基于分子印迹技术的细胞靶向识别研究进展
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摘要
分子印迹技术(Molecular imprinting technology,MIT)是一项模拟抗体等靶向生物分子识别专一性的仿生分子识别技术,由于其预定性强、识别选择性好、成本低廉等优势而被广泛应用。细胞靶向识别是MIT近些年发展起来的一个重要研究方向,在分子生物学、医疗诊断等领域极具应用前景。本文从分子印迹材料的合成方法、识别原理及其应用等方面介绍了MIT在细胞靶向识别领域的研究进展,最后提出了MIT在细胞靶向识别方面尚存的若干问题并对其未来可能的发展方向进行了展望。
Molecular imprinting technology( MIT) is a biomimetic molecular recognition technology to mimic the specificity of biomolecules,like antibody. It has been widely applied due to some merits,including fine forecast,nice selectivity and low cost. MIT-based cell targeting as an important branch developed in recent years is of hopeful potential in areas of molecular biology,medical diagnosis. Progress of MIT obtained in the field of cell targeting is introduced in this paper in terms of synthesis approach,recognition mechanism,as well as application. Some issues existed in this area are proposed and the future possibilities are also outlooked in the end.
Molecular imprinting technology( MIT) is a biomimetic molecular recognition technology to mimic the specificity of biomolecules,like antibody. It has been widely applied due to some merits,including fine forecast,nice selectivity and low cost. MIT-based cell targeting as an important branch developed in recent years is of hopeful potential in areas of molecular biology,medical diagnosis. Progress of MIT obtained in the field of cell targeting is introduced in this paper in terms of synthesis approach,recognition mechanism,as well as application. Some issues existed in this area are proposed and the future possibilities are also outlooked in the end.
引文
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[18]QIN L,HE X W,ZHANG W,et al. Surface-modified polystyrene beads as photografting imprinted polymer matrix for chromatographic separation of proteins[J]. Journal of Chromatography A,2009,1216(5):807-814.
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[20]ZHAO K,CHEN T,LIN B,et al. Adsorption and recognition of protein molecular imprinted calcium alginate/polyacrylamide hydrogel film with good regeneration performance and high toughness[J]. Reactive and Functional Polymers,2015,87:7-14.
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[24]PAN J,CHEN W,MA Y,et al. Molecularly imprinted polymers as receptor mimics for selective cell recognition[J]. Chemical Society Reviews,2018,47(15):5574-5587.
[25]WULFF,G. Molecular imprinting in cross-linked materials with the sid of c molecular templates-A way towards artificial antibodies[J]. Angewandte Chemie International Edition,1995,34:1812-1832.
[26]REN K,ZARE R N. Chemical recognition in cell-imprinted polymers[J]. American Chemical Society Nano,2012,6(5):4314-4318.
[27]SHEN X,SVENSSON B J,KAMRA T,et al. Bacterial imprinting at Pickering emulsion interfaces[J]. Angewandte Chemie International Edition,2014,53(40):10687-10690.
[28]KUNATH S,PANAGIOTOPOULOU M,MAXIMILIEN J,et al. Cell and tissue imaging with molecularly imprinted polymers as plastic antibody mimics[J]. Advanced Healthcare Materials,2015,4(9):1322-1326.
[29]WANG S,YIN D,WANG W,et al. Targeting and imaging of cancer cells via monosaccharide-imprinted fluorescent nanoparticles[J]. Scientific Reports,2016,6:22757.
[30]WANG S,WEN Y,WANG Y,et al. Pattern recognition of cells via multiplexed imaging with monosaccharide-imprinted quantum dots[J]. Analytical Chemistry,2017,89:5646-5652.
[31]DEMIR B,LEMBERGER M,PANAGIOTOPOULOU M,et al. Tracking hyaluronan:Molecularly imprinted polymer coated carbon dots for cancer cell targeting and imaging[J]. American Chemical Society Applied Materials&Interfaces,2018,10(4):3305-3313.
[32]KIM B Y,RUTKA J T,CHAN W C. Current concepts:Nanomedicine[J]. New England Journal of Medicine,2010,363(25):2434-2443.
