Lisbonne M., Leite-de-Moraes M., Dy M. 2004.Pro-Th1 cytokines promote Fas-dependent apoptosis of immature peripheral basophils. J Immunology,172(9):5262–5268.
Silha J.V.,Mushy L.J.2005.Insulin-like Growth Factor Binding Proteins in Development .Advances in Experimental Medicine and Biology, 567:55-89.
Simmen F.A.,Simmen R.C.,Geisen R.D., Martinat-Botte F. , Bazer F.W., and Terqui M .1992..Differential expression during the estrous cycle and pre- and postimplantation conceptus devclopment of messenger ribonueeic acids encofing compoents of the pig ulerine insulin-like growrh factor system..Endocrinology,130:1547-1556.
Singer I.I., Scott S., Chin J., Bayn E.K., Limjuco G., Weidner J., Miller D.K., Chapman K., Kostura M.J. 1995.The interleukin-1β-co-nverting enzyme(ICE) is localized on the external cell surface membranes and in the cytoplasmic ground substrance of human monocytes by immuno-electron microscopy. Exp Med,182(4):1 447-1459.
Shin H.D., Kim L.H., Park B.L., Choi Y.H., Park H.S., Hong S.J., Choi B.W., Lee J.H., Park C.S. 2005.Association of interleukin 18 (IL18) polymorphisms with specific IgE levels to mite allergensamong asthmatic patients. Allergy. 60(7):900-906.
Shu U., Kiniwa M., Wu C.Y., Maliszewski C., Vezzio N., Hakimi J., Gately M., Delespesse G. 1995.Activated T cells induce interleukin-12 production by monocytes via CD40-CD40 ligand interaction.Eur J Immunol,25(5):1125-1128.
Skaper S.D.2007.The brain as a target for inflammatory processes and nearo- protective strategies.Ann NY Acad Sci,1122:23-34.
Soderstrom K., Corliss B., Lanier L.L., Phillips J.H.1997.CD94/NKG2 is the predeminal inhibitory receptor involved in recognition of HLA-G by decidual and peripheral blood NK cells. The Journal of Immunology,159(3):1072-1075.
Spicer L.J., Santiago C.A., Davidson T.R., Bridges T.S., Chamberlain C.S.2005. Follicular fluid concentrations of free insulin-like growth factor (IGF)-I during follicular development in mares. Domest Anim Endocrinol, 29(4):573-581.
Stewart C.E., Rotwein P. 1996.Growth, differentiation, and survival: multiple physiological functions for insulin-like growth factors . Physiol Rev,76(4):1005-1026.
Stoll S., Miiller G.,Kurimoto M.1997. Production of IL-18 (IFN-γ-inducing factor) mRNA and functional protein by murine kerationcyter.J Immunol,159(1):298.
Sugama S., Cho B.P., Baker H., Joh T.H., Lucero J., Conti B. 2002.Neurons of the superior nucleus of the medial habenula and ependymal cells express IL-18 in rat CNS. Brain Res, 958(1):1–9.
Sugama S., Fujita M., Hashimoto M., Conti B.2007. Stress induced morphological microglial activation in the rodent brain: involvement of interleukin-18. Neuroscience , 146(3): 1388-1399.
Sugama S., Wang N., Shimokawa N., Koibuchi N., Fujita M., Hashimoto M., Dhabhar F.S., Conti B. 2006.The adrenal gland is a source of stress-induced circulating IL-18.Journal of Neuroimmunology, 172(1-2):59– 65.
Suk K.,Kim S. ,KIM Y.H ., Kim K.A., Chang I., Yagita H., Shong M., Lee M.S.2001.
IFN - gamma/ TNF - alpha syn-ergism as the final effector in autoimmue diabetes : a key role forSTAT1/ IFN ragulatory factory factor-1 pathway in pancreatic beta cell death. J Immunol, 166 (7) :4481 - 4489.
Sun Q.H, Peng J.G., Xia H.F., Yang Y.,Liu M.L.,2005.Effect on expression of RT1-A and RT1-DM molecules of treatment with interferon-γat the maternal-fetal interface of pregnant rats[J]. Hum Reprod, 20(9): 39-47.
Takeda K., Tsutsui H., Yoshimoto T., Adachi O., Yoshida N., Kishimoto T., Okamura H., Nakanishi K., Akira S.1998. Defective NK cell activity and Th1 response in IL-18-deficient mice. Immunity, 8(3):383-390.
Takeuchi M., Nishizaki Y., Sano O., Ohta T., Ikeda M., Kurimoto M. 1997.Immunohistochemical and immuno-electron-microscopic detection of interferon-gamma-inducing factor ("interleukin-18") in mouse intestinal epithelial cells.Cell Tissue Res,289(3):499-503.
Taniguchi M., Nagaoka K., Kunikata T., Kayano T., Yamauchi H., Nakamura S., Ikeda M., Orita K., Kurimoto M.1997. Characterization of anti human interleukin- 18(IL-18)/interferon-gamma inducing factor(IGIF) monoclonal antibodies and their application in the measurement of human IL-18 by ELISA. Immonology Methods,206 (1-2):107-113.
Thomas H.E. ,Darwiche K.,Corbett J.A. , Kay T.W. 2002.Interleukin-1 plusγ- interferon inducedpancreaticβcell dysfunction is mediate byβcell nitric oxide production. Diabetes ,2002,51(2):311-316.
Tokmadzi? V.S., Tsuji Y., Bogovi? T., Laskarin G., Cupurdija K., Strbo N., Koyama K., Okamura H., Podack E.R., Rukavina D. 2002.IL-18 is present at the maternal-fetal interface and enhances cytotoxic activity of decidual lymphocytes.Am J Reprod Immunol,48(4): 191- 200.
Tomura M., Zhou XY., Maruo S., Ahn H.J., Hamaoka T., Okamura H., Nakanishi K., Tanimoto T., Kurimoto M., Fujiwara H. 1998.A Critical Role for IL-18 in the Proliferation and Activation of NK1.1+CD_3- Cells.Immunology,160(10):4738- 4736.
Torres-Aleman I., Pons S., Arévalo M.A. 1994.The insulin-like growth factor 1 system in the rat cerebellum: developmental regulation and role in neuronal survival and differentiation . Neurosci Res,39(2):117-126.
Tsuji Y., Tamaoki T.H., Hasegawa A., Kashiwamura S., Iemoto A., Ueda H., Muranaka J., Adachi S., Furuyama J., Okamura H., Koyama K.2001. Expression of interleukin-18 and its receptor in mouse ovary. Am J Reprod Immunology, 46(5):349-357.
Tsutsui H., Nakanishi K., Matsui K., Higashino K., Okamura H , Miyazawa Y., Kaneda K. 1996.IFN-gamma-inducing factor up-regulates Fas ligand-mediated cytotoxic activity of murine natural killer cell clones.Immunology,157(8):3967-3973.
Udagawa N., Horwood N.J., Elliott J., Mackay A., Owens J., Okamura H., Kurimoto M., Chambers T.J., Martin T.J., Gillespie M.T. 1997.Interleukin-18 (interferon-gamma-inducing factor) is produced by osteoblasts and acts via granulocyte/macrophage colony-stimulating factor and not via interferon-gamma to inhibit osteoclast formation. Exp Med, 185(4):1005-1012.
Ushio S., Namba M., Okura T., Hattori K., Nukada Y., Akita K., Tanabe F., Konishi K., Micallef M., Fujii M., Torigoe K., Tanimoto T., Fukuda S., Ikeda M., Okamura H., Kurimoto M. 1996.Cloning of the cDNA for human IFN-γ-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein. Immunology,156(11):4274–4279.
