中西药结合治疗肾阴虚型经期延长的临床观察
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摘要
目的：观察左归饮加减联合安宫黄体酮治疗组与黄体酮对照组治疗肾阴虚型经期延长各30例的临床疗效,探讨左归饮加减治疗经期延长的临床疗效。
方法：根据入选标准、排除标准,选择病人60例,随机分为治疗组和对照组各30例。治疗组：左归饮加减,基本组成组成为熟地、山茱萸、山药、枸杞子、茯苓、炙甘草等水煎服,100m1日两次口服,每日1剂,于月经净后14天开始服,连服14天后停药。同时加服安宫黄体酮10mg,每天1次,连服10天。对照组：安宫黄体酮10mg,每天1次,于月经净后14天始服,连服10天后停药。以上两组治疗3个月经周期后停药,服药前后记录患者的症状改善情况,疗程结束后,继续对患者者进行3个月观察,观察各组患者病情有无进一步减轻、复发或加重,行疗效评定
结果：治疗组总有效率93.3%,治愈率33.3%,对照组总有效率70.0%,治愈率16.7%,经统计学处理两组总有效率有显著性差异(P<0.05)；用药3个月后,两组治疗前后组内症状积分与治疗后组间积分比较均有显著性差异(P均<0.05),说明两组均能明显改善相关症状,两组间无显著性差异(P>0.05),但治疗组在改善腰膝酸软、五心烦热、头晕耳鸣方面优于对照组(P均<0.05)；用药3个月后两组的BBT均出现显著性差异(P<0.01),呈高温相下降明显趋势,但两组间无显著性差异(P>0.05)；用药3个月后两组孕激素水平在治疗前后有明显差异(P<0.05),两组间无显著性差异(P>0.05)。用药6个月后,治疗组主要症状和体征均有改善(P均<0.05),且治疗组远期疗效(在经行时间、经质、腰膝酸软、BBT改善等方面)明显优于对照组(P<0.05)。
结论：左归饮加减治疗肾阴虚型经期延长具有显著疗效,且能明显改善BBT的形态与孕激素的水平,具有明显的远期疗效。
Objective:Observation on the clinical effect of ZGD combined with Medroxyprogesterone by curing Menostaxis of kidney yin deficiency pattern in 30 cases, compared with the treatment effect of Medroxyprogesterone group in 30 cases as control group. In order to discuss the treatment on Menostaxis by ZGD.
Methods:According to diagnosetic criteria,this observation divides 60 patients into two groups randomly.The treatment group:taking ZGD orally twice a day 14 days after the period, at the same time taking Medroxyprogesterone 10mg once a day.On the other hand,the control group only take Medroxyprogesterone.Recording the symptoms before and after three months'treatment,observing in the following 3 months without using any medicine,then recording the symptoms of the two groups.
Results:Recovery of the treatment group is 33.3%, the total effective is 93.3%, the recovery of control group is 16.7%, the total effective is 70.0%,by means of statistical analysis, there is remarkable difference between these two groups on the clinical effect(P<0.05), it states that the treatment group has better long-term effect on regulating the menstrual cycle. After three months' treatment, there are very significant differences between the total scores of sym-ptoms before and after the treatment of the two groups(P<0.05),showing that the two groups can obviously improve the symptoms. On the other hand, the treatment group is better than the control group at improving soreness and weakness of waist and knees, vexing heat in the chest, palms and soles, dizziness and tinnitus (P<0.05).At the same time, it appears that there is very evident differences before and after the treatment of the two groups(P<0.01) in the change of BBT. But there is no difference between the two groups(>0.05). So does the P. After six months' treatment, the treatment group has much more improvements in the main symptoms and signs than the control group(P<0.05). And it does have better long-term effect on many symptoms such as dizziness, tinnitus and so on than the control group.
Conclusions:The observation tells us that ZGD performs an efficient function in curing menostaxis of kidney yin deficiency pattern and improving the shape of BBT and the content of P, it also has an apparent long-term therapy.
