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情志致病源流探讨及情志因素与妇科疾病的相关性研究
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摘要
目的:
     在现代医学领域,传统的生物医学模式正在向生物—心理—社会医学模式转变。人们越来越重视心理(情志)、社会因素与躯体、疾病的关系。由于情志社会因素影响人们健康,因此情志与疾病的关系就成为医学各学科热衷研究的课题。而中医学,有关情志致病的理论认识和临床实践,都有十分丰富的内容。它是中医基础理论体系中的一个重要组成部分。因此,把散见于医籍中有关情志致病的内容挖掘出来,并加以条理化、系统化是本文的任务之一。
     同时,在中医整体观、心身合一、情志致病理论的指导下,本文旨在探讨情志因素与妇科疾病的关系,分析导致妇科疾病的有关生活事件和情绪方面的高危因素和保护因素,从群体水平探索病因假说,为中医“情志致病”理论和妇科疾病的预防提供循证依据。
     方法:
     采用文献分析法、心理测量学、临床流行病学和循证医学等科研方法,以团体用心理社会应激调查表(PSSG)和90项症状自评量表(SCL-90)为研究载体。对来自广东省中医院妇科门诊符合诊断标准、纳入标准的204例患者问卷调查,进行数据整合、处理、格式转换后,利用SPSS18.0软件进行描述性分析,组间比较采用卡方检验、秩和检验,影响因素分析采用Logistic回归分析。分析内容:1.分别比较月经失调组、子宫肌瘤组、更年期综合征组与健康对照组的SCL-90各维度总分、因子分、总均分,了解四组的情志状况。2.分别比较月经失调组、子宫肌瘤组、更年期综合征组与健康对照组的PSSG各指标,挖掘患者与健康对照者经历的生活事件、情志、应对方式的不同之处。3.分别做生活事件、情绪与月经失调、子宫肌瘤、更年期综合征三种妇科疾病的多因素Logistic回归分析。探讨生活事件、消极情绪与月经失调、子宫肌瘤、更年期综合征与妇科疾病的相关性。
     结果:
     1月经失调组与健康对照组PSSG各指标比较
     (1)月经失调组与健康对照组在劳累过度、家庭和婚姻、人际关系、子女前途、生活环境、个人健康方面存在差异,差异具有统计学意义(P<0.05)。月经失调者均较健康者发生频率多。
     (2)月经失调组与健康对照组在害怕、忧郁、气愤方面存在差异,差异具有统计学意义(P<0.05)。月经失调者均较健康对照者显著。
     (3)月经失调组与健康对照组在高兴、愉快、欢喜、欣慰方面存在差异,差异具有统计学意义(P<0.05)。健康对照者均较月经失调者显著。
     (4)月经失调组与健康对照组在陷入回忆、变得沉闷、痛哭一场、苦苦思索、独处方面存在差异,差异具有统计学意义(P<0.05)。月经失调者均较健康对照者严重。
     (5)月经失调组与健康对照组在尽快忘掉、当作未发生、想开些、算不了什么、积极转化、幽默方面存在差异,差异具有统计学意义(P<0.05)。健康者较月经失调者显著。
     2月经失调组与健康对照组SCL90各指标比较
     (1)月经失调组与健康对照组在躯体化总分得分、焦虑总分得分、偏执总分得分、精神病性总分得分、抑郁总分得分、敌对总分得分、恐怖总分得分、其它总分得分方面比较有明显差异,差异具有统计学意义(P<0.05)。月经失调组均高于健康对照组。
     (2)月经失调组与健康对照组在躯体化因子分、强迫症因子分、抑郁因子分、焦虑因子分、偏执因子分、敌对因子分、精神病性因子分、人际关系敏感因子分、恐怖因子分、其它因子分方面比较,有明显差异,差异具有统计学意义(P<0.05)。月经失调组均高于健康对照组。表明,月经失调患者躯体化症状、强迫症状、抑郁、焦虑、偏执、敌对、精神病性、人际敏感、恐怖、其它方面较健康人群严重。
     (3)月经失调组和健康对照组Sc190总均分比较有差异,差异具有统计学意义(P<0.05)。健康对照组没有症状较月经失调者多,而月经失调者有点症状和轻度者比健康对照组多。
     3.家庭不和婚姻问题、个人健康变化、忧郁、气愤是月经失调的危险因素,子女前途问题、愉快、欢喜、欣慰是月经失调的保护因素。
     4.子宫肌瘤组与健康对照组PSSG各指标比较
     (1)子宫肌瘤组与健康对照组在个人健康方面存在差异,差异具有统计学意义(P<0.05)。子宫肌瘤者较健康者发生频率多。
     (2)子宫肌瘤组与健康对照组在忧郁、着急、悲伤、无助方面存在差异,差异具有统计学意义(P<0.05)。在忧郁、着急、悲伤方面子宫肌瘤患者较健康者严重,而在无助方面健康者较子宫肌瘤者严重。
     (3)子宫肌瘤组与健康对照组在高兴、愉快、欢喜、兴奋、欣慰方面存在差异,差异具有统计学意义(P<0.05)。健康对照组较子宫肌瘤组显著。
     (4)子宫肌瘤组与健康对照组在变得沉闷、苦苦思索方面存在差异,差异具有统计学意义(P<0.05)。子宫肌瘤患者较健康者严重。
     (5)子宫肌瘤组与健康对照组在尽快忘掉、当作未发生、想开些、积极转化、幽默方面存在差异,差异具有统计学意义(P<0.05)。健康者较子宫肌瘤患者显著。
     5.子宫肌瘤组与健康对照组SCL90各指标比较
     (1)子宫肌瘤组与健康对照组在躯体化总分得分、焦虑总分得分、精神病性总分得分、抑郁总分得分、敌对总分得分方面比较有明显差异,差异具有统计学意义(P<0.05)。子宫肌瘤组均高于健康对照组。
     (2)子宫肌瘤组与健康对照组在躯体化因子分、强迫症因子分、抑郁因子分、焦虑因子分、其它因子分方面比较有明显差异,差异具有统计学意义(P<0.05)。子宫肌瘤组均高于健康对照组。表明,子宫肌瘤患者躯体化症状、强迫症状、抑郁、焦虑、其它方面较健康对照者严重。
     (3)子宫肌瘤组和健康对照组Sc190总均分比较有差异,差异具有统计学意义(P<0.05)。健康对照组没有症状较子宫肌瘤者多,而子宫肌瘤者有点症状比健康对照组多。
     6.个人健康变化、忧郁是子宫肌瘤的危险因素,愉快、欢喜、兴奋、欣慰是子宫肌瘤的保护因素。
     7.更年期综合征组与健康对照组PSSG各指标比较
