拉曼探头的发展及其生物医学应用
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摘要
在生物医学领域,拉曼光谱学越来越多地应用于目标样本或组织的在体原位无损探测。拉曼探头作为重要的拉曼检测部件,正朝着多样化和功能化方向发展。拉曼信号本身极其微弱,且易被其他噪声信号干扰,因此拉曼探头的设计生产要求极高。对现有拉曼探头的设计及构造进行了深入介绍,包括光纤选择、探头顶端设计、过滤膜/片添加和探头后端优化等;综述了拉曼探头技术在生物医学领域的拓展和应用。其中,拉曼与其他光谱或成像模式结合的探头应用,给生物医学及临床探测等领域带来了新的活力和广阔的应用前景。
In recent years,Raman spectroscopy is being used more frequently in biomedical analyses,especially for in-situ nondestructive detection of target samples or tissues.Raman probe,as the essential detection component in Raman spectroscopy,is also being developed for better diversity and functionality.Since Raman signal is extremely weak and noise interference is common,the new design and production of Raman probe are also extremely critical.This review provides an in-depth introduction to the existing general design and construction of Raman probe for biomedical applications,including the selection of fiber and filter/membranes,the design of probe tip,and the optimization of probe backend.Subsequently,the expansion and application of the Raman probe technology in the biomedical field are reviewed.The probes based on a combination of Raman and other spectra or imaging modes bring new vitality and prospects for broad applications in the biomedical and clinical detection of target samples or tissues.
In recent years,Raman spectroscopy is being used more frequently in biomedical analyses,especially for in-situ nondestructive detection of target samples or tissues.Raman probe,as the essential detection component in Raman spectroscopy,is also being developed for better diversity and functionality.Since Raman signal is extremely weak and noise interference is common,the new design and production of Raman probe are also extremely critical.This review provides an in-depth introduction to the existing general design and construction of Raman probe for biomedical applications,including the selection of fiber and filter/membranes,the design of probe tip,and the optimization of probe backend.Subsequently,the expansion and application of the Raman probe technology in the biomedical field are reviewed.The probes based on a combination of Raman and other spectra or imaging modes bring new vitality and prospects for broad applications in the biomedical and clinical detection of target samples or tissues.
引文
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[26]Dochow S,Ma D L,Latka I,et al.Combined fiber probe for fluorescence lifetime and Raman spectroscopy[J].Analytical and Bioanalytical Chemistry,2015,407(27):8291-8301.
[27]Du H C,Chen Z Y,Chen N,et al.Fabrication of a novel concave cone surface-enhanced Raman scattering fiber probe[J].Chinese Journal of Lasers,2017,44(2):0213001.杜怀超,陈振宜,陈娜,等.新型凹锥形表面增强拉曼散射光纤探针的制备[J].中国激光,2017,44(2):0213001.
[28]Zhu Y,Dluhy R A,Zhao Y P.Development of silver nanorod array based fiber optic probes for SERSdetection[J].Sensors and Actuators B:Chemical,2011,157(1):42-50.
[29]Zhao Y B,Monroy G L,You S X,et al.Rapid diagnosis and differentiation of microbial pathogens in otitis media with a combined Raman spectroscopy and low-coherence interferometry probe:toward in vivo implementation[J].Journal of Biomedical Optics,2016,21(10):107005.
[30]Camp J C J,Mantle M D,York A P E,et al.A new combined nuclear magnetic resonance and Raman spectroscopic probe applied to in situinvestigations of catalysts and catalytic processes[J].Review of Scientific Instruments,2014,85(6):063111.
[2]Shim M G,Wilson B C,Marple E,et al.Study of fiber-optic probes for in vivo medical Raman spectroscopy[J].Applied Spectroscopy,1999,53(6):619-627.
[3]May J,Li Y S.Fiber Raman background study and its application in setting up optical fiber Raman probes[J].Applied Optics,1996,35(15):2527-2533.
[4]de Lima C J,Sathaiah S,Silveira L,et al.Development of catheters with low fiber background signals for Raman spectroscopic diagnosis applications[J].Artificial Organs,2000,24(3):231-234.
[5]Meksiarun P,Andriana B B,Matsuyoshi H,et al.Non-invasive quantitative analysis of specific fat accumulation in subcutaneous adipose tissues using Raman spectroscopy[J].Scientific Reports,2016,6:37068.
[6]Yamamoto Y S,Oshima Y,Shinzawa H,et al.Subsurface sensing of biomedical tissues using a miniaturized Raman probe:study of thin-layered model samples[J].Analytica Chimica Acta,2008,619(1):8-13.
[7]Okagbare P I,Morris M D.Fluorocarbon fiber-optic Raman probe for non-invasive Raman spectroscopy[J].Applied Spectroscopy,2012,66(6):728-730.
[8]Motz J T,Hunter M,Galindo L H,et al.Optical fiber probe for biomedical Raman spectroscopy[J].Applied Optics,2004,43(3):542-554.
