载姜黄素香蕉纤维素微晶/PLGA多孔材料的制备及性能研究
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摘要
用香蕉纤维为原料,经化学脱胶后制取香蕉纤维素微晶;用溶胶-凝胶法制备多孔材料并载入姜黄素制成载药多孔材料。用FT-IR、TG-MS、DSC、BET等对载药多孔材料的性能进行分析和研究。BET结果显示,平均孔径为15.77nm;DSC结果表明,载药多孔材料的熔融温度为93℃;利用紫外测试该载姜黄素香蕉纤维素微晶/PLGA多孔材料的体外释放性能,载药量测得在10%左右,包封率在42%.对载药量等指标的研究,探讨本研究所制备的载姜黄素香蕉纤维/PLGA多孔材料的释药行为及可达到最优的条件。
With banana fiber as raw material, banana microcrystalline cellulose was prepared by chemical degumming,the mesoporous material which loaded into curcumin drug was preparedby the method of sol gel.the performances were studied by FT-IR, TG-MS, DSC, BET.BET results showed the average pore size of 15.77 nm, specific surface area of 0.644 g/m~2; DSC results show the melting temperature of the drugloaded mesoporous material was93 ℃;The in vitro release performance of curcumin banana microcrystalline cellulose/polylactic acid mesoporous materials were tested by UV, drug loading measured was about 10%,encapsulation efficiency was 42%, banana fibers/polylactic acid mesoporous material loadingcurcuminmay be optimal.
With banana fiber as raw material, banana microcrystalline cellulose was prepared by chemical degumming,the mesoporous material which loaded into curcumin drug was preparedby the method of sol gel.the performances were studied by FT-IR, TG-MS, DSC, BET.BET results showed the average pore size of 15.77 nm, specific surface area of 0.644 g/m~2; DSC results show the melting temperature of the drugloaded mesoporous material was93 ℃;The in vitro release performance of curcumin banana microcrystalline cellulose/polylactic acid mesoporous materials were tested by UV, drug loading measured was about 10%,encapsulation efficiency was 42%, banana fibers/polylactic acid mesoporous material loadingcurcuminmay be optimal.
引文
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[11]崔莉,贾军芳,张传杰,等.纤维素多孔材料的制备与性能[J].高分子材料科学与工程,2013,29(10):142-145.
[12]庞锦英,莫羡忠,刘钰馨.阻燃香蕉纤维增强聚乳酸复合材料的制备与表征[J].化工进展,2015,34(4):1050-1054.
[13]庞锦英,莫羡忠,谭登峰,等.香蕉纤维素微晶/ 聚乳酸气凝胶及其制备方法和用途 [P].中国,105017541,2015-07-09.
[14]李肖建,刘红霞,韦春,等.剑麻纤维素微晶的制备与表征[J].高分子材料科学与工程,2012,28(8):161-163.
[15]顾锦建,金朝辉,郑明琳,等.离子液体在药用活性成分中的应用[J].中国药业,2015,24(24):253-255.
[2]张英,李冬梅,邢颍.姜黄素的药理作用和研究进展[J].中国药理,2015,26(13):1850-1851.
[3]唐素芳.难溶性药物口服固体制剂溶出度测定法和体内相关性的研究进展[J].天津药业,2007,19(5):58-61.
[4]王涵.可降解高分子姜黄素纳米微球的制备、表征及其释药特性研究[D].湖北:武汉华中科技大学,2009.
[5]TANG Hua-dong ,CAITLIN J MURPHY,ZHANG Bo .Curcumin polymers as anticancer conjugates[J].Biomaterials,2010,31:7139-7149.
[6]S MANJU,K SREENIVASAN.Conjugation of curcumin onto hyaluronic acid enhances its aqueous solubility and stability[J].Journal of Colloid and Interface Science,2011,359:318-325.
[7]胡祥龙,曹冰,杨军,等.新型高载药量姜黄素聚前药两亲分子的制备与抗肿瘤研究[J].激光生物学报,2015,24(3):263-267.
[8]黄岳山,吴效明,臧松涛.改性聚乳酸的合成及缓释性能的研究[J].医疗卫生装备,2005,26(10):11-13.
[9]欧阳平,杨畅,康云清,等.超临界CO2抗溶剂法制备紫杉醇缓释微球[J].化工新型材料,2009,37(7):25-27.
[10]刘敬肖,曾淼,史非,等.SiO2气凝胶/壳聚糖复合药物载体材料的制备和表征[J].功能材料,2007,9(38):1527-1530.
[11]崔莉,贾军芳,张传杰,等.纤维素多孔材料的制备与性能[J].高分子材料科学与工程,2013,29(10):142-145.
[12]庞锦英,莫羡忠,刘钰馨.阻燃香蕉纤维增强聚乳酸复合材料的制备与表征[J].化工进展,2015,34(4):1050-1054.
[13]庞锦英,莫羡忠,谭登峰,等.香蕉纤维素微晶/ 聚乳酸气凝胶及其制备方法和用途 [P].中国,105017541,2015-07-09.
[14]李肖建,刘红霞,韦春,等.剑麻纤维素微晶的制备与表征[J].高分子材料科学与工程,2012,28(8):161-163.
[15]顾锦建,金朝辉,郑明琳,等.离子液体在药用活性成分中的应用[J].中国药业,2015,24(24):253-255.