方法：根据入选标准、排除标准,选择病人60例,随机分为治疗组和对照组各30例。治疗组：左归饮加减,基本组成组成为熟地、山茱萸、山药、枸杞子、茯苓、炙甘草等水煎服,100m1日两次口服,每日1剂,于月经净后14天开始服,连服14天后停药。同时加服安宫黄体酮10mg,每天1次,连服10天。对照组：安宫黄体酮10mg,每天1次,于月经净后14天始服,连服10天后停药。以上两组治疗3个月经周期后停药,服药前后记录患者的症状改善情况,疗程结束后,继续对患者者进行3个月观察,观察各组患者病情有无进一步减轻、复发或加重,行疗效评定
结果：治疗组总有效率93.3%,治愈率33.3%,对照组总有效率70.0%,治愈率16.7%,经统计学处理两组总有效率有显著性差异(P<0.05)；用药3个月后,两组治疗前后组内症状积分与治疗后组间积分比较均有显著性差异(P均<0.05),说明两组均能明显改善相关症状,两组间无显著性差异(P>0.05),但治疗组在改善腰膝酸软、五心烦热、头晕耳鸣方面优于对照组(P均<0.05)；用药3个月后两组的BBT均出现显著性差异(P<0.01),呈高温相下降明显趋势,但两组间无显著性差异(P>0.05)；用药3个月后两组孕激素水平在治疗前后有明显差异(P<0.05),两组间无显著性差异(P>0.05)。用药6个月后,治疗组主要症状和体征均有改善(P均<0.05),且治疗组远期疗效(在经行时间、经质、腰膝酸软、BBT改善等方面)明显优于对照组(P<0.05)。
结论：左归饮加减治疗肾阴虚型经期延长具有显著疗效,且能明显改善BBT的形态与孕激素的水平,具有明显的远期疗效。
Objective:Observation on the clinical effect of ZGD combined with Medroxyprogesterone by curing Menostaxis of kidney yin deficiency pattern in 30 cases, compared with the treatment effect of Medroxyprogesterone group in 30 cases as control group. In order to discuss the treatment on Menostaxis by ZGD.
Methods:According to diagnosetic criteria,this observation divides 60 patients into two groups randomly.The treatment group:taking ZGD orally twice a day 14 days after the period, at the same time taking Medroxyprogesterone 10mg once a day.On the other hand,the control group only take Medroxyprogesterone.Recording the symptoms before and after three months'treatment,observing in the following 3 months without using any medicine,then recording the symptoms of the two groups.
Results:Recovery of the treatment group is 33.3%, the total effective is 93.3%, the recovery of control group is 16.7%, the total effective is 70.0%,by means of statistical analysis, there is remarkable difference between these two groups on the clinical effect(P<0.05), it states that the treatment group has better long-term effect on regulating the menstrual cycle. After three months' treatment, there are very significant differences between the total scores of sym-ptoms before and after the treatment of the two groups(P<0.05),showing that the two groups can obviously improve the symptoms. On the other hand, the treatment group is better than the control group at improving soreness and weakness of waist and knees, vexing heat in the chest, palms and soles, dizziness and tinnitus (P<0.05).At the same time, it appears that there is very evident differences before and after the treatment of the two groups(P<0.01) in the change of BBT. But there is no difference between the two groups(>0.05). So does the P. After six months' treatment, the treatment group has much more improvements in the main symptoms and signs than the control group(P<0.05). And it does have better long-term effect on many symptoms such as dizziness, tinnitus and so on than the control group.
Conclusions:The observation tells us that ZGD performs an efficient function in curing menostaxis of kidney yin deficiency pattern and improving the shape of BBT and the content of P, it also has an apparent long-term therapy.
引文
1.卢苏.夏桂成治疗经期延长经验.湖北中医杂志,2001,23(12)：12.
2.刘敏如,谭万信.中医妇产科学.人民卫生出版社,2001,283-285.
3.罗元恺.实用中医妇科学,上海：上海科学技术出版社,1994,第1版：68-71.
4.冯蓓.逐瘀止血汤加减治疗经期延长35例.四川中医,2006,24(3)：77.
5.张慧英.化瘀汤治疗瘀阻胞宫型经期延长51例.新中医,2000,32(2)：49.
6.赵鹏.丹栀逍遥散加减治疗经期延长90例. 云南中医中药杂志,2004,25(6)：54.
7.赖亚萍,都匀.清经止带胶囊治疗湿热瘀阻型经期延长80例.河北中医,2001,23(10)：756.
8.夏桂成.月经周期与调周法(续1).南京中医药大学学报,1998,14(4)：203.