[9]Stevens O,Petterson I E I,Day J C C,et al.Developing fibre optic Raman probes for applications in clinical spectroscopy[J].Chemical Society Reviews,2016,45(7):1919-1934.
[10]Wang J F,Bergholt M S,Zheng W,et al.Development of a beveled fiber-optic confocal Raman probe for enhancing in vivo epithelial tissue Raman measurements at endoscopy[J].Optics Letters,2013,38(13):2321-2323.
[11]Mo J H,Zheng W,Huang Z W.Fiber-optic Raman probe couples ball lens for depth-selected Raman measurements of epithelial tissue[J].Biomedical Optics Express,2010,1(1):17-30.
[12]Dochow S,Latka I,Becker M,et al.Multicore fiber with integrated fiber Bragg gratings for backgroundfree Raman sensing[J].Optics Express,2012,20(18):20156-20169.
[13]Zhang Y J,Wang M,Wang Z F,et al.Fabrication of chirped and tilted fiber Bragg gratings and investigation of Raman filtering effect[J].Acta Optica Sinica,2017,37(1):0106002.张宇菁,王蒙,王泽锋,等.啁啾倾斜Bragg光纤光栅制作及Raman滤除研究[J].光学学报,2017,37(1):0106002.
[14]Huang Z W,Zeng H S,Hamzavi I,et al.Rapid near-infrared Raman spectroscopy system for realtime in vivo skin measurements[J].Optics Letters,2001,26(22):1782-1784.
[15]Miyagi M,Kawakami S.Design theory of dielectriccoated circular metallic waveguides for infrared transmission[J].Journal of Lightwave Technology,1984,2(2):116-126.
[16]Katagiri T,Yamamoto Y S,Ozaki Y,et al.High axial resolution Raman probe made of a single hollow optical fiber[J].Applied Spectroscopy,2009,63(1):103-107.
[17]Short M A,Lam S,McWilliams A,et al.Development and preliminary results of an endoscopic Raman probe for potential in vivo diagnosis of lung cancers[J].Optics Letters,2008,33(7):711-713.
[18]McGregor H C,Short M A,McWilliams A,et al.Real-time endoscopic Raman spectroscopy for in vivo early lung cancer detection[J].Journal of Biophotonics,2017,10(1):98-110.
[19]Wang W B,Zhao J H,Short M,et al.Real-time in vivo cancer diagnosis using Raman spectroscopy[J].Journal of Biophotonics,2015,8(7):527-545.
[20]Short M A,Wang W B,Tai I T,et al.Development and in vivo testing of a high frequency endoscopic Raman spectroscopy system for potential applications in the detection of early colonic neoplasia[J].Journal of Biophotonics,2016,9(1/2):44-48.
[21]Hattori Y,Komachi Y,Asakura T,etal.Invivo Raman study of the living rat esophagus and stomach using a micro-Raman probe under an endoscope[J].Applied Spectroscopy,2007,61(6):579-584.
[22]Day C,Bennett R,Smith B,et al.A miniature confocal Raman probe for endoscopic use[J].Physics in Medicine&Biology,2009,54(23):7077-7087.
[23]Almond L M,Hutchings J,Kendall C,et al.Assessment of a custom-built Raman spectroscopic probe for diagnosis of early oesophageal neoplasia[J].Journal of Biomedical Optics,2012,17(8):0814211.
[24]Day J C C,Stone N.A subcutaneous Raman needle probe[J].Applied Spectroscopy,2013,67(3):349-354.
[25]Kang J,Luo S,He J,et al.Preliminary exploration on diagnosis of laryngeal carcinoma based on Raman spectroscopy[J].Laser&Optoelectronics Progress,2017,54(11):111701.康竞,罗昰,何剑,等.拉曼光谱诊断喉癌的初步探究[J].激光与光电子学进展,2017,54(11):111701.
[26]Dochow S,Ma D L,Latka I,et al.Combined fiber probe for fluorescence lifetime and Raman spectroscopy[J].Analytical and Bioanalytical Chemistry,2015,407(27):8291-8301.
[27]Du H C,Chen Z Y,Chen N,et al.Fabrication of a novel concave cone surface-enhanced Raman scattering fiber probe[J].Chinese Journal of Lasers,2017,44(2):0213001.杜怀超,陈振宜,陈娜,等.新型凹锥形表面增强拉曼散射光纤探针的制备[J].中国激光,2017,44(2):0213001.
[28]Zhu Y,Dluhy R A,Zhao Y P.Development of silver nanorod array based fiber optic probes for SERSdetection[J].Sensors and Actuators B:Chemical,2011,157(1):42-50.
[29]Zhao Y B,Monroy G L,You S X,et al.Rapid diagnosis and differentiation of microbial pathogens in otitis media with a combined Raman spectroscopy and low-coherence interferometry probe:toward in vivo implementation[J].Journal of Biomedical Optics,2016,21(10):107005.
[30]Camp J C J,Mantle M D,York A P E,et al.A new combined nuclear magnetic resonance and Raman spectroscopic probe applied to in situinvestigations of catalysts and catalytic processes[J].Review of Scientific Instruments,2014,85(6):063111.