     (1)更年期综合征组与健康对照组在劳累过度、子女前途、个人成就、个人健康方面存在差异,差异具有统计学意义(P<0.05)。更年期综合征者较健康者发生频率多。
     (2)更年期综合征组与健康对照组在害怕、苦恼、忧郁、紧张、气愤、焦虑、着急、悲伤方面存在差异,差异具有统计学意义(P<0.05)。更年期综合征者较健康者严重。
     (3)更年期综合征组与健康对照组在高兴、愉快、欢喜、兴奋、欣慰方面存在差异,差异具有统计学意义(P<0.05)。
     (4)更年期综合征组与健康对照组在陷入回忆、迁怒别人、变得沉闷、压在心底、痛哭一场、苦苦思索、独处方面存在差异,差异具有统计学意义(P<0.05)。
     (5)更年期综合征组与健康对照组在尽快忘掉、当作未发生、算不了什么、换个环境方面存在差异,差异具有统计学意义(P<0.05)。健康者较子宫肌瘤者显著。
     8.更年期综合征组与健康对照组SCL90各指标比较
     (1)更年期综合征组与健康对照组在躯体化总分得分、焦虑总分得分、偏执总分得分、精神病性总分得分、抑郁总分得分、敌对总分得分、恐怖总分得分、其它总分得分方面比较有明显差异,差异具有统计学意义(P<0.05)。更年期综合征组均高于健康对照组。
     (2)更年期综合征与健康对照组在躯体化因子分、强迫症因子分、抑郁因子分、焦虑因子分、敌对因子分、精神病性因子分、人际关系敏感因子分、恐怖因子分、其它因子分方面比较有明显差异,差异具有统计学意义(P<0.05)。更年期综合征组均高于健康对照组。表明,更年期综合征患者躯体化症状、强迫症状、抑郁、焦虑、敌对、精神病性、人际关系敏感、恐怖、其它方面较健康者严重。
     (3)更年期综合征组和健康对照组Sc190总均分比较有差异,差异具有统计学意义(P<0.05)。健康对照组没有症状较更年期综合征者多,而更年期综合征者有点症状和轻度者比健康对照组多。
     9.劳累过度、个人健康变化、苦恼、忧郁、紧张、气愤、焦虑是是更年期综合征的危险因素,个人成就、愉快、欢喜、兴奋、欣慰是更年期综合征的保护因素。
     结论:
     情志因素在妇科疾病发生、发展、转归中起重要作用,面对不良生活事件时,应保持健康良好的心态,采取积极的应对方式,以减少妇科疾病的发生,有利于妇科疾病的康复。
Objective
     In the field of modern medicine, the traditional biomedical model is changing to bio-psycho-social medical mode. People pay more and more attention to the relation between psychological&social factors and body&disease. Psychological and social factors act on body through people's emotions, so the relationship between emotions and disease becomes a topic which all subjects of medicine are keen to study. However, the traditional Chinese medicine has very rich content regarding the cognitive theory and clinical practice of emotional disease, which is an important component of the basic theory system of traditional Chinese medicine. Therefore, one task of this paper is to dig out the content regarding emotional diseases that scattered in the medical books, and to make it methodized and systematic.
     Meanwhile, under the guidance of traditional Chinese medicine holism, psychosomatic unity and the theory of emotional diseases, this paper aims to explore the relationship between emotional factors and gynecological diseases, analyze high risk factors and protective factors related to life events and emotional aspects which lead to gynecological diseases, and explore etiological hypothesis at the population level, and provide evidence-based basis for "emotional diseases" theory and the prevention of gynecological diseases.
     Methods
