绿茶多酚在药物开发领域的研究进展
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摘要
阐述了绿茶多酚的化学组成、生物代谢以及在药物开发领域的进展,主要集中在对癌症、神经退行性疾病、糖尿病的预防和治疗方面.茶多酚潜在的抗肿瘤活性可以通过干预肿瘤发生、发展、转移等各个阶段来进行,但茶多酚发展成为治疗药物还是面临很多挑战,比如,低生物药效率.基于纳米颗粒的药物传递系统相比单纯的茶多酚具有特别的优势,同时,为了处理新出现的安全问题和潜在的局部药物过量效应,有必要确定包裹纳米粒子以后的药物实际用量和药理学机制.
Green tea polyphenols( GTP) chemical compositions and metabolic biotransformations were described,and their recent developments in drug discovery,focusing on their chemopreventive and therapeutic effects of cancer,neurodegenerative disease and diabetes. GTPs possess potent anticarcinogenic activities through interfering with the initiation,development and progression phases of cancer. There are several challenges( e.g.,poor bioavailability) in developing GTPs as therapeutic agents.By nanoparticle-based delivery systems has provided unique advantages over purified GTPs. However,there is still a need to determine the actual magnitude and pharmacological mechanisms of GTPs encapsulated in nanoparticles,in order to address newly emerging safety issues associated with the potential ‘local overdose'effect.
Green tea polyphenols( GTP) chemical compositions and metabolic biotransformations were described,and their recent developments in drug discovery,focusing on their chemopreventive and therapeutic effects of cancer,neurodegenerative disease and diabetes. GTPs possess potent anticarcinogenic activities through interfering with the initiation,development and progression phases of cancer. There are several challenges( e.g.,poor bioavailability) in developing GTPs as therapeutic agents.By nanoparticle-based delivery systems has provided unique advantages over purified GTPs. However,there is still a need to determine the actual magnitude and pharmacological mechanisms of GTPs encapsulated in nanoparticles,in order to address newly emerging safety issues associated with the potential ‘local overdose'effect.
引文
[1]LI F,WANG Y,LI D,et al. Perspectives on the recent developments with green tea polyphenols in drug discovery[J]. Expert Opin Drug Discov,2018,13(7):643-660.
[2]YANG C S,WANG H. Cancer preventive activities of tea catechins[J]. Molecules,2016,21(12):
[3]YANG C S,WANG H,SHERIDAN Z P. Studies on prevention of obesity,metabolic syndrome,diabetes,cardiovascular diseases and cancer by tea[J]. J Food Drug Anal,2018,26(1):1-13.
[4]张牧,宋新强,陈磊,等.绿茶提取物EGCG治疗乳腺癌分子机制的生物信息学分析[J].信阳师范学院学报(自然科学版),2017,30(3):498-503.ZHANG Mu,SONG Xinqiang,CHEN Lei,et al. Bioinformatics analysis on molecular mechanism of active compound of green tea(EGCG)in treatment of breast cancer[J]. Journal of Xinyang Normal University(Natural Science Edition),2017,30(3):498-503.
[5]LIU J,LIU S,ZHOU H,et al. Association of green tea consumption with mortality from all-cause,cardiovascular disease and cancer in a Chinese cohort of 165,000 adult men[J]. Eur J Epidemiol,2016,31(9):853-865.
[6]CHU C,DENG J,MAN Y,et al. Green tea extracts epigallocatechin-3-gallate for different treatments[J]. Biomed Res Int,2017,2017:1-9.
[7]ENG Q Y,THANIKACHALAM P V,RAMAMURTHY S. Molecular understanding of epigallocatechin gallate(EGCG)in cardiovascular and metabolic diseases[J]. J Ethnopharmacol,2018,210:296-310.
[8]XU Q,LANGLEY M,KANTHASAMY A G,et al. Epigallocatechin gallate has a neurorescue effect in a mouse model of parkinson disease[J]. J Nutr,2017,147(10):1926-1931.
[9]ULLMANN U,HALLER J,DECOURT J P,et al. A single ascending dose study of epigallocatechin gallate in healthy volunteers[J]. J Int Med Res,2003,31(2):88-101.
[10]MISAKA S,KAWABE K,ONOUE S,et al. Development of rapid and simultaneous quantitative method for green tea catechins on the bioanalytical study using UPLC/ESI-MS[J]. Biomed Chromatogr,2013,27(1):1-6.