[33]BAE K H,CHUNG H J,PARK T G. Nanomaterials for cancer therapy and imaging[J]. Molecules&Cells,2011,31(4):295-302.
[34]TAYLOR A,WILSON K M,MURRAY P,et al. Long-term tracking of cells using inorganic nanoparticles as contrast agents:are we there yet?[J]. Chemical Society Reviews,2012,41(7):2707-2717.
[35]PARISI O I,MORELLI C,PUOCI F,et al. Magnetic molecularly imprinted polymers(MMIPs)for carbazole derivative release in targeted cancer therapy[J]. Journal of Materials Chemistry B,2014,2:6619-6625.
[36]YIN D,LI X,MA Y,et al. Targeted cancer imaging and photothermal therapy via monosaccharide-imprinted gold nanorods[J]. Chemical Communication,2017,53:6716-6719.
[2]CHEN L,XU S,LI J. Recent advances in molecular imprinting technology:Current status,challenges and highlighted applications[J]. Chemical Society Reviews,2011,40:2922-2942.
[3] HOSHINO Y,KODAMA T,OKAHATA Y,et al. Peptide imprinted polymer nanoparticles:A plastic antibody[J].Journal of the American Chemical Society,2008,130(46):15242-15243.
[4]WANG S,LU X,CHENG J,et al. Advance in boronate affinity-based controllable oriented surface imprinting(in Chinese)[J]. Chinese Science Bulletin,2019,64:1-1,doi:10. 1360/N972018-01009.
[5]WANG H J,ZHOU W H,YIN X F,et al. Template synthesized molecularly imprinted polymer nanotube membranes for chemical separations[J]. Journal of the American Chemical Society,2006,128(50):15954-15955.
[6] PAN X,HE X,LIU Z. Molecularly imprinted mesoporous silica nanoparticles for specific extraction and efficient identification of amadori compounds[J]. Analytica Chimica Acta,2018,1019:65-73.
[7]HAUPT K,MOSBACH K. Molecularly imprinted polymers and their use in biomimetic sensors[J]. Chemical Reviews,2000,100(7):2495-2504.
[8]LI J,LI Y,ZHANG Y,et al. Highly sensitive molecularly imprinted electrochemical sensor based on the Double amplification by an Inorganic prussian blue catalytic polymer and the enzymatic effect of glucose oxidase[J]. Analytical Chemistry,2012,84(4):1888-1893.
[9]WULFF G. Enzyme-like catalysis by molecularly imprinted polymers[J]. Chemical Reviews,2002,102(1):1-27.
[10]YE J,CHEN Y,LIU Z. A boronate affinity sandwich assay:An appealing alternative to immunoassays for the determination of glycoproteins[J]. Angewandte Chemie International Edition,2014,53:10386-10389.
[11]KURCZEWSKA J,CEGOWSKI M,PECYNA P,et al. Molecularly imprinted polymer as drug delivery carrier in alginate dressing[J]. Materials Letters,2017,201:46-49.
[12]ZAIDI,ABBAS S. Molecular imprinted polymers as drug delivery vehicles[J]. Drug Delivery,2014,23:2262-2271.
[13]PANAGIOTOPOULOU M,SALINAS Y,BEYAZIT S,et al. Molecularly imprinted polymer coated quantum dots for multiplexed cell targeting and imaging[J]. Angewandte Chemie International Edition,2016,55:8244-8248.
[14]HOSHINO Y,KOIDE H,URAKAMI T,et al. Recognition,neutralization and clearance of target peptides in the blood stream of living mice by molecular imprinted polymer nanoparticles:a plastic antibody[J]. Journal of the American Chemical Society,2010,132(19):6644-6645.
[15]CECCHINI A,RAFFA V,CANFAROTTA F,et al. In vivo recognition of human vascular endothelial growth factor by molecularly imprinted polymers[J]. Nano Letters. 2017,17:2307-2312.
[16]OLIVER H,KARL-J M,STEFAN K,et al. Biomimetic ABO blood-group typing[J]. Angewandte Chemie International Edition. 2006,45:2626-2629.
[17]DEPORTER S M,LUI I,MCNAUGHTON B R. Programmed cell adhesion and growth on cell-imprinted polyacrylamide hydrogels[J]. Soft Matter,2012,8(40):10403-10408.