Vabulas,R.M.,Ahmad-Nejad P.,Dacosta T.,Kirschning C.J.,Hacker H.,Wagner H.2001.Endocytosed hsp60s use toll-like receptor2(tlr2)and tlr4 to activate the toll/interleukin-1 receptor-signaling pathway in innate immune cells. J Biol Chem,276(33): 31332-31339.
Vatten L.J.,Qdegard R.A.,Nilsen S.T.,Salvesen K.A.,Austgulen R.2002. Relationship of insulin-like growth factor-1and insulin-like growth binding proteins in umbilical cord plasma to preeclampsia and infant birth weight.Obstet Gynecol,99(1):85-90.
Verhaghe J., Bree R.V., Herck E.V., Laureys J., Bouillon R., Van Assche F.A.1993.C-Peptide ,insulin like growth factors 1 andⅡ,and insulin-like growth factor binding protein- l in umbilical cord serum correlations with birth weight.Am J Obster Gynecol,168(1):89-97.
Vidal-Vanaclocha F., Fantuzzi G., Mendoza L., Fuentes A.M., Anasagasti M.J., Martín J., Carrascal T., Walsh P, Reznikov L.L., Kim S.H., Novick D., Rubinstein M., Dinarello C.A.2000.IL-18 regulates IL-1beta-dependent hepatic melanoma metastsis via vascular cell adhension molecule-1.Proc Natl Acad Sci USA,97(2):734-739.
Voge J.L.,Aad P.Y., Santiago C.A., Goad D.W.,Malayer J.R.,Allen D.,Spicer L.J.2004. Effect of insulin-like growth factors , FSH, and leptin on IGF-binding-protein mRNA expression in bovine granulosa and theca cells:quantitative detection by real-time PCR.Pep tides,25(12):2195-2203.
Voss S.D., Daley J., Ritz J., Robertson M.J.1998. Participation of the CD94 receptor complex incostimulation of human natural killer cells. The Journal of Immunology,160: 1618-1626.
Wang N., Sugama S., Conti B., Teramoto A., Shibasaki T. 2006.Interleukin-18 mRNA expression in the rat pituitary gland.Neuroimmunol ,173(1-2):117-125.
Wang X., Hagberg H., Mallard C., Zhu C., Hedtj(?)rn M., Tiger C.F., Eriksson K., Rosen A., Jacobsson B. 2006.Disruption of interleukin-18, but not interleukin-1, increases vulnerability to preterm delivery and fetal mortality after intrauterine inflammation.Am J Pathol. 169(3):967-976.
Wilson R., Jenkins C., Miller H., Mclnnes L.B.,Moore J.,Mclean M.J.,James J.,Walker J.2004. Abnormal cytokine levels in nonp regnant women with a history of recurrent miscarriage. European Journal Obstetrics Gynecology Reproductive Biology, 115(1):51-54.
Wilson R., Moor J., Jenkins C., Miller H.,Walker J.J.,Mclean M.A.,Norman J.,Mclnnes I.B.2004. Abnormal first trimester serum interleukin 18 levels are associated with a poor outcome in women with a history of recurrent miscarriage. American Journal of Reproductive Immunology , 51(2):156-159.
Xia H.F.,Sun Q.H.,Peng J.P.2007.Effect of interferon-gamma treatment on the expression of interleukin-1beta at the maternal-fetal interface of pregnant rats. Reprod Fertil,19(3):510-519.
Xie X., He H., Colonna M., Seya T., Takai T., Croy B.A.2005. Pathways participating in activation of mouse uterine natural killer cells during pregnancy. Biol Reprod,73(3):510-518.
Xu D., Chan W.L., Leung B.P., Hunter D., Schulz K., Carter R.W., McInnes I.B., Robinson J.H., Liew F.Y.1998. Selective expression and functions of interleukin 18 receptor T helper (Th ) type 1 but not Th2 cells.Exp Med,188(8):1485-1492.
Yamaguchi M., Koike K., Yoshimoto Y., Matsuzaki N., Miyake A., Tanizawa O.1991. Interleukin-6 stimulates gonadotropin- releasing hormone secretion from rat hypothalamic cells. Horm Res,35:252–256.
Yoshimoto T., Okamura H., Tagawa Y.I., Iwakura Y., Nakanishi K. 1997.Interleukin -18 together with interleukin -12 inhibits IgE production by induction of interferon-gamma production from activated B cells. Proc Natl Acad Sci U S A, 94(8):3948-3953.
Yoshimoto T. ,Nakanishi K.2006. Roles of IL-18 in basophils and mast cells .Allergol Int, 55(2):105-13. Yuan X.J., Dixon-McCarthy B, Kunz H.W., Gill T.J.1994. Role of methylation in placental major histocompatibility complex antigen expression and fetal loss. Bio Reprod, 1994, 51(5): 31-42.
Zhang Y.F., Yang Y.S., Hong J., Gu W.Q.,Shen C.F.,Xu M.,Du P.F.,Li X.Y.,Ning G.2006. Elevated serum levels of interleukin-18 are associated with insulin resistance in women with polycystic ovary syndrome. Endocrine, 29(3):419-423.
Zygmunt M., Herr F., Münstedt K., Lang U., Liang O. D. 2003.Angiogenesis and vasculogenesis in pregnancy.European Journal Obstertics & Gynecology Reproductive Biology,110 (l ):S10-S18.
陈敬国,蒋犁.缺氧缺血脑组织生化免疫成分的改变. 2002.国外医学:儿科学分册,29(5):260-262.
陈竹钦,胡冬梅.1999.蜕膜细胞因子网络平衡状态与流产.中国实用妇科与产科杂志, 15(3):145-146
底建敏,闫晓娟,郭影,孙宏勋.2006.妊娠高血压疾病患者IGF-1与脂代谢相关性分析.中国妇幼保健,21(11):1494-1496.
管成浓,廖湘晖,罗海清,陈星明,陈宝英,张培文.2009.良恶性原发性肿瘤患者血IL-18及IL-18BP含量测定及临床意义.中国肿瘤临床,36(7):365-367.
韩纯.1994第二版.微生物学与寄生虫学.安徽:安徽科技出版社.
胡昌东,归绥琪.2004.自然流产患者滋养细胞肝素表皮生长因子的表达和意义.上海医学,27(7):491- 494.
晋柏,陈文玮,王海琦,陈炳兰. 2005.重组小鼠γ-干扰素对弓形虫感染妊娠早期孕鼠及鼠胚的影响.江苏医药,31(3):206-208.
金海燕,王自能,徐建平.2000.育龄妇女输卵管胰岛素样生长因子和受体的测定.中华妇产科杂志, 35 ( 11) : 689-690.
兰艳丽,张昌军,江成龙,罗清炳,彭海英,董毅飞,徐鸿毅.2009.来曲唑微刺激超排卵对卵泡液中IGF-1和IGFBP-1水平的影响.鄢阳医学院学报,28(1):9-12.
李昭荣,韩香,吕海侠,李牧,于玲,樊江波,王玉珍.2006.Th1/Th2型细胞因子与反复自然流产的关系.西安交通大学学报,24(3):255-257.
刘喆，杨颖，陈云,彭景楩.2002.人重组组γ-干扰素对兔妊娠的影响.动物学报,48(2):277-280.
骆方军.2006.重组小鼠干扰素-γ对感染弓形虫孕鼠T细胞亚群自然杀伤细胞的影响[J].中国寄生虫与寄生虫病杂志,24(2):125-128.
陶亚雄.灵长类的滋养层干扰素.1994.生理科学进展,25(2):137-140.