[11]MASUKAWA Y,MATSUI Y,SHIMIZU N,et al. Determination of green tea catechins in human plasma using liquid chromatography-electrospray ionization mass spectrometry[J]. J Chromatogr B Analyt Technol Biomed Life Sci,2006,834(1/2):26-34.
[12]COLL S,MATABOSCH X,GARROSTAS L,et al. The effect of tea consumption on the steroid profile[J]. Drug Test Anal,2018,10(9):1438-1447.
[13]MILLER R J,JACKSON K G,DADD T,et al. A preliminary investigation of the impact of catechol-O-methyltransferase genotype on the absorption and metabolism of green tea catechins[J]. Eur J Nutr,2012,51(1):47-55.
[14]PI M,KAPOOR K,YE R,et al. GPCR6a is a molecular target for the natural products gallate and EGCG in green tea[J].Mol Nutr Food Res,2018,62(8):e1700770.
[15]YANG C S,ZHANG J. Studies on the prevention of cancer and cardiometabolic diseases by tea:Issues on mechanisms,effective doses and toxicities[J]. J Agric Food Chem,2018,23:23-25
[16]PASTORIZA S,MESIAS M,CABRERA C,et al. Healthy properties of green and white teas:an update[J]. Food Funct,2017,8(8):2650-2662.
[17]KHAN N,MUKHTAR H. Modulation of signaling pathways in prostate cancer by green tea polyphenols[J]. Biochem Pharmacol,2013,85(5):667-672.
[18]WANG H,BIAN S,YANG C S. Green tea polyphenol EGCG suppresses lung cancer cell growth through upregulating miR-210 expression caused by stabilizing HIF-1alpha[J]. Carcinogenesis,2011,32(12):1881-1889.
[19]HENNING S M,WANG P,CARPENTER C L,et al. Epigenetic effects of green tea polyphenols in cancer[J]. Epigenomics,2013,5(6):729-741.
[20]ZHOU L,ELIAS R J. Antioxidant and pro-oxidant activity of(-)-epigallocatechin-3-gallate in food emulsions:Influence of p H and phenolic concentration[J]. Food Chem,2013,138(2/3):1503-1509.
[21]OIKAWA S,FURUKAWAA A,ASADA H,et al. Catechins induce oxidative damage to cellular and isolated DNA through the generation of reactive oxygen species[J]. Free Radic Res,2003,37(8):881-890.
[22]OH B,FIGTREE G,COSTA D,et al. Oxidative stress in prostate cancer patients:A systematic review of case control studies[J]. Prostate Int,2016,4(3):71-87.
[23]NAPONELLI V,MODERNELLI A,BETTUZZI S,et al. Roles of autophagy induced by natural compounds in prostate cancer[J]. Biomed Res Int,2015,15:12-18.
[24]TORRE L A,BRAY F,SIEGEL R L,et al. Global cancer statistics,2012[J]. CA Cancer J Clin,2015,65(2):87-108.
[25]SADAVA D,WHITLOCK E,KANE S E. The green tea polyphenol,epigallocatechin-3-gallate inhibits telomerase and induces apoptosis in drug-resistant lung cancer cells[J]. Biochem Biophys Res Commun,2007,360(1):233-237.
[26]GAO Z,XU Z,HUNG M S,et al. Promoter demethylation of WIF-1 by epigallocatechin-3-gallate in lung cancer cells[J].Anticancer Res,2009,29(6):2025-2030.
[27]MILLIGAN S A,BURKE P,COLEMAN D T,et al. The green tea polyphenol EGCG potentiates the antiproliferative activity of c-Met and epidermal growth factor receptor inhibitors in non-small cell lung cancer cells[J]. Clin Cancer Res,2009,15(15):4885-4894.
[28]KASPER B,SALAMEH A,KRAUSCH M,et al. Epigallocatechin gallate attenuates cardiopulmonary bypass-associated lung injury[J]. J Surg Res,2016,201(2):313-325.
[29]ZHOU H,CHEN J X,YANG C S,et al. Gene regulation mediated by microRNAs in response to green tea polyphenol EGCG in mouse lung cancer[J]. BMC Genomics,2014,15(S11):S3.
[30]LI M J,YIN Y C,WANG J,et al. Green tea compounds in breast cancer prevention and treatment[J]. World J Clin Oncol,2014,5(3):520-528.