9.刘小虹,周嘉洲.益气补肾汤治疗经期延长45例.河北中医,2001,23(11)：828.
10.张金辉.补肾固精法治疗经期延长94例.河南中医,2006,26(9)：42.
11.冯绮,徐涟.徐涟主任应用逍遥散治疗经期延长经验.云南中医中药杂志,2009,30(10)：1.
12.李文艳.完带汤治疗经期延长56例.四川中医,2001,19(3)：55.
13.吴丕中.二丹饮治疗月经延长60例.四川中医,1998,16(1)：50.
14.陈林兴等.经期延长的诊治特色.云南中医杂志,1999,20(4)：1.
15.陈林兴,苗晓玲等.经期延长的诊治特色.云南中医中药杂志,1999,20(4)：1-2.
16.夏桂成.运用易学思想探讨行经期变化及其调治.江苏中医,1997,18(9)：5.
17.朱可芳.潘佛岩治疗经期延长的经验.中国农村医学,1996,24(4)：58.
18.魏凤琴.张珍玉教授治疗经期延长特色摭拾.中医药学刊,2003,21(1)：21.
19.陈玩祯.曲安缩松存在非内膜增厚的经期延长的副作用的初步认识.中 国超声诊断杂志,2000,1(2)：125.
20.胡卫.基础体温变化与中医辨证论治的关系及临床应用举隅.长江大学学报(自然科学版),2009,6(4)：169.
21.王惠珍.试探基础体温变化与中医辨证关系.光明中医,2001,16(97)：12-13.
22.田炳照.基础体温在经期延长中的临床应用.基层医学论坛,2003,7(6)：576.
23.马宝璋.中医妇科学.第一版.北京：中国中医药出版社.2004：89-90.
24.吴玫.功能失调性子宫出血的分型证治.山东中医杂志,2001：20(9)：566.
25.李大剑.经验方桃红二丹四物汤临症举隅.安徽中医临床杂志,1998,10(5)：303-304.
26.姚金炬,陈凤英.四物汤加味治疗经期延长36例.长春中医学院学报1997,13(62)：35-36.
27.高于英.四逆安宫汤治疗经期延长45例.云南中医中药杂志,2003,24(2)：24-25.
28.茹红梅,肖昌庆.基础体温在月经周期出血病中的应用.安徽中医临床杂志,1998, 10(3)：189.
29.马静,金季玲.二至丸合两地汤化裁治疗阴虚型经期延长46例体会.承德医学院学报,2007,24(4)：387.
30.王伟.自拟鹿含草汤治疗经期延长60例.中医药学刊,2006,24(6)：1181.
31.徐萍.鲜益母草胶囊治疗经期延长.浙江中西医结合杂志,2004,14(12)：772.
32.王强, 田红. 安冲汤加减治疗少女经期延长32例.陕西中医,2000,21(5)：220.
33.任青玲,夏桂成等.夏桂成生殖节律理论的医学思维模式探析.江苏中医药,2004,25(4)：4.
34.俞华,林俐.升提药治疗经期延长.浙江中医学院学报,2000,24(4)：30.
35.张莉,陈晓勇等.宫血宁胶囊治疗经期延长型青春期功血.实用临床医 学,2007,8(6)：111-112.
36.王淑媛.加减逍遥散治疗更年期经期延长49例.吉林中医药,2005,25(12)：32.
37.张红,王丹辉等.妇血安片治疗经期延长30例临床观察.长春中医药大学学报,2009,25(6)：901.
38.冯淑英,陈学煌等.复方甲基炔诺酮对Norplant皮埋后经期延长的治疗中国计划生育学杂志,1997,5(31)：298-300.
39.金建岳.自拟益气固经汤治疗经期延长65例分析.实用中医内科杂志,2006,20(1)：43-44.
40.李莉.清经凉血止血汤.广西中医药,2005,28(1)：44.
41.李艳芬.固冲止血汤治疗经期延长82例.陕西中医,2001,22(12)：746.
42.林春,冯金英等.加减保阴煎治疗阴虚血热型经期延长48例.新中医2003,35 (3)：45.
43.赵焕云,庞保珍.经延丹贴脐治疗经期延长118例. Journal of External Therapy of TCM,2004,13(1):44.
44.李秀梅.针灸耳压并用治疗黄体萎缩不全性功血54例.中国民间疗法,2009,17 (1) ：24.
