壳聚糖膜包裹的聚磷酸钙生物陶瓷的制备及复合成骨细胞修复兔桡骨骨缺损的研究
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摘要
目的探索壳聚糖膜包裹的多孔聚磷酸钙生物陶瓷的制备方法,为骨缺损的治疗提供可行方案方法采用化学方法制备出壳聚糖微球作为致孔剂,通过煅烧、球磨、混浆、烧制等多个步骤制备出多孔聚磷酸钙生物陶瓷,并通过化学方法使多孔壳聚糖膜包裹于其上。对制成的壳聚糖膜包裹的多孔聚磷酸钙生物陶瓷的理化性质、生物力学、毒性、生物相容性等方面作相关研究结果成功制备出壳聚糖膜包裹的多孔聚磷酸钙生物陶瓷,无急性生物毒性,抗压强度高,为多孔状生物支架材料,动物实验证明,其能够修复兔骨缺损
结论壳聚糖膜包裹的多孔聚磷酸钙生物陶瓷是一种良好的多孔状生物的陶瓷支架材料,其生物力学性能好,能够满足骨替代物的要求,无毒性,可以成为骨替代物的优良材料。
Objective to investigate the preparation of chitosan encapsulated porus calcium polyphosphate bioceramic, provide a feasible project to solve the bone defection Method produceing the chitosan microball by chemical steps,producing the calcium polyphosphate bioceramic by many steps which are precalcinations, ball milling, admixing and calcinations. Using the chemical method to encapsule the calcinations bioceramic by chitosan. The physicochemical and biomechanics properties and toxicity of the sample were measured. Result The porous calcium polyphosphate bioceramic is a kind of porous bony framework materials.,it is anon-toxic and have good compressive strength.
Conclusion Chitosan cncapsulated porous calcium polyphosphate bioceramic is non-toxic and has a good biomechanics property. It is an excellent materials for bone replacement.
结论壳聚糖膜包裹的多孔聚磷酸钙生物陶瓷是一种良好的多孔状生物的陶瓷支架材料,其生物力学性能好,能够满足骨替代物的要求,无毒性,可以成为骨替代物的优良材料。
Objective to investigate the preparation of chitosan encapsulated porus calcium polyphosphate bioceramic, provide a feasible project to solve the bone defection Method produceing the chitosan microball by chemical steps,producing the calcium polyphosphate bioceramic by many steps which are precalcinations, ball milling, admixing and calcinations. Using the chemical method to encapsule the calcinations bioceramic by chitosan. The physicochemical and biomechanics properties and toxicity of the sample were measured. Result The porous calcium polyphosphate bioceramic is a kind of porous bony framework materials.,it is anon-toxic and have good compressive strength.
Conclusion Chitosan cncapsulated porous calcium polyphosphate bioceramic is non-toxic and has a good biomechanics property. It is an excellent materials for bone replacement.
引文
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