硒结合蛋白1的生物功能及其与疾病的关系
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摘要
硒结合蛋白1 (SELENBP1)是1989年发现的定位于细胞质和细胞核的一种结合硒原子的含硒蛋白质.以往的研究表明,SELENBP1在高尔基体中蛋白质的转运、泛素化/去泛素化介导的蛋白质降解、硫代谢、调节缺氧诱导因子的稳定性等方面发挥着重要作用.也与口臭、癌症、精神分裂症和肾损伤等疾病的发生发展密切相关.本文对SELENBP1的生物功能及其与疾病关系的最新研究进展进行了综述和展望.
elenium-binding protein 1(SELENBP1) is a selenium-containing protein localized in the cytoplasm and nucleus discovered in 1989. Previous studies have shown that SELENBP1 plays an important role in protein transport in Golgi, ubiquitination/deubiquitination-mediated protein degradation, sulfur metabolism, and regulation the stability of hypoxia-inducible factor(HIF). It is also closely related to the development of diseases such as halitosis, cancer, schizophrenia and kidney damage. In this paper, the recent research progress on the biological function of SELENBP1 and its relationship with disease is reviewed and prospected.
elenium-binding protein 1(SELENBP1) is a selenium-containing protein localized in the cytoplasm and nucleus discovered in 1989. Previous studies have shown that SELENBP1 plays an important role in protein transport in Golgi, ubiquitination/deubiquitination-mediated protein degradation, sulfur metabolism, and regulation the stability of hypoxia-inducible factor(HIF). It is also closely related to the development of diseases such as halitosis, cancer, schizophrenia and kidney damage. In this paper, the recent research progress on the biological function of SELENBP1 and its relationship with disease is reviewed and prospected.
引文
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[18]Silvers A L,Lin L,Bass A J,et al.Decreased selenium-binding protein 1 in esophageal adenocarcinoma results from posttranscriptional and epigenetic regulation and affects chemosensitivity.Clin Cancer Res,2010,16(7):2009-2021
[19]Wang N,Chen Y,Yang X,et al.Selenium-binding protein 1 is associated with the degree of colorectal cancer differentiation and is regulated by histone modification.Oncol Rep,2014,31(6)2506-2514
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[22]Jeong J Y,Zhou J R,Gao C,et al.Human selenium binding protein-1(h SP56)is a negative regulator of HIF-1αand suppresses the malignant characteristics of prostate cancer cells.BMB Rep,201447(7):411-416
[23]Blom H J,Tangerman A.Methanethiol metabolism in whole blood.J Lab Clin Med,1988,111(6):606-610
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[26]Carmeliet P,Dor Y,Herbert J M,et al.Role of HIF-1αin hypoxiamediated apoptosis,cell proliferation and tumour angiogenesis Nature,1998,394(6692):485-490
[27]Ivan M,Kondo K,Yang H,et al.HIF alpha targeted for VHL-mediated destruction by proline hydroxylation:implications for O2sensing.Science,2001,292(5516):464-468
[28]Semenza G L.Targeting HIF-1 for cancer therapy.Nat Rev Cancer2003,3(10):721-732
[29]Scortegagna M,Martin R J,Kladney R D,et al.Hypoxia-inducible factor-1 alpha suppresses squamous carcinogenic progression and epithelial-mesenchymal transition.Cancer Res,2009,69(6):2638-2646
[30]Huang C,Ding G,Gu C,et al.Decreased selenium-binding protein1 enhances glutathione peroxidase 1 activity and downregulates HIF-1αto promote hepatocellular carcinoma invasiveness.Clin Cancer Res,2012,18(11):3042-3053
[31]Fang W,Goldberg M L,Pohl N M,et al.Functional and physical interaction between the selenium-binding protein 1(SBP1)and the glutathione peroxidase 1 selenoprotein.Carcinogenesis,2010,31(8):1360-1366
[32]Jerome-Morais A,Wright M E,Liu R,et al.Inverse association between glutathione peroxidase activity and both seleniumbinding protein 1 levels and gleason score in human prostate tissue.Prostate,2012,72(9):1006-1012