45.朱文峰.中医诊断与鉴别诊断学.人民卫生出版社,1999,466.
46.乌毓明,范光升等.宫血宁在预防药物流产后出血的多中心临床效果观察.中国计划生育杂志,2002,10(1)：52-53.
47.赵振虎,李建勇等.皂苷提取物宫血宁缩宫作用与细胞外钙内流关系的研究.中国药物与临床,2005,5(6)：415-417.
48.付双慧.经血宁胶囊治疗月经过多、经期延长18例.广西中医药,2003,26(6)：22.
49.陆华,刘敏如等.养精汤促卵泡发育的临床观察.中国中西医结合杂志,1998, (4)：217-220.
50.苏玉萍,闫宏宇.经期延长的中医辨证分型与性激素的关系. 中医中药,2007,4(34)：61-62.
51.顾素娟,杜明昆等.WH086925Norplant上市后监测(中国部分).中国计划生育学杂志,1998,2(34)：55-58.
52.顾素娟,杜明昆等.Norplant皮下埋植剂法可接受性研究.中国计划生育学杂志,1992,1(1)：15-18.
53.李义居,马桂玲.酮康唑致月经过多经期延长1例.皮肤病与性病杂志,1998,20 (1) ：65.
54.乐杰.妇产科学.第七版.北京：人民卫生出版社,2008：307-308.
55.杜明昆.皮下埋植避孕法的不良反应及其防治.实用妇产科杂志,2008,24(3)：135.
56.郑筱萸.中药新药临床研究指导原则(试行).中国医药科技出版社2002：243,388-389.
57.余运初.关于针刺和中药促排卵机制的研究.中西医结合杂志,1985,(5)：201.
58.张炜,蔡德培.补肾中药对雌性青春期大鼠垂体GnRH受体mR-NA及其受体蛋白表达的影响.中国中西医结合杂志,2003,23(2)：120-123.
59. 蔡德培,张炜.补肾中药对下丘脑GnRH、垂体FSH、LH及成骨细胞基因表达的调节作用.中医杂志,2002,43(3)：221-223.
60.kawaguchi D, Fujii S, Konishi I, et al.Mitotic activity in uterine leiomyomas during the menstrual Cycle.Am I obstet Gynecol1989; 160: 637.
61. McEwen BS, Alves SE, Bulloch K, et al. Ovarian steroids and the brain:implications for cognition and aging. Neurology,1997, 48[5 Suppl 7]:S8-15.
62.林晓梅,张文智等.雌孕激素类药物对不孕妇女子宫内膜雌激素受体含量的影响. 中国计划生育学杂志,1996,3(23)：149-150.
63.石一复.基础体温测量的临床应用.中国医刊,2000,35(5)：6.
64.杜少雄,林丽云等.浅探基础体温变化与胞宫功能的关系.光明中医2009,24 (2) ：248.
65.夏桂成.基础体温在部分妇科疾病中的运用初探.中国医药学报,1991,6(5)：16-18.
66.田炳照.基础体温在正常月经性不孕的临床运用.基层医学论坛,2004,8(1)：89. 8(1)：89.
67.夏桂成.用基础体温观察补阳消症汤治疗子宫内膜异位性不孕症33例.新中医,1994(1)：41-42.
68.戴岳,杭秉茜等.山茱萸对炎症反应的抑制作用.中国中药杂志,1992,17(5)：307-309.
69.赵俊萍,高翠兰.山药的药理作用及临床应用.山西中医,2006,22(增刊)：84.
70.施仁潮.枸杞子.杭州：浙江科学技术出版社,2002：12-22.
72.王跃宏.识别生、炙甘草之功效.云南中医药杂志,1997,18(5)：47.
71.Gao Xuejun. The Pharmacological Research of FulingAnalyze and Its Beginnings Explore on Clinical Application[J]. ChineseMedicinal Herb,1985,16(4):40-44.
2.刘敏如,谭万信.中医妇产科学.人民卫生出版社,2001,283-285.
3.罗元恺.实用中医妇科学,上海：上海科学技术出版社,1994,第1版：68-71.
4.冯蓓.逐瘀止血汤加减治疗经期延长35例.四川中医,2006,24(3)：77.
5.张慧英.化瘀汤治疗瘀阻胞宫型经期延长51例.新中医,2000,32(2)：49.