[31]TU S H,KU C Y,HO C T,et al. Tea polyphenol(-)-epigallocatechin-3-gallate inhibits nicotine-and estrogen-induced alpha9-nicotinic acetylcholine receptor upregulation in human breast cancer cells[J]. Mol Nutr Food Res,2011,55(3):455-466.
[32]LI Y,YUAN Y Y,MEERAN S M,et al. Synergistic epigenetic reactivation of estrogen receptor-alpha(ERalpha)by combined green tea polyphenol and histone deacetylase inhibitor in ERalpha-negative breast cancer cells[J]. Mol Cancer,2010(9):274-277.
[33]BELGUISE K,GUO S,SONENSHEIN G E. Activation of FOXO3a by the green tea polyphenol epigallocatechin-3-gallate induces estrogen receptor alpha expression reversing invasive phenotype of breast cancer cells[J]. Cancer Res,2007,67(12):5763-5770.
[34]EDDY S F,KANE S E,SONENSHEIN G E. Trastuzumab-resistant HER2-driven breast cancer cells are sensitive to epigallocatechin-3 gallate[J]. Cancer Res,2007,67(19):9018-9023.
[35]DANDAWATE P R,SUBRAMANIAM D,JENSEN R A,et al. Targeting cancer stem cells and signaling pathways by phytochemicals:Novel approach for breast cancer therapy[J]. Semin Cancer Biol,2016(40/41):192-208.
[36]KHAN S I,AUMSUWAN P,KHAN I A,et al. Epigenetic events associated with breast cancer and their prevention by dietary components targeting the epigenome[J]. Chem Res Toxicol,2012,25(1):61-73.
[37]LEE W J,SHIM J Y,ZHU B T. Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids[J]. Mol Pharmacol,2005,68(4):1018-1030.
[38]JANG J Y,LEE J K,JEON Y K,et al. Exosome derived from epigallocatechin gallate treated breast cancer cells suppresses tumor growth by inhibiting tumor-associated macrophage infiltration and M2 polarization[J]. BMC Cancer,2013(13):421-425.
[39]WOBST H J,SHARMA A,DIAMOND M I,et al. The green tea polyphenol(-)-epigallocatechin gallate prevents the aggregation of tau protein into toxic oligomers at substoichiometric ratios[J]. FEBS Lett,2015,589(1):77-83.
[40]SINGH N A,MANDAL A K,KHAN Z A. Potential neuroprotective properties of epigallocatechin-3-gallate(EGCG)[J].Nutr J,2016,15(1):60-65.
[41]CHESSER A S,GANESHAN V,YANG J,et al. Epigallocatechin-3-gallate enhances clearance of phosphorylated tau in primary neurons[J]. Nutr Neurosci,2016,19(1):21-31.
[42]XU Y,ZHANG Y,QUAN Z,et al. Epigallocatechin gallate(EGCG)inhibits alpha-synuclein aggregation:A potential agent for parkinson's disease[J]. Neurochem Res,2016,41(10):2788-2796.
[43]YANG J,MAO Q X,XU H X,et al. Tea consumption and risk of type 2 diabetes mellitus:a systematic review and metaanalysis update[J]. BMJ Open,2014,4(7):e005632.
[44]ISO H,DATE C,WAKAI K,et al. The relationship between green tea and total caffeine intake and risk for self-reported type 2 diabetes among Japanese adults[J]. Ann Intern Med,2006,144(8):554-562.
[45]MICALI S,TERRITO A,PIROLA G M,et al. Effect of green tea catechins in patients with high-grade prostatic intraepithelial neoplasia:Results of a short-term double-blind placebo controlled phase II clinical trial[J]. Arch Ital Urol Androl,2017,89(3):197-202.
[46]HUANG Y Q,LU X,MIN H,et al. Green tea and liver cancer risk:A meta-analysis of prospective cohort studies in Asian populations[J]. Nutrition,2016,32(1):3-8.
[47]TESCHKE R,SCHULZE J. Green tea and the question of reduced liver cancer risk:the dawn of potential clinical relevance?[J]. Hepatobiliary Surg Nutr,2017,6(2):122-126.
[48]YANG C S,LI G,YANG Z,et al. Cancer prevention by tocopherols and tea polyphenols[J]. Cancer Lett,2013,334(1):79-85.