王根林. 1997.下丘脑-垂体-性腺轴在动物生殖中的作用.畜牧与兽医,29(4): 182-184.
吴浩,常雅萍,于永利.1999.Th1型/Th2型细胞因子与妊娠的免疫调节.国外医学.免疫学分册,22(2):57-66.
武季峰,李红真,范正红,郑淑蓉.2004.IGF-Ⅰ对卵泡内膜细胞增殖及其LH受体表达的影响.生殖与避孕,22(2):84-87.
谢端薇,欧汝强,杨宁.1999.卵巢早衰与细胞因子TNF-α,IFN-γ和IL-2的相关性研究.广东医学,20(11):23-25.
闫风亭.母胎界面免疫微环境及其功能.2000.国外医学:妇幼保健分册, 11(3): 107-110.
杨瑞宁,江淑芳.2002.脐血、孕妇外周血IL-18检测意义的初探.临床检验杂志,20(5):301-303.
姚文,庄临之.1998.干扰素-γ对妊娠小鼠黄体细胞孕酮分泌的影响.南京师范大学学报,21(3):88-89.
周坚红,石一复,董岳,贺晶,王正平.1999.胰岛素样生长因子-1及胰岛素与胎儿宫内发育迟缓发病的关系.中华妇产科杂志,1999,34(4):222-224.
钟文英,普雄明.2005.热休克蛋白的分子生物学研究进展.医学综述,11(2):148-150.
朱铭伟,夏燕萍,张振钧.1998.胰岛素样生长因子-1与胎儿出生体重的关系.中华妇产科杂志,33(11):667-669.
朱晓勇,李大金. 2000.母胎免疫调节机理的研究进展.生物医学杂志, 9(1): 56-60.
Aguet M.,Dembic Z.,Merlin G.1988.Molecular cloning and expression of the human interferon-gamma receptor.Cell,55(2),273-280.
Aloe L.,Iannitelli A. 2001.Neurotrophic factors and brain damage in hypoxicischemic encephalopathy: a role of nerve growth factor. Ann Ist Super Sanita, 37(4):73-80.
Andrea, R.,Wheelerb R.D., Collinsa P.D. 2003. Identification of a truncated IL-18Rh mRNA: a putative regulator of IL-18 expressed in rat brain. Biol Reprod, 145(1-2):40–45.
Ashkar A.A.,Croy B.A. 1999.Interferon-gamma contributes to the normalcy of murine pregnancy biology of reproduction.Biology of Reproduction,61:493-502.
Ashkat A.A.,Croy B.A.2001.Functions of uterine naturel killer cells are mediated by interferon gamma production during murine pregnancy.Semin Immunology,13:235-241.
Athanassakis I.,Thanassakis s.2002. Interplay between T helper type 1 and type 2 cytokines and soluble major histocompatibility complex molecules: a paradigm in pregnancy. Immunology, 107(3): 281–287.
Bazan J .F.,Timans T. C., Kastelein R. A.1996. A newly def-ined interleukin-1? Nature,379(6566):591. Bulla R.F, Fischetti F., Bossi F.2004.Feto-matemal immune interaction at the pleraction level.Lupus,13:155-157.
Bushley A.W.,Ferrell R.,Mcduffie K.,Terada K.y.,Carmey M.E.,Thompson P.J.,Wilkens L.R.,Tung K.H.,Ness R.B.,Goodmam M.T.2004.Polymorphisms of interleukin(IL)-1alpha, IL-1beta, IL-6,IL-10,and IL-18 and the risk of ovarian cancer. Gynecol Oncol,95(3):672-679.
Chandrasekar, B.2004. Activation of intrinsic and extrinsic pro-apoptotic signaling pathways in interleukin-18-mediated human cardiac endothelial cell death. J Biol. Chem, 279: 20221- 20233.
Chen H.L.,Kamath R.,Pace J.L.,Russell S.W.,Hunt J.S.1994.Expression of the interleion-r receptor gene in mouse placentas is related to stage of gestation and is restricted to specific subpopulations of trophoblast cells.Placenta,15(2):109-121.
Chungm K., Lee S.H., Cho S.W. 2002.The various mRNA expression pattern of insulin like growth factor IGF-1 and IGF-Ⅱand their receptor according to oocyte maturity in IVF cycle: compared with nonstimulated PCOS cycle.Fertil Steril,78(l1):278.
Claeys I. , Simonet G., Poels J., Van Loy T., Vercammen L., Loof A.D., Broeck J.V.2002. I nsulin-related peptides and their conserved signal transduction pathway. Peptides, 23 (4) : 807-816.
Conti B., Jahng J. W.,Tinti G., Son. J. H., Tong H. J. 1997.Induction of inter-feron-γinducing factor in the adrenal cortex.Biological Chemistry, 272:2035-2037.
Coughlin C .M., Salhany K E., Wysocka M. , Aruga E., Kurzawa H. , Chang A E., Hunter C. A ., Fox J. C., Trinchieri G. , Lee W. M . 1998.Interleukin-12 and interleukin-18 synergistically induce murine tumor regression which involves inhibition of angiogenesis.J Clin Invest, 101(6): 1441–1452.
Culhane A.C., Hall M.D., Rothwell N.J., Luheshi G.N. 1998.Cloning of rat brain interleukin-18 cDNA. Mol Psychiatry,3 (4) : 362-366.
Daher S., Kátia de Arruda Geraldes Denardi K., Blotta M.H., Mamoni R.L.,Reck A.P.,Camano L.,Mattar R.2004.Cytokines in recurrent pregnancy loss. Journal of Reproductive Immunology, 62(1-2):151-157.
Dao T., Ohashi K., Kayano T., Kurimoto M., Okamura H.1996. Interferon-gamma-inducing factor, a novelcytokine, enhances Fas ligand-mediated cytotoxicity of murine T helper 1 cells.Cell Immunol,173(2):230-235.
Daftary S.S.,Gore A.C. 2003.Developmental changes in hypothalamic in-sulin-like growth factorⅠrelationship to gonadotrop in release in hormone neurons. Endocrinology,144(5):2034-2045.
Darnell J.E.1997.Stats and gene regulation .Science,1997,277:1630.
Diaz E.,Halhali A.,Luna C.,Diaz L.,Larrea F.2002.Newborn birth weight correlates with placental zinc,umbilical insulinl ike growth factorI,and leptin levels in preeclampsia. Arch Med Res,33(1):40-47.
Druck Mann R., Rohr U. D.2002. IGF -1 in gynaecology and obstetrics:update . Maturitas, 41 (11) : S65-S83 .
Faulds G.,Conroy S.,Madaio M.,Isenberg D.,Latchman D.1995.Increased levels of antibodies to heat shock proteins with increasing age in Mrl/Mp-l/lpr mice.Br J Rheumatol ,34(7):610-615.
Feleder C., Arias P., Refojo D., Nacht S., Moguilevsky J.2000. Interleukin-1 inhibits NMDA-stimulated GnRH secretion: associated effects on the release of hypothalamic inhibitory amino acid neurotransmitters. Neuroimmunomodulation,7:46–50.
Felderhoff-Mueser U.,Schmidt O.I., Oberholzer A., Buhrer C.,Stahel P.F.2005.IL-18: a key player in neuroinflammation and neurodegeneration.Trends in Neurosciences, 28(9):487- 493.
Fink SL,Bergsbaken T.,Cookson R.T. 2008. Anthrax Iethal tox- in and Salmonella elicit the common cell death pathway of caspase-1-dependent pyroptosis via distinct mecha-nisms.Proc Natad Sci USA, 105(11):4312–4317.