     This paper adopts the research methods of literature analysis, psychometrics, clinical epidemiology and evidence-based medicine, and takes self-made questionnaire for general situation, psychosocial stress questionnaire for groups (PSSG) and90symptoms checklist (SCL-90) as the carrier of study. We make questionnaire survey upon204patients in gynecology outpatient from Guangdong Province Traditional Chinese Medical Hospital, who have obvious emotional incentives and are consistent with the diagnostic criteria and brought into criteria, after carrying out data integration, processing, format conversion, then use SPSS18.0software to undertake descriptive analysis; the comparison among groups adopts analysis of variance, the rank-sum test, and correlation analysis adopts Logistic regression analysis. The analysis content includes:1.through the comparing the total scores of all dimensions, factor scores, total average scores of SCL-90among four groups, to learn about the mental health status of three kinds of disease patients and the comparison persons.2. Through the comparison of the total scores of life events, negative emotions, positive emotions, positive coping ways and negative coping ways of PSSG among four groups, to dig out the difference of undergone life events, emotions and coping ways between patients and healthy comparison persons.3. To understand the correlation among life events, negative emotions and all gynecological diseases. Then make Logistic regression analysis respectively on life events, emotions and three kinds of gynecological diseases.
     Results
     1. The comparison of all indexes in PSSG between menstrual disorder group and health comparison group
     (1)There are difference regarding aspects of overstrain, family&marriage, interpersonal relations, the children's future, life environment and individual health between menstrual disorder group and health comparison group. These differences have statistical significance (P<0.05). The occurrence frequency of the menstrual disorder group is higher than that of the health comparison group.
     (2) There are differences regarding aspects of fear, melancholy and anger between menstrual disorder group and health comparison group. These differences have statistical significance (P<0.05). The menstrual disorder group is more obvious than the health comparison group.
     (3) There are differences regarding aspects of happiness, gladness, joy and delight between menstrual disorder group and health comparison group. These differences have statistical significance (P<0.05). The menstrual disorder group is more serious than the health comparison group.
     (4) There are differences regarding aspects of being lost in memory, getting oppression, crying, puzzling out and living alone between menstrual disorder group and health comparison group. These differences have statistical significance (P<0.05). The menstrual disorder group is more serious than the health comparison group.