[49]KIDA K,SUZUKI M,MATSUMOTO N,et al. Identification of biliary metabolites of(-)-epigallocatechin gallate in rats[J]. J Agric Food Chem,2000,48(9):4151-4155.
[50]SIDDIQUI I A,ADHAMI V M,BHARALI D J,et al. Introducing nanochemoprevention as a novel approach for cancer control:proof of principle with green tea polyphenol epigallocatechin-3-gallate[J]. Cancer Res,2009,69(5):1712-1716.
[51]WANG J,MAN G C W,CHAN T H,et al. A prodrug of green tea polyphenol(-)-epigallocatechin-3-gallate(Pro-EGCG)serves as a novel angiogenesis inhibitor in endometrial cancer[J]. Cancer Lett,2018,412:10-20.
[52]HEYZA J R,ARORA S,ZHANG H,et al. Targeting the DNA repair endonuclease ERCC1-XPF with green tea polyphenol epigallocatechin-3-gallate(EGCG)and its prodrug to enhance cisplatin efficacy in human cancer cells[J]. Nutrients,2018,10(11):66-76.
[2]YANG C S,WANG H. Cancer preventive activities of tea catechins[J]. Molecules,2016,21(12):
[3]YANG C S,WANG H,SHERIDAN Z P. Studies on prevention of obesity,metabolic syndrome,diabetes,cardiovascular diseases and cancer by tea[J]. J Food Drug Anal,2018,26(1):1-13.
[4]张牧,宋新强,陈磊,等.绿茶提取物EGCG治疗乳腺癌分子机制的生物信息学分析[J].信阳师范学院学报(自然科学版),2017,30(3):498-503.ZHANG Mu,SONG Xinqiang,CHEN Lei,et al. Bioinformatics analysis on molecular mechanism of active compound of green tea(EGCG)in treatment of breast cancer[J]. Journal of Xinyang Normal University(Natural Science Edition),2017,30(3):498-503.
[5]LIU J,LIU S,ZHOU H,et al. Association of green tea consumption with mortality from all-cause,cardiovascular disease and cancer in a Chinese cohort of 165,000 adult men[J]. Eur J Epidemiol,2016,31(9):853-865.
[6]CHU C,DENG J,MAN Y,et al. Green tea extracts epigallocatechin-3-gallate for different treatments[J]. Biomed Res Int,2017,2017:1-9.
[7]ENG Q Y,THANIKACHALAM P V,RAMAMURTHY S. Molecular understanding of epigallocatechin gallate(EGCG)in cardiovascular and metabolic diseases[J]. J Ethnopharmacol,2018,210:296-310.
[8]XU Q,LANGLEY M,KANTHASAMY A G,et al. Epigallocatechin gallate has a neurorescue effect in a mouse model of parkinson disease[J]. J Nutr,2017,147(10):1926-1931.
[9]ULLMANN U,HALLER J,DECOURT J P,et al. A single ascending dose study of epigallocatechin gallate in healthy volunteers[J]. J Int Med Res,2003,31(2):88-101.
[10]MISAKA S,KAWABE K,ONOUE S,et al. Development of rapid and simultaneous quantitative method for green tea catechins on the bioanalytical study using UPLC/ESI-MS[J]. Biomed Chromatogr,2013,27(1):1-6.
[11]MASUKAWA Y,MATSUI Y,SHIMIZU N,et al. Determination of green tea catechins in human plasma using liquid chromatography-electrospray ionization mass spectrometry[J]. J Chromatogr B Analyt Technol Biomed Life Sci,2006,834(1/2):26-34.
[12]COLL S,MATABOSCH X,GARROSTAS L,et al. The effect of tea consumption on the steroid profile[J]. Drug Test Anal,2018,10(9):1438-1447.
[13]MILLER R J,JACKSON K G,DADD T,et al. A preliminary investigation of the impact of catechol-O-methyltransferase genotype on the absorption and metabolism of green tea catechins[J]. Eur J Nutr,2012,51(1):47-55.
[14]PI M,KAPOOR K,YE R,et al. GPCR6a is a molecular target for the natural products gallate and EGCG in green tea[J].Mol Nutr Food Res,2018,62(8):e1700770.