6.赵鹏.丹栀逍遥散加减治疗经期延长90例. 云南中医中药杂志,2004,25(6)：54.
7.赖亚萍,都匀.清经止带胶囊治疗湿热瘀阻型经期延长80例.河北中医,2001,23(10)：756.
8.夏桂成.月经周期与调周法(续1).南京中医药大学学报,1998,14(4)：203.
9.刘小虹,周嘉洲.益气补肾汤治疗经期延长45例.河北中医,2001,23(11)：828.
10.张金辉.补肾固精法治疗经期延长94例.河南中医,2006,26(9)：42.
11.冯绮,徐涟.徐涟主任应用逍遥散治疗经期延长经验.云南中医中药杂志,2009,30(10)：1.
12.李文艳.完带汤治疗经期延长56例.四川中医,2001,19(3)：55.
13.吴丕中.二丹饮治疗月经延长60例.四川中医,1998,16(1)：50.
14.陈林兴等.经期延长的诊治特色.云南中医杂志,1999,20(4)：1.
15.陈林兴,苗晓玲等.经期延长的诊治特色.云南中医中药杂志,1999,20(4)：1-2.
16.夏桂成.运用易学思想探讨行经期变化及其调治.江苏中医,1997,18(9)：5.
17.朱可芳.潘佛岩治疗经期延长的经验.中国农村医学,1996,24(4)：58.
18.魏凤琴.张珍玉教授治疗经期延长特色摭拾.中医药学刊,2003,21(1)：21.
19.陈玩祯.曲安缩松存在非内膜增厚的经期延长的副作用的初步认识.中 国超声诊断杂志,2000,1(2)：125.
20.胡卫.基础体温变化与中医辨证论治的关系及临床应用举隅.长江大学学报(自然科学版),2009,6(4)：169.
21.王惠珍.试探基础体温变化与中医辨证关系.光明中医,2001,16(97)：12-13.
22.田炳照.基础体温在经期延长中的临床应用.基层医学论坛,2003,7(6)：576.
23.马宝璋.中医妇科学.第一版.北京：中国中医药出版社.2004：89-90.
24.吴玫.功能失调性子宫出血的分型证治.山东中医杂志,2001：20(9)：566.
25.李大剑.经验方桃红二丹四物汤临症举隅.安徽中医临床杂志,1998,10(5)：303-304.
26.姚金炬,陈凤英.四物汤加味治疗经期延长36例.长春中医学院学报1997,13(62)：35-36.
27.高于英.四逆安宫汤治疗经期延长45例.云南中医中药杂志,2003,24(2)：24-25.
28.茹红梅,肖昌庆.基础体温在月经周期出血病中的应用.安徽中医临床杂志,1998, 10(3)：189.
29.马静,金季玲.二至丸合两地汤化裁治疗阴虚型经期延长46例体会.承德医学院学报,2007,24(4)：387.
30.王伟.自拟鹿含草汤治疗经期延长60例.中医药学刊,2006,24(6)：1181.
31.徐萍.鲜益母草胶囊治疗经期延长.浙江中西医结合杂志,2004,14(12)：772.
32.王强, 田红. 安冲汤加减治疗少女经期延长32例.陕西中医,2000,21(5)：220.
33.任青玲,夏桂成等.夏桂成生殖节律理论的医学思维模式探析.江苏中医药,2004,25(4)：4.
34.俞华,林俐.升提药治疗经期延长.浙江中医学院学报,2000,24(4)：30.
35.张莉,陈晓勇等.宫血宁胶囊治疗经期延长型青春期功血.实用临床医 学,2007,8(6)：111-112.
36.王淑媛.加减逍遥散治疗更年期经期延长49例.吉林中医药,2005,25(12)：32.
37.张红,王丹辉等.妇血安片治疗经期延长30例临床观察.长春中医药大学学报,2009,25(6)：901.
38.冯淑英,陈学煌等.复方甲基炔诺酮对Norplant皮埋后经期延长的治疗中国计划生育学杂志,1997,5(31)：298-300.
39.金建岳.自拟益气固经汤治疗经期延长65例分析.实用中医内科杂志,2006,20(1)：43-44.
40.李莉.清经凉血止血汤.广西中医药,2005,28(1)：44.
41.李艳芬.固冲止血汤治疗经期延长82例.陕西中医,2001,22(12)：746.