     (5) There are differences regarding aspects of forgetting as soon as possible, regarding something non-occurrence, being optimistic, nothing, actively changing, and being humorous between menstrual disorder group and health comparison group. These differences have statistical significance (P<0.05). The menstrual disorder group is higher than the health comparison group.
     2. The comparison of all indexes in PSSG between menstrual disorder group and health comparison group
     (1) There are obvious differences through the comparison of the total scores of somatization, anxiety, paranoia, psychosis, depression, hostility, terror and other scores between menstrual disorder group and health comparison group. These differences have statistical significance (P<0.05). The menstrual disorder group is higher than the health comparison group.
     (2) There are obvious differences through the comparison of the factor scores of somatization, obsessive-compulsive, depression, anxiety, paranoia, hostility, psychosis, interpersonal sensitivity, terror and other between menstrual disorder group and health comparison group. These differences have statistical significance (P<0.05). The menstrual disorder group is higher than the health comparison group. It indicates that the systems of somatization, obsessive-compulsive, depression, anxiety, paranoia, hostility, psychosis, interpersonal sensitivity, terror and other aspects existing in the menstrual disorder group are more serious than the health group.
     (3) There are differences regarding the total average scores of SCL90between menstrual disorder group and health comparison group. These differences have statistical significance (P<0.05). The health comparison group is less than menstrual disorder group, but persons with some symptoms and slight degree in the menstrual disorder group are more than those in the health comparison group.
     3. Family marital problem, personal health change, depression&anger are dangerous factors of menstrual disorder; children's prospect, happiness, joy&comfort are protective factors of menstrual disorders.
     4. The comparison of all indexes in PSSG between the hysteromyoma group and the health comparison group
     (1) There are differences regarding the individual health between the hysteromyoma group and the health comparison group. These differences have statistical significance (P<0.05). The occurrence frequency of the hysteromyoma group is higher than that of the health comparison group.
     (2) There are differences regarding the aspects of depression, worry, sorrow and helplessness between the hysteromyoma group and the health comparison group. These differences have statistical significance (P<0.05). The hysteromyoma group is more serious than the health comparison group.
     (3)There are differences regarding the aspects of happiness, gladness, joy, excitement and delight between the hysteromyoma group and the health comparison group. These differences have statistical significance (P<0.05).
     (4) There are differences regarding the aspects of getting oppression, and puzzling out between the hysteromyoma group and the health comparison group. These differences have statistical significance (P<0.05). The hysteromyoma group is more serious than the health comparison group.
     (5)There are differences regarding the aspects of forgetting as soon as possible, regarding something non-occurrence, being optimistic, actively changing and being humorous between the hysteromyoma group and the health comparison group. These differences have statistical significance (P<0.05). The healthy persons are more obvious than the hysteromyoma patients.
     5. The comparison of all indexes in SCL90between the hysteromyoma group and the health comparison group
     (1)There are obvious differences through the comparison of the total scores of somatization, anxiety, psychosis, depression and hostility between the hysteromyoma group and the health comparison group. These differences have statistical significance (P<0.05). The hysteromyoma group is higher than the health comparison group.
     (2) There are obvious differences through the comparison of the factor scores of somatization, obsessive-compulsive, depression, anxiety and other between the hysteromyoma group and the health comparison group. These differences have statistical significance (P<0.05). The hysteromyoma group is higher than the health comparison group. It indicates that persons with the symptoms of somatization, obsessive-compulsive, depression, anxiety and other in the hysteromyoma group are more serious than the health comparison group.
     (3) There are differences regarding the total average scores of SCL90between the hysteromyoma group and the health comparison group. These differences have statistical significance (P<0.05). The health comparison group is less than the hysteromyoma group, but persons with some symptoms and slight degree in the hysteromyoma group are more than those in the health comparison group.
     6. Personal health change and depression are dangerous factors of hysteromyoma, and gladness, joy, excitement and delight are protective factors of hysteromyoma.
     7.The comparison of all indexes in PSSG between the climacteric syndrome group and the health comparison group
     (1)There are differences regarding the aspects of overstrain, children' s prospect, individual achievements and personal health between the climacteric syndrome group and the health comparison group. These differences have statistical significance (P<0.05). The occurrence frequency of the climacteric syndrome group is higher than that of the health comparison group.
