滋阴补阳中药序贯对多囊卵巢综合征促排卵周期干预的临床研究
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摘要
目的：观察滋阴补阳中药序贯联合克罗米芬(CC)、果纳芬(r-FSH)对多囊卵巢综合征(PCOS)不孕症患者促排卵周期的临床疗效,为PCOS的中西医结合助孕治疗提供思路和方法。
方法：将拟行促排卵治疗的PCOS不孕症患者随机分为滋阴补阳中药序贯联合CC/r-FSH组(试验组,30个周期)和CC/r-FSH组(对照组,32个周期),观察HCG注射日天数、子宫内膜厚度、HCG日≥14mm卵泡数、HCG日≥18mm卵泡数,比较两组在排卵率、妊娠率、卵巢过度刺激综合征(OHSS)以及卵泡未破裂黄素化综合征(LUFS)等方面的疗效。
结果：(1)试验组治愈率36.7%,总有效率86.7%；对照组治愈率12.5%,总有效率87.5%,两组在治愈率方面有有显著差异(P<0.05)。(2)两组用药天数即HCG日天数经统计学分析差异无显著性。(3)HCG日子宫内膜厚度、HCG日≥14mm卵泡数、HCG日≥18mm卵泡数,经统计学分析组间差异显著(P<0.05)。(4)试验组与对照组排卵周期率、LUFS发生率、OHSS发生率、无反应取消周期率差异均无显著性。(5)试验组妊娠率36.7%,对照组妊娠率12.5%,两组妊娠率具有统计学差异(P<0.05)。
结论：滋阴补阳中药序贯联合CC/r-FSH可以增加单卵泡发育周期,增加子宫内膜厚度,提高妊娠率。滋阴补阳中药序贯联合CC/r-FSH对PCOS促排卵周期有较好的临床疗效。
Objective:Observat the clinical efficacy on sequential therapy of nourishing Yin and supplementing Yang of traditional Chinese medicine combined with clomiphene (CC), Gonal-F(r-FSH) interventing ovulation induction cycle of infertility patients with poly cystic ovary syndrome (PCOS).Provide ideas and methods for integrated traditional Chinese and Western medicine treatment of PCOS.
Methods:Infertility patients with PCOS were randomly divided into two groups,namely, nourishing Yin and supplementing Yang of traditional Chinese medicine sequentially combined with CC/r-FSH group (experiment group,30cycles) and CC/r-FSH group (control group,32cycles). Observe treatment days until HCG injection day, endometrial thickness, above14mm and18mm follicles numbers in HCG injection day, and compare the two groups in the ovulation rate, pregnancy rate, ovarian hyperstimulation syndrome (OHSS) and luteinized unruptured follicle syndrome (LUFS) and so on.
Results:(1)The experiment group's cure rate was36.7%and a total efficiency of86.7%,as a cure rate of12.5%and total efficiency of87.5%in control group, significant difference (P<0.05).(2) The treatment days until HCG injection day had no significant difference between two group.(3)A statistically significant difference between groups of endometrial thickness, above14mm and18mm follicles numbers in HCG injection day(P<0.05).(4) The experiment group and the control group's ovulation rate, incidence rate of LUFS, OHSS, cycle cancelled rate had no significant difference.(5) The pregnancy rate of experiment group was36.7%, compared to control group, the pregnancy rate was12.5%, had statistical difference (P<0.05).
Conclusion:nourishing Yin and supplementing Yang of traditional Chinese medicine sequentially combined with CC/r-FSH can add single follicle development cycle, increase endometrial thickness, improve the pregnancy rate. The therapy has better clinical curative effect on PCOS induced ovulation cycle.
方法：将拟行促排卵治疗的PCOS不孕症患者随机分为滋阴补阳中药序贯联合CC/r-FSH组(试验组,30个周期)和CC/r-FSH组(对照组,32个周期),观察HCG注射日天数、子宫内膜厚度、HCG日≥14mm卵泡数、HCG日≥18mm卵泡数,比较两组在排卵率、妊娠率、卵巢过度刺激综合征(OHSS)以及卵泡未破裂黄素化综合征(LUFS)等方面的疗效。
结果：(1)试验组治愈率36.7%,总有效率86.7%；对照组治愈率12.5%,总有效率87.5%,两组在治愈率方面有有显著差异(P<0.05)。(2)两组用药天数即HCG日天数经统计学分析差异无显著性。(3)HCG日子宫内膜厚度、HCG日≥14mm卵泡数、HCG日≥18mm卵泡数,经统计学分析组间差异显著(P<0.05)。(4)试验组与对照组排卵周期率、LUFS发生率、OHSS发生率、无反应取消周期率差异均无显著性。(5)试验组妊娠率36.7%,对照组妊娠率12.5%,两组妊娠率具有统计学差异(P<0.05)。
结论：滋阴补阳中药序贯联合CC/r-FSH可以增加单卵泡发育周期,增加子宫内膜厚度,提高妊娠率。滋阴补阳中药序贯联合CC/r-FSH对PCOS促排卵周期有较好的临床疗效。
Objective:Observat the clinical efficacy on sequential therapy of nourishing Yin and supplementing Yang of traditional Chinese medicine combined with clomiphene (CC), Gonal-F(r-FSH) interventing ovulation induction cycle of infertility patients with poly cystic ovary syndrome (PCOS).Provide ideas and methods for integrated traditional Chinese and Western medicine treatment of PCOS.
Methods:Infertility patients with PCOS were randomly divided into two groups,namely, nourishing Yin and supplementing Yang of traditional Chinese medicine sequentially combined with CC/r-FSH group (experiment group,30cycles) and CC/r-FSH group (control group,32cycles). Observe treatment days until HCG injection day, endometrial thickness, above14mm and18mm follicles numbers in HCG injection day, and compare the two groups in the ovulation rate, pregnancy rate, ovarian hyperstimulation syndrome (OHSS) and luteinized unruptured follicle syndrome (LUFS) and so on.
Results:(1)The experiment group's cure rate was36.7%and a total efficiency of86.7%,as a cure rate of12.5%and total efficiency of87.5%in control group, significant difference (P<0.05).(2) The treatment days until HCG injection day had no significant difference between two group.(3)A statistically significant difference between groups of endometrial thickness, above14mm and18mm follicles numbers in HCG injection day(P<0.05).(4) The experiment group and the control group's ovulation rate, incidence rate of LUFS, OHSS, cycle cancelled rate had no significant difference.(5) The pregnancy rate of experiment group was36.7%, compared to control group, the pregnancy rate was12.5%, had statistical difference (P<0.05).
Conclusion:nourishing Yin and supplementing Yang of traditional Chinese medicine sequentially combined with CC/r-FSH can add single follicle development cycle, increase endometrial thickness, improve the pregnancy rate. The therapy has better clinical curative effect on PCOS induced ovulation cycle.
引文
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