Finotto S. 2004.Severe hepatic injury in interleukin-18 (IL-18) transgenic mice: a key role for IL-18 in regulating hepatocyte apoptosis in vivo. Gut , 53:392–400.
Fournel S., Aguerre-Girr M., Huc X., Lenfant F., Alam A., Toubert A., Bensussan A., Bouteiller P.L.2000. Cutting edge: soluble HLA-G1 triggers CD95/CD95 ligand-mediated apoptosis in activated CD8+ cells by interacting with CD8. The Journal of Immunology, 164: 6100-6104.
Fowden A.L. 2003.The insulin-like growth factors and feto-placental growth,Placenta,24(8-9):803-812. Gao H.M., Hong J.S.2008.Why neurodegenerative diseases are progressive:uncontrolled inflammation drives disease progression .Trends Immunology,29(8):357-365.
Giudice L.C.,Martin N.A.,Crystal R.A.,Tazuke S.,Druzin M.1997.Insulin-like growth factor binding protein1at the maternal fetal interfaceand insulin-like growth factor-1,insulin-like growth factor-Ⅱ,and insulin-like growth factor binding protein-1 in the circulation of women with severe preeclampsia. Am J Obstet Gynecol,1997,176(4):751-758.
Giudice L.G., Zegher F.D., Gargosky S.E., Dsupin B.A., Fuentes L.I., Crystal R.A., Hintz R.L., Rosenfeld R.G.1995. Insulin-like growth factors and their binding proteins in the term and preterm human fetus and neonate with normal and extremes of intrauterine growth . Journal of Clinical Endocrinology & Metabolism , 80: 1548-1555.
Gonzalez-Parra S.,Argente J.,Chowen J.A., Chowen M.,Van Kleffens M.,Van Neck J.W., Lindenbeigh-Kortleve D.J.,Drop S.L.S.2001.Gene exp ression of the insulin-like growth factor system during postnatal develop-ment of the rat pituitary gland. Neuroendocrinol,13(1):86-93.
Gracie J.A., Robertson S.E., McInnes I.B. 2003.Interleukin-18. J Leukoc Biol, 73(2):213–224. Gruber CJ, Huber JC. 2005.The role of dydrogesterone in recurrent abortion. J Steroid Biochen Mol Biol, 97 (5):426-430.
Guan J.,Williams C.E.,Skinner S.J.1996.The effects of insulin-like growth factor IGF-1,IGF-2,and des IGF-1 on neuronal loss aferhypoxic-ischemic brain in jur in adult rats: evidence for a role for IGF binding proteins . Endocrinolgy, 137(3):893-898.
Guilbert L. 1998.There is a bias against type 1 inflammatory cytokine expression and function in pregnancy. J Reprod Immunol,39:362-367.
Guillaudeux T., Rodriguez A.M., Girr M., Mallet V., Ellis S.A., Sargent I.L., Fauchet R., Alsat E., Bouteiller P.L.1995. Methylation status and transcriptional expression of the MHC class I loci in human trophoblast cells from term placenta. The Journal of Immunology,154(7):3283-3299.
Gurel D., Ozer E., Altunyurt S., Guclu S., Demir N.2003. Expression of IGR-IR and VEGF and trophoblastic proliferative activity in placentas from pregnancies complicated by IUGR.Pathol Res Pract, 199(12):803-809.
Gutman G., Soussan-Gutman L., Malcov M., Lessing J.B., Amit A., Azem F. 2004.Interleukin-18 is high in the serum of IVF pregnancies with ovarian hyperstimulation syndrome. Am J Reprod Immunology, 51(5): 381- 394.
Gu Y., Kuida K., Tsutsui H., Ku G., Hsiao K., Fleming M.A., Hayashi N., Higashino K.,Okamura H., Nakanishi K., Kurimoto M., Tanimoto T., Flavell R.A., Sato V., Harding M.W.,Livingston D.J., Su M.S.1997.Activation of interf-eron-γinducing factor mediated by interleukin-1βconverting enzyme. Science, 275(5297):206-209.
Haddad E.K., Duclos A.J., Antecka E., Lapp W.S., Baines M.G.1997. Role of interferon-gamma in the priming of decidual macrophages for nitric oxide production and early pregnancy loss.Cell Immunology,181(1):68-75.
Hastie P.M., Onagbesan O.M., Haresign W. 2004.Co-expression of messenger ribonucleic acids encoding IGF-1,IGF-Ⅱ, type I andⅡIGF recep tors and IGF2 binding proteins( IGFBP-1 to-6) during follicular development in the ovary of seasonally anoestrous ewes. Anim Rep rod Sci,84(122):93-105.
Hata H.,Yoshimoto T. , Hayashi N.2004.Toshikazu Hada and Kenji Nakanishi. International Immunology,16 (2):1733- 1739.
Hayakawa S., Fujikawa T., Fukuoka H.,Chisima F., Karsaki-suzzki M.,Ohkoshi E., O Ohi H., Fujiit K.,Tochigi M.,Satoh K.,Shimizu T.,Nishinarita S.,Nemoto N., Sakurai I.2000.Murine fetal resorption and experimental pre-eclampsia are induced by both excessive Th1 and Th2 activation. Journal Reproductive Immunology, 47(2):121-138.
Hedtjarn M.,Leverin K.,Eriksson K.,Blomagren K.,Mallard C.,Hagberg H.2002. Interleukin-18 involvement in hypoxic-ischemic brain injury. The Journal of Neuroscience , 22(14):5910-5919.
Herington J.L., Bany B.M.2007. Effect of the conceptus on uterine natural killer cell numbers and function in the mouse uterus during decidualization.Biol Reprod,76(4):579-588.
Hettmer S., Dannecker L., Foell J., Martin W. 2005.Elmlinger and Guenther E. Dannecker. Effects of insulin-like growth factors and insulin-like growth factor binding protein-2 on the in vitro proliferation of peripheral blood mononuclear cells . Human Immunology ,66(2):95-103.
Hirota Y., Osuga Y., Koga K., Yoshino O., Hirata T., Morimoto C., Harada M., Takemura Y., Nose E., Yano T., Tsutsumi O., Taketani Y. 2006.The expression and possible roles of chemokine CXCL11 and its receptor CXCR3 in the human endometrium.J Immunology,177(12):8813-8821.
Huang X.D., Huang H.F., Dong M.Y., Yao Q.W., Wang H.Z. 2005.Relationship between serum andplacental interleukin-18 levels and preeclampsia.Zhejiang Da Xue Xue Bao Yi Xue Ban,34(6): 495-498.
IanOstoji(?) S., Volk M., Medica I.,Kapovi? M.,Meden-Vrtovec H.,Peterlin B.2007. Polymorphisms in the interleukin-12/18 genes and recurrent spontaneous abortion. Am J Reprod Immunol,58(5):403-408.
Ida A., Tsuji Y., Muranaka J., Kanazawa R., Nakata Y., Adachi S., Okamura H., Koyama K. 2000.IL-18 in pregnancy; the elevation of IL-18 in maternal peripheral blood during labour and complicated pregnancies. J Reprod Immunol, 47(1):65-74.
Igaz P., Salvi R., Rey J.P., Glauser M., Pralong F.P., Gaillard R.C. 2006.Effects of Cytokines on Gonadotropin- Releasing Hormone (GnRH) Gene Expression in Primary Hypothalamic Neurons and in GnRH Neurons Immortalized Conditionally. Endocrinology , 147(2):1037–1043.
Jacobson N. G.,Szabo S. J.,Weber-Nordt R. M., Robert D. Z. 1995.Schreiber, James E. Darnell, Jr, and Kenneth M. Murphy. Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4. Exp Med,181(5): 1755–1762.