     (2)There are differences regarding the aspects of fear, affliction, depress, tension, anger, anxiety, worry and sorrow between the climacteric syndrome group and the health comparison group. These differences have statistical significance (P<0.05). The climacteric syndrome group is serious than the health comparison group.
     (3)There are differences regarding the aspects of happiness, gladness, joy and delight between the climacteric syndrome group and the health comparison group. These differences have statistical significance (P<0.05).
     (4)There are differences regarding aspects of being lost in memory, venting anger on others, getting oppression, putting into heart, crying, puzzling out and living alone between the climacteric syndrome group and the health comparison group. These differences have statistical significance (P<0.05).
     (5)There are differences regarding the aspects of forgetting as soon as possible, regarding something non-occurrence, nothing, adapting a new environment between the climacteric syndrome group and the health comparison group. These differences have statistical significance (P<0.05). The healthy persons are more obvious than the climacteric syndrome group.
     8. The comparison of all indexes in SCL90between the climacteric syndrome group and the health comparison group
     (1)There are obvious differences through the comparison of the total scores of somatization,anxiety, obsessive-compulsive, psychosis, depression, hostility, terror and other between the climacteric syndrome group and the health comparison group. These differences have statistical significance (P<0.05). The climacteric syndrome group is higher than the health comparison group.
     (2)There are obvious differences through the comparison of the factor scores of somatization, obsessive-compulsive, depression, anxiety, hostility, psychosis, interpersonal sensitivity, terror and other between the climacteric syndrome group and the health comparison group. These differences have statistical significance (P<0.05). The climacteric syndrome group is higher than the health comparison group. It indicates that persons with the symptoms of somatization, obsessive-compulsive, depression, anxiety, hostility, psychosis, interpersonal sensitivity, terror and other aspects in the climacteric syndrome group are more serious than the health comparison group.
     (3) There are differences regarding the total average scores of SCL90between the climacteric syndrome group and the health comparison group. These differences have statistical significance (P<0.05). The health comparison group is less than the climacteric syndrome group, but persons with some symptoms and slight degree in the climacteric syndrome group are more than those in the health comparison group.
     9. Overstrain, personal health change, distress, depression, tension, anger and anxiety are danger factors of climacteric syndrome; individual achievements, happiness, joy, excitement and comfort are protective factors of climacteric syndrome.
     Conclusion
     Emotional factors play an important role in occurrence, development and prognosis of gynecological disease. In the face of adverse life events, people should maintain good state of mind and adopt positive coping ways in order to reduce the occurrence of gynecological diseases and be in favor of the recovery of diseases.
引文
[1]明·张景岳著.范志霞校注.类经[M].北京:中国医药科技出版社,2011.
    [2]秦伯未编纂.清代名医医案精华[M].上海:上海科学技术出版社,2011.
    [3]老聃著,李泽伟译注.老子[M].西安:陕西师范大学出版社,2011.
    [4]左丘明著,李维琦,陈建初,李运富,等注.左传[M].长沙:岳麓书社,2001.
    [5]杨俏田,秦华,高金虎主编.中医心身疾病治疗学[M].太原:山西科学技术出版社,2001:8.
    [6]王米渠.中医情志学纲要[M].成都:四川科学技术出版社,1988.
    [7]匡调元主编.中医病理学史[M].上海:上海科学普及出版社,1994.
    [8]汉·司马迁撰,韩兆琦主译.史记[M].北京:中华书局,2008.
    [9]张登本,孙理军主编.王冰医学全书[M].北京:中国中医药出版社,2006.
    [10]叶锦先,何裕民主编.情志疾病学[M].南昌:江西科学技术出版社,1988:12.
    [11]高文柱,沈澎农主编.诸病源候论[M].北京:华夏出版社,2008.
    [12]晋·皇甫谧编集,黄龙祥整理.针灸甲乙经[M].北京:人民卫生出版社,2006.
    [13]张登本主编.王焘医学全书[M].北京:中国中医药出版社,2006.
    [14]王米渠.中国古代医学情志学[M].贵阳:贵州人民出版社,1988.
    [15]唐·孙思邈撰,刘清国,吴少祯,韩秀荣校注.千金方[M].北京:中国中医药出版社,1998.
    [16]王象礼主编.陈无择医学全书[M].北京:中国中医药出版社,2005.