[33]Tangerman A,Winkel E G.The portable gas chromatograph Oral Chroma:a method of choice to detect oral and extraoral halitosis.J Breath Res,2008,2(1):017010
[34]Tangerman A,Winkel E G.Intra-and extraoral halitosis:finding of a new form of extraoral blood-borne halitosis caused by dimethyl sulphide.J Clin Periodontol,2007,34(9):748-755
[35]Tangerman A,Winkel E G.Extraoral halitosis:an overview.JBreath Res,2010,4(1):017003
[36]Harvey-Woodworth C N.Dimethylsulphidemia:the significance of dimethyl sulphide in extraoral,blood borne halitosis.Br Dent J,2013,214(7):E20
[37]Zhao C,Zeng H,Wu R T,et al.Loss of selenium-binding protein 1decreases sensitivity to clastogens and intracellular selenium content in He La cells.Plos one,2016,11(7):e0158650
[38]Miyaguchi K.Localization of selenium-binding protein at the tips of rapidly extending protrusions.Histochem Cell Boil,2004,121(5):371-376
[39]Torrealba J R,Colburn M,Golner S,et al.Selenium-binding protein 1 in smooth muscle cells is downregulated in a rhesus monkey model of chronic allograft nephropathy.Am J Transplant,2005,5(1):58-67
[40]Glatt S J,Everall I P,Kremen W S,et al.Comparative gene expression analysis of blood and brain provides concurrent validation of SELENBP1 up-regulation in schizophrenia.Proc Natl Acad Sci USA,2005,102(43):15533-15538
[41]Kanazawa T,Chana G,Glatt S J,et al.The utility of SELENBP1gene expression as a bio-marker for major psychotic disorders:replication in schiz-ophrenia and extension to bipolar disorder with psychosis.Am J Med Genet B Neuropsychiatr Genet,2008,147B(6):686-689
[42]Udawela M,Money T T,Neo J,et al.SELENBP1 expression in the prefrontal cortex of subjects with schizophrenia.Transl Psychiatry,2015,5(8):e615
[43]Basu A,Chakrabarti A.Hemoglobin interacting proteins and implications of spectrin hemoglobin interaction.J Proteomics,2015,128:469-475
[44]Ishida Y I,Kayama T,Kibune Y,et al.Identification of an argpyrimidine-modified protein in human red blood cells from schizophrenic patients:a possible biomarker for diseases involving carbonyl stress.Biochem Biophys Res Commun,2017493(1):573-577
[45]Lee E K,Shin Y J,Park E Y,et al.Selenium-binding protein 1:a sensitive urinary biomarker to detect heavy metal-induced nephrotoxicity.Arch Toxicol,2017,91(4):1635-1648
[46]Jamba L,Nehru B,Bansal M P.Redox modulation of selenium binding proteins by cadmium exposures in mice.Mol Cell Biochem,1997,177(1-2):169-175
[47]Valassakis C,Livanos P,Minopetrou M,et al.Promoter analysis and functional implications of the selenium binding protein(SBP)gene family in Arabidopsis thaliana.J Plant Physiol,2018,224-225:19-29
[48]Kim K S,Yang H Y,Song H,et al.Identification of a sensitive urinary biomarker,selenium-binding protein 1,for early detection of acute kidney injury.J Toxicol Environ Health A,2017,80(9):453-464
[2]Fairweather-Tait S J,Bao Y,Broadley M R,et al.Selenium in human health and disease.Antioxid Redox Signal,2011,14(7):1337-1383
[3]Chang P W,Tsui S K,Liew C,et al.Isolation,characterization,and chromosomal mapping of a novel c DNA clone encoding human selenium binding protein.J Cell Biochem,1997,64(2):217-224
[4]Bansal M P,Oborn C J,Danielson K G,et al.Evidence for two selenium-binding proteins distinct from glutathione peroxidase in mouse liver.Carcinogenesis,1989,10(3):541-546
[5]Bansal M P,Mukhopadhyay T,Scott J,et al.DNA sequencing of a mouse liver protein that binds selenium:implications for selenium's mechanism of action in cancer prevention.Carcinogenesis,1990,11(11):2071-2073
[6]Chen G,Wang H,Miller C T,et al.Reduced selenium-binding protein 1 expression is associated with poor outcome in lung adenocarcinomas.J Pathol,2004,202(3):321-329
[7]Pol A,Renkema G H,Tangerman A,et al.Mutations in SELENBP1,encoding a novel human methanethiol oxidase,cause extraoral halitosis.Nat Genet,2018,50(1):120-129
