毛囊间充质干细胞研究进展
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摘要
毛囊间充质干细胞是来源于毛囊中胚层中的一类具有较强的增殖能力及多向分化能力的多能干细胞。毛囊间充质干细胞易于获得、对机体无损伤、无论理性争议,因此成为再生医学领域的重要种子细胞。毛囊间充质干细胞体外培养并定向分化的研究成为近年来一个热点研究方向。本文将对其近几年研究进展做一个阶段性的总结,并讨论其临床应用前景。
引文
[1] 张桂山,徐晶,姜怀志.MicroRNA对皮肤毛囊发育调控的研究进展[J].家畜生态学报,2013,34(6):1-4.
[2] WANG Y,LIU Z Y,ZHAO Q,et al.Future application of hair follicle stem cells:capable in differentiation into sweat gland cells[J].Chin Med J (Engl),2013,126(18):3545-3552.
[3] LI P D,LIU F L,WU C L,et al.Feasibility of human hair follicle-derived mesenchymal stem cells/CultiSpher(R)-G constructs in regenerative medicine[J].Cell Tissue Res,2015,362(1):69-86.
[4] COELHO DE OLIVEIRA V C,SILVA DOS SANTOS D,VAIRO L,et al.Hair follicle-derived mesenchymal cells support undifferentiated growth of embryonic stem cells[J].Exp Ther Med,2017,13(5):1779-1788.
[5] TEZUKA K,TOYOSHIMA K E,TSUJI T.Hair follicle regeneration by transplantation of a bioengineered hair follicle germ[J].Methods Mol Biol,2016,1453:71-84.
[6] 田瑞敏.龟板有效成分调控毛囊干细胞Wnt/BMP信号及其对压疮的影响[D].广州:广州中医药大学,2015.
[7] 刘菲,赵文杰,刘南,等.人参茎叶皂苷对毛囊间充质干细胞增殖的影响[J].黑龙江医药,2012,25(2):232-234.
[8] 刘菲.黄芩苷、人参茎叶皂苷对毛囊间充质干细胞的影响[D].长春:吉林农业大学,2012.
[9] BAI T T,LIU F L,ZOU F,et al.Epidermal growth factor induces proliferation of hair follicle-derived mesenchymal stem cells through epidermal growth factor receptor-mediated activation of ERK and AKT signaling pathways associated with upregulation of cyclin D1 and downregulation of p16[J].Stem Cells Dev,2017,26(2):113-122.
[10] KIRATIPAIBOON C,TENGAMNUAY P,CHANVORACHOTE P.Glycyrrhizic acid attenuates stem cell-like phenotypes of human dermal papilla cell[J].Phytomedicine,2015,22(14):1269-1278.
[11] 王瑶.毛囊干细胞的多分化潜能及其向汗腺细胞分化的实验研究[D].天津:南开大学,2013.
[12] QUAN R F,DU W B,ZHENG X,et al.VEGF165 induces differentiation of hair follicle stem cells into endothelial cells and plays a role in vivo angiogenesis[J].J Cell Mol Med,2017,21(8):1593-1604.
[13] WANG Z H,PANG L,ZHAO H Y,et al.miR-128 regulates differentiation of hair follicle mesenchymal stem cells into smooth muscle cells by targeting SMAD2[J].Acta Histochem,2016,118(4):393-400.
[14] LIU X J,SONG L,LIU J Y,et al.miR-18b inhibits TGF-β1-induced differentiation of hair follicle stem cells into smooth muscle cells by targeting SMAD2[J].Biochem Biophys Res Commun,2013,438(3):551-556.
[15] SON S,LIANG M S,LEI P,et al.Magnetofection mediated transient NANOG overexpression enhances proliferation and myogenic differentiation of human hair follicle derived mesenchymal stem cells[J].Bioconjug Chem,2015,26(7):1314-1327.
[16] LIU Z J,LU S J,LU Y,et al.Transdifferentiation of human hair follicle mesenchymal stem cells into red blood cells by OCT4[J].Stem Cells Int,2015,2015:389628.
[17] GAO Y H,LIU F L,ZHANG L H,et al.Acellular blood vessels combined human hair follicle mesenchymal stem cells for engineering of functional arterial grafts[J].Ann Biomed Eng,2014,42(10):2177-2189.
[18] ZHOU D,CHENG H J,LIU J Y,et al.Establishment of human hair follicle mesenchymal stem cells with overexpressed human hepatocyte growth factor[J].Iran J Basic Med Sci,2017,20(6):662-675.
[19] SHI X,Lü S,HE X,et al.Differentiation of hepatocytes from induced pluripotent stem cells derived from human hair follicle mesenchymal stem cells[J].Cell Tissue Res,2016,366(1):89-99.
[20] 石旭.人毛囊间充质源性iPSC向功能性肝细胞分化及低氧对其分化的调节作用[D].长春:吉林大学,2017.