    [17]陶汉华,徐风琴,张甦颖主编.中医病因病机学[M].北京:中国医药科技出版社,2002:142.
    [18]潘玲,曾倩,陈聪,等.论刘完素对情志病病机的新认识[J].现代中西医结合杂志,2006,15(10):1275.
    [19]杨卫东,柳亚平等,上善若水下愚如火—刘完素著作中蕴涵的情志学思想[J].中医药信息,2011,28(3):1.
    [20]宋乃光主编.刘完素医学全书[M].北京:中国中医药出版社,2006.
    [21]张年顺,吴少祯,张海凌,等主编.李东垣医学全书[M].北京:中国中医药出版社,2006.
    [22]金·张子和撰,邓铁涛,赖畴整理.儒门事亲[M].北京:人民卫生出版社,2005.
    [23]许又新.两晋南北朝及隋唐时代我国精神病学简介[J].中华神经精神科杂志,1965,11(1):15—17.
    [24]孙晓波.陈无择的医学情志学探讨[J].成都中医学院学报,1984,26(3):4638.
    [25]田思胜,高巧林,刘建青主编.朱丹溪医学全书[M].北京:中国中医药出版社,2006.
    [26]王道瑞,申好真,等主编.严用和医学全书[M].北京:中国中医药出版社,2006.
    [27]李志庸主编.张景岳医学全书[M].北京:中国中医药出版社,2002.
    [28]明张介宾著,李继明,王大涥,王小平整理.景岳全书[M].北京:人民卫生出版社,2007.
    [29]明·汪绮石撰,谭克陶,周慎整理.理虚元鉴[M].北京:人民卫生出版社,2005.
    [30]清·叶天士撰,苏礼,焦振廉,张琳叶,等整理.临证指南医案[M].北京:人民卫生出版社,2007.
    [31]清·叶天士,缪宜亭,薛生白著.三家医案合·沈氏医案[M].上海:上海科学技术出版社,2010.
    [32]秦伯未,编纂.清代名医医案精华[M].北京:人民卫生出版社,2006.
    [33]李刘坤主编.吴鞠通医学全书[M].北京:中国中医药出版社,1999.
    [34]清·傅山著,欧阳兵整理.傅青主女科[M].北京:人民卫生出版社,2006.
    [35]清·叶天士等著.清·沈鲁珍著.三家医案合刻·沈氏医案[M].上海:上海科技出版社,2010(4)
    [36]郑筱萸主编.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:239.
    [37]罗云坚,孙塑伦主编.中医临床治疗特色与优势指南[M].北京:中国医药科技出版社,2002.
    [38]中华医学会编著.临床诊疗指南妇产科学分册[M].北京:人民卫生出版社,2007:124.
    [39]姜乾金.情志社会应激因素的综合评估初探[J].中国行为医学科学,1998,7(3):182-184.
    [40]梁黎,顾艳,田媛媛.汶川地震后基层医务人员应对方式和情志健康状况的相关研究[J].神经疾病与精神卫生,2008,8(6):424-426.
    [41]谢华,戴海崎.SCL-90量表评价.精神疾病与精神卫生[J],2006,6(2):156-159.
    [42]汪向东,王希林,马弘.情志卫生评定量表乎册[J].中国情志卫生杂志,1999,(增刊):31-35.
    [43]杨金辉,汪耀,程红梅.SCL 90和EPQ及U PI 3个量表关系研究[J].中国校医,2008,22(3):249-255.
    [44]谢月爱,高端良,潘瑞华,等.某校女生月经障碍与心理健康相关性调查[J].中国校医,2007,21(6):249:664-665.
    [45]张敏婕,朱丁,徐勇,等.女生月经初潮早发与负性生活事件的关系[J].中国学校卫生,2011,32(9):1027-1028.
    [46]魏碧蓉,林朝芹,薛海燕.女大学生月经情况调查结果分析[J].中国妇幼保健,2005,20(11):1417-1419.
    [47]马丽然,管雁丞,丁丽仙.情志应激事件、个性特征与贵州省女大学生月经失调关系的探讨[C].第九次全国中医妇科学术大会论文集,2009:390-393.
    [48]邝鉴雅.广州市越秀区应元学校女生月经失调的调查分析[J].当代医学,2010,16(6):158-159.