[8]Eyice?,Myronova N,Pol A,et al.Bacterial SBP56 identified as a Cu-dependent methanethiol oxidase widely distributed in the biosphere.ISME J,2017,12(1):145-160
[9]Schild F,Kieffer-Jaquinod S,Palencia A,et al.Biochemical and biophysical characterization of the selenium-binding and reducing site in Arabidopsis thaliana homologue to mammals seleniumbinding protein 1.J Biol Chem,2014,289(46):31765-31776
[10]Wu C L,Zhang W B,Mai K S,et al.Molecular cloning,characterization and m RNA expression of selenium-binding protein in abalone(Haliotis discus hannai Ino):Response to dietary selenium,iron and zinc.Fish Shellfish Immunol,2010,29(1):117-125
[11]Li T,Yang W,Li M,et al.Expression of selenium-binding protein 1characterizes intestinal cell maturation and predicts survival for patients with colorectal cancer.Mol Nutr Food Res,2008,52(11):1289-1299
[12]Yang W,Diamond A M.Selenium-binding protein 1 as a tumor suppressor and a prognostic indicator of clinical outcome.Biomark Res,2013,1(1):15
[13]Raucci R,Colonna G,Guerriero E,et al.Structural and functiona studies of the human selenium binding protein-1 and its involvement in hepatocellular carcinoma.Biochim Biophys Acta2011,1814(4):513-522
[14]Suzuki M,Lee D Y,Inyamah N,et al.Solution NMR structure of selenium-binding protein from Methanococcus vannielii.J Bio Chem,2008,283(38):25936-25943
[15]Ying Q,Ansong E,Diamond A M,et al.A critical role for cysteine57 in the biological functions of selenium binding protein-1.Int JMol Sci,2015,16(11):27599-27608
[16]Wang Y,Fang W,Huang Y,et al.Reduction of selenium-binding protein 1 sensitizes cancer cells to selenite via elevating extracellular glutathione:a novel mechanism of cancer-specific cytotoxicity of selenite.Free Radic Biol Med,2015,79:186-196
[17]Pohl N M,Tong C,Fang W,et al.Transcriptional regulation and biological functions of selenium-binding protein 1 in colorecta cancer in vitro and in nude mouse xenografts.Plos One,20094(11):e7774
[18]Silvers A L,Lin L,Bass A J,et al.Decreased selenium-binding protein 1 in esophageal adenocarcinoma results from posttranscriptional and epigenetic regulation and affects chemosensitivity.Clin Cancer Res,2010,16(7):2009-2021
[19]Wang N,Chen Y,Yang X,et al.Selenium-binding protein 1 is associated with the degree of colorectal cancer differentiation and is regulated by histone modification.Oncol Rep,2014,31(6)2506-2514
[20]Porat A,Sagiv Y,Elazar Z.A 56-k Da selenium-binding protein participates in intra-Golgi protein transport.J Biol Chem,2000275(19):14457-14465
[21]Jeong J Y,Wang Y,Sytkowski A J.Human selenium binding protein-1(h SP56)interacts with VDU1 in a selenium-dependen manner.Biochem Biophys Res Commun,2009,379(2):583-588
[22]Jeong J Y,Zhou J R,Gao C,et al.Human selenium binding protein-1(h SP56)is a negative regulator of HIF-1αand suppresses the malignant characteristics of prostate cancer cells.BMB Rep,201447(7):411-416
[23]Blom H J,Tangerman A.Methanethiol metabolism in whole blood.J Lab Clin Med,1988,111(6):606-610
[24]Walker V,Mills G A,Fortune P M,et al.Neonatal encephalopathy with a pungent body odour.Arch Dis Child Fetal Neonatal Ed1997,77(1):F65-F66
[25]Engelke U F,Tangerman A,Willemsen M A,et al.Dimethy sulfone in human cerebrospinal fluid and blood plasma confirmed by one-dimensional 1H and two-dimensional 1H-13C NMR.NMRBiomed,2005,18(5),331-336
[26]Carmeliet P,Dor Y,Herbert J M,et al.Role of HIF-1αin hypoxiamediated apoptosis,cell proliferation and tumour angiogenesis Nature,1998,394(6692):485-490
[27]Ivan M,Kondo K,Yang H,et al.HIF alpha targeted for VHL-mediated destruction by proline hydroxylation:implications for O2sensing.Science,2001,292(5516):464-468