[18]QIN L,HE X W,ZHANG W,et al. Surface-modified polystyrene beads as photografting imprinted polymer matrix for chromatographic separation of proteins[J]. Journal of Chromatography A,2009,1216(5):807-814.
[19]ZHAO K,LIN B,CUI W,et al. Preparation and adsorption of bovine serum albumin-imprinted polyacrylamide hydrogel membrane grafted on non-woven polypropylene[J].Talanta,2014,121:256-262.
[20]ZHAO K,CHEN T,LIN B,et al. Adsorption and recognition of protein molecular imprinted calcium alginate/polyacrylamide hydrogel film with good regeneration performance and high toughness[J]. Reactive and Functional Polymers,2015,87:7-14.
[21]ZHU D,CHEN Z,ZHAO K,et al. Polypropylene non-woven supported fibronectin molecular imprinted calcium alginate/polyacrylamide hydrogel film for cell adhesion[J].Chinese Chemical Letters,2015,26(6):807-810.
[22]EERSELS K,VAN G B,ETHIRAJAN A,et al. Selective identification of macrophages and cancer cells based on thermal transport through surface-imprinted polymer layers[J]. Applied Materials&Interfaces,2013,5(15):7258-7267.
[23]LV S W,LIU Y,XIE M,et al. Near-infrared light-responsive hydrogel for specific recognition and photothermal site-release of circulating tumor cells[J]. American Chemical Society Nano,2016,10(6):6201-6210.
[24]PAN J,CHEN W,MA Y,et al. Molecularly imprinted polymers as receptor mimics for selective cell recognition[J]. Chemical Society Reviews,2018,47(15):5574-5587.
[25]WULFF,G. Molecular imprinting in cross-linked materials with the sid of c molecular templates-A way towards artificial antibodies[J]. Angewandte Chemie International Edition,1995,34:1812-1832.
[26]REN K,ZARE R N. Chemical recognition in cell-imprinted polymers[J]. American Chemical Society Nano,2012,6(5):4314-4318.
[27]SHEN X,SVENSSON B J,KAMRA T,et al. Bacterial imprinting at Pickering emulsion interfaces[J]. Angewandte Chemie International Edition,2014,53(40):10687-10690.
[28]KUNATH S,PANAGIOTOPOULOU M,MAXIMILIEN J,et al. Cell and tissue imaging with molecularly imprinted polymers as plastic antibody mimics[J]. Advanced Healthcare Materials,2015,4(9):1322-1326.
[29]WANG S,YIN D,WANG W,et al. Targeting and imaging of cancer cells via monosaccharide-imprinted fluorescent nanoparticles[J]. Scientific Reports,2016,6:22757.
[30]WANG S,WEN Y,WANG Y,et al. Pattern recognition of cells via multiplexed imaging with monosaccharide-imprinted quantum dots[J]. Analytical Chemistry,2017,89:5646-5652.
[31]DEMIR B,LEMBERGER M,PANAGIOTOPOULOU M,et al. Tracking hyaluronan:Molecularly imprinted polymer coated carbon dots for cancer cell targeting and imaging[J]. American Chemical Society Applied Materials&Interfaces,2018,10(4):3305-3313.
[32]KIM B Y,RUTKA J T,CHAN W C. Current concepts:Nanomedicine[J]. New England Journal of Medicine,2010,363(25):2434-2443.
[33]BAE K H,CHUNG H J,PARK T G. Nanomaterials for cancer therapy and imaging[J]. Molecules&Cells,2011,31(4):295-302.
[34]TAYLOR A,WILSON K M,MURRAY P,et al. Long-term tracking of cells using inorganic nanoparticles as contrast agents:are we there yet?[J]. Chemical Society Reviews,2012,41(7):2707-2717.
[35]PARISI O I,MORELLI C,PUOCI F,et al. Magnetic molecularly imprinted polymers(MMIPs)for carbazole derivative release in targeted cancer therapy[J]. Journal of Materials Chemistry B,2014,2:6619-6625.
[36]YIN D,LI X,MA Y,et al. Targeted cancer imaging and photothermal therapy via monosaccharide-imprinted gold nanorods[J]. Chemical Communication,2017,53:6716-6719.