[15]YANG C S,ZHANG J. Studies on the prevention of cancer and cardiometabolic diseases by tea:Issues on mechanisms,effective doses and toxicities[J]. J Agric Food Chem,2018,23:23-25
[16]PASTORIZA S,MESIAS M,CABRERA C,et al. Healthy properties of green and white teas:an update[J]. Food Funct,2017,8(8):2650-2662.
[17]KHAN N,MUKHTAR H. Modulation of signaling pathways in prostate cancer by green tea polyphenols[J]. Biochem Pharmacol,2013,85(5):667-672.
[18]WANG H,BIAN S,YANG C S. Green tea polyphenol EGCG suppresses lung cancer cell growth through upregulating miR-210 expression caused by stabilizing HIF-1alpha[J]. Carcinogenesis,2011,32(12):1881-1889.
[19]HENNING S M,WANG P,CARPENTER C L,et al. Epigenetic effects of green tea polyphenols in cancer[J]. Epigenomics,2013,5(6):729-741.
[20]ZHOU L,ELIAS R J. Antioxidant and pro-oxidant activity of(-)-epigallocatechin-3-gallate in food emulsions:Influence of p H and phenolic concentration[J]. Food Chem,2013,138(2/3):1503-1509.
[21]OIKAWA S,FURUKAWAA A,ASADA H,et al. Catechins induce oxidative damage to cellular and isolated DNA through the generation of reactive oxygen species[J]. Free Radic Res,2003,37(8):881-890.
[22]OH B,FIGTREE G,COSTA D,et al. Oxidative stress in prostate cancer patients:A systematic review of case control studies[J]. Prostate Int,2016,4(3):71-87.
[23]NAPONELLI V,MODERNELLI A,BETTUZZI S,et al. Roles of autophagy induced by natural compounds in prostate cancer[J]. Biomed Res Int,2015,15:12-18.
[24]TORRE L A,BRAY F,SIEGEL R L,et al. Global cancer statistics,2012[J]. CA Cancer J Clin,2015,65(2):87-108.
[25]SADAVA D,WHITLOCK E,KANE S E. The green tea polyphenol,epigallocatechin-3-gallate inhibits telomerase and induces apoptosis in drug-resistant lung cancer cells[J]. Biochem Biophys Res Commun,2007,360(1):233-237.
[26]GAO Z,XU Z,HUNG M S,et al. Promoter demethylation of WIF-1 by epigallocatechin-3-gallate in lung cancer cells[J].Anticancer Res,2009,29(6):2025-2030.
[27]MILLIGAN S A,BURKE P,COLEMAN D T,et al. The green tea polyphenol EGCG potentiates the antiproliferative activity of c-Met and epidermal growth factor receptor inhibitors in non-small cell lung cancer cells[J]. Clin Cancer Res,2009,15(15):4885-4894.
[28]KASPER B,SALAMEH A,KRAUSCH M,et al. Epigallocatechin gallate attenuates cardiopulmonary bypass-associated lung injury[J]. J Surg Res,2016,201(2):313-325.
[29]ZHOU H,CHEN J X,YANG C S,et al. Gene regulation mediated by microRNAs in response to green tea polyphenol EGCG in mouse lung cancer[J]. BMC Genomics,2014,15(S11):S3.
[30]LI M J,YIN Y C,WANG J,et al. Green tea compounds in breast cancer prevention and treatment[J]. World J Clin Oncol,2014,5(3):520-528.
[31]TU S H,KU C Y,HO C T,et al. Tea polyphenol(-)-epigallocatechin-3-gallate inhibits nicotine-and estrogen-induced alpha9-nicotinic acetylcholine receptor upregulation in human breast cancer cells[J]. Mol Nutr Food Res,2011,55(3):455-466.
[32]LI Y,YUAN Y Y,MEERAN S M,et al. Synergistic epigenetic reactivation of estrogen receptor-alpha(ERalpha)by combined green tea polyphenol and histone deacetylase inhibitor in ERalpha-negative breast cancer cells[J]. Mol Cancer,2010(9):274-277.
[33]BELGUISE K,GUO S,SONENSHEIN G E. Activation of FOXO3a by the green tea polyphenol epigallocatechin-3-gallate induces estrogen receptor alpha expression reversing invasive phenotype of breast cancer cells[J]. Cancer Res,2007,67(12):5763-5770.
[34]EDDY S F,KANE S E,SONENSHEIN G E. Trastuzumab-resistant HER2-driven breast cancer cells are sensitive to epigallocatechin-3 gallate[J]. Cancer Res,2007,67(19):9018-9023.