Jacobsson B., Holst R.M., Mattsby-Baltzer I., Nikolaitchouk N.,Wennerolm U.B.,Hagberg H.2003. Interleukin-18 in cervical mucus and amniotic fluid: relationship to microbial inva sion of the amniotic fluid, intra-amniotic inflammation and preterm delivery.BJOG,110(6):598-603.
Jeon G.S.,Park S.K.,Park S.W.,Kim D.W.,Chung C.K.,Cho S.S.2008.Glial expression of interleukin-18 and its receptor after excitotoxie damage in the mouse hippocampus.Neurochemical Research,33(1):179-184.
Jin M., Jung H.J., Choi J.J., Jeon H., Oh J.H., Kim B., Shin S.S., Lee J.K., Yoon K., Kim S. 2003.Activation of selective transcription factors and cytokines by water-soluble extract from Lentinus lepideus. Exp Biol Med (Maywood), 228(6):749-758.
Kapur S.,Tamada H.,Dey S.K.1992.Expression of the insulin-like growth IGF-1 and its receptor in the peri implantation mouse and cell specific regulation of IGF-1 gene expression by estr adiol and progeslerone.Biol Reprod,46:208-209.
Kanno T., Nagata T., Yamamoto S., Okamura H., Nishizaki T. 2004.Interleukin-18 stimulates synaptically released glutamate and enhances postsynaptic AMPA receptor responses in the CA1 region of mouse hippocampal slices. Brain Res ,1012(1–2):190–193.
Kar S., Chabot J.G., Quirion R. 1993.Quantitative autoradiographic localization of insulin-like growth factor I, [125I]insulin-like growth factor II, and [125I]insulin receptor binding sites in developing and adult rat brain.Comp Neurol,333(3):375-397.
Kang S.S., Kim S.R., Leonhardt S., Wuttke. J.2000. Effect of interleukin-1βon gonadotropin- releasing hormone (GnRH) and GnRH receptor gene expression in castrated male rats. J Neuroendocrinol, 12(5):421–429.
Kevin D.1998. Bunting, Mark Y. Sangster, James N. Ihle & Brian P. Sorrentino. Resto ration of Lymphocyte function in Janus kinase deficient mice by retroviral-mediated gene transfer .Nature, 4(1):58-64.
Kiefer R., Kreutzberg G. W. 1990.Gamma interferon-like immunoreactivity in the rat nervous system.Neurosci,37(3):725-734.
Kikuchi T., Akasaki Y., Joki T., Abe T., Kurimoto M., Ohno T.2000. Antitumor activity of interleukin-18 on mouse glioma cells. Immunother,23(2):184-189.
Kim D. H.,Zhao X.,R.,Tu C. H., Casaccia-Bonnefil P.,Chao M.V.2004.Prevention of apoptotic but not necrotic cell death following neuronal injury by neurotrophins signaling through the tyrosine kinase receptor.Journal of Neurosurgery,100(1):79-87.
King A, Birkby L, Loke YW.1989. Early human decidual cells exhibit NK activity against the K562 cell line but not against first trimester trophoblast. Cellular Immunology,118(7):337-344.
King A., Boocock C., Sharkey A.M., Gardner L., Beretta A., Siccardi A.G., Loke Y.W.1996. Evidence for the expression of HLA-C class I mRNA and protein by human first trimester trophoblast. The Journal of Immunology, 156(6):2068-2076.
Kohka H., Yoshino T., Iwagaki H., Sakuma I., Tanimoto T., Matsuo Y., Kurimoto M., Orita K., Akagi T., Tanaka N.1998.Interleukin-18/Interferon-gamma-ingucing factor,a novel cytokine,up-regulates ICAM-1(CD54)expression in KG-1 cells.J Leukoc Biol,64(6):519-527.
Kohno K., Kataoka J., Ohtsuki T., Suemoto Y., Okamoto I., Usui M., Ikeda M and M Kurimoto. 1997.IFN-gamma-inducing factor (IGIF) is a costimulatory factor on the activation of Th1 but not Th2 cells and exerts its effect independently of IL-12.The Journal of Immunology, 158(4): 1541-1550.
Kovats S., Main E.K., Librach C., Stubblebine M., Fisher S.J., DeMars R.D.1990. A class I antigen HLA-G, expressed in human trophoblasts. Science,248(4952):220-223.
Krishnan L., Guibert L.J., Wegmann T.G., Belosevic M., Mosmann T.R.1996.Thelper 1 response against leishmnia major in pregnant C57BL/6 mice increases implantation failure and fetal resorptions Correlation with increased IFN-gamma and TNF and reduced IL-10 production by placental cells.The Journal of Immunology,156(2): 653-662.
Lackey B.R., Gray S.L., Henricks D.M. 1999.The insulin-like growth factor (IGF) system and gonadotropin regulation: actions and interactions. Cytokine Growth Factor Rev,10(3-4):201-217.
Laskarin G., Strbo N., Bogovic Crncic T., Juretic K., Ledee Bataille N., Chaouat G., Rukavina D. 2005.Physiological role of IL-15 and IL-18 at the maternal-fetal interface. Immunology of Pregnancy ,Chem Immunoogyl Allergy, 89:10- 25.
Lanier LL, Phillips JH.1996. Inhibitory MHC class I receptors on NK cells and T cells. Immunology Today, 17(2):86-91.
Lédée-Bataille N.,Dubanchet S., Lombroso R., Ville Y., Chaouat G. 2006.Downregulation of human endometrial IL-18 by exogenous ovarian steroids.Am J Reprod Immunol. 56(2):119-123.
Lédée-Bataille N., Olivennes F., Kadoch J., Dubanchet S., Frydman N., Chaouat G.,Frydman R. 2004.Detectable levels of interleukin-18 in uterine luminal secretions at oocyte retrieval predict failure of the embryo transfer. Hum Reprod, 19(9):1968-1973.
Leng J., Yao H., Shen J.2008.Co-expression of IL-18 binding protein and IL-4 regulates Th1?Th2 cylokine response in murine collagen-induced arthritis.Acta Biochim Biophys Sin,40(2):116-124.
Liu J.P., Baker J., Perkins A.S., Robertson E.J., Efstratiadis A. 1993.Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r).Cell,75(1):59-72.
Liu Z., Chen Y., Yang Y., Peng J.P. 2002.The effeet on MHC classⅡexpression and apoptosis in placenta by IFN- administration.Annu Rev Immunol,65(2):177-184.
Lin H., Mosmann T.R., Guilbert L., Tuntipopipat S., Wegmann T.G. 1993.Synthesis of T helper 2-type cytokines at the maternal-fetal interface.The Journal of Immunology, 151(9): 4562-4573.
Lopez M.F., Dikkes P., Zurakowski D., Villa-Komaroff L., Majzoub J.A.1999. Regulation of hepatic 113glycogen in the insulin-like growth factor II-deficient mouse.Endocrinology, 140(3):1442-1448.
Luo Q., Ning W., Wu Y., Zhu X.,Jin F.,Sheng J.,Huang H.2006.Altered expression of interleukin-18 in the ectopic and eutopic endometrium of women with endometriosis. Journal of Reproductive Immunology,72 (1-2):108-117.
Makarevich A .V., Sirotki N. 1997.The involvement of the GH / IGF-Ⅰaxis in the regulation on of secret ory activity by bovine oviduct ep ithelial cells . Anim Reprod Sci,48(2-4):197-207.
Marzi M., Vigano A., Trabattoni D., Villa M.L.,Salvaggio A.,Clerici E.,Clerici M.1996. Characterization of Type 1 and Type 2 cytokine production profile in physiologic and pathologic human pregnancy. Clinical & Experimental Immunology , 106(1):127-133.