42.林春,冯金英等.加减保阴煎治疗阴虚血热型经期延长48例.新中医2003,35 (3)：45.
43.赵焕云,庞保珍.经延丹贴脐治疗经期延长118例. Journal of External Therapy of TCM,2004,13(1):44.
44.李秀梅.针灸耳压并用治疗黄体萎缩不全性功血54例.中国民间疗法,2009,17 (1) ：24.
45.朱文峰.中医诊断与鉴别诊断学.人民卫生出版社,1999,466.
46.乌毓明,范光升等.宫血宁在预防药物流产后出血的多中心临床效果观察.中国计划生育杂志,2002,10(1)：52-53.
47.赵振虎,李建勇等.皂苷提取物宫血宁缩宫作用与细胞外钙内流关系的研究.中国药物与临床,2005,5(6)：415-417.
48.付双慧.经血宁胶囊治疗月经过多、经期延长18例.广西中医药,2003,26(6)：22.
49.陆华,刘敏如等.养精汤促卵泡发育的临床观察.中国中西医结合杂志,1998, (4)：217-220.
50.苏玉萍,闫宏宇.经期延长的中医辨证分型与性激素的关系. 中医中药,2007,4(34)：61-62.
51.顾素娟,杜明昆等.WH086925Norplant上市后监测(中国部分).中国计划生育学杂志,1998,2(34)：55-58.
52.顾素娟,杜明昆等.Norplant皮下埋植剂法可接受性研究.中国计划生育学杂志,1992,1(1)：15-18.
53.李义居,马桂玲.酮康唑致月经过多经期延长1例.皮肤病与性病杂志,1998,20 (1) ：65.
54.乐杰.妇产科学.第七版.北京：人民卫生出版社,2008：307-308.
55.杜明昆.皮下埋植避孕法的不良反应及其防治.实用妇产科杂志,2008,24(3)：135.
56.郑筱萸.中药新药临床研究指导原则(试行).中国医药科技出版社2002：243,388-389.
57.余运初.关于针刺和中药促排卵机制的研究.中西医结合杂志,1985,(5)：201.
58.张炜,蔡德培.补肾中药对雌性青春期大鼠垂体GnRH受体mR-NA及其受体蛋白表达的影响.中国中西医结合杂志,2003,23(2)：120-123.
59. 蔡德培,张炜.补肾中药对下丘脑GnRH、垂体FSH、LH及成骨细胞基因表达的调节作用.中医杂志,2002,43(3)：221-223.
60.kawaguchi D, Fujii S, Konishi I, et al.Mitotic activity in uterine leiomyomas during the menstrual Cycle.Am I obstet Gynecol1989; 160: 637.
61. McEwen BS, Alves SE, Bulloch K, et al. Ovarian steroids and the brain:implications for cognition and aging. Neurology,1997, 48[5 Suppl 7]:S8-15.
62.林晓梅,张文智等.雌孕激素类药物对不孕妇女子宫内膜雌激素受体含量的影响. 中国计划生育学杂志,1996,3(23)：149-150.
63.石一复.基础体温测量的临床应用.中国医刊,2000,35(5)：6.
64.杜少雄,林丽云等.浅探基础体温变化与胞宫功能的关系.光明中医2009,24 (2) ：248.
65.夏桂成.基础体温在部分妇科疾病中的运用初探.中国医药学报,1991,6(5)：16-18.
66.田炳照.基础体温在正常月经性不孕的临床运用.基层医学论坛,2004,8(1)：89. 8(1)：89.
67.夏桂成.用基础体温观察补阳消症汤治疗子宫内膜异位性不孕症33例.新中医,1994(1)：41-42.
68.戴岳,杭秉茜等.山茱萸对炎症反应的抑制作用.中国中药杂志,1992,17(5)：307-309.
69.赵俊萍,高翠兰.山药的药理作用及临床应用.山西中医,2006,22(增刊)：84.
70.施仁潮.枸杞子.杭州：浙江科学技术出版社,2002：12-22.
72.王跃宏.识别生、炙甘草之功效.云南中医药杂志,1997,18(5)：47.
71.Gao Xuejun. The Pharmacological Research of FulingAnalyze and Its Beginnings Explore on Clinical Application[J]. ChineseMedicinal Herb,1985,16(4):40-44.