[21] 寇俊娜.毛囊源性间充质干细胞在小鼠体内迁移及归巢的实验研究[D].长春:吉林大学,2016.
[22] WU C L,LIU F L,LI P D,et al.Engineered hair follicle mesenchymal stem cells overexpressing controlled-release insulin reverse hyperglycemia in mice with type L diabetes[J].Cell Transplant,2015,24(5):891-907.
[2] WANG Y,LIU Z Y,ZHAO Q,et al.Future application of hair follicle stem cells:capable in differentiation into sweat gland cells[J].Chin Med J (Engl),2013,126(18):3545-3552.
[3] LI P D,LIU F L,WU C L,et al.Feasibility of human hair follicle-derived mesenchymal stem cells/CultiSpher(R)-G constructs in regenerative medicine[J].Cell Tissue Res,2015,362(1):69-86.
[4] COELHO DE OLIVEIRA V C,SILVA DOS SANTOS D,VAIRO L,et al.Hair follicle-derived mesenchymal cells support undifferentiated growth of embryonic stem cells[J].Exp Ther Med,2017,13(5):1779-1788.
[5] TEZUKA K,TOYOSHIMA K E,TSUJI T.Hair follicle regeneration by transplantation of a bioengineered hair follicle germ[J].Methods Mol Biol,2016,1453:71-84.
[6] 田瑞敏.龟板有效成分调控毛囊干细胞Wnt/BMP信号及其对压疮的影响[D].广州:广州中医药大学,2015.
[7] 刘菲,赵文杰,刘南,等.人参茎叶皂苷对毛囊间充质干细胞增殖的影响[J].黑龙江医药,2012,25(2):232-234.
[8] 刘菲.黄芩苷、人参茎叶皂苷对毛囊间充质干细胞的影响[D].长春:吉林农业大学,2012.
[9] BAI T T,LIU F L,ZOU F,et al.Epidermal growth factor induces proliferation of hair follicle-derived mesenchymal stem cells through epidermal growth factor receptor-mediated activation of ERK and AKT signaling pathways associated with upregulation of cyclin D1 and downregulation of p16[J].Stem Cells Dev,2017,26(2):113-122.
[10] KIRATIPAIBOON C,TENGAMNUAY P,CHANVORACHOTE P.Glycyrrhizic acid attenuates stem cell-like phenotypes of human dermal papilla cell[J].Phytomedicine,2015,22(14):1269-1278.
[11] 王瑶.毛囊干细胞的多分化潜能及其向汗腺细胞分化的实验研究[D].天津:南开大学,2013.
[12] QUAN R F,DU W B,ZHENG X,et al.VEGF165 induces differentiation of hair follicle stem cells into endothelial cells and plays a role in vivo angiogenesis[J].J Cell Mol Med,2017,21(8):1593-1604.
[13] WANG Z H,PANG L,ZHAO H Y,et al.miR-128 regulates differentiation of hair follicle mesenchymal stem cells into smooth muscle cells by targeting SMAD2[J].Acta Histochem,2016,118(4):393-400.
[14] LIU X J,SONG L,LIU J Y,et al.miR-18b inhibits TGF-β1-induced differentiation of hair follicle stem cells into smooth muscle cells by targeting SMAD2[J].Biochem Biophys Res Commun,2013,438(3):551-556.
[15] SON S,LIANG M S,LEI P,et al.Magnetofection mediated transient NANOG overexpression enhances proliferation and myogenic differentiation of human hair follicle derived mesenchymal stem cells[J].Bioconjug Chem,2015,26(7):1314-1327.
[16] LIU Z J,LU S J,LU Y,et al.Transdifferentiation of human hair follicle mesenchymal stem cells into red blood cells by OCT4[J].Stem Cells Int,2015,2015:389628.
[17] GAO Y H,LIU F L,ZHANG L H,et al.Acellular blood vessels combined human hair follicle mesenchymal stem cells for engineering of functional arterial grafts[J].Ann Biomed Eng,2014,42(10):2177-2189.
[18] ZHOU D,CHENG H J,LIU J Y,et al.Establishment of human hair follicle mesenchymal stem cells with overexpressed human hepatocyte growth factor[J].Iran J Basic Med Sci,2017,20(6):662-675.
[19] SHI X,Lü S,HE X,et al.Differentiation of hepatocytes from induced pluripotent stem cells derived from human hair follicle mesenchymal stem cells[J].Cell Tissue Res,2016,366(1):89-99.
[20] 石旭.人毛囊间充质源性iPSC向功能性肝细胞分化及低氧对其分化的调节作用[D].长春:吉林大学,2017.
[21] 寇俊娜.毛囊源性间充质干细胞在小鼠体内迁移及归巢的实验研究[D].长春:吉林大学,2016.
[22] WU C L,LIU F L,LI P D,et al.Engineered hair follicle mesenchymal stem cells overexpressing controlled-release insulin reverse hyperglycemia in mice with type L diabetes[J].Cell Transplant,2015,24(5):891-907.