Matsui K., Yoshimoto T., Tsutsui H., Hyodo Y., Hayashi N., Hiroishi K., Kawada N., Okamura H., Nakanishi K., Higashino K.1997. Propionibacterium acnes treatment diminishes CD~(4+) NK1.1~+ T cells but induces type I T cells in the liver by induction of IL-12 and IL-18 production from Kupffer cells. Immunology, 159(1):97-106.
Matsumoto S., Tsuji-Takayama K., Aizawa Y., Koide K., Takeuchi M., Ohta T., Kurimoto M.1997. Interleukin-18 activates NF-kappaB in murine T helper type 1 cells.Biochem Biophys Res Commun, 234(2):454-457.
Mattsson R., Mattsson A.,Holmdahl R. Scheynius A., Van der Meide P.H. 1992.In vivo treatment with interferon-gamma during early pregnancy in mice induces strong expression of major histocompatibility complex classⅠandⅡmolecules in uterus and decidua but not in extra-embryonic tissues. Bio Reprod, 46(6):1176-1186.
Mansouri R., Akbari F., Vodjgani M., Mahboudi F., Kalantar F., Mirahmadian M .2007.Serum cytokines profiles in Iranian patients with preeclampsia. Iran J Immunol. 4(3):179-185.
Micallef M.J., Ohtsuki T., Kohno K., Tanabe F., Ushio S., Namba M., Tanimoto T., Torigoe K., Fujii M., Ikeda M., Fukuda S., Kurimoto M.1996. Interferon-gamma-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin-12 for interferon-gamma production.Immunology, 26(7):1647-1651.
Micallef M.J., Yoshida K., Kawai S., Hanaya T., Kohno K., Arai S., Tanimoto T., Torigoe K., Fujii M., Ikeda M., Kurimoto M. 1997.In vivo antitumor effects of murine interferon-gamma-inducing factor/interleukin-18 in mice bearing syngeneic Meth A sarcoma malignant ascites. Cancer Immunol Immunother, 43(6):361-367.
Moreira F., Paula-Lopes F.F., Hansen P.J., Badinga L., Thatcher W.W.2002.Effects of growth hor mone and insulin-like growth fact or-Ion de-velopment of in vitro derived bovine embryos. Theriogenology,57(2):895–907.
Murakami Y., Otsuki M., Kusumoto K., Takeuchi S., Takahashi S.2005. Estrogen inhibits interleukin-18 mRNA expression in the mouse uterus.J Reprod Dev, 51(5):639-647.
Naeimi S, Ghiam A. F., Mojtahedi Z.,Dehaghani A.S.,Amani D.,Ghaderi A.2006. Interleukin-18 gene promoter polymorphisms and recurrent spontaneous abortion[J]. Eur J Obstet Gynecol Reprod Biol, 128(1-2): 5- 9.
Nagai Y., Nochi T., Watanabe K., Watanabe K., Aso H., Kitazawa H., Matsuzaki M., Ohwada S., Yamaguchi T. 2005.Localization of interleukin-18 and its receptor in somatotrophs of the bovine anterior pituitary gland.Cell Tissue Res, 322(3):455- 462.
Nagai Y., Watanabe K., Aso H., Ohwada S., Muneta Y., Yamaguchi T. 2006.Cellular localization of IL-18 and IL-18 receptor in pig anterior pituitary gland.Domest Anim Endocrinol, 30(2):144-154.
Naumnik W., Chyczewska E., Kovalchuk O., Ta?a?aj J., Izycki T., Panek B. 2004.Serum levels of interleukin-18 (IL-18) and soluble interleukin-2 receptor (sIL-2R) in lung cancer. Rocz Akad Med Bialymst, 49:246 -251.
Numan S., Russell D.S. 1999.Discrete expression of insulin re-ceptor substrate-4 mRNA in adult rat brain. Brain Res MolBrain Res72 (1) : 97-102 .
Okamura H., Nagata K., Komatsu T., Tanimoto T., Nukata Y., Tanabe F., Akita K., Torigoe K., Okura T., Fukuda S. 1995.A novel costimulatory factor for gamma interferon induction found in the livers of mice causes endotoxic shock..Infect Immun,63(11):3966-3972.
Okamura H., Tsutsi H., Komatsu T., Yutsudo M., Hakura A., Tanimoto T., Torigoe K., Okura T., Nukada Y., Hattori K.1995. Cloning of a new cytokine that induces IFN-gamma production by T cells.Nature,378(6552):88-91.
Okano F., Yamada K. 2000.Canine interleukin-18 induced apop tosis and enhances Fas ligand mRNA exp ression in a canine carcinoma cell line. Anticancer Res, 20: 3411-3416.
Ostoji(?) S., Volk M., Medica I.,Kapovi? M.,Meden-Vrtovec H.,Peterlin B.2007.Polymorphisms in the interleukin-12/18 genes and recurrent spontaneous abortion. American Journal of Reproductive Immunology. 58(5):403-408.
O’Shea J.J.1997. Cytokine signal transduction and immunoregulation are we there yet?.Jmunity,7:1-11. Park C.C., Morel J.C., Amin M.A., Connors M.A., Harlow LA, Koch A.E. 2001.Evidence of IL-18 as a novel angiogenic mediator. J Immunology,167(3):1644-1653.
Park J.,Liu A.Y.2001.JNK phosphorylates the HSF1 transcriptional activation domain: role of JNK in the regulation of the heat shock response.J Cell Biochem,82(2):326-338.
Pazos F., SanchezZ-Franco F., Balsa J., Escalada J.,Cacicedo L.2004.Differential regulation of gonadotrop ins and glycop rotein hormone alpha2subunit by IGF-1 in anterior p ituitary cells from male rats[J].J Endocrinol Invest,27(7):670-675.
Petersen A.M., Penkowa M., Lversen M., Frydelund-Larsen L.,Andersen J.,Mortensen J.,Lange P.,Pedersen B.K.2007.Elevated levels of IL-18 in plasma and skeletal muscle in chronic obstructive pulmonary disease.Lung,185(3):161-171.
Piccinni M.P., Maggi E., Romagnani S.2000.Role of hormone-controlled T-cell cytokines in the maintenance of pregency. Biochemical Society Transactions, 28(2): 212-215.
Rabinovitch A. ,Suarez-pinzon W.L .,Strynadka K.,Lakey J.R.,Rajotte R.V.1996.Human pancreatic islet βcell destruction by cytokines involves oxygen free radi-cals and Aldehyde production.J Clin Endocrinol Metab, 81(9):3197 - 3202.
Raghupathy R. 1997.Th1-type immunity is incompatible with sucessful pregency. Immunol Today, 18(10):78-82.
Reddy P. 2004.Interleukin-18: recent advances.Curr Opin Hematol, 11(6):405-410.
Reece E.A.,Wiznitzer A.,Le E. Homko C.J., Behrman H.,Spencer E.M.1994.The relation between human fetal growth and fetal blood levels of insulinlike growth factorⅠandⅡ,their binding proteins,and receptors. Obstet Gynecol,84(1):88-95.
Rehfeldt C., Nissen P.M., Kuhn G., Vestergaard M., Ender K., Oksbjerg N.2004. Effects of maternalnutrition and porcine growth hormone (pGH) treatment during gestation on endocrine and metabolic factors in sows, fetuses and pigs, skeletal muscle development, and postnatal growth.Domest Anim Endocrinol,27(3):267-285.