[28]Semenza G L.Targeting HIF-1 for cancer therapy.Nat Rev Cancer2003,3(10):721-732
[29]Scortegagna M,Martin R J,Kladney R D,et al.Hypoxia-inducible factor-1 alpha suppresses squamous carcinogenic progression and epithelial-mesenchymal transition.Cancer Res,2009,69(6):2638-2646
[30]Huang C,Ding G,Gu C,et al.Decreased selenium-binding protein1 enhances glutathione peroxidase 1 activity and downregulates HIF-1αto promote hepatocellular carcinoma invasiveness.Clin Cancer Res,2012,18(11):3042-3053
[31]Fang W,Goldberg M L,Pohl N M,et al.Functional and physical interaction between the selenium-binding protein 1(SBP1)and the glutathione peroxidase 1 selenoprotein.Carcinogenesis,2010,31(8):1360-1366
[32]Jerome-Morais A,Wright M E,Liu R,et al.Inverse association between glutathione peroxidase activity and both seleniumbinding protein 1 levels and gleason score in human prostate tissue.Prostate,2012,72(9):1006-1012
[33]Tangerman A,Winkel E G.The portable gas chromatograph Oral Chroma:a method of choice to detect oral and extraoral halitosis.J Breath Res,2008,2(1):017010
[34]Tangerman A,Winkel E G.Intra-and extraoral halitosis:finding of a new form of extraoral blood-borne halitosis caused by dimethyl sulphide.J Clin Periodontol,2007,34(9):748-755
[35]Tangerman A,Winkel E G.Extraoral halitosis:an overview.JBreath Res,2010,4(1):017003
[36]Harvey-Woodworth C N.Dimethylsulphidemia:the significance of dimethyl sulphide in extraoral,blood borne halitosis.Br Dent J,2013,214(7):E20
[37]Zhao C,Zeng H,Wu R T,et al.Loss of selenium-binding protein 1decreases sensitivity to clastogens and intracellular selenium content in He La cells.Plos one,2016,11(7):e0158650
[38]Miyaguchi K.Localization of selenium-binding protein at the tips of rapidly extending protrusions.Histochem Cell Boil,2004,121(5):371-376
[39]Torrealba J R,Colburn M,Golner S,et al.Selenium-binding protein 1 in smooth muscle cells is downregulated in a rhesus monkey model of chronic allograft nephropathy.Am J Transplant,2005,5(1):58-67
[40]Glatt S J,Everall I P,Kremen W S,et al.Comparative gene expression analysis of blood and brain provides concurrent validation of SELENBP1 up-regulation in schizophrenia.Proc Natl Acad Sci USA,2005,102(43):15533-15538
[41]Kanazawa T,Chana G,Glatt S J,et al.The utility of SELENBP1gene expression as a bio-marker for major psychotic disorders:replication in schiz-ophrenia and extension to bipolar disorder with psychosis.Am J Med Genet B Neuropsychiatr Genet,2008,147B(6):686-689
[42]Udawela M,Money T T,Neo J,et al.SELENBP1 expression in the prefrontal cortex of subjects with schizophrenia.Transl Psychiatry,2015,5(8):e615
[43]Basu A,Chakrabarti A.Hemoglobin interacting proteins and implications of spectrin hemoglobin interaction.J Proteomics,2015,128:469-475
[44]Ishida Y I,Kayama T,Kibune Y,et al.Identification of an argpyrimidine-modified protein in human red blood cells from schizophrenic patients:a possible biomarker for diseases involving carbonyl stress.Biochem Biophys Res Commun,2017493(1):573-577
[45]Lee E K,Shin Y J,Park E Y,et al.Selenium-binding protein 1:a sensitive urinary biomarker to detect heavy metal-induced nephrotoxicity.Arch Toxicol,2017,91(4):1635-1648
[46]Jamba L,Nehru B,Bansal M P.Redox modulation of selenium binding proteins by cadmium exposures in mice.Mol Cell Biochem,1997,177(1-2):169-175
[47]Valassakis C,Livanos P,Minopetrou M,et al.Promoter analysis and functional implications of the selenium binding protein(SBP)gene family in Arabidopsis thaliana.J Plant Physiol,2018,224-225:19-29
[48]Kim K S,Yang H Y,Song H,et al.Identification of a sensitive urinary biomarker,selenium-binding protein 1,for early detection of acute kidney injury.J Toxicol Environ Health A,2017,80(9):453-464