    [49]公维红,陈清.女研究生月经失调情况调查与分析[J].健康医学研究与实践,2010,7(4):62-63.
    [50]杨文梅,蒋凤艳.广西少女月经情况调查分析[J].广西医学,2011,33(3):296-299.
    [51]何晓翠,张新宇,陈雪飞.女大学生发生月经失调的原因探讨[J].中外妇儿健康,2011,19(6):156-157.
    [52]李洁,王坚,赵旦,等.水上漂浮、力竭运动对大鼠下丘脑-垂体-性腺轴功能的影响[J].第二军医大学学报,2007,28(7):805.
    [53]李宁川,李仪,黄美蓉,等.运动训练对情志应激大鼠下丘脑-垂体-性腺轴的影响[J].中国运动医学杂志,2008,27(6):711-714.
    [54]李艳彦,谢鸣,王洪海,等.肝郁脾虚证模型大鼠甲状腺轴的变化及柴疏四君汤的作用观察[J],中国中医基础医学杂志,2008,14(3):191-192.
    [55]蒋蓝英,郦旦明,何炳荣,等.应激对老年危重患者下丘脑-垂体-甲状腺轴激素的影响[J].中国老年学杂志,2007,27(21):2117-2118.
    [56]李炜.女大学生月经失调的因素分析[J].中国妇幼保健,2008,23(22):3078-3079.
    [57]李萍.586名女中专生月经失调调查分析与对策[J].中国妇幼保健,2009,24(1):97-98.
    [58]李丽琼,李海燕,文金莲.大专女生月经失调的因素研究[J].中国现代医学杂志,2011,21(7):854-856.
    [59]贺丰杰,符小航,朱虹丽,等.抑郁在经断前后月经失调发病中的作用[J].山东中医杂志,2011,30(9):613-614.
    [60]刘光明,姚乾坤,符永健,等.女性抑郁症患者生命质量与月经失调相关性研究[J].海南医学院学报,2011,17(7):974-976.
    [61]刘光明,姚乾坤,占达飞,等.月经失调的女性生命质量与其人格特征相关性研究[J].海南医学院学报,2011,17(7):1254-1256.
    [62]卢莉,李建平,薛云珍,赵红卫,梁执群.情绪反应、个性特征与月经失调的关系[J].中国情志卫生杂志,2005,(03)
    [63]赵红艳.太原市卫校学生青春期功血的患病情况及影响因素分析.硕士论文.山西医科大学,2010.
    [64]李玲,王淑芬.滨州职业学院女生月经失调的相关因素分析[J].中国妇幼保健,2007,22(20):2785-2787
    [65]北京市中医学校编,医宗金鉴·妇科心法要诀白话解[M].北京:人民卫生出版社,1974.
    [66]清·沈尧封辑,女科辑要[M].北京:人民卫生出版社,1988.
    [67]清·陈莲舫撰,杜杰慧,王敬,赵美丽,等审定.女科秘诀大全[M].藁城:中国妇女出版社,1991.
    [68]王如跃,邱幸凡,张六通.社会情志因素与妇科肿瘤关系的研究[J].医学与哲学,2006,27(2):34-36.
    [69]徐全香.情志因素在子宫肌瘤发病中的作用[J].河北中医,2006,28(7):506-507.
    [70]杜晓丽.子宫肌瘤的中医证型特点及患病相关因素的研究.硕士论文.广州中医药大学,26-27,2006.
    [71]薛辉.子宫肌瘤易感体质的相关性研究.硕士论文.山东中医药大学,8-9,2008.
    [72]徐雅,陈思东,朱春燕.子宫肌瘤发病危险因素1:2配比病例对照研究[J].中华流行病学杂志,2000,21(5):366-368.
    [73]中宝林,苗宇船.情志因素与子宫肌瘤的相关性研究[J].世界中西医结合杂志,2010,5(2):156-157.
    [74]田传胜,孙菲,王生.急性和重复性情志应激大鼠某些细胞免疫功能变化[J].中国职业医,2009,36(1):11-17.
    [75]柴淑娟,夏天.谈情志—情志应激与子宫肌瘤发病的相关性[J].辽宁中医药大学学报,2011,13(2):31-32.