Reid G.J., Flozak A.S., Simmons R.A.2002.Placental expression of insulin-like growth factor receptor-1 and insulin receptor in the growth-restricted fetal rat .J Soc Gynecol Investig.9(4):210-214.
Renhai C., Farnebo J., Kurimoto M., Cao Y .1999. Interleukin-18 acts as an angiogenesis and tumor suppressor. FASEB J, 13(15):2195-2202.
Richardson H.N,.Parfitt D.B.,Thomp son R.C., Thompson R.C.,Sisk C.L.2002. Redefining gonadotrop in-releasing hormone (GnRH) cell groups in the male Syrian hamster testosterone regulates GnRH mRNA in the tenia tecta.. Neuroendocrinol,14(5):375-383.
Rothe H., Jenkins N.A., Copeland N.G., Kolb H.1997.Active stage of autoimmune diabetes is associated with the expression of a novel cytokine, IGIF, which is located near Idd2.Clin Invest,99(3):469-474.
Roy R.N., Gerulath A.H., Cecutti A., Bhavnani B.R. 2000.Effect of tamoxifen treatment on the endometrial expression of human insulin-like growth factors and their receptor mRNAs. Mol Cell Endocrinol. 165(1-2):173-178.
Richards R.G., Klotz D.M., Walker M.P., DiAugustine R.P.2004. Mammary gland branchingmorphogenesis is diminished in mice with a deficiency of insulin-like gr owth factor-I ( IGF-I) , but not in mice with a liver-specific deleti on of IGF-I. Endocrinology, 145(7) : 31062-3110.
Sakai M., Shiozaki A., Sasaki Y., Yoneda S., Saito S. 2004.The ratio of interleukin (IL)-18 to IL-12 secreted by peripheral blood mononuclear cells is increased in normal pregnant subjects and decreased in pre-eclamptic patients. J Reprod Immunol.,61(2):133-143.
Sarkar N.N. 2002.The potential of mifepristone (RU486) as a female contraceptive drug. Int J Clin Pract ,56 (2) :140-144.
Schams D., Berisha B., Kosmann M., Amselgruber W.M.2002. Expression and localization of IGF familymembers in bovine antral follicles during final growth and in luteal tissue during different stages of estrous cycle and pregnancy . Domest Anim Endocrinol,22(1):51-72.
Schneider E., Tonanny M.B., Lisbonne M., Leite-de-Moraes M., Dy M. 2004.Pro-Th1 cytokines promote Fas-dependent apoptosis of immature peripheral basophils. J Immunology,172(9):5262–5268.
Silha J.V.,Mushy L.J.2005.Insulin-like Growth Factor Binding Proteins in Development .Advances in Experimental Medicine and Biology, 567:55-89.
Simmen F.A.,Simmen R.C.,Geisen R.D., Martinat-Botte F. , Bazer F.W., and Terqui M .1992..Differential expression during the estrous cycle and pre- and postimplantation conceptus devclopment of messenger ribonueeic acids encofing compoents of the pig ulerine insulin-like growrh factor system..Endocrinology,130:1547-1556.
Singer I.I., Scott S., Chin J., Bayn E.K., Limjuco G., Weidner J., Miller D.K., Chapman K., Kostura M.J. 1995.The interleukin-1β-co-nverting enzyme(ICE) is localized on the external cell surface membranes and in the cytoplasmic ground substrance of human monocytes by immuno-electron microscopy. Exp Med,182(4):1 447-1459.
Shin H.D., Kim L.H., Park B.L., Choi Y.H., Park H.S., Hong S.J., Choi B.W., Lee J.H., Park C.S. 2005.Association of interleukin 18 (IL18) polymorphisms with specific IgE levels to mite allergensamong asthmatic patients. Allergy. 60(7):900-906.
Shu U., Kiniwa M., Wu C.Y., Maliszewski C., Vezzio N., Hakimi J., Gately M., Delespesse G. 1995.Activated T cells induce interleukin-12 production by monocytes via CD40-CD40 ligand interaction.Eur J Immunol,25(5):1125-1128.
Skaper S.D.2007.The brain as a target for inflammatory processes and nearo- protective strategies.Ann NY Acad Sci,1122:23-34.
Soderstrom K., Corliss B., Lanier L.L., Phillips J.H.1997.CD94/NKG2 is the predeminal inhibitory receptor involved in recognition of HLA-G by decidual and peripheral blood NK cells. The Journal of Immunology,159(3):1072-1075.
Spicer L.J., Santiago C.A., Davidson T.R., Bridges T.S., Chamberlain C.S.2005. Follicular fluid concentrations of free insulin-like growth factor (IGF)-I during follicular development in mares. Domest Anim Endocrinol, 29(4):573-581.
Stewart C.E., Rotwein P. 1996.Growth, differentiation, and survival: multiple physiological functions for insulin-like growth factors . Physiol Rev,76(4):1005-1026.
Stoll S., Miiller G.,Kurimoto M.1997. Production of IL-18 (IFN-γ-inducing factor) mRNA and functional protein by murine kerationcyter.J Immunol,159(1):298.
Sugama S., Cho B.P., Baker H., Joh T.H., Lucero J., Conti B. 2002.Neurons of the superior nucleus of the medial habenula and ependymal cells express IL-18 in rat CNS. Brain Res, 958(1):1–9.
Sugama S., Fujita M., Hashimoto M., Conti B.2007. Stress induced morphological microglial activation in the rodent brain: involvement of interleukin-18. Neuroscience , 146(3): 1388-1399.
Sugama S., Wang N., Shimokawa N., Koibuchi N., Fujita M., Hashimoto M., Dhabhar F.S., Conti B. 2006.The adrenal gland is a source of stress-induced circulating IL-18.Journal of Neuroimmunology, 172(1-2):59– 65.
Suk K.,Kim S. ,KIM Y.H ., Kim K.A., Chang I., Yagita H., Shong M., Lee M.S.2001.
IFN - gamma/ TNF - alpha syn-ergism as the final effector in autoimmue diabetes : a key role forSTAT1/ IFN ragulatory factory factor-1 pathway in pancreatic beta cell death. J Immunol, 166 (7) :4481 - 4489.
Sun Q.H, Peng J.G., Xia H.F., Yang Y.,Liu M.L.,2005.Effect on expression of RT1-A and RT1-DM molecules of treatment with interferon-γat the maternal-fetal interface of pregnant rats[J]. Hum Reprod, 20(9): 39-47.
Takeda K., Tsutsui H., Yoshimoto T., Adachi O., Yoshida N., Kishimoto T., Okamura H., Nakanishi K., Akira S.1998. Defective NK cell activity and Th1 response in IL-18-deficient mice. Immunity, 8(3):383-390.
Takeuchi M., Nishizaki Y., Sano O., Ohta T., Ikeda M., Kurimoto M. 1997.Immunohistochemical and immuno-electron-microscopic detection of interferon-gamma-inducing factor ("interleukin-18") in mouse intestinal epithelial cells.Cell Tissue Res,289(3):499-503.
Taniguchi M., Nagaoka K., Kunikata T., Kayano T., Yamauchi H., Nakamura S., Ikeda M., Orita K., Kurimoto M.1997. Characterization of anti human interleukin- 18(IL-18)/interferon-gamma inducing factor(IGIF) monoclonal antibodies and their application in the measurement of human IL-18 by ELISA. Immonology Methods,206 (1-2):107-113.
Thomas H.E. ,Darwiche K.,Corbett J.A. , Kay T.W. 2002.Interleukin-1 plusγ- interferon inducedpancreaticβcell dysfunction is mediate byβcell nitric oxide production. Diabetes ,2002,51(2):311-316.