[35]DANDAWATE P R,SUBRAMANIAM D,JENSEN R A,et al. Targeting cancer stem cells and signaling pathways by phytochemicals:Novel approach for breast cancer therapy[J]. Semin Cancer Biol,2016(40/41):192-208.
[36]KHAN S I,AUMSUWAN P,KHAN I A,et al. Epigenetic events associated with breast cancer and their prevention by dietary components targeting the epigenome[J]. Chem Res Toxicol,2012,25(1):61-73.
[37]LEE W J,SHIM J Y,ZHU B T. Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids[J]. Mol Pharmacol,2005,68(4):1018-1030.
[38]JANG J Y,LEE J K,JEON Y K,et al. Exosome derived from epigallocatechin gallate treated breast cancer cells suppresses tumor growth by inhibiting tumor-associated macrophage infiltration and M2 polarization[J]. BMC Cancer,2013(13):421-425.
[39]WOBST H J,SHARMA A,DIAMOND M I,et al. The green tea polyphenol(-)-epigallocatechin gallate prevents the aggregation of tau protein into toxic oligomers at substoichiometric ratios[J]. FEBS Lett,2015,589(1):77-83.
[40]SINGH N A,MANDAL A K,KHAN Z A. Potential neuroprotective properties of epigallocatechin-3-gallate(EGCG)[J].Nutr J,2016,15(1):60-65.
[41]CHESSER A S,GANESHAN V,YANG J,et al. Epigallocatechin-3-gallate enhances clearance of phosphorylated tau in primary neurons[J]. Nutr Neurosci,2016,19(1):21-31.
[42]XU Y,ZHANG Y,QUAN Z,et al. Epigallocatechin gallate(EGCG)inhibits alpha-synuclein aggregation:A potential agent for parkinson's disease[J]. Neurochem Res,2016,41(10):2788-2796.
[43]YANG J,MAO Q X,XU H X,et al. Tea consumption and risk of type 2 diabetes mellitus:a systematic review and metaanalysis update[J]. BMJ Open,2014,4(7):e005632.
[44]ISO H,DATE C,WAKAI K,et al. The relationship between green tea and total caffeine intake and risk for self-reported type 2 diabetes among Japanese adults[J]. Ann Intern Med,2006,144(8):554-562.
[45]MICALI S,TERRITO A,PIROLA G M,et al. Effect of green tea catechins in patients with high-grade prostatic intraepithelial neoplasia:Results of a short-term double-blind placebo controlled phase II clinical trial[J]. Arch Ital Urol Androl,2017,89(3):197-202.
[46]HUANG Y Q,LU X,MIN H,et al. Green tea and liver cancer risk:A meta-analysis of prospective cohort studies in Asian populations[J]. Nutrition,2016,32(1):3-8.
[47]TESCHKE R,SCHULZE J. Green tea and the question of reduced liver cancer risk:the dawn of potential clinical relevance?[J]. Hepatobiliary Surg Nutr,2017,6(2):122-126.
[48]YANG C S,LI G,YANG Z,et al. Cancer prevention by tocopherols and tea polyphenols[J]. Cancer Lett,2013,334(1):79-85.
[49]KIDA K,SUZUKI M,MATSUMOTO N,et al. Identification of biliary metabolites of(-)-epigallocatechin gallate in rats[J]. J Agric Food Chem,2000,48(9):4151-4155.
[50]SIDDIQUI I A,ADHAMI V M,BHARALI D J,et al. Introducing nanochemoprevention as a novel approach for cancer control:proof of principle with green tea polyphenol epigallocatechin-3-gallate[J]. Cancer Res,2009,69(5):1712-1716.
[51]WANG J,MAN G C W,CHAN T H,et al. A prodrug of green tea polyphenol(-)-epigallocatechin-3-gallate(Pro-EGCG)serves as a novel angiogenesis inhibitor in endometrial cancer[J]. Cancer Lett,2018,412:10-20.
[52]HEYZA J R,ARORA S,ZHANG H,et al. Targeting the DNA repair endonuclease ERCC1-XPF with green tea polyphenol epigallocatechin-3-gallate(EGCG)and its prodrug to enhance cisplatin efficacy in human cancer cells[J]. Nutrients,2018,10(11):66-76.
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