    [76]柯江维,王建红,段荣.情志应激大鼠卵巢促卵泡刺激素及黄体生成素受体的变化[J]天津医药,2007,35(6):430-432.
    [77]Gordon P, Flake, Janet Andersen, et al. Etiology and pathogenesis of uterine leiomyomas:A review [J]. Environmental Health Perspectives,2003,111:1037-1054.
    [78]T. Maruol, N. Ohara, J. Wang, et al. Matsuosex steroidal regulation of uterine leiomyoma growth and apoptosis [J]. Human Reproduction Update,2004,10:207-220.
    [79]骆益宙,王杰军,郭子姮,等.慢性情志应激对小鼠肿瘤新生血管形成影响的观察[J].中华肿瘤防治杂志,2009,16(11):845-848.
    [80]朱静,夏天,刘兆娟.情肝郁—情志应激对子宫肌瘤大鼠性激素及免疫因子影响的实验研究[J].辽宁中医药大学学报,2011,13(9):52-56.
    [81]明·武之望编,李明廉主校.济阴纲目[M].北京:人民卫生出版社,1996.
    [82]清·沈金鳌著,红慧芳,等点校.妇科玉尺[M].中医古籍出版社,1996.
    [83]杨十财,王云霞.女性更年期综合征现状调查及干预研究[J].辽宁医学杂志,2011,25(3):126-127.
    [84]桑海静,陈长香,李淑杏,等.女性更年期综合征及其影响因素的研究[J].中国妇幼保健,2010,(6):807-809.
    [85]董胜莲,刘瑞华,陈长香.22省(市)女性更年期综合征现状调查和影响因素分析[J].中国妇幼保健,2010,25(25):3604-3605.
    [86]陈丽苹,陈长香,李淑杏,等.更年期女性的婚姻质量、伴侣状况及与更年期综合征的相关性研究[J].卫生职业教育,2009,27(5):126-127.
    [87]马丽爽,陈长香,李淑杏,等.女性更年期妇女及抑郁影响因素的研究[J].中国老年学杂志,2009,29(3):354-355.
    [88]黎清婵,马春远.围经期女性健康与丈夫支持的关系[J].中国临床康复,2004,8(15):2955.
    [90]Feng YL, Wang ZK, Liu LH, et al. Investigation of anxiety and depression among 452 menopausal residents[J]. J Clin Psychol Med,2000,10:149.
    [91]王伟炳,徐飚,栾荣生,等.中国三城市更年期综合征门诊妇女抑郁和焦虑症状现况调查[J].卫生研究,2008,37(2):211-213.
    [92]张剑萍,李芬,盛秋,等.西安市高校女教师围绝经期综合征患病状况调查[J].中国老年学杂志,2008,28(3):286-288.
    [93]刘春梅,孙爱军,等.门诊更年期妇女更年期症状与抑郁焦虑的情况调查[J].生殖医学杂志,2007,16(3):157-160.
    [94]吴庆文,陈长香,李建民,等.女性更年期综合征影响因素分析[J].中国公共卫生,2010,26(5):518-519.
    [95]何志晖,张晓薇,麦小玲,等.围绝经期妇女抑郁症相关因素及预防策略[J].中国实用妇科与产科杂志,2007,23(12):935.
    [96]岳静玲,杨宇飞.唐山市更年期女性抑郁情绪影响因素调查分析[J].中国妇幼保健年,2010,25(34):5079-5082.
    [97]王虹.更年期女性260例的抑郁情绪及更年期症状[J].中国老年学杂志,2010,30(7):971-972.
    [98]董胜莲,李丹,陈长香,等.22省(市)女性更年期抑郁现状调查[J].中国卫生事业管理,2010,27(5):347.
    [99]顾磊,杜莉,施红,等.上海社区内更年期妇女焦虑现况调查[J].中国妇幼保健,2012,27(1):129-132
    [100]谢萍.围绝经期妇女焦虑状态及其影响因素的研究[J].护理实践与研究,2009,6(23):1-3.
    [101]李文静.更年期综合征女性情志障碍的调查研究.广州中医药大学,2008.
    [102]杨洪艳,王小云,许英,等.中医心身同治方案治疗更年期综合征抑郁症状的随机对照研究[J].广东医学,2011,32(16):2209-2211.

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