Tokmadzi? V.S., Tsuji Y., Bogovi? T., Laskarin G., Cupurdija K., Strbo N., Koyama K., Okamura H., Podack E.R., Rukavina D. 2002.IL-18 is present at the maternal-fetal interface and enhances cytotoxic activity of decidual lymphocytes.Am J Reprod Immunol,48(4): 191- 200.
Tomura M., Zhou XY., Maruo S., Ahn H.J., Hamaoka T., Okamura H., Nakanishi K., Tanimoto T., Kurimoto M., Fujiwara H. 1998.A Critical Role for IL-18 in the Proliferation and Activation of NK1.1+CD_3- Cells.Immunology,160(10):4738- 4736.
Torres-Aleman I., Pons S., Arévalo M.A. 1994.The insulin-like growth factor 1 system in the rat cerebellum: developmental regulation and role in neuronal survival and differentiation . Neurosci Res,39(2):117-126.
Tsuji Y., Tamaoki T.H., Hasegawa A., Kashiwamura S., Iemoto A., Ueda H., Muranaka J., Adachi S., Furuyama J., Okamura H., Koyama K.2001. Expression of interleukin-18 and its receptor in mouse ovary. Am J Reprod Immunology, 46(5):349-357.
Tsutsui H., Nakanishi K., Matsui K., Higashino K., Okamura H , Miyazawa Y., Kaneda K. 1996.IFN-gamma-inducing factor up-regulates Fas ligand-mediated cytotoxic activity of murine natural killer cell clones.Immunology,157(8):3967-3973.
Udagawa N., Horwood N.J., Elliott J., Mackay A., Owens J., Okamura H., Kurimoto M., Chambers T.J., Martin T.J., Gillespie M.T. 1997.Interleukin-18 (interferon-gamma-inducing factor) is produced by osteoblasts and acts via granulocyte/macrophage colony-stimulating factor and not via interferon-gamma to inhibit osteoclast formation. Exp Med, 185(4):1005-1012.
Ushio S., Namba M., Okura T., Hattori K., Nukada Y., Akita K., Tanabe F., Konishi K., Micallef M., Fujii M., Torigoe K., Tanimoto T., Fukuda S., Ikeda M., Okamura H., Kurimoto M. 1996.Cloning of the cDNA for human IFN-γ-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein. Immunology,156(11):4274–4279.
Vabulas,R.M.,Ahmad-Nejad P.,Dacosta T.,Kirschning C.J.,Hacker H.,Wagner H.2001.Endocytosed hsp60s use toll-like receptor2(tlr2)and tlr4 to activate the toll/interleukin-1 receptor-signaling pathway in innate immune cells. J Biol Chem,276(33): 31332-31339.
Vatten L.J.,Qdegard R.A.,Nilsen S.T.,Salvesen K.A.,Austgulen R.2002. Relationship of insulin-like growth factor-1and insulin-like growth binding proteins in umbilical cord plasma to preeclampsia and infant birth weight.Obstet Gynecol,99(1):85-90.
Verhaghe J., Bree R.V., Herck E.V., Laureys J., Bouillon R., Van Assche F.A.1993.C-Peptide ,insulin like growth factors 1 andⅡ,and insulin-like growth factor binding protein- l in umbilical cord serum correlations with birth weight.Am J Obster Gynecol,168(1):89-97.
Vidal-Vanaclocha F., Fantuzzi G., Mendoza L., Fuentes A.M., Anasagasti M.J., Martín J., Carrascal T., Walsh P, Reznikov L.L., Kim S.H., Novick D., Rubinstein M., Dinarello C.A.2000.IL-18 regulates IL-1beta-dependent hepatic melanoma metastsis via vascular cell adhension molecule-1.Proc Natl Acad Sci USA,97(2):734-739.
Voge J.L.,Aad P.Y., Santiago C.A., Goad D.W.,Malayer J.R.,Allen D.,Spicer L.J.2004. Effect of insulin-like growth factors , FSH, and leptin on IGF-binding-protein mRNA expression in bovine granulosa and theca cells:quantitative detection by real-time PCR.Pep tides,25(12):2195-2203.
Voss S.D., Daley J., Ritz J., Robertson M.J.1998. Participation of the CD94 receptor complex incostimulation of human natural killer cells. The Journal of Immunology,160: 1618-1626.
Wang N., Sugama S., Conti B., Teramoto A., Shibasaki T. 2006.Interleukin-18 mRNA expression in the rat pituitary gland.Neuroimmunol ,173(1-2):117-125.
Wang X., Hagberg H., Mallard C., Zhu C., Hedtj(?)rn M., Tiger C.F., Eriksson K., Rosen A., Jacobsson B. 2006.Disruption of interleukin-18, but not interleukin-1, increases vulnerability to preterm delivery and fetal mortality after intrauterine inflammation.Am J Pathol. 169(3):967-976.
Wilson R., Jenkins C., Miller H., Mclnnes L.B.,Moore J.,Mclean M.J.,James J.,Walker J.2004. Abnormal cytokine levels in nonp regnant women with a history of recurrent miscarriage. European Journal Obstetrics Gynecology Reproductive Biology, 115(1):51-54.
Wilson R., Moor J., Jenkins C., Miller H.,Walker J.J.,Mclean M.A.,Norman J.,Mclnnes I.B.2004. Abnormal first trimester serum interleukin 18 levels are associated with a poor outcome in women with a history of recurrent miscarriage. American Journal of Reproductive Immunology , 51(2):156-159.
Xia H.F.,Sun Q.H.,Peng J.P.2007.Effect of interferon-gamma treatment on the expression of interleukin-1beta at the maternal-fetal interface of pregnant rats. Reprod Fertil,19(3):510-519.
Xie X., He H., Colonna M., Seya T., Takai T., Croy B.A.2005. Pathways participating in activation of mouse uterine natural killer cells during pregnancy. Biol Reprod,73(3):510-518.
Xu D., Chan W.L., Leung B.P., Hunter D., Schulz K., Carter R.W., McInnes I.B., Robinson J.H., Liew F.Y.1998. Selective expression and functions of interleukin 18 receptor T helper (Th ) type 1 but not Th2 cells.Exp Med,188(8):1485-1492.
Yamaguchi M., Koike K., Yoshimoto Y., Matsuzaki N., Miyake A., Tanizawa O.1991. Interleukin-6 stimulates gonadotropin- releasing hormone secretion from rat hypothalamic cells. Horm Res,35:252–256.
Yoshimoto T., Okamura H., Tagawa Y.I., Iwakura Y., Nakanishi K. 1997.Interleukin -18 together with interleukin -12 inhibits IgE production by induction of interferon-gamma production from activated B cells. Proc Natl Acad Sci U S A, 94(8):3948-3953.
Yoshimoto T. ,Nakanishi K.2006. Roles of IL-18 in basophils and mast cells .Allergol Int, 55(2):105-13. Yuan X.J., Dixon-McCarthy B, Kunz H.W., Gill T.J.1994. Role of methylation in placental major histocompatibility complex antigen expression and fetal loss. Bio Reprod, 1994, 51(5): 31-42.
Zhang Y.F., Yang Y.S., Hong J., Gu W.Q.,Shen C.F.,Xu M.,Du P.F.,Li X.Y.,Ning G.2006. Elevated serum levels of interleukin-18 are associated with insulin resistance in women with polycystic ovary syndrome. Endocrine, 29(3):419-423.
Zygmunt M., Herr F., Münstedt K., Lang U., Liang O. D. 2003.Angiogenesis and vasculogenesis in pregnancy.European Journal Obstertics & Gynecology Reproductive Biology,110 (l ):S10-S18.